Model eye tool for retinal optical coherence tomography instrument calibration
Journal of Innovative Optical Health Sciences, Ahead of Print. Optical coherence tomography (OCT) has been extensively used as noninvasive tool for biological tissues owing to its three-dimensional imaging ability and high axial resolution. OCT quality assurance is vital in these occasions to keep the reliability and accuracy in medical diagnosis. It is necessary to develop a calibration tool for OCT product manufacture, calibration, and quality control. A practical tool is demanded in the OCT quality control and calibration of OCT. So far, there is no such a practical tool that can test all the key parameters of OCT. We d...
Source: Journal of Innovative Optical Health Sciences - April 7, 2021 Category: Biomedical Science Authors: Hongting Wang Wenli Liu Zhixiong Hu Xiuyu Li Fei Li Liangcheng Duan Source Type: research

Investigation of artifacts by mapping SAR in thermoacoustic imaging
In this study, to reveal the underlying mechanisms of artifacts, we deeply investigate the distribution of specific absorption rate (SAR) inside tissue-mimicking phantoms with varied morphological features using both mathematical simulations and corresponding experiments. Our simulated results, which are confirmed by the associated experimental results, show that the SAR distribution highly depends on the geometries of the imaging targets and the polarizing features of the microwave. In addition, we propose the potential mechanisms including Mie-scattering, Fabry-Perot-feature, small curvature effect to interpret the diffr...
Source: Journal of Innovative Optical Health Sciences - April 5, 2021 Category: Biomedical Science Authors: Xiao Liang Qiang Liu Zezhou Sun Weizhi Qi Yubin Gong Lei Xi Source Type: research

Depth perception on fundus images using a single-channel stereomicroscopy
Journal of Innovative Optical Health Sciences, Ahead of Print. Typical fundus photography produces a two-dimensional image. This makes it difficult to observe the microvascular and neural abnormalities, because the depth of the image is missing. To provide depth appreciation, we develop a single-channel stereoscopic fundus video imaging system based on a rotating refractor. With respect to the pupil center, the rotating refractor laterally displaces the optical path and the illumination. This allows standard monocular fundus cameras to generate stereo-parallax and image disparity through sequential image acquisition. We op...
Source: Journal of Innovative Optical Health Sciences - March 29, 2021 Category: Biomedical Science Authors: Edalat Radfar Hyunseon Yu Tien Son Ho Seung Ho Choi Byungjo Jung Source Type: research

Differentiation of different antifungals with various mechanisms using dynamic surface-enhanced Raman spectroscopy combined with machine learning
Journal of Innovative Optical Health Sciences, Ahead of Print. With the increase in mortality caused by pathogens worldwide and the subsequent serious drug resistance owing to the abuse of antibiotics, there is an urgent need to develop versatile analytical techniques to address this public issue. Vibrational spectroscopy, such as infrared (IR) or Raman spectroscopy, is a rapid, noninvasive, nondestructive, real-time, low-cost, and user-friendly technique that has recently gained considerable attention. In particular, surface-enhanced Raman spectroscopy (SERS) can provide a highly sensitive readout for bio-detection with u...
Source: Journal of Innovative Optical Health Sciences - March 25, 2021 Category: Biomedical Science Authors: Hao Li Yongbing Cao Feng Lu Source Type: research

Binary organic nanoparticles with enhanced reactive oxygen species generation capability for photodynamic therapy
In this study, we report a strategy to overwhelm the ACQ of porphyrin by doping it with a type of aggregation-induced emission (AIE) luminogen to produce a binary NPs with high biocompatibility, and enhanced fluorescence and ROS generation capability. Such NPs can be readily synthesized by mixing a porphyrin derivative, Ce6 with a typical AIE luminogen, TPE-Br. Here, our experimental results have demonstrated the feasibility and effectiveness of this strategy, endowing it a great potential in clinical applications. (Source: Journal of Innovative Optical Health Sciences)
Source: Journal of Innovative Optical Health Sciences - March 12, 2021 Category: Biomedical Science Authors: Xiaofu Weng Zhouzhou Bao Xunbin Wei Source Type: research

