Efficacy of photobiomodulation therapy in recurrent herpes labialis management: a randomized controlled trial
CONCLUSIONS: Photobiomodulation therapy of herpes labialis reduced pain significantly faster than acyclovir, but there was no difference in healing time between the groups in light of the parameters used in this study.CLINICAL RELEVANCE: PBMT is a promising treatment that may be an effective alternative to acyclovir in the management of recurrent herpes labialis.TRIAL REGISTRATION ISRCTN: com ID: ISRCTN87606522.PMID:38376628 | DOI:10.1007/s00784-024-05541-5 (Source: Herpes)
Source: Herpes - February 20, 2024 Category: Infectious Diseases Authors: Mai Adnan Gaizeh Al-Hallak Karim Chalhoub Jamileh Ali Hsaian Abeer Ahmad Aljoujou Source Type: research
Efficacy of photobiomodulation therapy in recurrent herpes labialis management: a randomized controlled trial
ConclusionsPhotobiomodulation therapy of herpes labialis reduced pain significantly faster than acyclovir, but there was no difference in healing time between the groups in light of the parameters used in this study.Clinical relevancePBMT is a promising treatment that may be an effective alternative to acyclovir in the management of recurrent herpes labialis.Trial registrationisrctn.com ID: ISRCTN87606522. (Source: Clinical Oral Investigations)
Source: Clinical Oral Investigations - February 20, 2024 Category: Dentistry Source Type: research
A Rare Case of Varicella-Zoster Virus Meningitis With High Intracranial Pressure in an Immunocompetent Adult
Cureus. 2024 Jan 17;16(1):e52437. doi: 10.7759/cureus.52437. eCollection 2024 Jan.ABSTRACTVaricella-zoster virus (VZV) is an alphaherpesvirus causing varicella (chickenpox) and herpes zoster. While varicella typically presents with a vesicular rash, latent VZV may reactivate within the sensory ganglia causing shingles, characterized by painful vesicular rash, which may lead to neurologic complications such as aseptic meningitis. This case explores an atypical presentation in an immunocompetent young man with VZV meningitis lacking the characteristic skin rash but featuring elevated intracranial pressure. A literature revie...
Source: Herpes - February 19, 2024 Category: Infectious Diseases Authors: Awad Al Harbi Jameelah Saeedi Enas Almowalad Razan Alahmari Hana A Alzuabi Leenah Almanea AlAnoud AlAbdulhadi Source Type: research
A Rare Case of Varicella-Zoster Virus Meningitis With High Intracranial Pressure in an Immunocompetent Adult
Cureus. 2024 Jan 17;16(1):e52437. doi: 10.7759/cureus.52437. eCollection 2024 Jan.ABSTRACTVaricella-zoster virus (VZV) is an alphaherpesvirus causing varicella (chickenpox) and herpes zoster. While varicella typically presents with a vesicular rash, latent VZV may reactivate within the sensory ganglia causing shingles, characterized by painful vesicular rash, which may lead to neurologic complications such as aseptic meningitis. This case explores an atypical presentation in an immunocompetent young man with VZV meningitis lacking the characteristic skin rash but featuring elevated intracranial pressure. A literature revie...
