Herpetic Keratouveitis: Missed Diagnosis Leading to Corneal Perforation
We report a case of a 70-year-old female who presented with redness and painless blurry vision in her right eye and was treated with topical corticosteroid drops for presumed idiopathic anterior uveitis. Despite initial symptomatic improvement, she reattended with a significant deterioration in vision and was found to have a large corneal infiltrate and associated perforation. The perforation was sealed with corneal gluing, and she was treated for presumed herpetic anterior uveitis with oral acyclovir. Corneal polymerase chain reaction (PCR) specimen was positive for herpes simplex virus DNA. The perforation started to lea...
Source: Herpes - March 6, 2024 Category: Infectious Diseases Authors: Kirupakaran Arun Panagiotis Georgoudis Source Type: research
A Multicenter Assessment of the Outcomes and Toxicities of Foscarnet for Treatment of Acyclovir-Resistant Mucocutaneous Herpes Simplex in Immunocompromised Patients
CONCLUSIONS: Among 31 episodes of HSV treated with foscarnet, only half resolved with treatment, and adverse events were common.PMID:38444818 | PMC:PMC10914364 | DOI:10.1093/ofid/ofae046 (Source: Herpes)
Source: Herpes - March 6, 2024 Category: Infectious Diseases Authors: Sarah P Hammond Manickam Rangaraju Melanie Sumner Burkhard Timmler Pranatharthi Chandrasekar Robin K Avery Source Type: research
Herpetic Keratouveitis: Missed Diagnosis Leading to Corneal Perforation
We report a case of a 70-year-old female who presented with redness and painless blurry vision in her right eye and was treated with topical corticosteroid drops for presumed idiopathic anterior uveitis. Despite initial symptomatic improvement, she reattended with a significant deterioration in vision and was found to have a large corneal infiltrate and associated perforation. The perforation was sealed with corneal gluing, and she was treated for presumed herpetic anterior uveitis with oral acyclovir. Corneal polymerase chain reaction (PCR) specimen was positive for herpes simplex virus DNA. The perforation started to lea...
Source: Herpes - March 6, 2024 Category: Infectious Diseases Authors: Kirupakaran Arun Panagiotis Georgoudis Source Type: research
A Multicenter Assessment of the Outcomes and Toxicities of Foscarnet for Treatment of Acyclovir-Resistant Mucocutaneous Herpes Simplex in Immunocompromised Patients
CONCLUSIONS: Among 31 episodes of HSV treated with foscarnet, only half resolved with treatment, and adverse events were common.PMID:38444818 | PMC:PMC10914364 | DOI:10.1093/ofid/ofae046 (Source: Herpes)
Source: Herpes - March 6, 2024 Category: Infectious Diseases Authors: Sarah P Hammond Manickam Rangaraju Melanie Sumner Burkhard Timmler Pranatharthi Chandrasekar Robin K Avery Source Type: research
Herpes simplex encephalitis initially presenting without fever or cerebrospinal fluid pleocytosis and with typical neuroimaging findings
Encephalitis. 2024 Mar 5. doi: 10.47936/encephalitis.2023.00220. Online ahead of print.ABSTRACTHerpes simplex encephalitis (HSE) is a common viral encephalitis that can be fatal if not adequately treated. Fever, cerebrospinal fluid (CSF) pleocytosis, and typical neuroimaging findings are commonly observed in HSE cases. We encountered a patient with HSE who did not exhibit these classic clinical features. A 63-year-old male presented with his first-ever seizure. Fever did not develop until the fourth day of admission, and neither neuroimaging nor CSF analysis revealed abnormalities. Under suspicion of autoimmune encephaliti...
Source: Herpes - March 5, 2024 Category: Infectious Diseases Authors: Yoonjeong Na Jung-Ju Lee Byung Kun Kim Woong-Woo Lee Yong Soo Kim Ilhan Yoo Source Type: research
Development and Fabrication of a Molecularly Imprinted Polymer-Based Electroanalytical Sensor for the Determination of Acyclovir
ACS Omega. 2024 Feb 12;9(8):9564-9576. doi: 10.1021/acsomega.3c09399. eCollection 2024 Feb 27.ABSTRACTAcyclovir (ACV), a synthetic nucleoside derivative of purine, is one of the most potent antiviral medications recommended in the specific management of varicella-zoster and herpes simplex viruses. The molecularly imprinted polymer (MIP) was utilized to create an effective and specific electrochemical sensor using a straightforward photopolymerization process to determine ACV. The polymeric thin coating was developed using the template molecule ACV, a functional monomer acrylamide, a basic monomer 2-hydroxyethyl methacrylat...