Release characteristics of different diameter ultrafine fibers as antibacterial materials
Journal of Innovative Optical Health Sciences,Volume 14, Issue 02, March 2021. Although the electrospinning technique has been devoted to promoting therapeutic purposes as a drug carrier, however, there are still many fundamental problems in this area. This work focuses on a comparison of various diameter polyethersulfone (PES) electrospun ultrafine fibers as antimicrobial materials. The fibrous morphology, antimicrobial agent distribution, thermally property, and biocompatibility evaluation of PES-based ultrafine fibers were systematically investigated. The results demonstrated that the PES-based ultrafine fibers were sui...
Source: Journal of Innovative Optical Health Sciences - February 27, 2021 Category: Biomedical Science Authors: Zhiqiang Wei Erniao Liu Hao Li Zhimei Wei Zhi lv Source Type: research

Optical penetration of surface-enhanced micro-scale spatial offset Raman spectroscopy in turbid gel and biological tissue
Journal of Innovative Optical Health Sciences, Ahead of Print. The limited penetration of photons in biological tissue restricts the deep-tissue detection and imaging application. The micro-scale spatially offset Raman spectroscopy (micro-SORS) with an optical fiber probe, colleting photons from deeper regions by offsetting the position of laser excitation from the collection optics in a range of hundreds of microns, shows great potential to be integrated with endoscopy for inside-body noninvasive detection by circumventing this restriction, particularly with the combination of surface-enhanced Raman spectroscopy (SERS). H...
Source: Journal of Innovative Optical Health Sciences - February 22, 2021 Category: Biomedical Science Authors: Yumin Zhang Li Lin Jing He Jian Ye Source Type: research

Simulation of stimulated Raman scattering signal generation in scattering tissues excited by Bessel beams
Journal of Innovative Optical Health Sciences, Ahead of Print. Stimulated Raman scattering (SRS) microscopy has the ability of noninvasive imaging of specific chemical bonds and been increasingly used in biomedicine in recent years. Two pulsed Gaussian beams are used in traditional SRS microscopes, providing with high lateral and axial spatial resolution. Because of the tight focus of the Gaussian beam, such an SRS microscopy is difficult to be used for imaging deep targets in scattering tissues. The SRS microscopy based on Bessel beams can solve the imaging problem to a certain extent. Here, we establish a theoretical mod...
Source: Journal of Innovative Optical Health Sciences - February 20, 2021 Category: Biomedical Science Authors: Xinyu Wang Lin Wang Peng Lin Hui Xie Xinyi Xu Qi Zeng Yonghua Zhan Xueli Chen Source Type: research

Antiviral optical techniques as a possible novel approach to COVID-19 treatment
This study will point out some new antimicrobial technologies that have great potentials for eradicating and preventing emerging infections. They can be considered as treatments of choice for viral infections in the future. (Source: Journal of Innovative Optical Health Sciences)
Source: Journal of Innovative Optical Health Sciences - February 6, 2021 Category: Biomedical Science Authors: Fereshteh Moshfegh Farshad Khosraviani Negar Moghaddasi Seyedeh Fatemeh Seyed Javadi Limoodi Ebrahim Boluki Source Type: research

Automated retinal layer segmentation on optical coherence tomography image by combination of structure interpolation and lateral mean filtering
Journal of Innovative Optical Health Sciences,Volume 14, Issue 01, January 2021. Segmentation of layers in retinal images obtained by optical coherence tomography (OCT) has become an important clinical tool to diagnose ophthalmic diseases. However, due to the susceptibility to speckle noise and shadow of blood vessels etc., the layer segmentation technology based on a single image still fail to reach a satisfactory level. We propose a combination method of structure interpolation and lateral mean filtering (SI-LMF) to improve the signal-to-noise ratio based on one retinal image. Before performing one-dimensional lateral me...
Source: Journal of Innovative Optical Health Sciences - February 3, 2021 Category: Biomedical Science Authors: Yushu Ma Yingzhe Gao Zhaolin Li Ang Li Yi Wang Jian Liu Yao Yu Wenbo Shi Zhenhe Ma Source Type: research

Introduction to the Special Issue on Optical Coherence Tomography (OCT)
Journal of Innovative Optical Health Sciences,Volume 14, Issue 01, January 2021. (Source: Journal of Innovative Optical Health Sciences)
Source: Journal of Innovative Optical Health Sciences - February 3, 2021 Category: Biomedical Science Authors: Zhihua Ding Peng Li Ruikang Ricky Wang Source Type: research

