The long non-coding RPPH1 is decreased in leukocytes and increased in plasma from women developing pre-eclampsia
In conclusion, RPPH1 expression in leukocytes was significantly decreased in women with pre-eclampsia, and the expression at 22-24 weeks associated with the subsequent development of pre-eclampsia. RPPH1 in leukocytes may be a useful biomarker for prediction and/or early detection of pre-eclampsia and an unknown regulator of the signaling affecting immune cells.PMID:38685609 | DOI:10.1093/biolre/ioae069 (Source: Biology of Reproduction)
Source: Biology of Reproduction - April 30, 2024 Category: Reproduction Medicine Authors: Dina-Marie Munkelien Myhrer Monica Fr øystad Marie Cecilie Paasche Roland Thor Ueland Tove Lekva Source Type: research
Hydralazine use can be associated with IgM-dominated immune complex-mediated glomerulonephritis
CONCLUSION: The hydralazine-induced autoimmune phenomenon can be seen in IgM-dominant ICMGN, which should be classified as a subtype of membranoproliferative glomerulonephritis.PMID:38685716 | DOI:10.1080/01913123.2024.2346660 (Source: Ultrastructural Pathology)
Source: Ultrastructural Pathology - April 30, 2024 Category: Pathology Authors: Ping L Zhang Brandon D Metcalf Sarang Khan Jamal Abukhaled Khalid Zafar Wei Li Hassan D Kanaan Source Type: research
Evaluation of the Efficacy and Safety of Tenofovir Disoproxil Fumarate in Intercepting Mother-to-Child Transmission of Hepatitis B Virus
This study assessed the effects of tenofovir disoproxil fumarate (TDF) in pregnant women for mother-to-infant transmission of HBV. A total of 122 pregnant women at our hospital met the inclusion criteria for high HBV DNA viral loads. They were randomly divided into TDF-treatment (n=70) and placebo (n=52) groups. Maternal liver function and serum HBV DNA load were tested before and after treatment. Clinical and laboratory data of infants were assayed at delivery and 7-months post-partum visit and compared between the two groups. There was no difference in clinical characteristics of participants between the two groups. Ther...
Source: Acta Med Okayama - April 30, 2024 Category: Universities & Medical Training Authors: Dongxiang Han Jianxiu Du Wei Wang Cui Wang Source Type: research
'Playing catch-up': safety and optimal tackle outcomes in women's rugby union (PhD Academy Award)
Br J Sports Med. 2024 Apr 30:bjsports-2024-108251. doi: 10.1136/bjsports-2024-108251. Online ahead of print.NO ABSTRACTPMID:38688696 | DOI:10.1136/bjsports-2024-108251 (Source: British Journal of Sports Medicine)
Source: British Journal of Sports Medicine - April 30, 2024 Category: Sports Medicine Authors: Kathryn Dane Source Type: research
Women's Under-representation in Aortic Arch Treatments: Revisiting the Evidence
Eur J Vasc Endovasc Surg. 2024 Apr 27:S1078-5884(24)00374-5. doi: 10.1016/j.ejvs.2024.04.038. Online ahead of print.NO ABSTRACTPMID:38685312 | DOI:10.1016/j.ejvs.2024.04.038 (Source: PubMed: Eur J Vasc Endovasc ...)
Source: PubMed: Eur J Vasc Endovasc ... - April 30, 2024 Category: Surgery Authors: Pere Altes Mas Luc ía Martínez Carnovale Source Type: research
Age group-specific changes in keratinocyte cancer treatment rates in Australia, 2012- 2021: a retrospective cohort study based on MBS claims data
CONCLUSIONS: Rates of MBS-subsidised treatment for keratinocyte cancers increased during 2012-2019, but BCC/SCC treatment rates declined among younger Australians, who have probably been exposed to less sunlight than earlier generations because of public health interventions and population-wide lifestyle changes related to technology use.PMID:38685827 | DOI:10.5694/mja2.52293 (Source: Med J Aust)
Source: Med J Aust - April 30, 2024 Category: General Medicine Authors: Catherine M Olsen Nirmala Pandeya Rachel E Neale David C Whiteman Source Type: research
Burden and outcomes of postpartum haemorrhage in Nigerian referral-level hospitals
CONCLUSIONS: A PPH prevalence of 3.2% can be reduced with improved access to skilled birth attendants.PMID:38686455 | DOI:10.1111/1471-0528.17822 (Source: BJOG : An International Journal of Obstetrics and Gynaecology)
Source: BJOG : An International Journal of Obstetrics and Gynaecology - April 30, 2024 Category: OBGYN Authors: Tajudeen Adebayo Ayodeji Adefemi Idowu Adewumi Opeyemi Akinajo Bola Akinkunmi David Awonuga Olufemi Aworinde Ekundayo Ayegbusi Iyabode Dedeke Iretiola Fajolu Zainab Imam Olusoji Jagun Olumide Kuku Ezra Ogundare Timothy Oluwasola Lawal Oyeneyin Damilola Ad Source Type: research
Factors associated with caregiver burden in primary caregivers of older adults with type2 diabetes
CONCLUSIONS: Prevention programs are required to avoid CC and complications, as well as interventions to improve the quality of life of the CPI and patients in care, incorporating strategies to generate and/or increase their family and social support networks.PMID:38688187 | DOI:10.1016/j.aprim.2024.102948 (Source: Atencion Primaria)
Source: Atencion Primaria - April 30, 2024 Category: Primary Care Authors: Ricardo Alejandro S ánchez Bárcenas Daniel L ópez Hernández Leticia Brito-Aranda Brenda Berenice Garc ía Mantilla Mar ía Del Rocío Thompson Bonilla Ernestina Pav ón Delgado Luis Beltr án Lagunes Roberto Dur án Rojo Emmanuel Melgarejo-Estefan Tan Source Type: research
Psychometric Evaluation of the Family Willingness for Caregiving Scale
CONCLUSIONS: Further testing of the FWCS is needed. After refinement, the FWCS could be used to evaluate factors contributing to caregiving willingness of family members of ICU patients and advance the science related to family engagement in the ICU. Additionally, it could be used as a practical tool to suggest family caregiving activities in the ICU.PMID:38688853 | DOI:10.4037/ajcc2024809 (Source: American Journal of Critical Care)
Source: American Journal of Critical Care - April 30, 2024 Category: Nursing Authors: Cindy Wilk Amy Petrinec Source Type: research
Bioequivalence of Related GelShield < sup > Ⓡ < /sup > Sustained-Release Formulations of Metformin: A Pooled Pharmacokinetic Analysis
Clin Ther. 2024 Apr 29:S0149-2918(24)00077-8. doi: 10.1016/j.clinthera.2024.03.011. Online ahead of print.ABSTRACTPURPOSE: GlucophageⓇ (Merck Healthcare KGaA, Darmstadt, Germany) is the originator brand of metformin hydrochloride, an oral antidiabetic drug. Metformin is recommended in guidelines as first-line treatment of type 2 diabetes mellitus and increasingly in related insulin-resistant conditions, such as prediabetes and polycystic ovary syndrome. The GelShieldⓇ sustained-release formulation tablet of GlucophageⓇ has been improved from the historic version marketed in 2000. Bioequivalence has been demonstrated ...
