A miniaturized fluorescence imaging device for rapid early skin cancer detection
Journal of Innovative Optical Health Sciences, Ahead of Print. Fluorescence imaging is very useful for skin cancer lesions detection because of its properties of noninvasion and fast imaging. However, conventional fluorescence imaging devices ’ excitation light source and camera are usually separated, which will cause problems such as complicated structure, large volume, and poor illumination homogeneity. In this paper, we introduce a miniature portable fluorescence imaging device to diagnose skin cancer. A coaxial design has been intr oduced to combine the exciting light source and fluorescence receiver as an integr...
Source: Journal of Innovative Optical Health Sciences - September 16, 2020 Category: Biomedical Science Authors: Jingyue Pan Qingquan Liu Hao Sun Weibo Zheng Peiru Wang Long Wen Junli Duan Zhiyi Xuan Xiang Yu Shaowei Wang Xiuli Wang Tao Zhang Wei Lu Source Type: research

Effects of stimulating frequency of NIR LEDs light irradiation on forehead as quantified by EEG measurements
Conclusions: Larger frequency of the NIR LED light would cause more distinct brain activities in the stimulated areas. It indicates that NIR LED light may have a positive effect on modulating brain activity. These results may help improve the design of photobiomodulation treatments in the future. (Source: Journal of Innovative Optical Health Sciences)
Source: Journal of Innovative Optical Health Sciences - September 9, 2020 Category: Biomedical Science Authors: Liuye Yao Zhiyu Qian Yangyang Liu Zhou Fang Weitao Li Lidong Xing Source Type: research

Synthesis of a dithieno[3,2-b:2 ′,3′-d]silole-based conjugated polymer and characterization of its short wave near-infrared fluorescence properties
Journal of Innovative Optical Health Sciences, Ahead of Print. Short wave near-infrared (SWIR, 900 –1700[math]nm) fluorescence imaging has attracted extensive research interest from scientists due to its high imaging quality. However, the variety of SWIR fluorescence imaging agents are quite limited and the corresponding quantum efficiency is relatively low. In this work, a novel conjugated pol ymer PDTSDTBT was reported, consisting of a donor unit with a tetrahedral Si (sp3) named DTS and an acceptor unit named DTBT with branched side chains. The design approach of endowing the donor–acceptor structure with th...
Source: Journal of Innovative Optical Health Sciences - September 3, 2020 Category: Biomedical Science Authors: Chuantao Gu Chunying Zheng Bing Liu Tingyu Feng Jiping Ma Haofen Sun Source Type: research

Electrospun antibacterial nanofibers for wound dressings and tissue medicinal fields: A Review
Journal of Innovative Optical Health Sciences, Ahead of Print. Bacterial infections are a major cause of chronic infections. Thus, antibacterial material is an urgent need in clinics. Antibacterial nanofibers, with expansive surface area, enable efficient incorporation of antibacterial agents. Meanwhile, structure similar to the extracellular matrix can accelerate cell growth. Electrospinning, the most widely used technique to fabricate nanofiber, is often used in many biomedical applications including drug delivery, regenerative medicine, wound healing and so on. Thus, this review provides an overview of all recently publ...
Source: Journal of Innovative Optical Health Sciences - September 2, 2020 Category: Biomedical Science Authors: Zhimei Wei Liqun Wang Shouyu Zhang Tonghai Chen Jie Yang Shengru Long Xiaojun Wang Source Type: research

In vivo assessment of structural changes of the urethra in lower urinary tract disease using cross-polarization optical coherence tomography
This study could form the basis of a scoring system for assessing the state of the urethral tract using CP OCT images in real time. The CP OCT method provides information on the state of urethral tissues that cannot be obtained with traditional cystoscopy. (Source: Journal of Innovative Optical Health Sciences)
Source: Journal of Innovative Optical Health Sciences - August 28, 2020 Category: Biomedical Science Authors: Elena B. Kiseleva Alexander A. Moiseev Anton S. Kuyarov Muhammat A. Molvi Grigory V. Gelikonov Anna V. Maslennikova Olga S. Streltsova Source Type: research