Determination of the immunoglobulin G precipitation end-point by an intelligent near-infrared spectroscopy system
In conclusion, all results indicated that the integrated NIR system could be used to monitor the biopharmaceutical process to help us understand the pharmaceutical process. (Source: Journal of Innovative Optical Health Sciences)
Source: Journal of Innovative Optical Health Sciences - January 29, 2021 Category: Biomedical Science Authors: Chen Yu Shuang Quan Cui Yang Chengliang Zhang Jiajin Fan Lian Li Hengchang Zang Source Type: research

Refractive index characteristics of edible oils based on spectrometry and effects of oil dispersion on OCT
In this study, by deriving the refractive index equations of the double glass sheet holding device and oil, the reflectance spectra of three different types of oil samples, namely, peanut oil, colza oil, and kitchen waste oil, were measured via a spectrometer. Furthermore, the refractive index model of these different types of oil samples was investigated. Additionally, based on the oil dispersion characteristics, the dispersion of oil in optical coherence tomography (OCT) was compensated via deconvolution. In the wavelength range of [math] (380, 1500)[math]nm, the analytical expressions of the double glass sheet holding d...
Source: Journal of Innovative Optical Health Sciences - January 27, 2021 Category: Biomedical Science Authors: ShiJun Xu XiaoKang Li Source Type: research

Swept source intraoperative OCT angiography
Journal of Innovative Optical Health Sciences, Ahead of Print. To accurately guide surgical instruments during ophthalmic procedures, some necessary intraoperative depth perception is required, which standard surgical microscopes supply limitedly. Intraoperative optical coherence tomography (iOCT), combining optical coherence tomography (OCT) technology and surgical microscope, enables noninvasive, real-time and high-resolution cross-sectional imaging. Currently, though iOCT enables structural imaging, little research has been done on intraoperative angiography. In this work, we presented a swept-source intraoperative OCT ...
Source: Journal of Innovative Optical Health Sciences - January 19, 2021 Category: Biomedical Science Authors: Ziyi Zhang Tiepei Zhu Tongtong Cao Zhaoyu Gong Lin Yao Kaiyuan Liu Juan Ye Peng Li Source Type: research

ID-OCTA: OCT angiography based on inverse SNR and decorrelation features
Journal of Innovative Optical Health Sciences, Ahead of Print. Optical coherence tomography angiography (OCTA) takes the flowing red blood cells (RBCs) as intrinsic contrast agents, enabling fast and three-dimensional visualization of vasculature perfusion down to capillary level, without a requirement of exogenous fluorescent injection. Various motion-contrast OCTA algorithms have been proposed to effectively extract dynamic blood flow from static tissues utilizing the different components of OCT signals (including amplitude, phase and complex) with various operations (such as differential, variance and decorrelation). Th...
Source: Journal of Innovative Optical Health Sciences - January 18, 2021 Category: Biomedical Science Authors: Huakun Li Kaiyuan Liu Lin Yao Xiaofeng Deng Ziyi Zhang Peng Li Source Type: research

Constrained polynomial fit-based [math]-domain interpolation in swept-source optical coherence tomography
Journal of Innovative Optical Health Sciences, Ahead of Print. We propose a [math]-domain spline interpolation method with constrained polynomial fit based on spectral phase in swept-source optical coherence tomography (SS-OCT). A Mach –Zehnder interferometer (MZI) unit is connected to the swept-source of the SS-OCT system to generate calibration signal in sync with the fetching of interference spectra. The spectral phase of the calibration signal is extracted by Hilbert transformation. The fitted phase–time relationship is ob tained by polynomial fitting with the constraint of passing through the central spect...
Source: Journal of Innovative Optical Health Sciences - January 13, 2021 Category: Biomedical Science Authors: Tao Han Jianrong Qiu Di Wang Jia Meng Zhiyi Liu Zhihua Ding Source Type: research

