Does the use of bisphosphonates during pregnancy affect fetal outcomes? A systematic review
ConclusionAlthough previous reports have linked BPs before or during pregnancy with adverse neonatal outcomes, these associations should be interpreted with caution. Given the complexity of these findings, further research is necessary to provide more definitive insights to guide clinical decisions regarding the use of BPs in pregnant women. (Source: European Journal of Clinical Pharmacology)
Source: European Journal of Clinical Pharmacology - May 1, 2024 Category: Drugs & Pharmacology Source Type: research
Response to the Letter to the Editor by Jorge Violante-Cumpa; Marina Norde & amp; Geloneze Geloneze “Fat-free mass index is a feasible predictor of insulin resistance in women with polycystic ovary syndrome: evidence from a cross-sectional study”
(Source: Endocrine)
Source: Endocrine - May 1, 2024 Category: Endocrinology Source Type: research
Alterations of cardiometabolic risk profile in polycystic ovary syndrome: 13 years follow-up in an unselected population
ConclusionsAging women with PCOS in the population have higher androgen levels and similar cardiometabolic risk profile compared to age- and BMI-matched healthy women. Epicardial fat thickness, a marker of cardiometabolic risk, appear to be associated with hyperandrogenism. Further research is needed on larger community-based cohorts where older patients are assessed with a longer follow-up. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - May 1, 2024 Category: Endocrinology Source Type: research
Risks of suboptimal and excessive thyroid hormone replacement across ages
ConclusionSuboptimal and excessive LT4 replacement of the preventable non-communicable disease hypothyroidism requires more focus from the healthcare system and from the global political systems to prevent the personally devastating and socioeconomically challenging consequences. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - May 1, 2024 Category: Endocrinology Source Type: research
Does gestational diabetes mellitus increase the risk of cardiovascular disease? A Mendelian randomization study
ConclusionWomen with a prior history of GDM face an elevated risk of future CAD. This increased risk of CAD cannot be solely attributed to the subsequent onset of diabetes. Regular CAD risk assessment and primary prevention strategies are of paramount importance for women with a history of GDM. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - May 1, 2024 Category: Endocrinology Source Type: research
Cost-effectiveness of pessary therapy versus surgery for symptomatic pelvic organ prolapse: an economic evaluation alongside a randomised non-inferiority controlled trial
Conclusions
Non-inferiority of pessary therapy regarding the PGI-I could not be shown and no statistically significant differences in QALYs between interventions were found. Due to significantly lower costs, pessary therapy is likely to be cost-effective compared with surgery as an initial treatment option for women with symptomatic POP treated in secondary care.
Trial registration number
NTR4883. (Source: BMJ Open)
Source: BMJ Open - May 1, 2024 Category: General Medicine Authors: Ben, A. J., van der Vaart, L. R., E. Bosmans, J., Roovers, J.-P. W. R., Lagro-Janssen, A. L. M., van der Vaart, C. H., Vollebregt, A., PEOPLE group, Milani, Bon, Bongers, Bos, Broekman, Dietz, van Eijndhoven, Hakvoort, Janszen, Kluivers, Link, Massop-Helm Tags: Open access, Health economics Source Type: research
The Women ’s Health Initiative Randomized Trials and Clinical Practice
This review of the Women ’s Health Initiative (WHI) summarizes the results of the 4 WHI clinical trials on menopausal hormone therapy, calcium plus vitamin D supplementation, and low-fat diet and their applications to current clinical practice. (Source: JAMA - Journal of the American Medical Association)
Source: JAMA - Journal of the American Medical Association - May 1, 2024 Category: General Medicine Source Type: research
Race and Ethnicity of Reproductive-Age Females Affected by US Abortion Bans
This study compares the race and ethnicity of reproductive-age females between states that implemented restrictive abortion policies after the Dobbs v Jackson Women ’s Health Organization decision and states that did not. (Source: JAMA - Journal of the American Medical Association)
Source: JAMA - Journal of the American Medical Association - May 1, 2024 Category: General Medicine Source Type: research
Determinants of unmet need for modern contraceptives in Ethiopia
Conclusions