The short wave near-infrared fluorescence properties of two p-azaquinodimethane (p-AQM)-based conjugated polymers
Journal of Innovative Optical Health Sciences, Ahead of Print. The absorption, scattering, and autofluorescence of biological tissues in short-wave infrared region (SWIR, 900 –1700[math]nm) are relatively low, so SWIR fluorescence usually has deeper penetration into living tissues, and can show a higher signal-to-noise ratio when used for imaging in vivo. However, there are few types of organic SWIR fluorescent materials currently. In this work, [math]-azaquinodimethan e ([math]-AQM) with a quinoid structure is used as the acceptor unit, and carbazole or fluorene with sp3 hybridization are used as the donor units, tw...
Source: Journal of Innovative Optical Health Sciences - August 26, 2020 Category: Biomedical Science Authors: Yaowei Zhu Yawei Miao Tingting Xue Youchang Liu Chunying Zheng Jiping Ma Weiqiang Tan Shuguang Wen Chuantao Gu Source Type: research

Applications of Raman spectroscopy in two-dimensional materials
Journal of Innovative Optical Health Sciences, Ahead of Print. At present, two-dimensional (2D) materials have shown great application potential in numerous fields based on their physical chemical and electronic properties. Raman spectroscopy and derivative techniques are effective tools for characterizing 2D materials. Raman spectroscopy conveys lots of knowledge on 2D materials, including layer number, doping type, strain and interlayer coupling. This review summarized advanced applications of Raman spectroscopy in 2D materials. The challenges and possible applied directions of Raman spectroscopy to 2D materials are disc...
Source: Journal of Innovative Optical Health Sciences - August 18, 2020 Category: Biomedical Science Authors: Pengkun Yin Qingyu Lin Yixiang Duan Source Type: research

Effect of antibacterial photodynamic therapy on Streptococcus mutans plaque biofilm in vitro
Journal of Innovative Optical Health Sciences, Ahead of Print. The main objective of this study is to evaluate the antibacterial effect of antibacterial photodynamic therapy (aPDT) on Streptococcus mutans (S. mutans) biofilm model in vitro. The selection of photosensitizers is the key step for the efficacy of photodynamic therapy (PDT). However, no studies have been conducted in the oral field to compare the functional characteristics and application effects of PDT mediated by various photosensitizers. In this research, the antibacterial effect of Methylene blue (MB)/650[math]nm laser and Hematoporphyrin monomethyl ether (...
Source: Journal of Innovative Optical Health Sciences - August 8, 2020 Category: Biomedical Science Authors: Xiaoyue Liang Zhaohui Zou Zheng Zou Changyi Li Xiaoxi Dong Huijuan Yin Guohui Yan Source Type: research

Photoacoustic detection of circulating melanoma cells in late stage patients
Journal of Innovative Optical Health Sciences, Ahead of Print. Melanoma is the deadliest skin cancer and is responsible for over 7000 deaths in the US annually. The spread of cancer, or metastasis, is responsible for these deaths, as secondary tumors interrupt normal organ function. Circulating tumor cells, or those cells that spread throughout the body from the primary tumor, are thought to be responsible for metastasis. We developed an optical method, photoacoustic flow cytometry, in order to detect and enumerate circulating melanoma cells (CMCs) from blood samples of patients. We tested the blood of Stage IV melanoma pa...
Source: Journal of Innovative Optical Health Sciences - August 5, 2020 Category: Biomedical Science Authors: John A. Viator Marc Hazur Andrea Sajewski Ahmad Tarhini Martin E. Sanders Robert H. Edgar Source Type: research

Application of digital micromirror devices (DMD) in biomedical instruments
Journal of Innovative Optical Health Sciences, Ahead of Print. There is an ongoing technological revolution in the field of biomedical instruments. Consequently, high performance healthcare devices have led to remarkable economic developments in the medical hardware industry. Until now, nearly all optical bio-imaging systems are based on the 2-dimensional imaging chip architecture. In fact, recent developments in digital micromirror devices (DMDs) are gradually making their way from conventional optical projection displays into biomedical instruments. As an ultrahigh-speed spatial light modulator, the DMD may offer a range...
Source: Journal of Innovative Optical Health Sciences - August 5, 2020 Category: Biomedical Science Authors: Ziyun Zhuang Ho Pui Ho Source Type: research