The biostimulative effectiveness of photobiomodulation therapy application on thawed dental pulp stem cells
This study was conducted to understand the cellular proliferative effect of Photobiomodulation Therapy (PBMT) on thawed dental pulp stem cells (DPSCs) stored for 2 years. For this purpose, cells were exposed to PBMT for short period of time to evaluate the most appropriate PBMT parameter for stimulating cellular proliferation that can be used for future tissue engineering therapies. Fully characterized DPSCs were seperated into three groups according to the laser energy densities (5[math]J/cm2 or 7[math]J/cm2) applied and a group was served as control in which cells did not receive any laser irradiation. The cells in laser...
Source: Journal of Innovative Optical Health Sciences - January 11, 2021 Category: Biomedical Science Authors: Cenk Serhan Özverel Aylin İslam Hasan G üney Yılmaz Source Type: research

Research on optical properties of cardiovascular tissues based on OCT data
Journal of Innovative Optical Health Sciences, Ahead of Print. As a high-resolution optical imaging technology, Optical Coherence Tomography (OCT) has been widely used in the diagnosis and treatment of cardiovascular diseases. It has played an important role in the detection and identification of atherosclerotic plaques and has significant advantages. In this paper, we realized to extract the optical characteristic parameters of the target sample based on the OCT data by establishing optical transmission models conforming to the OCT principle. The optical phantoms and coronary artery of domestic pig were used as research s...
Source: Journal of Innovative Optical Health Sciences - January 9, 2021 Category: Biomedical Science Authors: Na Qin Yana Liu Lin Huang Yi Xin Xiao Zhang Xiaoming Hu Qin Li Source Type: research

Monitoring of edema progression in permanent and transient MCAO model using SS-OCT
In this study, we have monitored the edema formation and progression in both permanent and transient middle cerebral artery occlusion models in rats. Edema was reflected by the decrease of optical attenuation coefficient (OAC) value in OCT system. By utilizing swept-source optical coherence tomography (SS-OCT), we found that in photochemically induced permanent focal stroke model, both the edema size and edema index, steadily developed until the end of monitor (7[math]h). Comparatively, when transient ischemia was introduced with endothelin-1 (ET-1), the edema was detected as early as 15[math]min, and began to recover afte...
Source: Journal of Innovative Optical Health Sciences - January 4, 2021 Category: Biomedical Science Authors: Yao Yu Ziyue Meng Ang Li Yang Lin Jian Liu Yushu Ma Yi Wang Zhenhe Ma Source Type: research

Determination of diffusion coefficient by image-based fluorescence recovery after photobleaching and single particle tracking system implemented in a single platform
Journal of Innovative Optical Health Sciences,Volume 14, Issue 02, March 2021. Fluorescence recovery after photobleaching (FRAP) and single particle tracking (SPT) techniques determine the diffusion coefficient from average diffusive motion of high-concentration molecules and from trajectories of low-concentration single molecules, respectively. Lateral diffusion coefficients measured by FRAP and SPT techniques for the same biomolecule on cell membrane have exhibited inconsistent values across laboratories and platforms with larger diffusion coefficient determined by FRAP, but the sources of the inconsistency have not been...
Source: Journal of Innovative Optical Health Sciences - December 30, 2020 Category: Biomedical Science Authors: Donghee Lee Jeonghoon Lee Jung Kyung Kim Source Type: research

Determination of diffusion coefficient by image-based fluorescence recovery after photobleaching and single particle tracking system implemented in a single platform
Journal of Innovative Optical Health Sciences, Ahead of Print. Fluorescence recovery after photobleaching (FRAP) and single particle tracking (SPT) techniques determine the diffusion coefficient from average diffusive motion of high-concentration molecules and from trajectories of low-concentration single molecules, respectively. Lateral diffusion coefficients measured by FRAP and SPT techniques for the same biomolecule on cell membrane have exhibited inconsistent values across laboratories and platforms with larger diffusion coefficient determined by FRAP, but the sources of the inconsistency have not been investigated th...
Source: Journal of Innovative Optical Health Sciences - December 30, 2020 Category: Biomedical Science Authors: Donghee Lee Jeonghoon Lee Jung Kyung Kim Source Type: research

