CD28 Individual Signaling Up-regulates Human IL-17A Expression by Promoting the Recruitment of RelA/NF- κB and STAT3 Transcription Factors on the Proximal Promoter

This study was carried out in accordance with the recommendation of Ethical Committee of the Policlinico Umberto I (Sapienza University, Rome, Italy). All subjects gave written informed consent in accordance with the Declaration of Helsinki. Author Contributions MK and MM performed the research and data analyses. NP and SC performed parts of the research. SA contributed samples for the study. EM contributed with STAT3C construct and commented on manuscript. LT designed the study, coordinated the work, and wrote the manuscript. Funding The work was supported by: Progetto Ateneo (Sapienza University of Rome, Italy) and FISM - Fondazione Italiana Sclerosi Multipla - cod. 2016/R/29. Conflict of Interest Statement The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. Acknowledgments We thank Valeria Poli for reagents. Supplementary Material The Supplementary Material for this article can be found online at: https://www.frontiersin.org/articles/10.3389/fimmu.2019.00864/full#supplementary-material References 1. Stockinger B, Veldhoen M. Differentiation and function of Th17 T cells. Curr Opin Immunol. (2007) 19:281–6. doi: 10.1016/j.coi.2007.04.005 PubMed Abstract | CrossRef Full Text | Google Scholar 2. Cosmi L, Santarlasci V, Maggi L, Liotta F, Annunziato F. Th17 plasticity: pathophysiology and treatment of chronic inflammatory disorders...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research