Source: Herpes - March 4, 2024 Category: Infectious Diseases Authors: Abdullah Al Faysal Ahmet Cetinkaya Sariye Irem Kaya Taner Erdo ğan Sibel A Ozkan Ay şegül Gölcü Source Type: research
Development and Fabrication of a Molecularly Imprinted Polymer-Based Electroanalytical Sensor for the Determination of Acyclovir
ACS Omega. 2024 Feb 12;9(8):9564-9576. doi: 10.1021/acsomega.3c09399. eCollection 2024 Feb 27.ABSTRACTAcyclovir (ACV), a synthetic nucleoside derivative of purine, is one of the most potent antiviral medications recommended in the specific management of varicella-zoster and herpes simplex viruses. The molecularly imprinted polymer (MIP) was utilized to create an effective and specific electrochemical sensor using a straightforward photopolymerization process to determine ACV. The polymeric thin coating was developed using the template molecule ACV, a functional monomer acrylamide, a basic monomer 2-hydroxyethyl methacrylat...
Source: Herpes - March 4, 2024 Category: Infectious Diseases Authors: Abdullah Al Faysal Ahmet Cetinkaya Sariye Irem Kaya Taner Erdo ğan Sibel A Ozkan Ay şegül Gölcü Source Type: research
Ramsay Hunt Syndrome Associated with Varicella-Zoster Virus Encephalitis in a Child
We report the case of an 8-year-old previously healthy boy who presented to a tertiary care hospital in Muscat, Oman in 2021 with fever, progressive left ear pain, vesicular rash around his ear pinna and left-sided facial nerve palsy. His course was complicated by VZV encephalitis where he was managed with intravenous (IV) acyclovir and IV corticosteroids. He improved significantly and was asymptomatic with a normal neurology examination at the 6-months follow-up.PMID:38434459 | PMC:PMC10906755 | DOI:10.18295/squmj.3.2023.020 (Source: Herpes)
Source: Herpes - March 4, 2024 Category: Infectious Diseases Authors: Eman Y Ahmed Hatem Al Rawahi Fatema Al Amrani Laila Al Masaoudi Laila Al Yazidi Source Type: research
Effect of resveratrol on herpesvirus encephalitis: Evidences for its mechanisms of action
CONCLUSION: Resveratrol acted as a non-classical HSP90β inhibitor, binding to the STING-HSP90β interaction site to promote STING degradation and attenuate HSV-1-induced encephalitis and neuroinflammation. These findings suggest the alternative strategy of targeting HSP90β and resveratrol-mediated inhibition of HSP90β as a potential antiviral approach.PMID:38430586 | DOI:10.1016/j.phymed.2024.155476 (Source: Herpes)
Source: Herpes - March 2, 2024 Category: Infectious Diseases Authors: Ziwei Huang Shan Li Lishan Zhong Yuan Su Menghe Li Xiaohui Wang Zexu Wang Zhiping Wang Cuifang Ye Zhe Ren Xiao Wang Qiongzhen Zeng Kai Zheng Yifei Wang Source Type: research
Effect of resveratrol on herpesvirus encephalitis: Evidences for its mechanisms of action
CONCLUSION: Resveratrol acted as a non-classical HSP90β inhibitor, binding to the STING-HSP90β interaction site to promote STING degradation and attenuate HSV-1-induced encephalitis and neuroinflammation. These findings suggest the alternative strategy of targeting HSP90β and resveratrol-mediated inhibition of HSP90β as a potential antiviral approach.PMID:38430586 | DOI:10.1016/j.phymed.2024.155476 (Source: Herpes)
Source: Herpes - March 2, 2024 Category: Infectious Diseases Authors: Ziwei Huang Shan Li Lishan Zhong Yuan Su Menghe Li Xiaohui Wang Zexu Wang Zhiping Wang Cuifang Ye Zhe Ren Xiao Wang Qiongzhen Zeng Kai Zheng Yifei Wang Source Type: research
Hemophagocytic lymphohistiocytosis caused by herpes simplex virus type 1 in a young adult: a case report with literature review
This study aims to provide a comprehensive overview of the clinical characteristics and treatment outcomes associated with HSV-1-induced HLH. We herein report an adult case of hemophagocytic lymphohistiocytosis caused by herpes simplex virus type 1, diagnosed on the basis of peripheral blood metagenomic next-generation sequencing results. The patient exhibited a favorable response to treatment, involving dexamethasone, intravenous immunoglobulin, and acyclovir. Notably, etoposide administration was deemed unnecessary, and there has been no recurrence of the disease within the year following treatment. Early and sensitive r...