Development of a hydrogen peroxide-responsive and oxygen-carrying nanoemulsion for photodynamic therapy against hypoxic tumors using phase inversion composition method
Journal of Innovative Optical Health Sciences,Volume 14, Issue 02, March 2021. Photodynamic therapy (PDT) has become an attractive tumor treatment modality because of its noninvasive feature and low side effects. However, extreme hypoxia inside solid tumors severely impedes PDT therapeutic outcome. To overcome this obstacle, various strategies have been developed recently. Among them, in situ oxygen generation, which relies on the decomposition of tumor endogenous H2O2, and oxygen delivery tactic using high oxygen loading capacity of hemoglobin or perfluorocarbons, have been widely studied. The in situ oxygen generation st...
Source: Journal of Innovative Optical Health Sciences - December 23, 2020 Category: Biomedical Science Authors: Liang Hong Jia Zhang Junxian Geng Junle Qu Liwei Liu Source Type: research

Development of a hydrogen peroxide-responsive and oxygen-carrying nanoemulsion for photodynamic therapy against hypoxic tumors using phase inversion composition method
Journal of Innovative Optical Health Sciences, Ahead of Print. Photodynamic therapy (PDT) has become an attractive tumor treatment modality because of its noninvasive feature and low side effects. However, extreme hypoxia inside solid tumors severely impedes PDT therapeutic outcome. To overcome this obstacle, various strategies have been developed recently. Among them, in situ oxygen generation, which relies on the decomposition of tumor endogenous H2O2, and oxygen delivery tactic using high oxygen loading capacity of hemoglobin or perfluorocarbons, have been widely studied. The in situ oxygen generation strategy has high ...
Source: Journal of Innovative Optical Health Sciences - December 23, 2020 Category: Biomedical Science Authors: Liang Hong Jia Zhang Junxian Geng Junle Qu Liwei Liu Source Type: research

Deep learning algorithms to segment and quantify the choroidal thickness and vasculature in swept-source optical coherence tomography images
Journal of Innovative Optical Health Sciences, Ahead of Print. Accurate segmentation of choroidal thickness (CT) and vasculature is important to better analyze and understand the choroid-related ocular diseases. In this paper, we proposed and implemented a novel and practical method based on the deep learning algorithms, residual U-Net, to segment and quantify the CT and vasculature automatically. With limited training data and validation data, the residual U-Net was capable of identifying the choroidal boundaries as precise as the manual segmentation compared with an experienced operator. Then, the trained deep learning a...
Source: Journal of Innovative Optical Health Sciences - December 23, 2020 Category: Biomedical Science Authors: Gu Zheng Yanfeng Jiang Ce Shi Hanpei Miao Xiangle Yu Yiyi Wang Sisi Chen Zhiyang Lin Weicheng Wang Fan Lu Meixiao Shen Source Type: research

Corneal damage effects induced by infrared optical parametric oscillator radiation at 3743 nm
Journal of Innovative Optical Health Sciences,Volume 14, Issue 02, March 2021. The main aim of this paper is to investigate the corneal damage effects induced by mid-infrared optical parametric oscillator (OPO) radiation. Experiments were performed to determine the corneal damage thresholds of New Zealand white rabbit at the wavelength of 3743[math]nm for exposure durations of 0.1[math]s, 1.0[math]s and 10.0[math]s. Through slit-lamp biomicroscope and histopathology, corneal injury characteristics were revealed. The damage thresholds were 3.73[math]J/cm2, 7.91[math]J/cm2 and 31.1[math]J/cm2, respectively, for exposure dura...
Source: Journal of Innovative Optical Health Sciences - December 21, 2020 Category: Biomedical Science Authors: Luguang Jiao Chao Wang Kaizeng Zhang Jiarui Wang Zaifu Yang Source Type: research

Corneal damage effects induced by infrared optical parametric oscillator radiation at 3743 nm
Journal of Innovative Optical Health Sciences, Ahead of Print. The main aim of this paper is to investigate the corneal damage effects induced by mid-infrared optical parametric oscillator (OPO) radiation. Experiments were performed to determine the corneal damage thresholds of New Zealand white rabbit at the wavelength of 3743[math]nm for exposure durations of 0.1[math]s, 1.0[math]s and 10.0[math]s. Through slit-lamp biomicroscope and histopathology, corneal injury characteristics were revealed. The damage thresholds were 3.73[math]J/cm2, 7.91[math]J/cm2 and 31.1[math]J/cm2, respectively, for exposure durations of 0.1[mat...
Source: Journal of Innovative Optical Health Sciences - December 21, 2020 Category: Biomedical Science Authors: Luguang Jiao Chao Wang Kaizeng Zhang Jiarui Wang Zaifu Yang Source Type: research

