Institute and Center Award Rates and Funding Disparities

In 2011, Ginther et al. first demonstrated that African American and Black applicants to the National Institutes of Health received grant awards at a lower rate than their white counterparts (Ginther 2011). Since then, multiple studies have reproduced and extended this finding (Ginther 2011; Ginther 2016; Hoppe 2019; Erosheva 2020). Recently we reported that African American and Black (AAB) PIs are more likely to propose research on topics that are less likely  to be funded (Hoppe 2019). We found that topic choice has little or no effect on whether an application is chosen for discussion, but after considering a number of confounders, it accounts for over 20% of the gap in funding success for applications that are discussed (Hoppe 2019). Why are applications linked to certain topics less likely to be funded?  Review is not the only determinant that considers whether any given application will be funded. At the same time that applications are assigned to a study section for review, they are also independently assigned to a funding Institute or Center (IC), based in large part on the topic of the work.  Figure 1 shows that ICs have widely varying award rates (the ratio of funded applications to all applications). These marked variations (from 9.1% to 26.9%) may explain funding differences, a possibility that we did not consider in Hoppe 2019. Figure 1. IC award rates for R01 applications, FY11-FY15. MD, Minority Health and Health Dispar...
Source: NIH Extramural Nexus - Category: Research Authors: Tags: blog Open Mike Funding data Source Type: funding

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This study estimated the prevalence, awareness, treatment, and control of hypertension among young and middle-aged adults in rural Morogoro, Tanzania. Furthermore, it explored factors associated with both prevalence and awareness of hypertension. Methods: A cross-sectional survey was conducted as part of the cluster randomized controlled study of community health workers (CHWs) interventions for reduction of blood pressure in a randomly selected sample of young and middle-aged population in rural Morogoro. Sociodemographics, lifestyle-related factors, history of diagnosis, and treatment for hypertension were collected ...
Source: International Journal of Hypertension - Category: Cardiology Tags: Int J Hypertens Source Type: research
Conclusions: The caregivers of patients with cancer or chronic severe illnesses experience high levels of fatigue: the longer the disease duration, the greater the degrees of depression, anxiety, and physical fatigue experienced by the caregivers. Such caregivers need strategies to manage their fatigue and depression. PMID: 32963657 [PubMed - in process]
Source: Pain Research and Management - Category: Anesthesiology Authors: Tags: Pain Res Manag Source Type: research
Conclusion: Our study supported the physicians' assumption regarding the effect of climate on pain in RA patients. PMID: 32963656 [PubMed - in process]
Source: Pain Research and Management - Category: Anesthesiology Authors: Tags: Pain Res Manag Source Type: research
Authors: Niri T, Horie I, Kawahara H, Ando T, Fukuhara N, Nishioka H, Inoshita N, Fujisawa H, Suzuki A, Sugimura Y, Abiru N, Kawakami A Abstract Idiopathic hypothalamitis is a rare condition that can cause anterior pituitary dysfunction and central diabetes insipidus (CDI), occasionally accompanied by a disturbance of autonomic regulation known as hypothalamic syndrome. This condition has been described as a subtype of autoimmune (lymphocytic) hypophysitis; however, some cases of isolated hypothalamic involvement with no inflammatory lesions in either the pituitary gland or infundibulum have been reported. The deta...
Source: Endocrine Journal - Category: Endocrinology Tags: Endocr J Source Type: research
Conclusions: HDAC may be a new biological target for cerebral ischemic stroke. Future drug development targeting HDAC may make it a potentially effective anticerebral ischemic stroke drug. PMID: 32963637 [PubMed - in process]
Source: Disease Markers - Category: Laboratory Medicine Tags: Dis Markers Source Type: research
Authors: Chen P, Wang H, Li M, Yang L, Mou F, Singh B, He JY, Zhang W Abstract 6,12-Diphenyl-3,9-diazatetraasterane-1, 5, 7, 11-tetracarboxylate (DDTC) has been synthesized by the photodimerization of 4-phenyl-1,4-dihydropyridine-3,5-dicarboxylate. The potential of theercvantitumor activity and mechanism were investigated in vitro using MTT assay in human lung cancer cell line A549, ovarian cancer cell lines SKOV3 and A2780, breast cancer cell line MCF-7, gastric cancer cell line BGC-823, colon cancer cell line HT29, prostate cancer cell line DU145, and liver cancer cell line SMMC7721. The results show that DDTC ca...
Source: Disease Markers - Category: Laboratory Medicine Tags: Dis Markers Source Type: research
Authors: Bertoli F, Veritti D, Danese C, Samassa F, Sarao V, Rassu N, Gambato T, Lanzetta P Abstract The novel pandemic coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has challenged the medical community. While diagnostic and therapeutic efforts have been focused on respiratory complications of the disease, several ocular implications have also emerged. SARS-CoV-2 RNA has been found in tears of the infected patients, and reports suggest that the ocular surface could serve as a portal of entry and a reservoir for viral transmission. Clinically, COVID-...
Source: Journal of Ophthalmology - Category: Opthalmology Tags: J Ophthalmol Source Type: research
ConclusionThe association of eosinophilic pneumonia with Ustekinumab, a drug used in the treatment of psoriasis and other autoimmune diseases, is rare and there is a paucity of literature regarding this association. PMID: 32962463 [PubMed - as supplied by publisher]
Source: Journal of Asthma - Category: Respiratory Medicine Tags: J Asthma Source Type: research
Authors: Park SK, Park JA, Yang SY, Shin JY, Koh H Abstract Objectives: Recognizing the value of anticancer treatments based on progression-free survival and overall survival may help decision making in healthcare policy. We aimed to measure and compare the impact of disease progression and terminal state prior to death on healthcare costs in HR+, HER2- ABC patients.Methods: We conducted a retrospective study using Korean nationwide health insurance claims database between 9/1/2012-8/31/2017. The impact of disease progression was estimated by measuring the average incremental monthly cost per patient during 1 year ...
Source: Current Medical Research and Opinion - Category: Research Tags: Curr Med Res Opin Source Type: research
CONCLUSION: Post-stroke depressive symptoms form a complex and multifactorial problem. Treatment outcome is influenced by the characteristics of the stroke, the patient, and their spouse. The results show that psychological distress is probably no obstacle to attempting to improve participation. The personalized predictions (prognostic index scores) of treatment outcome show promising results, which, after further replication and validation, could aid clinicians with treatment selection. PMID: 32965505 [PubMed - as supplied by publisher]
Source: Journal of Rehabilitation Medicine - Category: Rehabilitation Tags: J Rehabil Med Source Type: research
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