A Case of Refractory Anemia in Patient of Chronic Kidney Disease and the Challenges in its Management
J Assoc Physicians India. 2023 Oct;71(10):94-95. doi: 10.59556/japi.71.0331.ABSTRACTAnemia is a common complication of chronic kidney disease (CKD) that has been classically attributed to inadequate production of endogenous erythropoietin.1 Though there are many other common causes of refractory anemia in CKD like iron deficiency, vitamin B12, and folic acid deficiency, noncompliance to dialysis and erythropoietin therapy rare causes like blood loss, bone marrow failure, infections causing aplastic crisis like CMV, parvovirus B19 should be ruled out. Parvovirus has an extreme tropism for erythroid cells and is an uncommon ...
Source: Journal of the Association of Physicians of India - May 8, 2024 Category: General Medicine Authors: Komal Gade Charulata Londhe Sangeeta Pednekar Dharmendra Pandey Namita Padwal Ashish Agrwal Source Type: research
Efficacy of multivitamin support following bariatric surgery in patients with obesity: a prospective observational study
CONCLUSION: Following VSG or RYGB, Bariatrifast administration was associated with normal values of essential micronutrients, and it was well-tolerated without evidence of gastrointestinal side effects. Clinical Trial Registration ClinicalTrials.gov, identifiers NCT06152965.PMID:38714632 | PMC:PMC11076347 | DOI:10.1007/s40519-024-01655-7 (Source: Eating and weight disorders : EWD)
Source: Eating and weight disorders : EWD - May 7, 2024 Category: Eating Disorders & Weight Management Authors: Alessio Basolo Susanna Bechi Genzano Jacopo Vitti Guido Salvetti Donatella Gilio Giovanni Ceccarini Giovanna Scartabelli Chita Lippi Rosario Bellini Rudi Mancini Simone D'Imporzano Carlo Moretto Valentina Angeli Daniela Troiani Paola Fierabracci Roberta J Source Type: research
160 folic acid deficiency exacerbates biliary inflammation in primary biliary cholangitis by promoting cholangiocyte senescence
(Source: Gastroenterology)
Source: Gastroenterology - May 6, 2024 Category: Gastroenterology Authors: Hao Jia, Xue Zhang, Hui Yang, Xiaoyi Wang, Hongyu Chu, Man Liu, Bangmao Wang, Ying Ran, Long Li, Lu Zhou Tags: AASLD Abstracts Source Type: research
Effect of multiple micronutrient-fortified bouillon on micronutrient status among women and children in the Northern Region of Ghana: Protocol for the Condiment Micronutrient Innovation Trial (CoMIT), a community-based randomized controlled trial
This study aims to evaluate the impact of multiple micronutrient-fortified bouillon cubes, compared to control bouillon cubes (fortified with iodine only), on micronutrient status and hemoglobin concentrations among lactating and non-lactating WRA and young children in northern Ghana. MethodsThis randomized, controlled doubly-masked trial will be conducted in the Kumbungu and Tolon districts in the Northern Region of Ghana, where prior data indicate multiple micronutrient deficiencies are common. Participants will be: 1) non-pregnant non-lactating WRA (15 –49 y), 2) children 2–5 y, and 3) non-pregnant lactating women 4...
