What Are Common Cross-reactivities with Other Allergens?
Discussion The most common allergic foods are cow’s milk (most common), egg, peanut, tree nut, soy, wheat, fish and shellfish. Egg, milk, soy and wheat tend to occur in young children and these are more likely to be outgrown over time. Peanut, tree nut, shellfish, and fish occur at all ages and are less likely to be outgrown. Peanut and tree nut allergies also tend to be more severe than other foods. Ninety percent of food fatalities were attributed to tree nuts and peanuts. In a study of anaphylaxis in schools, food was the most likely trigger (54%) with nuts and fruits being the most commonly identified foods. Co-factors of food-induced anaphylaxis include asthma, exercise, non-steroidal anti-inflammatory drugs, infections and alcohol. Treatment for food allergy is strict avoidance of the food(s), management and avoidance of potential co-factors, and immediate management of reactions. Immunotherapy is one option for some allergens and a review of its indications can be found here. Cross-reactivities within a plant group are common. For example the Rosacae family has many agriculturally important trees and plants and cross-reactivities between the them is common. Cross-reactivity syndromes do occur. Oral allergy syndrome or pollen food allergy syndrome is caused by shared homology between pollens, fruits, vegetables and tree nuts. Patients usually are sensitized to an environmental pollen and then have reactions with oral ingestion of various foods. Symptoms are usu...
Conclusions: tTGIgA were increasingly tested, while the rate of positive results decreased in recent years, possibly reflecting the impact of current alimentary trends on clinical practice. Associated autoimmune disease was frequently found in CD. High levels of tTGIgA accurately predicted CD diagnosis. WA was rarely investigated and deserves more attention, in particular in children with atopic background. WA does not seem to be associated with CD.Int Arch Allergy Immunol
Conclusion: Substitution of parenteral thiamine in individuals with suspected WE is a well-established treatment regimen. However, suggestions according to guidelines vary widely. Furthermore, hardly any evidence-based recommendations exist on a more general use of thiamine as a preventative intervention in individuals with AUD. Further research is of utmost importance to raise awareness for this potentially undervalued problem.Eur Addict Res 2019;25:103 –110
European populations are overrepresented in genetic and genomic studies, contributing to healthcare inequities.Medscape Medical News
In this study, aqueous suspensions of various active ingredients (A.I.s) were utilized to generate Engineered Water Nanostructures (EWNS) nano-sanitizers, containing the A.I. utilized to produced them (termed iEWNS). These iEWNS had nanoscale size, were loaded with ROS and contained the A.I. utilized to produce them. They were challenged with Influenza H1N1/PR/8 and Acinetobacter baumannii on surfaces and in air. The results indicate that a nanogram dose of A.I. is effective in producing significant inactivation in Influenza H1N1/PR/8 and Acinetobacter baumannii.
Pain is a tremendous health care burden associated with prediabetes and diabetes. However, not everyone with prediabetes or diabetes develops pain and the factors that increase susceptibility to painful neuropathy remain elusive. The epidermis is innervated by both peptidergic and nonpeptidergic axons and our studies in mice reveal that mechanical allodynia induced by consuming a high fat diet increases peptidergic epidermal axons. We hypothesize that patients with prediabetes and painful neuropathy have an abnormal proportion of epidermal peptidergic axons.
Patient-Reported Outcomes Measurement Information System (PROMIS) measures are reliable, brief instruments to measure patient health. The PROMIS pediatric anxiety short form assesses anxiety symptoms; however, its ability to capture a clinically meaningful understanding of anxiety is unknown. Within pediatric chronic pain, anxiety is generally assessed by legacy measures examining anxiety symptoms specific to pain [e.g., Pain Catastrophizing Scale for Children, (PCS-C)] or broadly [The Screen for Child Related Anxiety Disorders, (SCARED)], which have been shown to predict pain-related outcomes.
Early life stress is associated with the development of chronic pain, mood, and obesity-related metabolic disorders in adulthood. Although the underlying mechanisms of these syndromes are unknown, altered regulation of the hypothalamic-pituitary-adrenal (HPA) axis has been implicated. It is hypothesized that early life stress induces HPA axis dysfunction leading to the development of overlapping disorders. We have established a mouse model of early life stress, neonatal maternal separation (NMS), that displays molecular evidence of altered HPA axis regulation and urogenital hypersensitivity and dysfunction, which can be mi...
Acute pain is prevalent following burn injury and can transition to chronic pain in over 50% of patients. Prolonged acute pain is an important component that leads to chronic pain. Our research investigates burn injury-related pain and searches for risk factors that influence acute-to-chronic pain transitions. The present work tests whether dietary intervention, genetic background or pre-injury stress affects thermal and mechanical hypersensitivity associated with 2 ° burn of the mouse hindpaw. Under Avertin anesthesia, (200 µL/10g body weight), the paw of the mouse was placed on a metal block with a surface temp...
Obesity is a pro-inflammatory state that can contribute to chronic pain. Additionally, a poor-quality diet, high in carbohydrates can activate the immune system, further leading to inflammation. We have shown that our Standard American Diet (SAD) can increase peripheral markers of inflammation and prolong recovery from injury presumably through increased activation of immune cells in the spinal cord. Here, we demonstrate that long-term consumption of the SAD can enhance immune cell activation in the spinal cord, increase immune cell infiltration into the cord and that immune cells are required for enhanced SAD-related nega...
Opioid addiction is the number one health care issue in the United States with spinal ailments the leading medical condition associated with opioid addiction. In the literature, patients with chronic pain syndrome and opioid addiction going for spine surgery have poor post-operative clinical outcomes and likely to be on opioids for life. Current evidence-based methods to optimize patients prior to spine surgery have been: 1) transition from opioids to non-opioid medications, 2) cardiovascular exercise program, 3) smoking cessation, 4) alcohol cessation, and 5) psychotherapy to treat mood and maladaptive pain behavior.
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