Source: Herpes - February 19, 2024 Category: Infectious Diseases Authors: Awad Al Harbi Jameelah Saeedi Enas Almowalad Razan Alahmari Hana A Alzuabi Leenah Almanea AlAnoud AlAbdulhadi Source Type: research
Acyclovir Dosing in Herpes Encephalitis: A Scoping Review
CONCLUSION: Overall, there is a lack of consistency on which body weight to use to calculate acyclovir dose in obese patients. So it is recommended that further interventional studies compare the concentration of intravenous acyclovir between obese and non-obese patients and relating the resultant concentration with the kidney function of the patients.PMID:38364888 | DOI:10.1016/j.japh.2024.02.013 (Source: Herpes)
Source: Herpes - February 16, 2024 Category: Infectious Diseases Authors: Asma Aboelezz Sherif Hanafy Mahmoud Source Type: research
Image Significance in the Diagnosis of Another Case of Herpetic Encephalitis
We present the case of a 70-year-old male who came to the emergency department (ED) with fever and confusion. Despite an unclear cerebrospinal fluid (CSF) result, the CT scan showed a spot of hypodensity in the mesial aspect of the left temporal lobe. He was given 21 days of intravenous acyclovir, and his neurological condition normalized. These cranial CT alterations, although not pathognomonic, indicate a strong suspicion of herpetic encephalitis.PMID:38343703 | PMC:PMC10853675 | DOI:10.7759/cureus.53883 (Source: Herpes)
Source: Herpes - February 12, 2024 Category: Infectious Diseases Authors: Jos é Pedro Manata Bernardo Silva Mafalda Sousa Jo ão Matos Costa Source Type: research
Sensors, Vol. 24, Pages 1125: First Acyclovir Determination Procedure via Electrochemically Activated Screen-Printed Carbon Electrode Coupled with Well-Conductive Base Electrolyte
Keller
In this work, a new voltammetric procedure for acyclovir (ACY) trace-level determination has been described. For this purpose, an electrochemically activated screen-printed carbon electrode (aSPCE) coupled with well-conductive electrolyte (CH3COONH4, CH3COOH and NH4Cl) was used for the first time. A commercially available SPCE sensor was electrochemically activated by conducting cyclic voltammetry (CV) scans in 0.1 mol L−1 NaOH solution and rinsed with deionized water before a series of measurements were taken. This treatment reduced the charge transfer resistance, increased the electrode active s...
Source: Sensors - February 8, 2024 Category: Biotechnology Authors: Katarzyna Tyszczuk-Rotko Katarzyna Staniec Damian Gorylewski Aleksy Keller Tags: Article Source Type: research
Diagnosis of primary vitreoretinal lymphoma masquerading infectious retinitis by retinal biopsy
Conclusions and importanceAlthough uncommon, patients with vitreoretinal lymphoma may masquerade as infectious retinitis, and vitreoretinal lymphoma should be suspected when refractory to antiviral therapy and in the setting of a negative workup for viral etiologies. Vitrectomy with retinal biopsy may be considered to aid the diagnosis of vitreoretinal lymphoma although careful consideration of the risks and benefits is warranted. (Source: Journal of Ophthalmic Inflammation and Infection)
Source: Journal of Ophthalmic Inflammation and Infection - February 7, 2024 Category: Opthalmology Source Type: research
Viral Keratitis, Surgical Intervention in Viral Keratitis, Challenges in Diagnosis and Treatment of Viral Keratitis, HSV, HZV
Semin Ophthalmol. 2024 Feb 1:1-13. doi: 10.1080/08820538.2024.2309533. Online ahead of print.ABSTRACTViral keratitis is a significant cause of ocular morbidity and visual impairment worldwide. In recent years, there has been a growing understanding of the pathogenesis, clinical manifestations, and diagnostic modalities for viral keratitis. The most common viral pathogens associated with this condition are adenovirus, herpes simplex (HSV), and varicella-zoster virus (VZV). However, emerging viruses such as cytomegalovirus (CMV), Epstein-Barr virus (EBV), and Vaccinia virus can also cause keratitis. Non-surgical intervention...
Source: Seminars in Ophthalmology - February 2, 2024 Category: Opthalmology Authors: Anitha Venugopal Josephine Christy Vaidehi Raut Preethi P Veena Patwardhan Veeramma V Aditee Madkaikar Mangala P Ravindran Meenakshi Rangappa Ramakrishnan Source Type: research
Impact of High Dose Acyclovir Prophylaxis for the Prevention of Cytomegalovirus Reactivation after Pediatric Allogeneic Stem Cell Transplant
In the absence of cytomegalovirus (CMV) prophylaxis (ppx), CMV DNAemia occurs in up to 70% of allogeneic hematopoietic cell transplants (HCT). Post-HCT CMV infection can be life-threatening. Letermovir is routine for CMV ppx adult HCT, but not FDA approved for (Source: Biology of Blood and Marrow Transplantation)
Source: Biology of Blood and Marrow Transplantation - February 1, 2024 Category: Hematology Authors: Susie Long, Abbey Krebs, Beth Thielen, Christen L. Ebens Tags: 636 Source Type: research
Cytokine storm and severe hepatitis in pregnancy due to herpes simplex virus 2
AbstractCase presentationA pregnant woman developed hepatitis due to a herpes simplex virus 2 primary infection with a severe systemic inflammatory response. Treatment with acyclovir and human immunoglobulin was given and both mother and baby survived.PurposeWe provide the first description of the inflammatory response associated with herpetic hepatitis in pregnancy. (Source: Infection)
Source: Infection - January 25, 2024 Category: Infectious Diseases Source Type: research
Human conjunctiva organoids to study ocular surface homeostasis and disease
Cell Stem Cell. 2024 Feb 1;31(2):227-243.e12. doi: 10.1016/j.stem.2023.12.008. Epub 2024 Jan 11.ABSTRACTThe conjunctival epithelium covering the eye contains two main cell types: mucus-producing goblet cells and water-secreting keratinocytes, which present mucins on their apical surface. Here, we describe long-term expanding organoids and air-liquid interface representing mouse and human conjunctiva. A single-cell RNA expression atlas of primary and cultured human conjunctiva reveals that keratinocytes express multiple antimicrobial peptides and identifies conjunctival tuft cells. IL-4/-13 exposure increases goblet and tuf...