A measurement of epidermal thickness of fingertip skin from OCT images using convolutional neural network
In this study, we proposed a method to measure the epidermal thickness (ET) of skin based on deep convolutional neural network, which was used to determine the boundaries of skin surface and the ridge portion in dermal –epidermis junction (DEJ) in cross-section optical coherence tomography (OCT) images of fingertip skin. The ET was calculated based on the row difference between the surface and the ridge top, which is determined by search the local maxima of boundary of the ridge portion. The results demonstrated that the region of ridge portion in DEJ was well determined and the ET measurement in this work can reduce...
Source: Journal of Innovative Optical Health Sciences - December 21, 2020 Category: Biomedical Science Authors: Yongping Lin Dezi Li Wang Liu Zhaowei Zhong Zhifang Li Youwu He Shulian Wu Source Type: research

Feasibility and utility of intraoperative optical coherence tomography during vitreoretinal surgery: A 4-year report in Chinese population
Conclusion: The application of iOCT has a significant clinical functionality in vitreoretinal surgery, providing the surgeon with a new surgical understanding, guiding the selection of a more reasonable operative procedure during surgery, predicting postoperative recovery and improving postoperative outcomes. (Source: Journal of Innovative Optical Health Sciences)
Source: Journal of Innovative Optical Health Sciences - December 16, 2020 Category: Biomedical Science Authors: Jiwei Tao Huan Chen Jiafeng Yu Dan Cheng Yiqi Chen Jianbo Mao Jia Fang Lijun Shen Source Type: research

A method of removing retardance induced by scattering of collagenous fiber bundles
Journal of Innovative Optical Health Sciences, Ahead of Print. In this work, we report a method of removing scattering induced retardance in polarization sensitive full field optical coherence tomography (PS-FFOCT). First, the Mueller matrix that describes its operation is derived. The thickness invariant retardance induced by the scattering of collagenous fiber bundles is then used to find the accurate values of the birefringence of the layers that consist collagenous fibers. Finally, the initial en face birefringent images of in vitro beef tendon samples are presented to demonstrate the capability of our method. (Source:...
Source: Journal of Innovative Optical Health Sciences - December 16, 2020 Category: Biomedical Science Authors: Wanrong Gao Siyu Liu Source Type: research

Identification of oral squamous cell carcinoma in optical coherence tomography images based on texture features
Journal of Innovative Optical Health Sciences, Ahead of Print. Surgical excision is an effective treatment for oral squamous cell carcinoma (OSCC), but exact intraoperative differentiation OSCC from the normal tissue is the first premise. As a noninvasive imaging technique, optical coherence tomography (OCT) has the nearly same resolution as the histopathological examination, whose images contain rich information to assist surgeons to make clinical decisions. We extracted kinds of texture features from OCT images obtained by a home-made swept-source OCT system in this paper, and studied the identification of OSCC based on ...
Source: Journal of Innovative Optical Health Sciences - December 16, 2020 Category: Biomedical Science Authors: Zihan Yang Jianwei Shang Chenlu Liu Jun Zhang Yanmei Liang Source Type: research

Inertial gradient method for fluorescence molecular tomography
Journal of Innovative Optical Health Sciences,Volume 14, Issue 02, March 2021. Image reconstruction in fluorescence molecular tomography involves seeking stable and meaningful solutions via the inversion of a highly under-determined and severely ill-posed linear mapping. An attractive scheme consists of minimizing a convex objective function that includes a quadratic error term added to a convex and nonsmooth sparsity-promoting regularizer. Choosing [math]-norm as a particular case of a vast class of nonsmooth convex regularizers, our paper proposes a low per-iteration complexity gradient-based first-order optimization alg...
Source: Journal of Innovative Optical Health Sciences - December 9, 2020 Category: Biomedical Science Authors: Lei Wang Hui Huang Source Type: research

