Pan ‑cancer analysis of transmembrane protease serine 2 and cathepsin L that mediate cellular SARS‑CoV‑2 infection leading to COVID-19.
Pan‑cancer analysis of transmembrane protease serine 2 and cathepsin L that mediate cellular SARS‑CoV‑2 infection leading to COVID-19. Int J Oncol. 2020 May 26;: Authors: Katopodis P, Anikin V, Randeva HS, Spandidos DA, Chatha K, Kyrou I, Karteris E Abstract Severe acute respiratory syndrome (SARS) coronavirus‑2 (SARS‑CoV2) is the cause of a new disease (COVID‑19) which has evolved into a pandemic during the first half of 2020. Older age, male sex and certain underlying diseases, including cancer, appear to significantly increase the risk for severe COVID‑19. SARS‑CoV‑2 infection of host cells is facilitated by the angiotensin‑converting enzyme 2 (ACE‑2), and by transmembrane protease serine 2 (TMPRSS2) and other host cell proteases such as cathepsin L (CTSL). With the exception of ACE‑2, a systematic analysis of these two other SARS‑CoV2 infection mediators in malignancies is lacking. Here, we analysed genetic alteration, RNA expression, and DNA methylation of TMPRSS2 and CTSL across a wide spectrum of tumors and controls. TMPRSS2 was overexpressed in cervical squamous cell carcinoma and endocervical adenocarcinoma, colon adenocarcinoma, prostate adenocarcinoma (PRAD), rectum adenocarcinoma (READ), uterine corpus endometrial carcinoma and uterine carcinosarcoma, with PRAD and READ exhibiting the highest expression of all cancers. CTSL was upregulated in lymphoid neoplasm diffuse large B‑cell lymphoma, oesophage...
Publication date: Available online 3 July 2020Source: The Annals of Thoracic SurgeryAuthor(s): Vignesh Raman, Oliver K. Jawitz, Soraya L. Voigt, Kristen E. Rhodin, Anthony W. Kim, Betty C. Tong, Thomas A. D’Amico, David H. Harpole
Publication date: Available online 3 July 2020Source: The Annals of Thoracic SurgeryAuthor(s): Jun-Feng Wang, Can-Qiong Tian, Qiang-Bo Kan
Publication date: Available online 2 July 2020Source: Artificial Intelligence in MedicineAuthor(s): Jacques Bouaud, Sylvia Pelayo, Jean-Baptiste Lamy, Coralie Prebet, Charlotte Ngo, Luis Teixeira, Gilles Guézennec, Brigitte Seroussi
Publication date: Available online 25 June 2020Source: Journal of Microbiology, Immunology and InfectionAuthor(s): Md. Golzar Hossain, Aneela Javed, Sharmin Akter, Sukumar Saha
Conclusions: Operative laparoscopy under conscious sedation and local anesthesia appears to be a feasible technique in gynecologic surgery with no adverse patient outcomes. PMID: 32612345 [PubMed - in process]
CONCLUSION: recommendations emphasize isolation, proper rest, sleep, nutrition, hydration, medications, and in the more severe cases, oxygen support, monitoring of vital signs, emotional support, and multiprofessional and individualized care. Medications should be used with caution due to a lack of evidence. Future research is needed to analyze the impact of the infection at the beginning of pregnancy and the psychological aspects of pregnant women infected with the virus. PMID: 32609284 [PubMed - in process]
CONCLUSION: the number of infected patients will continue to increase. Chile needs to remain vigilant and adjust the strategies around the prevention and control measures. The behavior of the population plays a fundamental role. We suggest not relaxing restrictions and further improving epidemiological surveillance. Emergency preparations are needed and more resource elements need to be added to the current health support. This prediction is provisional and depends on keeping all intervening variables constant. Any alteration will modify the prediction. PMID: 32609283 [PubMed - in process]
CONCLUSION: the estimates of the transmission rate, epidemiological peak, and number of deaths from coronavirus in Brazilian metropolises presented expressive and important numbers the Brazilian Ministry of Health needs to consider. The results confirm the rapid spread of the virus and its high mortality in the country. PMID: 32609282 [PubMed - in process]
Abstract OBJECTIVE: to analyze the relationship between per capita income and the cumulative incidence of COVID-19 in the neighborhoods of the city of Rio de Janeiro, RJ, Brazil. METHOD: an ecological study using neighborhoods as units of analysis. The cumulative incidence rate per 100,000 inhabitants and the median of potential confounding variables (sex, race, and age) were calculated. Multiple analysis included quantile regression, estimating the regression coefficients of the variable income for every five percentiles from the 10th to 90th percentiles to verify the relationship between income and incidenc...
CONCLUSION: it became evident that palliative care in primary health care has been gradually developed, but it is necessary to consider the organization of primary health care and the social policies that support or weaken it, being considered a complex challenge. PMID: 32609270 [PubMed - in process]
More News: Adenocarcinoma | Brain Tumor | Cancer | Cancer & Oncology | Cancer of the Uterus | Carcinoma | Carcinosarcoma | Cervical Cancer | Colon Cancer | Colorectal Cancer | COVID-19 | Endometrial Cancer | Esophagus Cancer | Gastric (Stomach) Cancer | Genetics | Glioma | Head and Neck Cancer | HNSCC | Lymphoma | Melanoma | Pancreas | Pancreatic Cancer | Pandemics | Respiratory Medicine | SARS | Skin | Skin Cancer | Squamous Cell Carcinoma | Study