Bilateral Acute Retinal Necrosis Treated With Antivirals and Corticosteroids
We report on the case of a Hispanic male with bilateral acute retinal necrosis (BARN), whose disease was managed with intravenous acyclovir, topical prednisolone, topical atropine, intravitreal ganciclovir, oral valacyclovir, and oral prednisone. The oral corticosteroid was added to his treatment regimen eight days after his initial presentation. The 55-year-old patient presented with a two-week history of bilateral blurred vision. His medical history was pertinent for remote varicella and herpes zoster (the latter limited to the forehead). His best-corrected visual acuity (BCVA) was counting fingers in both eyes (OU). His...
Source: Herpes - November 29, 2023 Category: Infectious Diseases Authors: Estefania Ramirez Marquez Alejandra Santiago Israel Mendez Jan C Santiago Jos é J López-Fontanet Noraliz Garcia Armando L Oliver Source Type: research
Viruses, Vol. 15, Pages 2340: Flavonoids with Anti-Herpes Simplex Virus Properties: Deciphering Their Mechanisms in Disrupting the Viral Life Cycle
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The herpes simplex virus (HSV) is a double-stranded DNA human virus that causes persistent infections with recurrent outbreaks. HSV exists in two forms: HSV-1, responsible for oral herpes, and HSV-2, primarily causing genital herpes. Both types can lead to significant complications, including neurological issues. Conventional treatment, involving acyclovir and its derivatives, faces challenges due to drug resistance. This underscores the imperative for continual research and development of new drugs, with a particular emphasis on exploring the potential of natural antivirals. Flavonoids have demonstrated promise in...
Source: Viruses - November 29, 2023 Category: Virology Authors: Miroslava Šudomová Sherif T. S. Hassan Tags: Review Source Type: research
Unique Attributes of Guinea Pigs as New Models to Study Ocular Herpes Pathophysiology and Recurrence
CONCLUSIONS: This study demonstrates the potential suitability of guinea pigs as new models for ocular HSV-1 investigations, filling a critical preclinical void of models capable of showcasing spontaneous HSV reactivation in the eye. The observed similarities and differences in the reactions of guinea pigs and rabbits to HSV-1 infection and treatments provide crucial insights, laying the foundation for future studies on ocular HSV pathogenesis, latency, and improved treatment options.PMID:38015175 | DOI:10.1167/iovs.64.14.41 (Source: Herpes)
Source: Herpes - November 28, 2023 Category: Infectious Diseases Authors: Tejabhiram Yadavalli Chandrashekhar Patil Pankaj Sharma Ipsita Volety Hemant Borase Divya Kapoor Deepak Shukla Source Type: research
Unique Attributes of Guinea Pigs as New Models to Study Ocular Herpes Pathophysiology and Recurrence
CONCLUSIONS: This study demonstrates the potential suitability of guinea pigs as new models for ocular HSV-1 investigations, filling a critical preclinical void of models capable of showcasing spontaneous HSV reactivation in the eye. The observed similarities and differences in the reactions of guinea pigs and rabbits to HSV-1 infection and treatments provide crucial insights, laying the foundation for future studies on ocular HSV pathogenesis, latency, and improved treatment options.PMID:38015175 | DOI:10.1167/iovs.64.14.41 (Source: Herpes)
Source: Herpes - November 28, 2023 Category: Infectious Diseases Authors: Tejabhiram Yadavalli Chandrashekhar Patil Pankaj Sharma Ipsita Volety Hemant Borase Divya Kapoor Deepak Shukla Source Type: research
Synergistic In Vitro Antiviral Effect of Combinations of Ivermectin, Essential Oils, and 18-(Phthalimid-2-yl)ferruginol against Arboviruses and Herpesvirus
Pharmaceuticals (Basel). 2023 Nov 13;16(11):1602. doi: 10.3390/ph16111602.ABSTRACTCombining antiviral drugs with different mechanisms of action can help prevent the development of resistance by attacking the infectious agent through multiple pathways. Additionally, by using faster and more economical screening methods, effective synergistic drug candidates can be rapidly identified, facilitating faster paths to clinical testing. In this work, a rapid method was standardized to identify possible synergisms from drug combinations. We analyzed the possible reduction in the antiviral effective concentration of drugs already ap...