Highly-efficient quantitative fluorescence resonance energy transfer measurements based on deep learning
Journal of Innovative Optical Health Sciences, Ahead of Print. Intensity-based quantitative fluorescence resonance energy transfer (FRET) is a technique to measure the distance of molecules in scale of a few nanometers which is far beyond optical diffraction limit. This widely used technique needs complicated experimental process and manual image analyses to obtain precise results, which take a long time and restrict the application of quantitative FRET especially in living cells. In this paper, a simplified and automatic quantitative FRET (saqFRET) method with high efficiency is presented. In saqFRET, photoactivatable acc...
Source: Journal of Innovative Optical Health Sciences - July 30, 2020 Category: Biomedical Science Authors: Lin Ge Fei Liu Jianwen Luo Source Type: research

Visualizing veins from color skin images using convolutional neural networks
Journal of Innovative Optical Health Sciences,Volume 13, Issue 04, July 2020. Intravenous cannulation is the most important phase in medical practices. Currently, limited literature is available about visibility of veins and the characteristics of patients associated with difficult intravenous access. In modern medical treatment, a major challenge is locating veins for patients who have difficult venous access. Presently, some products of vein locators are available in the market to improve vein access, but they need auxiliary equipment such as near infrared (NIR) illumination and camera, which add weight and cost to the d...
Source: Journal of Innovative Optical Health Sciences - July 21, 2020 Category: Biomedical Science Authors: Chaoying Tang Yimin Yuan Shuhang Xia Gehua Ma Biao Wang Source Type: research

A microvascular image analysis method for optical-resolution photoacoustic microscopy
Journal of Innovative Optical Health Sciences, Ahead of Print. Optical-resolution photoacoustic microscopy (OR-PAM) has been shown to be an excellent tool for high-resolution imaging of microvasculature, and quantitative analysis of the microvasculature can provide valuable information for the early diagnosis and treatment of various vascular-related diseases. In order to address the characteristics of weak signals, discontinuity and small diameters in photoacoustic microvascular images, we propose a method adaptive to the microvascular segmentation in photoacoustic images, including Hessian matrix enhancement and the morp...
Source: Journal of Innovative Optical Health Sciences - July 16, 2020 Category: Biomedical Science Authors: Jingxiu Zhao Qian Zhao Riqiang Lin Jing Meng Source Type: research

Variable spot size optical system for a dual-wavelength laser therapy device
Journal of Innovative Optical Health Sciences, Ahead of Print. The majority of existing high-power laser therapeutic instruments employ a single wavelength for a single target; thus, they do not meet the requirements for clinical treatment. Therefore, this study designs an optical system for a dual-wavelength high-power laser therapeutic device with a variable spot size. The waist of the short arm of the optical cavity and the G1G2 parameter (G-parameter equivalent cavity method) is calculated using MATLAB software, the spot size and divergence angle on the lens are calculated using an ABCD matrix, and the distance between...
Source: Journal of Innovative Optical Health Sciences - July 4, 2020 Category: Biomedical Science Authors: Ningning dong Jinjiang Cui Jiangen Xu Source Type: research

Ultrabright bimetallic AuAg complex: From luminescence mechanism to biological application
Journal of Innovative Optical Health Sciences, Ahead of Print. Metal clusters have attracted wide interests due to their unique electronic and optical properties, but the low luminescence quantum yield (QY) prevents them from potential biomedical applications. In this work, silver-doped Au nanoclusters (NCs) are shown to be able to improve the QY of metal clusters. We succeeded in synthesizing ultrabright glutathione (GSH) protected AuAg clusters with 10.8% QY by a one-pot route. Their florescence is about 7.5 times brighter than pure Au NCs, with super photostability and good biocompatibility in physiological environment....
Source: Journal of Innovative Optical Health Sciences - June 27, 2020 Category: Biomedical Science Authors: Junchi Chen Lingfang Liu Haile Liu Yonghui Li Junying Wang Xiaoyu Mu Fujuan Xu Tianyu Liu Xiao-Dong Zhang Source Type: research

