Incretins and SGLT-2i Therapy of Type 2 Diabetes – Real Life Study of Their Therapeutic and Economic Effects

Conclusion: Incretins [dipeptidyl peptidase-4 inhibitors (DPP-4i) and glucagon-like peptide 1 receptor agonists (GLP-1 RA)] and sodium-glucose linked transporter-2 inhibitors (SGLT-2i) therapy steadily decreases the HbA1c level, and risk of developing diabetic incidents is reduced to between 333 and 465 cases among 6122 treated patients. Avoided cost for therapy of diabetes incidents account for between 305 and 510 thousand BGN. Introduction Incretin (DPP-4i and GLP-1 RA) and SGLT-2i groups are now routinely used for type 2 diabetes therapy and comprise a large number of medicinal products (Cheung et al., 2009; Lovshin and Drucker, 2009; Drucker et al., 2010). They may be used as a second or third line medication for people with type 2 diabetes after prescribing MET and sulphonylureas, and as an alternative to thiazolidinedione medication (American Diabetes Association, 2016). DPP-4i are a new, developing group, a regulator of incretin hormones, prolonging the incretin’s effects (Anitha et al., 2013; Röhrborn et al., 2015). GLP-1 receptor agonists or incretin mimetics are agonists of the GLP-1 receptor (Freeman and Unger, 2008). SGLT-2i inhibitors have been approved for type 2 diabetes therapy since 2013 and are a new group of oral medications, acting by helping the kidneys to lower blood glucose levels (Nauck, 2013). As relatively new medicines for diabetes therapy, their efficacy, safety, and cost-effectiveness are intensively studied all over the world ...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research

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