Source: Journal of Hematopathology - February 29, 2024 Category: Pathology Source Type: research
Hemophagocytic lymphohistiocytosis caused by herpes simplex virus type 1 in a young adult: a case report with literature review
This study aims to provide a comprehensive overview of the clinical characteristics and treatment outcomes associated with HSV-1-induced HLH. We herein report an adult case of hemophagocytic lymphohistiocytosis caused by herpes simplex virus type 1, diagnosed on the basis of peripheral blood metagenomic next-generation sequencing results. The patient exhibited a favorable response to treatment, involving dexamethasone, intravenous immunoglobulin, and acyclovir. Notably, etoposide administration was deemed unnecessary, and there has been no recurrence of the disease within the year following treatment. Early and sensitive r...
Source: Herpes - February 28, 2024 Category: Infectious Diseases Authors: Hanqing Zhang Peng Zhang Zhifang Xiao Yang Gao Na Han Xianjun He Jinfeng Zhang Yonghua Li Source Type: research
Herpes Simplex Keratitis as a Complication of Pterygium Surgery
CONCLUSIONS HSK is a rare but serious complication that can arise after uneventful pterygium surgery. It is worthy of attention that both epithelial and stromal forms can occur. Timely diagnosis and treatment are crucial to prevent unfavorable outcomes. Consequently, routine corneal fluorescein staining, tear sIgA examination, and corneal scraping for polymerase chain reaction or next-generation sequencing of metagenomics should be performed in any suspected cases.PMID:38400535 | DOI:10.12659/AJCR.942401 (Source: Herpes)
Source: Herpes - February 24, 2024 Category: Infectious Diseases Authors: Xinhan Cui Jini Qiu Feifei Huang Chaoran Zhang Tingting Shao Yan Wang Source Type: research
Kaposi varicelliform eruption: an unusual presentation caused by varicella zoster virus in a healthy adult patient - a case report
CONCLUSION: This case underscores the importance of prompt KVE identification and consideration of antiviral therapy to enhance patient outcomes. Further research is warranted to elucidate predisposing factors for this rare condition.PMID:38388418 | DOI:10.1186/s12879-024-09115-4 (Source: Herpes)
Source: Herpes - February 22, 2024 Category: Infectious Diseases Authors: Hassan El-Masry Safia Essam Hamed Gaber Nour Shaheen Ahmed Abdelbary Naglaa Mohamed Sayed Salma Samir Omar Source Type: research
Efficacy of photobiomodulation therapy in recurrent herpes labialis management: a randomized controlled trial
CONCLUSIONS: Photobiomodulation therapy of herpes labialis reduced pain significantly faster than acyclovir, but there was no difference in healing time between the groups in light of the parameters used in this study.CLINICAL RELEVANCE: PBMT is a promising treatment that may be an effective alternative to acyclovir in the management of recurrent herpes labialis.TRIAL REGISTRATION ISRCTN: com ID: ISRCTN87606522.PMID:38376628 | DOI:10.1007/s00784-024-05541-5 (Source: Herpes)
Source: Herpes - February 20, 2024 Category: Infectious Diseases Authors: Mai Adnan Gaizeh Al-Hallak Karim Chalhoub Jamileh Ali Hsaian Abeer Ahmad Aljoujou Source Type: research