Source: Clinical Therapeutics - April 30, 2024 Category: Drugs & Pharmacology Authors: Axel Krebs-Brown Kerstin M G Brand Marco A F Nogueira Filho Sumedh Gaikwad Yvonne Schnaars Source Type: research
Oridonin promotes RSL3-induced ferroptosis in breast cancer cells by regulating the oxidative stress signaling pathway JNK/Nrf2/HO-1
This study provides a theoretical basis for the application of ORI based on the mechanism of ferroptosis, and provides potential natural drug candidates for cancer prevention and treatment.PMID:38685305 | DOI:10.1016/j.ejphar.2024.176620 (Source: European Journal of Pharmacology)
Source: European Journal of Pharmacology - April 30, 2024 Category: Drugs & Pharmacology Authors: Shiying Ye Xiangyan Hu Shaowei Sun Bo Su Jiye Cai Jinhuan Jiang Source Type: research
Seroprevalence of Toxoplasma gondii and Associated Risk Factors among Pregnant Women in Algeria
Am J Trop Med Hyg. 2024 Apr 30:tpmd230187. doi: 10.4269/ajtmh.23-0187. Online ahead of print.ABSTRACTToxoplasma gondii is an obligate intracellular protozoan parasite affecting all warm-blooded vertebrates, including humans. Infections in humans can lead to severe clinical manifestations in pregnant women and immunocompromised patients. The aim of the present study was to assess seroprevalence of T. gondii infection and to identify the associated risk factors among pregnant women from southern Algeria. A cross-sectional study was conducted from March 2021 to May 2022 among 1,345 pregnant women. A structured questionnaire w...
Source: Am J Trop Med Hyg - April 30, 2024 Category: Infectious Diseases Authors: Soumia Sebaa Jerzy M Behnke Amina Labed Marawan A Abu-Madi Source Type: research
Zibotentan Can Be Co-administered with Contraceptives Containing Ethinyl Estradiol and Levonorgestrel: A Pharmacokinetic Drug-Drug Interaction Study
In conclusion, contraception containing ethinyl estradiol/levonorgestrel is regarded possible under zibotentan-containing treatments. This expands choices for women of childbearing potential, supporting diversity in the ZENITH High Proteinuria trial.PMID:38686600 | DOI:10.1002/cpt.3280 (Source: Clinical Pharmacology and Therapeutics)
Source: Clinical Pharmacology and Therapeutics - April 30, 2024 Category: Drugs & Pharmacology Authors: Anne-Kristina Mercier Abigail K Kois Deeyen Karsanji Richard Baldry Filip Birve Maria Hedwall Oleksandr Molodetskyi Michael Gillen Source Type: research
Basal Hyperglycemia Contributes More Than Fifty Percent to Time in Range in Pregnant Women with Type 1 Diabetes
CONCLUSIONS: Basal hyperglycemia was the major contributor to TIR during pregnancy. Along with controlling the postprandial hyperglycemia, pregnant women with T1DM who did not reach the target of TIR may benefit more from the optimization of insulin regimens focusing on reducing basal glucose.PMID:38686666 | DOI:10.1210/clinem/dgae291 (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - April 30, 2024 Category: Endocrinology Authors: Ping Ling Daizhi Yang Chaofan Wang Xueying Zheng Sihui Luo Xubin Yang Hongrong Deng Wen Xu Jinhua Yan Jianping Weng Source Type: research
Age group-specific changes in keratinocyte cancer treatment rates in Australia, 2012- 2021: a retrospective cohort study based on MBS claims data
CONCLUSIONS: Rates of MBS-subsidised treatment for keratinocyte cancers increased during 2012-2019, but BCC/SCC treatment rates declined among younger Australians, who have probably been exposed to less sunlight than earlier generations because of public health interventions and population-wide lifestyle changes related to technology use.PMID:38685827 | DOI:10.5694/mja2.52293 (Source: Medical Journal of Australia)
Source: Medical Journal of Australia - April 30, 2024 Category: General Medicine Authors: Catherine M Olsen Nirmala Pandeya Rachel E Neale David C Whiteman Source Type: research
