CD28 Individual Signaling Up-regulates Human IL-17A Expression by Promoting the Recruitment of RelA/NF- κB and STAT3 Transcription Factors on the Proximal Promoter

CD28 Individual Signaling Up-regulates Human IL-17A Expression by Promoting the Recruitment of RelA/NF-κB and STAT3 Transcription Factors on the Proximal Promoter Martina Kunkl1†, Marta Mastrogiovanni1,2†, Nicla Porciello3, Silvana Caristi1, Emanuele Monteleone4, Stefano Arcieri5 and Loretta Tuosto1* 1Department of Biology and Biotechnology Charles Darwin, Sapienza University, Rome, Italy 2Lymphocyte Cell Biology Unit, INSERM U1221, Department of Immunology, Pasteur Institute, Paris, France 3Sir William Dunn School of Pathology, University of Oxford, Oxford, United Kingdom 4Department of Molecular Biotechnology and Health Sciences, University of Torino, Turin, Italy 5Department of Surgical Sciences, Sapienza University of Rome, Rome, Italy CD28 is an important co-stimulatory receptor for T lymphocytes that, in humans, delivers TCR-independent signal leading to the up-regulation of pro-inflammatory cytokines. We have recently reported that CD28 autonomous signaling induces the expression of IL-17A in peripheral CD4+ T lymphocytes from healthy donors, multiple sclerosis, and type 1 diabetes patients. Due to the relevance of IL-17A in the pathophysiology of several inflammatory and autoimmune diseases, we characterized the mechanisms and signaling mediators responsible for CD28-induced IL-17A expression. Here we show that CD28-mediated up-regulation of IL-17A gene expression depends on RelA/NF-κB and IL-6-associated STAT3 transcriptions fac...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research

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Conclusions: We found that perceived stigma in health care settings was a potential barrier to good health. Prior studies have illustrated that negative health outcomes are common for patients who avoid or delay care; thus, the unfortunate conclusion is that even in a diverse, heterogeneous community, stigma persists and may negatively affect well-being. Therefore, eliminating stigma in clinical settings should be a top priority for health care providers and public health professionals seeking to improve health equity.
Source: Medical Care - Category: Health Management Tags: Original Articles Source Type: research
[VOA] On the eve of World Diabetes Day, November 14, the World Health Organization is launching a new initiative it believes will allow greater access to life-saving insulin at lower prices for a greater number of people suffering from diabetes.
Source: AllAfrica News: Health and Medicine - Category: African Health Source Type: news
Abstract An important harmonization effort was produced by the scientific community to standardize both the preanalytical and interpretative phases of programmed death-ligand 1 (PD-L1) immunohistochemical (IHC) testing in non-small-cell lung cancer (NSCLC). This analysis is crucial for the selection of patients with advanced-stage tumors eligible for treatment with pembrolizumab and potentially with other anti-PD-1/PD-L1 checkpoint inhibitors. This multicentric retrospective study evaluated the reproducibility of PD-L1 testing in the Italian scenario both for closed and open platforms. In the evaluation of the wel...
Source: Biomed Res - Category: Research Authors: Tags: Biomed Res Int Source Type: research
Publication date: January 2020Source: Learning and Individual Differences, Volume 77Author(s): Marion Reindl, Maria Tulis, Markus DreselAbstractUniversity students may combine regulation strategies differently in response to a specific learning situation, namely after making errors. Strategy combinations may differ in how they support students' learning. These assumptions were investigated based on a sample of 469 German university students (undergraduate teacher trainees). Using latent profile analysis, we identified three distinct profiles with different values of cognitive reappraisal, mastery self-talk, performance-app...
Source: Learning and Individual Differences - Category: Psychiatry & Psychology Source Type: research
(Duke-NUS Medical School) World's foremost society of kidney specialists highlights Singapore-led DYNAMO study that aims to improve understanding of diabetic kidney disease (DKD) complications and reduce DKD prevalence in Singapore by 30% over 5 years. Study is led by Duke-NUS Medical School Dean, Prof. Thomas Coffman.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
(European Society of Cardiology) Women are most affected by the vascular complications of diabetes -- a situation likely to escalate in the coming decades, reports a paper published on World Diabetes Day in the European Journal of Preventive Cardiology, a journal of the European Society of Cardiology (ESC).
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
Publication date: Available online 12 November 2019Source: Brain, Behavior, and ImmunityAuthor(s): Célia Fourrier, Camille Kropp, Agnès Aubert, Julie Sauvant, Carole Vaysse, Jean-Michel Chardigny, Sophie Layé, Corinne Joffre, Nathalie CastanonAbstractMetabolic syndrome represents a major risk factor for severe comorbidities such as cardiovascular diseases or diabetes. It is also associated with an increased prevalence of emotional and cognitive alterations that in turn aggravate the disease and related outcomes. Identifying therapeutic strategies able to improve those alterations is therefore a major s...
Source: Brain, Behavior, and Immunity - Category: Neurology Source Type: research
TYPE 2 diabetes is a serious condition which affects a person ’s blood sugar levels, and left untreated, serious health conditions can occur. Medical expert, Dr Haris Ruther offers advice on spotting the symptoms and tips on how to deal with them.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
CONCLUSIONS This was the first study to demonstrate an association between UNC13B gene polymorphisms and the susceptibility to DKD in a Chinese Han population with T2DM. The haplotype GGCCG was significantly associated with an increased risk of DKD. The findings highlight the joint effect of SNP markers in the pathogenesis of DKD. PMID: 31713534 [PubMed - in process]
Source: Medical Science Monitor - Category: Research Tags: Med Sci Monit Source Type: research
Authors: Tao G, Mao P, Guan H, Jiang M, Chu T, Zhong C, Liu J Abstract Objective: To explore the regulation relationship between miR-181a-3p and BMP10, and their mechanism of osteogenic differentiation of human bone marrow-derived mesenchymal stem cells (MSCs).Methods: After osteogenic induction of MSCs, the ALP activity was detected by ELISA. The expression of miRNA-181a-3p and BMP10 was detected by RT-qPCR, and the protein levels of BMP10 and osteogenic differentiation marker proteins ALK and RUNX2 were detected by Western blot. The TargetScan online website was used to predict the putative target of miR-181a-3p,...
Source: Artificial Cells, Nanomedicine and Biotechnology - Category: Biotechnology Tags: Artif Cells Nanomed Biotechnol Source Type: research
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