Inertial gradient method for fluorescence molecular tomography
Journal of Innovative Optical Health Sciences, Ahead of Print. Image reconstruction in fluorescence molecular tomography involves seeking stable and meaningful solutions via the inversion of a highly under-determined and severely ill-posed linear mapping. An attractive scheme consists of minimizing a convex objective function that includes a quadratic error term added to a convex and nonsmooth sparsity-promoting regularizer. Choosing [math]-norm as a particular case of a vast class of nonsmooth convex regularizers, our paper proposes a low per-iteration complexity gradient-based first-order optimization algorithm for the [...
Source: Journal of Innovative Optical Health Sciences - December 9, 2020 Category: Biomedical Science Authors: Lei Wang Hui Huang Source Type: research

Author index Volume 13 (2020)
Journal of Innovative Optical Health Sciences,Volume 13, Issue 06, November 2020. (Source: Journal of Innovative Optical Health Sciences)
Source: Journal of Innovative Optical Health Sciences - November 1, 2020 Category: Biomedical Science Source Type: research

Assessment of myocardial viability using a minimally invasive laser Doppler flowmetry on pig model
Journal of Innovative Optical Health Sciences,Volume 14, Issue 02, March 2021. The intra-operative real-time assessment of tissue viability can potentially improve therapy delivery and clinical outcome in cardiovascular therapies. Cardiac ablation therapy for the treatment of supraventricular or ventricular arrhythmia continues to be done without being able to assess if the intended lesion and lesion size have been achieved. Here, we report a method for continuous measurements of cardiac muscle microcirculation to provide an instrument for real-time ablation monitoring. We performed two acute open chest animal studies to a...
Source: Journal of Innovative Optical Health Sciences - October 28, 2020 Category: Biomedical Science Authors: Karina Litvinova Berthold Stegemann Francisco Leyva Source Type: research

Quantification of potassium concentration with Vis –SWNIR spectroscopy in fresh lettuce
In this study, visible –short-wave near-infrared (Vis–SWNIR) spectroscopy and chemometric algorithms were investigated as nondestructive methods for assessing the potassium concentration in fresh lettuce to benefit the CKD patients’ health. Interactance and transmittance measurements were performed and the competenc ies were compared based on the multivariate methods of partial least-square regression (PLS) and support vector machine regression (SVR). Meanwhile, several preprocessing methods [first- and second-order derivatives in combination with standard normal variate (SNV)] and wavelength selection me...
Source: Journal of Innovative Optical Health Sciences - October 28, 2020 Category: Biomedical Science Authors: Yating Xiong Shintaroh Ohashi Kazuhiro Nakano Weizhong Jiang Kenichi Takizawa Kazuyuki Iijima Phonkrit Maniwara Source Type: research

Stick-slip nonuniform rotation distortion correction in distal scanning optical coherence tomography catheters
We present a robust and fiducial-marker-free algorithm that can identify and correct stick-slip distortion caused by nonuniform rotation (or beam scanning) in distally scanned catheters for endoscopic optical coherence tomography (OCT) images. This algorithm employs spatial frequency analysis to select and remove distortions. We demonstrate the feasibility of this algorithm on images acquired from ex vivo rat colon with a distally scanned DC motor-based endoscope. The proposed algorithm can be applied to general endoscopic OCT images for correcting nonuniform rotation distortion. (Source: Journal of Innovative Optical Health Sciences)
Source: Journal of Innovative Optical Health Sciences - October 28, 2020 Category: Biomedical Science Authors: Jessica Mavadia-Shukla Jianlin Zhang Kaiyan Li Xingde Li Source Type: research

Assessment of myocardial viability using a minimally invasive laser Doppler flowmetry on pig model
Conclusion: In vivo assessing the local microcirculation during RF ablation by laser Doppler can potentially be useful to differentiate between viable and nonviable ablated beating heart in real time. (Source: Journal of Innovative Optical Health Sciences)
Source: Journal of Innovative Optical Health Sciences - October 28, 2020 Category: Biomedical Science Authors: Karina Litvinova Berthold Stegemann Francisco Leyva Source Type: research

