Analysis of antiviral drug properties of thymidine kinase of herpes B virus using recombinant herpes simplex virus 1

In this study, we examined the property of BV thymidine kinase (TK) against anti-herpes drugs using a recombinant herpes simplex virus type 1 (HSV-1) carrying BV TK gene. We found that HSV-1 carrying BV TK was similarly sensitive to GCV as HSV-1 carrying varicella zoster virus TK. In addition, we demonstrated that BV TK was not mutated in the GCV- and ACV-resistant HSV-1 carrying BV TK, suggesting that ACV- or GCV-resistant BV might be rare during treatment with these antiviral drugs. These data can provide a new insight into the properties of BV TK in terms of the development of drug resistance.PMID:38095468 | DOI:10.1128/spectrum.03091-23
Source: Herpes - Category: Infectious Diseases Authors: Source Type: research