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Associations between Different Antivirals and Hospital acquired Acute Kidney Injury in Adults with Herpes Zoster
CONCLUSIONS: Among antiviral therapies for herpes zoster, we found different risks of hospital acquired AKI among the patients receiving different antivirals, in particular, those administered intravenously. Among intravenous antivirals, acyclovir was associated with highest risk of hospital acquired AKI, followed by penciclovir/ganciclovir and foscarnet. Confirmation studies with large samples from other populations are warranted.PMID:38527975 | DOI:10.2215/CJN.0000000000000452 (Source: Clinical Journal of the American Society of Nephrology : CJASN)
Source: Clinical Journal of the American Society of Nephrology : CJASN - March 26, 2024 Category: Urology & Nephrology Authors: Ruqi Xu Qi Gao Yuping Zhang Yuxin Lin Yanqin Li Licong Su Shiyu Zhou Yue Cao Peiyan Gao Pingping Li Fan Luo Ruixuan Chen Xiaodong Zhang Sheng Nie Xin Xu CRDS study Investigators Source Type: research

Varicella-Zoster Meningitis and Myelitis After Herpes Zoster Dermatitis Treatment With Amenamevir: A Case Series and Literature Review
In this report, we present four cases of VZV meningitis and myelitis following amenamevir treatment for HZ dermatitis with positive VZV DNA in cerebrospinal fluid (CSF) revealed by polymerase chain reaction (PCR). Three of them were considered immunocompromised hosts given the fact that two of these patients were taking immunosuppressive drugs for rheumatoid arthritis, and one patient had a history of sigmoid colon cancer (four months after resection). After HZ onset, amenamevir, which has poor CSF transfer, was prescribed for all the patients, and all of them developed central nervous complications by VZV (meningitis in t...
Source: Herpes - March 25, 2024 Category: Infectious Diseases Authors: Satoru Tada Yuta Kaito Akihiro Watanabe Yukio Sugiyama Akira Nishigaichi Takashi Miwa Kotaro Watanabe Takanori Hazama Daisuke Takahashi Source Type: research

Viruses, Vol. 16, Pages 464: Brincidofovir Effectively Inhibits Proliferation of Pseudorabies Virus by Disrupting Viral Replication
Xiangru Wang Pseudorabies is an acute and febrile infectious disease caused by pseudorabies virus (PRV), a member of the family Herpesviridae. Currently, PRV is predominantly endemoepidemic and has caused significant economic losses among domestic pigs. Other animals have been proven to be susceptible to PRV, with a mortality rate of 100%. In addition, 30 human cases of PRV infection have been reported in China since 2017, and all patients have shown severe neurological symptoms and eventually died or developed various neurological sequelae. In these cases, broad-spectrum anti-herpesvirus drugs and integrated treatm...
Source: Viruses - March 18, 2024 Category: Virology Authors: Huihui Guo Qingyun Liu Dan Yang Hao Zhang Yan Kuang Yafei Li Huanchun Chen Xiangru Wang Tags: Article Source Type: research

Trigeminal Neuralgia Secondary to Herpes Simplex Virus Type 1 Infection Treated With Oral Acyclovir
We report the case of a 30-year-old woman who developed oral HSV-1 lesions followed by right-sided TN pain. MRI of the brain did not reveal neurovascular compression. TN pain completely resolved with oral acyclovir treatment alone, without anticonvulsants. This highlights the importance of considering atypical etiologies such as HSV-1 reactivation in TN evaluation. Early antiviral therapy may treat underlying inflammation and provide sustained symptom relief in HSV-associated TN.PMID:38487110 | PMC:PMC10939157 | DOI:10.7759/cureus.54128 (Source: Herpes)
Source: Herpes - March 15, 2024 Category: Infectious Diseases Authors: Amal J Alfaifi Ohood S Wasli Thamer M Almalki Ahmad Y Alqassim Source Type: research

Clinical features of atypical presentations of mucocutaneous herpes simplex virus infection observed in immunosuppressed individuals. Part I: herpetic geometric glossitis
Herpetic geometric glossitis is a unique morphologic variant of HSV (herpes simplex virus) type 1 infection on the dorsum of the tongue that presents as an extremely painful linear central lingual fissure with a branched pattern. in the center of the tongue; there is a branched pattern of fissures that extend bilaterally from the central linear fissure. Herpetic geometric glossitis has been reported in 11 patients; 8 of these individuals were immunocompromised. Medical conditions and immunosuppressive medication treatment (7 patients) or only medical disorders (3 patients) or neither (1 patient) were present. HSV type 1 in...
Source: Dermatology Online Journal - March 12, 2024 Category: Dermatology Authors: Cohen, Philip R Source Type: research

Resorbable nanofibrous membranes for local and sustained co-delivery of acyclovir and ketorolac in herpes therapy
This study used electrospinning to develop biodegradable nanofibrous poly(lactic-co-glycolic acid) (PLGA) membranes for delivery of both acyclovir and ketorolac. The structure of the spun nanofibers was assessed via scanning electron microscopy (SEM), and the appearance of loaded acyclovir and ketorolac in the nanofibers was confirmed with Fourier-transform infrared spectroscopy (FTIR) and differential scanning calorimetry (DSC). Release profiles of these drugs from the nanofibrous membranes were assessed using in vitro elution studies, high-performance liquid chromatography (HPLC) assays, and in vivo drug release patterns...
Source: Herpes - March 11, 2024 Category: Infectious Diseases Authors: Shih-Jyun Shen Pin-Chao Feng Ren-Chin Wu Yi-Hua Kuo Shih-Jung Liu Hiroshi Ito Source Type: research

Four new resin glycosides from Ipomoea muricata seeds: muricatins XIV-XVII
J Nat Med. 2024 Mar 8. doi: 10.1007/s11418-024-01787-1. Online ahead of print.ABSTRACTIpomoea muricata (L.) Jacq. seeds (Convolvulaceae) are used as a traditional laxative and carminative medicine. Muricatins XIV (1), XV (2), XVI (3), and XVII (4), were isolated from I. muricata seeds as four new resin glycosides, along with seven known compounds, three of which were isolated for the first time as natural products; their structures were determined using MS and NMR spectroscopy. Compounds 1-4 are macrolactones (jalapins); the sugar moieties of 1, 2, and 4 are partially acylated with 2S-methylbutyric acid, while that of 3 is...
Source: Herpes - March 8, 2024 Category: Infectious Diseases Authors: Masateru Ono Daiki Tenmaya Maki Tarumi Syouri Satou Kotone Tsuji Hirotaka Nishikawa Shin Yasuda Hiroyuki Miyashita Jian-Rong Zhou Kazumi Yokomizo Hitoshi Yoshimitsu Ryota Tsuchihashi Masafumi Okawa Junei Kinjo Source Type: research

Four new resin glycosides from Ipomoea muricata seeds: muricatins XIV –XVII
AbstractIpomoea muricata (L.) Jacq. seeds (Convolvulaceae) are used as a traditional laxative and carminative medicine. Muricatins XIV (1), XV (2), XVI (3), and XVII (4), were isolated from I. muricata seeds as four new resin glycosides, along with seven known compounds, three of which were isolated for the first time as natural products; their structures were determined using MS and NMR spectroscopy. Compounds1–4 are macrolactones (jalapins); the sugar moieties of1,2, and4 are partially acylated with 2S-methylbutyric acid, while that of3 is esterified with 2S-methylbutyric and 2S-methyl-3S-hydroxybutyric acids. In addit...
Source: Journal of Natural Medicines - March 8, 2024 Category: Drugs & Pharmacology Source Type: research