Multi-manufacturer drug identification based on near infrared spectroscopy and deep transfer learning
Journal of Innovative Optical Health Sciences, Ahead of Print. Near infrared (NIR) spectrum analysis technology has outstanding advantages such as rapid, nondestructive, pollution-free, and is widely used in food, pharmaceutical, petrochemical, agricultural products production and testing industries. Convolutional neural network (CNN) is one of the most successful methods in big data analysis because of its powerful feature extraction and abstraction ability, and it is especially suitable for solving multi-classification problems. CNN-based transfer learning is a machine learning technique, which migrates parameters of tra...
Source: Journal of Innovative Optical Health Sciences - June 16, 2020 Category: Biomedical Science Authors: Lingqiao Li Xipeng Pan Wenli Chen Manman Wei Yanchun Feng Lihui Yin Changqin Hu Huihua Yang Source Type: research

Tunable absorption characteristics in multilayered structures with graphene for biosensing
Journal of Innovative Optical Health Sciences, Ahead of Print. Graphene derivatives, possessing strong Raman scattering and near-infrared absorption intrinsically, have boosted many exciting biosensing applications. The tunability of the absorption characteristics, however, remains largely unexplored to date. Here, we proposed a multilayer configuration constructed by a graphene monolayer sandwiched between a buffer layer and one-dimensional photonic crystal (1DPC) to achieve tunable graphene absorption under total internal reflection (TIR). It is interesting that the unique optical properties of the buffer-graphene-1DPC m...
Source: Journal of Innovative Optical Health Sciences - June 10, 2020 Category: Biomedical Science Authors: Li Jin Jun Zhou Puxiang Lai Source Type: research

Photocyanine: A novel and effective phthalocyanine-based photosensitizer for cancer treatment
Journal of Innovative Optical Health Sciences,Volume 13, Issue 03, May 2020. As one of the three key components of photodynamic therapy (PDT), photosensitizers (PSs) greatly influence the photodynamic efficiency in the treatment of tumors. Photosensitizers with tetrapyrrole structure, such as porphyrins, chlorins and phthalocyanines, have been extensively investigated for PDT and some of them have already received clinical approval. However, only a few of porphyrin-based photosensitizers are available for clinical applications, and PDT has not received wide recognition in clinical practice. In this regard, PSs remain a lim...
Source: Journal of Innovative Optical Health Sciences - May 23, 2020 Category: Biomedical Science Authors: Dan Chen Meiru Song Jinling Huang Naishen Chen Jinping Xue Mingdong Huang Source Type: research

Spectra selection methods: A novel optimization way for treating dynamic spectra and in-line near infrared modeling
In this study, a novel NIR sensor and a cosine distance method were introduced to solve this problem in order to make the fluidized process into “visualization”. A NIR sensor was fixed on the side of the expansion chamber to acquire the NIR spectra. Then valid spectra were selected based on a cosine distance method to reduce the influence of dynamic disturbances. Finally, spectral pretreatment and wavelength selection methods were invest igated to establish partial least squares (PLS) models to monitor the moisture content. The results showed that the root mean square error of prediction (RMSEP) was 0.124% for ...
Source: Journal of Innovative Optical Health Sciences - May 20, 2020 Category: Biomedical Science Authors: Haiyan Wang Ronghua Liu Lei Nie Dongbo Xu Wenping Yin Lian Li Hengchang Zang Source Type: research

