Estimating HIV-1 Genetic Diversity in Brazil Through Next-Generation Sequencing
This study was carried out and approved in accordance with the recommendations of the Ethics Committees in Research of the Brazilian National Cancer Institute – INCA and of HFI (CAAE 52862016.9.0000.5274), HUCFF-UFRJ (CAAE 56604816.2.0000.5257), and HU-FURG (CAAE 52862016.9.3001.5324), with written informed consent from all subjects. All subjects gave written informed consent in accordance with the Declaration of Helsinki.
Author Contributions
BA, ES, and MS conceived the study. BA and VDH collected and processed the samples. BA, JS, IP, and OB performed all molecular biology experiments and all the bioinformatics analyses. SS contributed with previously published HIV-1 NGS sequences from Brazil. PR-P and HF contributed reagents and provided critical reading of the manuscript. BA, JS, and MS wrote the manuscript. All authors read the manuscript and agreed with its final version and submission.
Funding
This work was supported by the Rio de Janeiro State Science Foundation – FAPERJ (Grant # E-26/201.331/2014 to MS), by the Brazilian National Research Council – CNPq (Grants # 454623/2014-3 to MS and # 460346/2014-8 to ES), and by MSD Avenir (Grant DS-2016-0005 to HF with a subcontract to MS). Intramural funding by the Brazilian Ministry of Health through INCA in the form of fellowships was provided to BA and JS at the post-doc level, to IP at the Ph.D. level and to OB at the undergraduate level.
Conflict of Interest Statement
The authors declare that t...
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
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