Observations of intracellular second-harmonic generation imaging in black phosphorus nanosheets
Journal of Innovative Optical Health Sciences,Volume 14, Issue 02, March 2021. Functionalized black phosphorus (BP) nanosheets have been considered as promising nanoagents in cancer therapy due to their excellent photothermal conversion efficiency. However, it is still difficult to visually monitor the dynamic localization of BP nanoagents in cancer cells. In this paper, we systematically studied the second-harmonic generation (SHG) signals originating from exfoliated BP nanosheets. Interestingly, under the excitation of a high frequency pulsed laser at 950 nm, the SHG signals of BP nanosheets in vitro are almost undetecta...
Source: Journal of Innovative Optical Health Sciences - October 21, 2020 Category: Biomedical Science Authors: Xiao Peng Yiwan Song Zheng Peng Kaixuan Nie Hao Liu Yingxin Zhou Feifan Zhou Yufeng Yuan Jun Song Junle Qu Source Type: research

Observations of intracellular second-harmonic generation imaging in black phosphorus nanosheets
Journal of Innovative Optical Health Sciences, Ahead of Print. Functionalized black phosphorus (BP) nanosheets have been considered as promising nanoagents in cancer therapy due to their excellent photothermal conversion efficiency. However, it is still difficult to visually monitor the dynamic localization of BP nanoagents in cancer cells. In this paper, we systematically studied the second-harmonic generation (SHG) signals originating from exfoliated BP nanosheets. Interestingly, under the excitation of a high frequency pulsed laser at 950 nm, the SHG signals of BP nanosheets in vitro are almost undetectable because of t...
Source: Journal of Innovative Optical Health Sciences - October 21, 2020 Category: Biomedical Science Authors: Xiao Peng Yiwan Song Zheng Peng Kaixuan Nie Hao Liu Yingxin Zhou Feifan Zhou Yufeng Yuan Jun Song Junle Qu Source Type: research

Structured illumination microscopy based on asymmetric three-beam interference
Journal of Innovative Optical Health Sciences,Volume 14, Issue 02, March 2021. Structured illumination microscopy (SIM) is a rapidly developing super-resolution technology. It has been widely used in various application fields of biomedicine due to its excellent two- and three-dimensional imaging capabilities. Furthermore, faster three-dimensional imaging methods are required to help enable more research-oriented living cell imaging. In this paper, a fast and sensitive three-dimensional structured illumination microscopy based on asymmetric three-beam interference is proposed. An innovative time-series acquisition method i...
Source: Journal of Innovative Optical Health Sciences - October 17, 2020 Category: Biomedical Science Authors: Linyu Xu Yanwei Zhang Song Lang Hongwei Wang Huijie Hu Jingkai Wang Yan Gong Source Type: research

Structured illumination microscopy based on asymmetric three-beam interference
Journal of Innovative Optical Health Sciences, Ahead of Print. Structured illumination microscopy (SIM) is a rapidly developing super-resolution technology. It has been widely used in various application fields of biomedicine due to its excellent two- and three-dimensional imaging capabilities. Furthermore, faster three-dimensional imaging methods are required to help enable more research-oriented living cell imaging. In this paper, a fast and sensitive three-dimensional structured illumination microscopy based on asymmetric three-beam interference is proposed. An innovative time-series acquisition method is employed to ha...
Source: Journal of Innovative Optical Health Sciences - October 17, 2020 Category: Biomedical Science Authors: Linyu Xu Yanwei Zhang Song Lang Hongwei Wang Huijie Hu Jingkai Wang Yan Gong Source Type: research

Diffuse transmitted spectroscopy in conjunction with spectral peak averaging as a potential tool for noninvasive creatinine screening
Journal of Innovative Optical Health Sciences, Ahead of Print. Creatinine (Cr) is a biochemical waste molecule generated from muscle metabolism and primarily cleared from the bloodstream by the kidneys. If kidney function declines, Cr levels in the blood tend to increase. Therefore, Cr serves as an indicator of kidney function. In this work, we present a simple method for the rapid screening for impaired renal function based on the subject ’s Cr concentration. In our setup, broadband white light is delivered to a finger clamp through a fiber-optic cable to illuminate the patient’s finger. The light is transmitt...
Source: Journal of Innovative Optical Health Sciences - September 30, 2020 Category: Biomedical Science Authors: Zvi Hai Barnea Shmuel Zimlichman David Abookasis Source Type: research