Source: Cell Stem Cell - January 12, 2024 Category: Stem Cells Authors: Marie Bannier-H élaouët Jeroen Korving Ziliang Ma Harry Begthel Amir Giladi Mart M Lamers Willine J van de Wetering Nobuyo Yawata Makoto Yawata Vanessa L S LaPointe Mor M Dickman Rachel Kalmann Saskia M Imhoff Johan H van Es Carmen L ópez-Iglesias Pete Source Type: research
Maximum likelihood estimation of renal transporter ontogeny profiles for pediatric PBPK modeling
AbstractOptimal treatment of infants with many renally cleared drugs must account for maturational differences in renal transporter (RT) activity. Pediatric physiologically-based pharmacokinetic (PBPK) models may incorporate RT activity, but this requires ontogeny profiles for RT activity in children, especially neonates, to predict drug disposition. Therefore, RT expression measurements from human kidney postmortem cortical tissue samples were normalized to represent a fraction of mature RT activity. Using these data, maximum likelihood estimated the distributions of RT activity across the pediatric age spectrum, includin...
Source: CPT: Pharmacometrics and Systems Pharmacology - January 10, 2024 Category: Drugs & Pharmacology Authors: J. Porter Hunt,
Samuel Dubinsky,
Autumn M. McKnite,
Kit Wun Kathy Cheung,
Bianca D. van Groen,
Kathleen M. Giacomini,
Saskia N. de Wildt,
Andrea N. Edginton,
Kevin M. Watt Tags: ARTICLE Source Type: research
Maximum likelihood estimation of renal transporter ontogeny profiles for pediatric PBPK modeling
AbstractOptimal treatment of infants with many renally cleared drugs must account for maturational differences in renal transporter (RT) activity. Pediatric physiologically based pharmacokinetic (PBPK) models may incorporate RT activity, but this requires ontogeny profiles for RT activity in children, especially neonates, to predict drug disposition. Therefore, RT expression measurements from human kidney postmortem cortical tissue samples were normalized to represent a fraction of mature RT activity. Using these data, maximum likelihood estimated the distributions of RT activity across the pediatric age spectrum, includin...
Source: CPT: Pharmacometrics and Systems Pharmacology - December 30, 2023 Category: Drugs & Pharmacology Authors: J. Porter Hunt,
Samuel Dubinsky,
Autumn M. McKnite,
Kit Wun Kathy Cheung,
Bianca D. van Groen,
Kathleen M. Giacomini,
Saskia N. de Wildt,
Andrea N. Edginton,
Kevin M. Watt Tags: ARTICLE Source Type: research
Virucidal effect of mouthwash on acyclovir-resistant herpes simplex virus
CONCLUSION: The findings of this analysis revealed that the tested oral rinses demonstrated in-vitro antiviral activity against ACV-resistant HSV. Comparative clinical trials are required to establish the clinical effectiveness of daily use of oral rinses in reducing the appearance of oral HSV lesions in immunocompromised patients.PMID:38151043 | DOI:10.1111/odi.14843 (Source: Herpes)
Source: Herpes - December 27, 2023 Category: Infectious Diseases Authors: M Bar Ilan S Dovrat R Cohen M Georgaki E Papadopoulou N G Nikitakis N Yarom Source Type: research
