Reuse of a Small Molecule to Increase Autophagy in the Brain is Trialed for Alzheimer's Disease
Today I'll point out an example of drug reuse and autophagy upregulation. The processes of autophagy are responsible for recycling molecular waste and broken cellular structures. Autophagy is upregulated in response to stress placed upon cells, whether by heat, cold, lack of nutrients, a toxic local environment, and so forth. This is beneficial to tissue function, health, and longevity, and thus there is considerable interest in the research community in producing therapies that boost the operation of autophagy. This hasn't made a great deal of progress towards the clinic, but nonetheless in any of the sizable databases of small molecule compounds there are some that result in increased autophagy - the question is always whether the side-effects are tolerable. The cancer research community in particular tests a great many compounds and attempts to influence a great many core cellular processes, autophagy included. So when we see attempts at drug reuse, it is often the case that the drug in question is a small molecule that is either present used, used in the past, or was at least considered for chemotherapy. In the trial noted here, the drug is nilotinib. Researchers propose that it produces the observed reduction of toxic protein aggregates in the Alzheimer's disease brain by spurring increased autophagy, and can do so at low enough doses to avoid the worst of the side-effects noted to date. Of course, as is sadly standard in the mainstream of Alzheimer's development,...
Lab Chip, 2020, Accepted Manuscript DOI: 10.1039/D0LC00361A, PaperZhixing Ge, Junhua Zhao, Haibo Yu, Wenguang Yang, Peilin Zhou, Zhenning Wang, Lianqing Liu Currently, the mechanisms underlying the peritoneal metastasis of gastric cancer cells and the function of mesothelial cells during this process are unclear, primarily due to the absence of an effective... The content of this RSS Feed (c) The Royal Society of Chemistry
Chem. Soc. Rev., 2020, Advance Article DOI: 10.1039/D0CS00107D, Review ArticleKayoung Kim, Chang Heon Lee, Chan Beum Park This review provides an overview of recent advances in optical and electrical detection of Alzheimer's disease biomarkers in clinically relevant fluids. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
Chem. Commun., 2020, Advance Article DOI: 10.1039/D0CC03614E, CommunicationWentao Zhang, Hyunjun Choi, Bo Yu, Dong-Hyun Kim Iron oxide nanocube patched Janus magnetic porous silica nanocarriers are synthesized and it is expected to be used for a new type of multifunctional carriers in image guided cancer therapeutic applications. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Publication date: Available online 5 July 2020Source: Genes &DiseasesAuthor(s): Xi Liu, Jimin Xu, Jia Zhou, Qiang Shen
This paper is about the experiences of migration of middle class Iranians living in London, with focus on the psychosocial experiences of one woman. Her story is representative of the stories of Iranians who 'make it' in exile. There is scant study of the ...
Survivors of interpersonal violence are at increased risk of negative mental health outcomes; however, scant research has explored the relationship between violence exposure and mental health symptoms among formerly incarcerated individuals. This cross-sec...
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