An Open Letter to Oprah Winfrey

Ms. Winfrey, Can you lose weight while continuing to consume bread and other products made with wheat flour and grains? You absolutely can—though it is quite difficult physically and emotionally, requiring monumental willpower, as you already know. But I fear that you have overlooked crucial issues in your campaign for Weight Watchers and the exoneration of bread. You have, unfortunately, propagated some destructive misconceptions. And the people who you have hurt the most I suspect are the people who you would have preferred to help the most. Losing weight by avoiding processed food products made with wheat and related grains is exceptionally easy because it means that you avoid the gliadin protein-derived opiates that stimulate appetite. The fact that you lost 26 pounds is testimony more to the power of your will than it is to the power of the Weight Watchers program. You have succeeded in losing weight—at least temporarily—despite having, I’m sure, to fight back against overwhelming hunger and cravings due to this effect of grains that you have chosen to remain in your diet. Yes: it can be done. But it is a test of willpower. Willpower wanes over time for most people, explaining why the majority of people who lose weight successfully by reducing calories and portion sizes regain the weight over time, often ending up heavier than at the start. I’d love to see you fit back into a size 4 dress, but it is far more likely that the 26 pounds you lo...
Source: Wheat Belly Blog - Category: Cardiology Authors: Tags: Wheat Belly Lifestyle bread gluten grains oprah Weight Loss weight watchers Source Type: blogs

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This article presents a unique 3D biocompatible Aluminum-based quantum structure (QS) for in vitro cancer detection using Surface Enhanced Raman Scattering (SERS). The Al-based QSs fabricated using ultrashort pulsed laser are of two distinct surface characters, wrinkled and smooth spherical. The limit of detection for chemical sensing of Crystal Violet and Rhodamine 6G by the Al-QS was driven up to single molecule sensing (femtomolar concentration). Biological sensing of cysteine, a disease biomarker and carcinoembryonic antigen (CEA), a cancer biomarker was also tested by the Al-QS. The ability of in vitro cell detection ...
Source: Biosensors and Bioelectronics - Category: Biotechnology Source Type: research
In this study, four different weight% of Punica granatum fruit peel extract were used as green stabilizers to synthesize IONPs followed by a series of characterization experiments and in vitro anticancer evaluation. Results revealed that all synthesized IONPs have high degree of crystallinity and purity. The optimum saturation magnetization, and hydrodynamic size were found to be ∼69 emu.g−1, and 26.52 nm, respectively. Morphological studies demonstrated that adding peel extract decreased size of NPs with the average particle size below 11 nm. Cytotoxicity assay showed that the IONPs were not react...
Source: Journal of Molecular Structure - Category: Molecular Biology Source Type: research
Publication date: 15 March 2020Source: Journal of Molecular Structure, Volume 1204Author(s): A.D. Herrera-España, J. Us-Martín, S. Hernández-Ortega, G. Mirón-López, L. Quijano, J.R. Villanueva-Toledo, G.J. Mena-RejónAbstractThe structural modification of natural products has shown to be a remarkable tool in the generation of novel bioactive molecules. Herein, the synthesis, structural analysis and anticancer activity of the novel triterpenoid thiazole 3 is reported. The synthesis was carried out through the bromination of ochraceolide A (1) and the subsequent heterocyclic condensat...
Source: Journal of Molecular Structure - Category: Molecular Biology Source Type: research
ConclusionInfliximab was not efficient in reducing depressive symptoms according to the HAM-D, only when the patients already had increased inflammatory genes, including TNF and C-reactive protein (CRP).
Source: Pharmacology Biochemistry and Behavior - Category: Biochemistry Source Type: research
Publication date: Available online 14 December 2019Source: Chemico-Biological InteractionsAuthor(s): Ryan N. Serio, Lorraine J. GudasAbstractEthanol (EtOH) is a recreationally ingested compound that is both teratogenic and carcinogenic in humans. Because of its abundant consumption worldwide and the vital role of stem cells in the formation of birth defects and cancers, delineating the effects of EtOH on stem cell function is currently an active and urgent pursuit of scientific investigation to explicate some of the mechanisms contributing to EtOH toxicity. Stem cells represent a primordial, undifferentiated phase of devel...
Source: Chemico Biological Interactions - Category: Biochemistry Source Type: research
Publication date: Available online 14 December 2019Source: Sensors and Actuators B: ChemicalAuthor(s): Xinxin Shi, Yalei Hu, Hong-Min Meng, Jie Yang, Lingbo Qu, Xiao-Bing Zhang, Zhaohui LiAbstractIntracellular polarity has a large impact on the activity of a series of biomolecules or maintain the function of particular domains. Therefore, monitoring the changing of intracellular polarity can great improve the understanding its functions in living cell level. Herein, by employing p-phenylenediamine as precursor, we prepared a red emissive carbon dots based nanoprobe for real-time sensing polarity in living cells. With the i...
Source: Sensors and Actuators B: Chemical - Category: Chemistry Source Type: research
This study demonstrates that the concentrations of PM-bound PAHs are mutagenic and that the Excess Cancer Risks exceed the USEPA standard limits. PMs cause cytotoxicity and can also induce genotoxicity to human health analyzed by cell culture and gel electrophoresis. This study helps to promote research to evaluate the PMs bound PHEs toxicity in diverse human cell lines and also their relationship with climatic factors as well as quantitative source apportionment for mitigation purposes.Graphical abstract
Source: Journal of Hazardous Materials - Category: Environmental Health Source Type: research
Publication date: 15 February 2020Source: Journal of Hazardous Materials, Volume 384Author(s): Syed Tahir Ata-Ul-Karim, Long Cang, Yujun Wang, Dongmei ZhouAbstractAppraising cadmium (Cd) phytoavailability and transfer in soil-plant system is imperative and it requires timely and accurate monitoring of Cd to ensure food safety. However, ambiguities regarding the factors regulating Cd mobility and transfer in soil-plant system makes understanding of Cd accumulation mechanism in wheat grain challenging. In present study, we attempted to explore the interrelationship among soil-plant-N management factors governing Cd transfer ...
Source: Journal of Hazardous Materials - Category: Environmental Health Source Type: research
In this study, we verified that ferroptosis occurred in animal models of arsenic-induced pancreatic dysfunction through assessing proferroptotic markers and morphological changes in mitochondria. In vitro, arsenic caused execution of ferroptosis in a dose-dependent manner, which could be significantly reduced by ferrostatin-1. Additionally, arsenic damaged mitochondria manifested as diminishing of mitochondrial membrane potential, reduced cytochrome c level and production of mitochondrial reactive oxygen species (MtROS) in MIN6 cells. Using the Mito-TEMPO, we found the autophagy level and subsequent ferroptotic cell death ...
Source: Journal of Hazardous Materials - Category: Environmental Health Source Type: research
Authors: Escudero-Hernández C, Bernardo D, Arranz E, Garrote JA Abstract Celiac disease (CeD) and inflammatory bowel disease (IBD) are chronic gastrointestinal disorders of inflammatory origin that develop in response to environmental triggers in genetically predisposed individuals. CeD localizes in the duodenal mucosa, where intolerance develops to dietary gluten from wheat, barley, rye, and some varieties of oats. IBD, in turn, is subdivided primarily into Crohn's disease (CD) and colitis, with ulcerative colitis (UC) being the most thoroughly investigated form. PMID: 31830796 [PubMed - as supplied by publisher]
Source: Revista Espanola de Enfermedades Digestivas - Category: Gastroenterology Tags: Rev Esp Enferm Dig Source Type: research
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