Source: PLoS One - May 6, 2024 Category: Biomedical Science Authors: Reina Engle-Stone Source Type: research
Sirenomelia or mermaid syndrome with a cleft lip in a Tanzanian newborn: a case report
ConclusionSirenomelia is a rare congenital malformation with very poor prognosis. Specific interventions during pre-conception and early prenatal care are critical in the prevention of specific congenital anomalies. Early obstetric ultrasonography is invaluable for diagnosis of sirenomelia as well as counseling for possible termination of pregnancy. (Source: Journal of Medical Case Reports)
Source: Journal of Medical Case Reports - May 6, 2024 Category: General Medicine Source Type: research
A quality of care assessment for women of childbearing potential with epilepsy in Bhutan: An observational study
CONCLUSIONS: Based on data about WWE participants' ASM, supplement, and substance use, our study identified the high use of first generation ASMs (including valproate), frequently in polytherapy, and betel nut use as treatment gaps in women of childbearing potential age with active epilepsy in Bhutan. To address these gaps for locations such as Bhutan, we propose modifications to the QUIET tool's "Chronic Epilepsy Care for Women" section.PMID:38704988 | DOI:10.1016/j.yebeh.2024.109819 (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - May 5, 2024 Category: Neurology Authors: Maya L Mastick Lhab Tshering Ugyen Dema Bikram Chhetri Chencho Dorji Damber K Nirola Puja Subedi Sonam Lhamo Kiran Diyali Sonam R Chodden Andrew S Ham Farrah J Mateen Bhutan Epilepsy Project Source Type: research
A quality of care assessment for women of childbearing potential with epilepsy in Bhutan: An observational study
CONCLUSIONS: Based on data about WWE participants' ASM, supplement, and substance use, our study identified the high use of first generation ASMs (including valproate), frequently in polytherapy, and betel nut use as treatment gaps in women of childbearing potential age with active epilepsy in Bhutan. To address these gaps for locations such as Bhutan, we propose modifications to the QUIET tool's "Chronic Epilepsy Care for Women" section.PMID:38704988 | DOI:10.1016/j.yebeh.2024.109819 (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - May 5, 2024 Category: Neurology Authors: Maya L Mastick Lhab Tshering Ugyen Dema Bikram Chhetri Chencho Dorji Damber K Nirola Puja Subedi Sonam Lhamo Kiran Diyali Sonam R Chodden Andrew S Ham Farrah J Mateen Bhutan Epilepsy Project Source Type: research
The role of singlet oxygen and hydroxyl radical in the photobleaching of meso-substituted cationic pyridyl porphyrins in the presence of folic acid
Journal of Innovative Optical Health Sciences, Ahead of Print. Using a photosensitizer (PS), light, and oxygen, photodynamic therapy creates cytotoxic reactive oxygen species, such as singlet oxygen (1O2), that kill cancer cells. Many cancer cell lines have up to 300 times more folic acid receptors than healthy cells. Therefore, folic acid is often used to improve selectivity of PSs. Photobleaching poses a disadvantage for PSs. In this paper, we have studied the photoinduced changes of meso-substituted cationic pyridyl porphyrins in the presence of folic acid using fluorescence and absorption spectroscopy. In this work, it...
Source: Journal of Innovative Optical Health Sciences - May 4, 2024 Category: Biomedical Science Authors: Lusine Mkrtchyan Torgom Seferyan Marina Parkhats Sergei Lepeshkevich Boris Dzhagarov Gagik Shmavonyan Elena Tuchina Valery Tuchin Grigor Gyulkhandanyan Source Type: research
Role of vitamin B12 and folic acid in treatment of Alzheimer's disease: a meta-analysis of randomized control trials
Aging (Albany NY). 2024 May 2;16. doi: 10.18632/aging.205788. Online ahead of print.ABSTRACTVitamin B12 and folic acid could reduce blood homocysteine levels, which was thought to slow down the progression of Alzheimer's disease (AD), but previous studies regarding the effect of vitamin B12 and folic acid in treatment of AD have not reached conclusive results. We searched PubMed and Embase until January 12, 2023. Only randomized control trials involving participants clearly diagnosed with AD and who received vitamin B12 and folic acid were enrolled. Five studies that met the criteria were selected for inclusion in the meta...
Source: Aging - May 3, 2024 Category: Biomedical Science Authors: Chih-Ying Lee Lung Chan Chaur-Jong Hu Chien-Tai Hong Jia-Hung Chen Source Type: research
Role of vitamin B12 and folic acid in treatment of Alzheimer's disease: a meta-analysis of randomized control trials
Aging (Albany NY). 2024 May 2;16. doi: 10.18632/aging.205788. Online ahead of print.ABSTRACTVitamin B12 and folic acid could reduce blood homocysteine levels, which was thought to slow down the progression of Alzheimer's disease (AD), but previous studies regarding the effect of vitamin B12 and folic acid in treatment of AD have not reached conclusive results. We searched PubMed and Embase until January 12, 2023. Only randomized control trials involving participants clearly diagnosed with AD and who received vitamin B12 and folic acid were enrolled. Five studies that met the criteria were selected for inclusion in the meta...
Source: Aging - May 3, 2024 Category: Biomedical Science Authors: Chih-Ying Lee Lung Chan Chaur-Jong Hu Chien-Tai Hong Jia-Hung Chen Source Type: research
Role of vitamin B12 and folic acid in treatment of Alzheimer's disease: a meta-analysis of randomized control trials
Aging (Albany NY). 2024 May 2;16. doi: 10.18632/aging.205788. Online ahead of print.ABSTRACTVitamin B12 and folic acid could reduce blood homocysteine levels, which was thought to slow down the progression of Alzheimer's disease (AD), but previous studies regarding the effect of vitamin B12 and folic acid in treatment of AD have not reached conclusive results. We searched PubMed and Embase until January 12, 2023. Only randomized control trials involving participants clearly diagnosed with AD and who received vitamin B12 and folic acid were enrolled. Five studies that met the criteria were selected for inclusion in the meta...