Source: Herpes - November 25, 2023 Category: Infectious Diseases Authors: Liliana Betancur-Galvis Orlando Jos é Jimenez-Jarava Fatima Rivas William E Mendoza-Hern ández Miguel A Gonz ález-Cardenete Source Type: research
Korean Chestnut Honey Suppresses HSV-1 Infection by Regulating the ROS-NLRP3 Inflammasome Pathway
Antioxidants (Basel). 2023 Oct 30;12(11):1935. doi: 10.3390/antiox12111935.ABSTRACTHerpes simplex virus 1 (HSV-1) is double-stranded DNA virus that belongs to the Orthoherpesviridae family. It causes serious neurological diseases of the central nervous system, such as encephalitis. The current U.S. Food and Drug Administration (FDA)-approved drugs for preventing HSV-1 infection include acyclovir (ACV) and valacyclovir; however, their long-term use causes severe side effects and often results in the emergence of drug-resistant strains. Therefore, it is important to discover new antiviral agents that are safe and effective a...
Source: Herpes - November 25, 2023 Category: Infectious Diseases Authors: Eun-Bin Kwon Young Soo Kim Buyun Kim Se-Gun Kim Sung-Joon Na Younghoon Go Hong Min Choi Hye Jin Lee Sang Mi Han Jang-Gi Choi Source Type: research
Synergistic In Vitro Antiviral Effect of Combinations of Ivermectin, Essential Oils, and 18-(Phthalimid-2-yl)ferruginol against Arboviruses and Herpesvirus
Pharmaceuticals (Basel). 2023 Nov 13;16(11):1602. doi: 10.3390/ph16111602.ABSTRACTCombining antiviral drugs with different mechanisms of action can help prevent the development of resistance by attacking the infectious agent through multiple pathways. Additionally, by using faster and more economical screening methods, effective synergistic drug candidates can be rapidly identified, facilitating faster paths to clinical testing. In this work, a rapid method was standardized to identify possible synergisms from drug combinations. We analyzed the possible reduction in the antiviral effective concentration of drugs already ap...
Source: Herpes - November 25, 2023 Category: Infectious Diseases Authors: Liliana Betancur-Galvis Orlando Jos é Jimenez-Jarava Fatima Rivas William E Mendoza-Hern ández Miguel A Gonz ález-Cardenete Source Type: research
Korean Chestnut Honey Suppresses HSV-1 Infection by Regulating the ROS-NLRP3 Inflammasome Pathway
Antioxidants (Basel). 2023 Oct 30;12(11):1935. doi: 10.3390/antiox12111935.ABSTRACTHerpes simplex virus 1 (HSV-1) is double-stranded DNA virus that belongs to the Orthoherpesviridae family. It causes serious neurological diseases of the central nervous system, such as encephalitis. The current U.S. Food and Drug Administration (FDA)-approved drugs for preventing HSV-1 infection include acyclovir (ACV) and valacyclovir; however, their long-term use causes severe side effects and often results in the emergence of drug-resistant strains. Therefore, it is important to discover new antiviral agents that are safe and effective a...
Source: Herpes - November 25, 2023 Category: Infectious Diseases Authors: Eun-Bin Kwon Young Soo Kim Buyun Kim Se-Gun Kim Sung-Joon Na Younghoon Go Hong Min Choi Hye Jin Lee Sang Mi Han Jang-Gi Choi Source Type: research
Varicella-associated disseminated intravascular coagulation secondary to Henoch-Sch önlein purpura with renal and gastrointestinal system involvement in a child: A case report
Medicine (Baltimore). 2023 Nov 17;102(46):e36203. doi: 10.1097/MD.0000000000036203.ABSTRACTRATIONALE: Immunocompromised patients who developed varicella-zoster virus (VZV)-associated disseminated intravascular coagulation (DIC) previously included recipients of bone marrow, hematopoietic stem cell, or organ transplantations, patients with primary nephropathy receiving corticosteroid therapy, cancer patients receiving chemotherapy, and patients with human immune deficiency virus infection. The case reported here is novel because, to our knowledge, there has been no report of VZV-associated DIC after the onset of Henoch-SchÃ...
Source: Cancer Control - November 21, 2023 Category: Cancer & Oncology Authors: Jing Jiang Kai Liao Hui Guo Xiu-Ying Chen Source Type: research
Large Subunit of the Human Herpes Simplex Virus Terminase as a Promising Target in Design of Anti-Herpesvirus Agents
Molecules. 2023 Oct 31;28(21):7375. doi: 10.3390/molecules28217375.ABSTRACTHerpes simplex virus type 1 (HSV-1) is an extremely widespread pathogen characterized by recurrent infections. HSV-1 most commonly causes painful blisters or sores around the mouth or on the genitals, but it can also cause keratitis or, rarely, encephalitis. First-line and second-line antiviral drugs used to treat HSV infections, acyclovir and related compounds, as well as foscarnet and cidofovir, selectively inhibit herpesvirus DNA polymerase (DNA-pol). It has been previously found that (S)-4-[6-(purin-6-yl)aminohexanoyl]-7,8-difluoro-3,4-dihydro-3...
