Estimating HIV-1 Genetic Diversity in Brazil Through Next-Generation Sequencing

In this study, we included data previously published by our group from patients followed-up at HFI and all HIV-1 sequences obtained by NGS publicly available. A detailed description of the studied populations can be found in their respective articles (Pessoa et al., 2015, 2016; Alves et al., 2017). We focused on the HIV-1 subtype classification, identification of HIV recombinants and multiple infection investigation for our novel patients. As previous published, the patients from HFI were mostly males (75%) with a median age of 38 years at the time of sample collection. Regarding our new cohort, we also found a prevalence of males (67%) among the patients from HU-UFRJ with a median age of 43.5 years. Unlike the other centers, a greater number of female patients (62%) were observed among patients from HU-FURG, with a median age of 43 years. Clinical and epidemiological characteristics of the three cohorts are compiled in Table 1. Regarding antiretroviral treatment, 19 patients from HI (19/32, 59%), four patients from HU-UFRJ (4/12, 33%), and 23 patients from HU-FURG (23/40, 58%), were under the HAART scheme preconized by Brazilian Ministry of Healthy at the time of sample collection, composed of tenofovir (TDF), lamivudine (3TC), and efavirenz (EFV). All schemes used by the patients are described in Table 2. TABLE 1 Table 1. Demographic and clinical characteristics of HIV-positive patients. TABLE 2 Table 2. Distribution of subtypes and HAART regimen exp...
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research

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Authors: Lamy S, Houivet E, Benichou J, Marret S, Thibaut F, Perinatal network of Upper-Normandy Abstract Many pregnant women, in the world, drink caffeine-containing beverages. Maternal caffeine consumption during pregnancy may have adverse effects on foetus but results are conflicting. Our goals were to estimate the prevalence of caffeine use in a cohort of French pregnant women using maternal self-reports and to evaluate the association between caffeine consumption during pregnancy and delivery and newborn characteristics. All pregnant women who gave birth in a large French urban area during a limited period of ...
Source: European Archives of Psychiatry and Clinical Neuroscience - Category: Psychiatry Tags: Eur Arch Psychiatry Clin Neurosci Source Type: research
CONCLUSION: This study shows that participants with dyslexia fail to use normal brain regions specialized in language processing, but rather use different areas. PMID: 32086175 [PubMed - as supplied by publisher]
Source: Asian Journal of Psychiatry - Category: Psychiatry Tags: Asian J Psychiatr Source Type: research
AbstractThree BODIPY ‐peptide conjugates designed to target the epidermal growth factor receptor (EGFR) at the extracellular domain were synthesized and their specificity for binding to EGFR was investigated. Peptide sequences containing seven amino acids, GLARLLT (2) and KLARLLT (3), and 13 amino acids, GYHWYGYTPQNVI (4), were conjugated to carboxyl BODIPY dye (1) by amide bond formation in up to 73% yields. The BODIPY ‐peptide conjugates and their “parent” peptides were determined to bind to EGFR experimentally using SPR analysis, and were further investigated using computational methods (AUTODOCK). Resul...
Source: Photochemistry and Photobiology - Category: Science Authors: Tags: SPECIAL ISSUE RESEARCH ARTICLE Source Type: research
AbstractWe study interdependent risks in security, and shed light on the economic and policy implications of increasing security interdependence in presence of reactive attackers. We investigate the impact of potential public policy arrangements on the security of a group of interdependent organizations, namely, airports. Focusing on security expenditures and costs to society, as assessed by a social planner, to individual airports and to attackers, we first develop a game ‐theoretic framework, and derive explicit Nash equilibrium and socially optimal solutions in the airports network. We then conduct numerical experimen...
Source: Risk Analysis - Category: International Medicine & Public Health Authors: Tags: Original Research Article Source Type: research
Hi SDN, I used to frequent these forms as a medical student. I am now nearing the end of my residency in Family Medicine. I am Canadian, on a J-1 visa. I have been with an American girl for 4 years now. We are thinking to get married but I would need a J-1 visa waiver job in order to remain in the country. My girlfriend works for a company that has locations that are mainly in North New Jersey and New York City. However this company also has locations in Florida, Colorado, California... J-1 visa waiver
Source: Student Doctor Network - Category: Universities & Medical Training Authors: Tags: Family Medicine Source Type: forums
Publication date: 2020Source: NeuroImage: Clinical, Volume 26Author(s): Anna Vasilevskaya, Foad Taghdiri, Charles Burke, Apameh Tarazi, Seyed Ali Naeimi, Mozghan Khodadadi, Ruma Goswami, Christine Sato, Mark Grinberg, Danielle Moreno, Richard Wennberg, David Mikulis, Robin Green, Brenda Colella, Karen D. Davis, Pablo Rusjan, Sylvain Houle, Charles Tator, Ekaterina Rogaeva, Maria C. TartagliaAbstractBackgroundGenetic polymorphisms like apolipoprotein E (APOE) and microtubule-associated protein tau (MAPT) genes increase the risk of neurodegeneration.Methods38 former players (age 52.63±14.02) of contact sports underwen...
Source: NeuroImage: Clinical - Category: Radiology Source Type: research
The objective of this study was to investigate whether the association between family income and adult self-rated health in Canada is causal in nature. The data came from the 2012, 2014 and 2016 waves of the Longitudinal and International Study of Adults linked to current and historical family income data from the Canada Revenue Agency. We used fixed effects models to describe associations between changes in self-rated health between 2012, 2014 and 2016 and changes in equivalized family income between (i) 2011, 2013 and 2015, (ii) 2008, 2009 and 2010, i(ii) 2005, 2006 and 2007, (iv) 2002, 2003 and 2004 and (v) 1999, 2000 a...
Source: Social Science and Medicine - Category: Psychiatry & Psychology Source Type: research
Authors: McConnell-Nzunga J, Weatherson KA, Masse L, Carson V, Faulkner G, Lau E, McKay H, Temple V, Wolfenden L, Naylor PJ Abstract BACKGROUND: Physical activity (PA) is critical to early child development, and child care is a key setting for promotion. The authors investigated differences in daily PA and sedentary behavior practices as well as physical environments between family child care (FCC) and group child care (GCC) settings for children aged 3-5 years in Canada. METHODS: Group child care (n = 581) and FCC (n = 357) managers completed surveys assessing the implementation of PA promoting practices and d...
Source: Journal of Physical Activity and Health - Category: Sports Medicine Tags: J Phys Act Health Source Type: research
Contributors : Samuel Jacques ; Almer M van der Sloot ; Caroline Huard ; Jasmin Coulombe-Huntington ; Sarah Tsao ; Sylvain Tollis ; Thierry Bertomeu ; Elizabeth J Culp ; Daniel Pallant ; Michael A Cook ; Eric Bonneil ; Pierre Thibault ; Gerard D Wright ; Michael TyersSeries Type : OtherOrganism : Homo sapiensSystematic genetic interaction profiles can reveal the mechanism-of-action of bioactivecompounds. The imipridone ONC201, which is currently in cancer clinical trials, has beenascribed a variety of different targets. To investigate the genetic dependencies of imipridoneaction, we screened a genome-wide CRISPR knockout l...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Other Homo sapiens Source Type: research
Fears grew on Monday that the coronavirus outbreak in China will grow into a pandemic with disruptive and deadly consequences for countries around the world, after sharp rises in infections in South Korea, Italy and Iran.
Source: Reuters: Health - Category: Consumer Health News Tags: healthNews Source Type: news
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