Source: Aging - May 3, 2024 Category: Biomedical Science Authors: Chih-Ying Lee Lung Chan Chaur-Jong Hu Chien-Tai Hong Jia-Hung Chen Source Type: research
Role of vitamin B12 and folic acid in treatment of Alzheimer's disease: a meta-analysis of randomized control trials
Aging (Albany NY). 2024 May 2;16. doi: 10.18632/aging.205788. Online ahead of print.ABSTRACTVitamin B12 and folic acid could reduce blood homocysteine levels, which was thought to slow down the progression of Alzheimer's disease (AD), but previous studies regarding the effect of vitamin B12 and folic acid in treatment of AD have not reached conclusive results. We searched PubMed and Embase until January 12, 2023. Only randomized control trials involving participants clearly diagnosed with AD and who received vitamin B12 and folic acid were enrolled. Five studies that met the criteria were selected for inclusion in the meta...
Source: Aging - May 3, 2024 Category: Biomedical Science Authors: Chih-Ying Lee Lung Chan Chaur-Jong Hu Chien-Tai Hong Jia-Hung Chen Source Type: research
Targeted photodynamic therapy technique of Janus nanoparticles on breast cancer
Artif Cells Nanomed Biotechnol. 2024 Dec;52(1):270-277. doi: 10.1080/21691401.2024.2347369. Epub 2024 May 2.ABSTRACTSpherical gold/polyacrylic acid (Au/PAA) polymer-inorganic Janus nanoparticles (JNPs) with simultaneous therapeutic and targeting functions were fabricated. The obtained Au/PAA JNPs were further selectively functionalized with folic acid (FA) and thiol PEG amine (SH-PEG-NH2) on Au sides to provide superior biocompatibility and active targeting, while the other PAA sides were loaded with 5-aminolevulinic acid (5-ALA) to serve as a photosensitizer (PS) for photodynamic therapeutic (PDT) effects on MCF-7 cancer ...
Source: Artificial Cells, Nanomedicine and Biotechnology - May 2, 2024 Category: Biotechnology Authors: Hanieh Montaseri Heidi Abrahamse Source Type: research
Functionalized liposomes as a potential drug delivery systems for colon cancer treatment: A systematic review
Int J Biol Macromol. 2024 Apr 30:132023. doi: 10.1016/j.ijbiomac.2024.132023. Online ahead of print.ABSTRACTColon cancer is one of the lethal diseases in the world with approximately 700,000 fatalities annually (Abdulzehra et al., 2023 [1]). Nowadays, due to the side effects of existing methods in the treatment of colon cancer such as radiotherapy and chemotherapy, the use of targeted nanocarriers in cancer treatment has received wide attention, and among them, especially liposomes have been studied a lot. Based on this, anti-tumor drugs hidden in targeted active liposomes can selectively act on cancer cells. In this syste...
Source: International Journal of Biological Macromolecules - May 2, 2024 Category: Biochemistry Authors: Eskandar Moghimipour Somayeh Handali Source Type: research
Targeted photodynamic therapy technique of Janus nanoparticles on breast cancer
Artif Cells Nanomed Biotechnol. 2024 Dec;52(1):270-277. doi: 10.1080/21691401.2024.2347369. Epub 2024 May 2.ABSTRACTSpherical gold/polyacrylic acid (Au/PAA) polymer-inorganic Janus nanoparticles (JNPs) with simultaneous therapeutic and targeting functions were fabricated. The obtained Au/PAA JNPs were further selectively functionalized with folic acid (FA) and thiol PEG amine (SH-PEG-NH2) on Au sides to provide superior biocompatibility and active targeting, while the other PAA sides were loaded with 5-aminolevulinic acid (5-ALA) to serve as a photosensitizer (PS) for photodynamic therapeutic (PDT) effects on MCF-7 cancer ...
Source: Artificial Cells, Nanomedicine and Biotechnology - May 2, 2024 Category: Biotechnology Authors: Hanieh Montaseri Heidi Abrahamse Source Type: research