Source: Herpes - November 14, 2023 Category: Infectious Diseases Authors: Victor P Krasnov Valeriya L Andronova Alexander V Belyavsky Sophia S Borisevich George A Galegov Oleg F Kandarakov Dmitry A Gruzdev Olga A Vozdvizhenskaya Galina L Levit Source Type: research
In Silico Pharmacokinetics, Molecular Docking and Molecular Dynamics Simulation Studies of Nucleoside Analogs for Drug Discovery- A Mini Review
This article portrays the current status of these methods and highlights some remarkable contributions to the development of nucleoside analogs with optimized bioactivity.PMID:37957918 | DOI:10.2174/0113895575258033231024073521 (Source: Mini Reviews in Medicinal Chemistry)
Source: Mini Reviews in Medicinal Chemistry - November 14, 2023 Category: Chemistry Authors: Sarkar M A Kawsar Nasrin S Munia Supriyo Saha Yasuhiro Ozeki Source Type: research
Large Subunit of the Human Herpes Simplex Virus Terminase as a Promising Target in Design of Anti-Herpesvirus Agents
Molecules. 2023 Oct 31;28(21):7375. doi: 10.3390/molecules28217375.ABSTRACTHerpes simplex virus type 1 (HSV-1) is an extremely widespread pathogen characterized by recurrent infections. HSV-1 most commonly causes painful blisters or sores around the mouth or on the genitals, but it can also cause keratitis or, rarely, encephalitis. First-line and second-line antiviral drugs used to treat HSV infections, acyclovir and related compounds, as well as foscarnet and cidofovir, selectively inhibit herpesvirus DNA polymerase (DNA-pol). It has been previously found that (S)-4-[6-(purin-6-yl)aminohexanoyl]-7,8-difluoro-3,4-dihydro-3...
Source: Herpes - November 14, 2023 Category: Infectious Diseases Authors: Victor P Krasnov Valeriya L Andronova Alexander V Belyavsky Sophia S Borisevich George A Galegov Oleg F Kandarakov Dmitry A Gruzdev Olga A Vozdvizhenskaya Galina L Levit Source Type: research
In Silico Pharmacokinetics, Molecular Docking and Molecular Dynamics Simulation Studies of Nucleoside Analogs for Drug Discovery- A Mini Review
This article portrays the current status of these methods and highlights some remarkable contributions to the development of nucleoside analogs with optimized bioactivity.PMID:37957918 | DOI:10.2174/0113895575258033231024073521 (Source: Mini Reviews in Medicinal Chemistry)
Source: Mini Reviews in Medicinal Chemistry - November 14, 2023 Category: Chemistry Authors: Sarkar M A Kawsar Nasrin S Munia Supriyo Saha Yasuhiro Ozeki Source Type: research
In Silico Pharmacokinetics, Molecular Docking and Molecular Dynamics Simulation Studies of Nucleoside Analogs for Drug Discovery- A Mini Review
This article portrays the current status of these methods and highlights some remarkable contributions to the development of nucleoside analogs with optimized bioactivity.PMID:37957918 | DOI:10.2174/0113895575258033231024073521 (Source: Mini Reviews in Medicinal Chemistry)
Source: Mini Reviews in Medicinal Chemistry - November 14, 2023 Category: Chemistry Authors: Sarkar M A Kawsar Nasrin S Munia Supriyo Saha Yasuhiro Ozeki Source Type: research
In Silico Pharmacokinetics, Molecular Docking and Molecular Dynamics Simulation Studies of Nucleoside Analogs for Drug Discovery- A Mini Review
This article portrays the current status of these methods and highlights some remarkable contributions to the development of nucleoside analogs with optimized bioactivity.PMID:37957918 | DOI:10.2174/0113895575258033231024073521 (Source: Mini Reviews in Medicinal Chemistry)
Source: Mini Reviews in Medicinal Chemistry - November 14, 2023 Category: Chemistry Authors: Sarkar M A Kawsar Nasrin S Munia Supriyo Saha Yasuhiro Ozeki Source Type: research