High levels of unmet need for modern contraceptives were observed in Ethiopia, showing geographical variations. It is essential to address the key factors affecting women and work towards reducing disparities in modern contraceptive unmet needs among different regions. (Source: BMJ Open)
Source: BMJ Open - May 1, 2024 Category: General Medicine Authors: Gebrekidan, H., Alemayehu, M., Debelew, G. T. Tags: Open access, Public health Source Type: research
Status of the midwifery workforce and childbirth services and the impact of midwife staffing on birth outcomes in China: a multicentre cross-sectional study
Conclusion
The rates of childbirth interventions including the overall caesarean section in China and the episiotomy rate, especially in the central region, remain relatively high. Improved midwife staffing was associated with reduced rates of instrumental vaginal delivery and episiotomy, indicating that further investments in the midwifery workforce could produce better childbirth outcomes. (Source: BMJ Open)
Source: BMJ Open - May 1, 2024 Category: General Medicine Authors: Zhu, W., Zhu, C., Min, H., Li, L., Wang, X., Wu, J., Zhu, X., Gu, C. Tags: Open access, Health services research Source Type: research
Novel point-of-care cytokine biomarker lateral flow test for the screening for sexually transmitted infections and bacterial vaginosis: study protocol of a multicentre multidisciplinary prospective observational clinical study to evaluate the performance and feasibility of the Genital InFlammation Test (GIFT)
Introduction
A prototype lateral flow device detecting cytokine biomarkers interleukin (IL)-1α and IL-1β has been developed as a point-of-care test—called the Genital InFlammation Test (GIFT)—for detecting genital inflammation associated with sexually transmitted infections (STIs) and/or bacterial vaginosis (BV) in women. In this paper, we describe the rationale and design for studies that will be conducted in South Africa, Zimbabwe and Madagascar to evaluate the performance of GIFT and how it could be integrated into routine care.
Methods and analysis
We will conduct a prospective, multidisciplinar...
Source: BMJ Open - May 1, 2024 Category: General Medicine Authors: Ramboarina, S., Crucitti, T., Gill, K., Bekker, L. G., Harding-Esch, E. M., van de Wijgert, J. H. H. M., Huynh, B.-T., Fortas, C., Harimanana, A., Mayouya Gamana, T., Randremanana, R. V., Mangahasimbola, R., Dziva Chikwari, C., Kranzer, K., Mackworth-Youn Tags: Open access, Diagnostics Source Type: research
Pilsner Modification of Mesh Sacrohysterocolpopexy (PiMMS): An Initial Report on Safety and Efficacy
ConclusionsThe PiMMS technique seems to have comparable safety profile and patient-reported outcomes with the sLSH technique. However, there is a trend toward reduced anterior compartment failures with this modification. The findings of this preliminary report need to be re-evaluated in a well-powered prospective study. (Source: International Urogynecology Journal and Pelvic Floor Dysfunction)
Source: International Urogynecology Journal and Pelvic Floor Dysfunction - May 1, 2024 Category: OBGYN Source Type: research
Understanding the meaning of the lived experience “maternal role” in women with multiple sclerosis and planning a supportive program: a combined exploratory study protocol
The maternal role is one of the most challenging yet rewarding roles that women experience in their lives. It begins when a woman becomes pregnant, and as the pregnancy progresses, she prepares to fulfill her ... (Source: Reproductive Health)
Source: Reproductive Health - May 1, 2024 Category: OBGYN Authors: Elaheh Mansouri Ghezelhesari, Mohamad Ali Nahayati, Abbas Heydari, Hosein Ebrahimipour and Talat Khadivzadeh Tags: Study Protocol Source Type: research
Contraceptive behavior of women in India after induced abortion
Putting an end to the silent pandemic of unsafe abortion is a major public health concern globally. Adoption of post-abortion contraception is documented as a significant contributor to reduce the number of un... (Source: Reproductive Health)
Source: Reproductive Health - May 1, 2024 Category: OBGYN Authors: Labhita Das and Chander Shekhar Tags: Research Source Type: research
Randomized placebo-controlled, double-blind clinical trial of nanoemulsion curcumin in women with aromatase inhibitor-induced arthropathy: an Alliance/NCORP pilot trial
ConclusionNEC versus placebo in a multisite randomized trial is feasible and well-tolerated. Additional studies with larger sample size are needed to further evaluate the efficacy and safety of NEC in treatment of AIIA.ClinicalTrials.gov Identifier: NCT03865992, first posted March 7, 2019. (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - May 1, 2024 Category: Cancer & Oncology Source Type: research
