Monk fruit –More than a healthy sweetener?

Because I wanted a benign and healthy way for followers of the Wheat Belly lifestyle to recreate dishes such as chocolate chip cookies, cheesecake, and pies with none of the health problems of grains or sugars, I helped Wheat-Free Market develop its Virtue Sweetener  product. Yes, you could do without such sweeteners. But I learned long ago when I introduced Wheat Belly concepts to patients in my cardiology practice that having options while entertaining friends, during holidays, and pleasing kids was important for staying on course on this lifestyle. Before I understood how to use such natural sweeteners, patients would come back from, say, the Thanksgiving holiday 14 pounds heavier with disastrous changes in blood sugar, triglycerides, blood pressure, and small LDL particles that increased risk for heart attack. Given access to benign natural sweeteners, patients would come back with no weight gain, no change in blood sugar, no rise in small LDL, or any other measure—they would just enjoy the holiday with no observable downside. It has also become clear in the last two years that synthetic sweeteners such as sucralose, saccharine, and aspartame have unhealthy implications, specifically adverse changes in bowel flora composition that explain why these sweeteners have been associated with weight gain and increased type 2 diabetes risk. So Virtue Sweetener has emerged front and center because it allows you to end your wonderful grain-free meal with, say, a delicious...
Source: Wheat Belly Blog - Category: Cardiology Authors: Tags: Open blood sugar diabetes Dr. Davis Inflammation insulin low-carb monk fruit natural sweeteners undoctored virtue sweetener Weight Loss wheat Wheat Belly Total Health Source Type: blogs

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AbstractTo evaluate the efficacy of selective retina therapy (SRT) in patients with diabetic macular edema (DME) based on pretreatment central foveal thickness (CFT). Seventy-two eyes of 63 patients with DME who had previously undergone SRT were included. Patients were divided into two groups based on the CFT at baseline. Group 1 was composed of 35 eyes with CFT  
Source: Lasers in Medical Science - Category: Laser Surgery Source Type: research
Authors: Furaz Czerpak K, Gruss Vergara E, Barril Cuadrado G, Pérez Fernández E, Benavides N, de la Flor J, Mendez Á, Martín R Abstract INTRODUCTION: Hypertension is very common in haemodialysis (HD) patients, and is associated with increased morbidity and mortality rates. The goals of our research were to: 1. Measure blood pressure (BP) during HD sessions; 2. Study BP in between HD sessions with 44-hour Ambulatory Blood Pressure Monitoring (ABPM); 3. Identify differences between the BP recorded during HD and with the ABPM; 4. Evaluate changes in treatment after the ABPM; 5. Perform bioi...
Source: Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia - Category: Urology & Nephrology Tags: Nefrologia Source Type: research
Tumor immunosuppression is a limiting factor for successful cancer therapy. The lipid sphingosine-1-phosphate (S1P), which signals through 5 distinct G protein–coupled receptors (S1PR1–5), has emerged as an important regulator of carcinogenesis. However, the utility of targeting S1P in tumors is hindered by S1P’s impact on immune cell trafficking. Here, we report that ablation of the immune cell–specific receptor S1PR4, which plays a minor role in immune cell trafficking, delayed tumor development and improved therapy success in murine models of mammary and colitis-associated colorectal cancer throu...
Source: Journal of Clinical Investigation - Category: Biomedical Science Authors: Source Type: research
Transcription infidelity (TI) is a mechanism that increases RNA and protein diversity. We found that single-base omissions (i.e., gaps) occurred at significantly higher rates in the RNA of highly allergenic legumes. Transcripts from peanut, soybean, sesame, and mite allergens contained a higher density of gaps than those of nonallergens. Allergen transcripts translate into proteins with a cationic carboxy terminus depleted in hydrophobic residues. In mice, recombinant TI variants of the peanut allergen Ara h 2, but not the canonical allergen itself, induced, without adjuvant, the production of anaphylactogenic specific IgE...
Source: Journal of Clinical Investigation - Category: Biomedical Science Authors: Source Type: research
New J. Chem., 2020, Accepted Manuscript DOI: 10.1039/D0NJ03863F, PaperSk. Abdul Amin, Kalyan Ghosh, Dipayan Mondal, Tarun Jha, Shovanlal Gayen In human, the over-expression of Mcl-1 protein causes the different cancers and it is also responsible for cancer resistance to different cytotoxic agents. Thus, discovery of potential inhibitors of Mcl-1... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - New J. Chem. latest articles - Category: Chemistry Authors: Source Type: research
Contributor : Shengtao ZhouSeries Type : Expression profiling by high throughput sequencing ; Non-coding RNA profiling by high throughput sequencingOrganism : Homo sapiensOvarian cancer is a heterogeneous disease that constitutes great menace to female health and poses tremendous clinical challenge. Based on unsupervised classification of whole-genome gene expression profiles, four molecular subtypes of ovarian cancer were recently identified. However, currently it is still unelucidated on the immune infiltration pattern of different molecular subtypes of ovarian cancer. we used a computational approach (CIBERSORT) to bulk...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Non-coding RNA profiling by high throughput sequencing Homo sapiens Source Type: research
Contributors : M Schmidt ; M GehrmannSeries Type : Expression profiling by arrayOrganism : Homo sapiensInterferons are crucial for adaptive immunity and play an important role in the immune landscape of breast cancer. Using microarray-based gene expression analysis, we examined the subtype specific prognostic significance of interferon- γ (IFN-γ) as a single gene as well as an IFN-γ signature covering the signaling pathway in 461 breast cancer patients. Prognostic significance of IFN-γ as well as the IFN-γ signature for metastasis-free survival (MFS) were examined using Kaplan Meier as well as...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by array Homo sapiens Source Type: research
Contributors : Ralf Janknecht ; Willard FreemanSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensWe identified that ETV1 downregulation affects growth of HCT116 cells, and concomitantly affects their transcriptome. This suggests that ETV1 might be involved in colon cancer formation and/or progression.
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
This study aims to elucidate nutrient dependent changes to the circadian transcriptome of whole flies. In particular, we aim to identify how dietary restriction influence circadian transcriptional output. Circadian analyses were performed to invesitigate diet-dependent changes in the number of circadian transcripts as well as their phases and circadian amplitude.
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by array Drosophila melanogaster Source Type: research
Contributors : Jose C Reyes ; Jose A Guerrero-Mart ínezSeries Type : OtherOrganism : Mus musculusTGF β cytokines have crucial roles in development, proliferation, tissue homeostasis, differentiation, and immune regulation. Consequently, alterations in TGFβ signaling underlie numerous diseases, including cancer. Moreover TGFβ is one of the most potent inductors of EMT (epithelial to mesenchymal transition) in normal and oncogenic epithelial cells from different origins. During EMT, cells undergo an extensive reorganization of cell adhesion complexes, cytoskeletal architecture, and extracellular matrix ...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Other Mus musculus Source Type: research
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