Optical design and simulation of an integrated OCT and video rigid laryngoscope
Journal of Innovative Optical Health Sciences, Ahead of Print. An integrated optical coherence tomography (OCT) and video rigid laryngoscope have been designed to acquire surface and subsurface tissue images of larynx simultaneously. The dual-modality system that is based on a common-path design with components as few as possible effectively maintains the light transmittance without compromising the imaging quality. In this paper, the field of view (FOV) of the system can reach [math] by use of a gradient index (GRIN) lens as the relay element and a four-lens group as the distal objective, respectively. The simulation show...
Source: Journal of Innovative Optical Health Sciences - May 11, 2020 Category: Biomedical Science Authors: Jiajing Kang Xinyu Li Mingming Wan Jiahui Wang Shanshan Liang Jun Zhang Source Type: research

Black phosphorus as a versatile nanoplatform: From unique properties to biomedical applications
Journal of Innovative Optical Health Sciences, Ahead of Print. Black phosphorus (BP) or phosphorene, a new superstar among two-dimensional (2D) materials, has sparked huge scientific interest since its discovery in 2014. BP offers unique characteristics including high drug loading efficiency, excellent photodynamic and photothermal properties and good biocompatibility. These characteristics expand versatility of BP in nanomedicine. Although the outlook of BP seems promising, its practical biomedical applications are still at the very initial stage especially in comparison to other thoroughly investigated inorganic nanomate...
Source: Journal of Innovative Optical Health Sciences - May 11, 2020 Category: Biomedical Science Authors: Sha Xiong Xiaojia Chen Yao Liu Taojian Fan Qi Wang Han Zhang Tongkai Chen Source Type: research

Automated classification of dual channel dental imaging of auto-fluorescence and white lightby convolutional neural networks
Journal of Innovative Optical Health Sciences, Ahead of Print. Prevention is the most effective way to reduce dental caries. In order to provide a simple way to achieve oral healthcare direction in daily life, dual Channel, portable dental Imaging system that combine white light with autofluorescence techniques was established, and then, a group of volunteers were recruited, 7200 tooth pictures of different dental caries stage and dental plaque were taken and collected. In this work, a customized Convolutional Neural Networks (CNNs) have been designed to classify dental image with early stage caries and dental plaque. Eigh...
Source: Journal of Innovative Optical Health Sciences - May 7, 2020 Category: Biomedical Science Authors: Cheng Wang Haotian Qin Guangyun Lai Gang Zheng Huazhong Xiang Jun Wang Dawei Zhang Source Type: research

A novel fluorogenic probe for visualizing the hydrogen peroxide in Parkinson ’s disease models
Journal of Innovative Optical Health Sciences, Ahead of Print. Parkinson ’s disease (PD) is closely related to the oxidative stress induced by excess hydrogen peroxide (H2O2) in organisms. Developing an efficient method for noninvasive and real-time H2O2 detection is beneficial to investigate the role played by H2O2 in PD. In this work, a novel fluorogenic probe (CBH) for living organisms H2O2 detection has been designed, synthesized and characterized. The emission of CBH in PBS solution is very weak. However, when H2O2 was added, the fluorescence of CBH solution was sharply increased for 12-fold, accompanied by the ...
Source: Journal of Innovative Optical Health Sciences - April 30, 2020 Category: Biomedical Science Authors: Gaobin Zhang Zheng Li Fangjie Chen Duoteng Zhang Wenhui Ji Zhengpeng Yang Qiong Wu Chengwu Zhang Lin Li Wei Huang Source Type: research

Optically-excited simultaneous photoacoustic and ultrasound imaging based on a flexible gold-PDMS film
Journal of Innovative Optical Health Sciences, Ahead of Print. We constructed a flexible gold-polydimethylsiloxane (gold-PDMS) nanocomposites film with controllable thickness and light transmittance, to realize optically-excited simultaneous photoacoustic (PA) and ultrasound (US) imaging under a single laser pulse irradiation. Benefiting from the excellent thermoelastic properties, the gold-PDMS film absorbs part of the incident laser energy and produces a high-intensity US, which is used to realize US imaging. Meanwhile, the partly transmitted light is used to excite samples for PA imaging. By controlling the thickness of...
Source: Journal of Innovative Optical Health Sciences - April 17, 2020 Category: Biomedical Science Authors: Dandan Cui Zhenhui Zhang Yujiao Shi Source Type: research

A comparative study on water and dry coupling in photoacoustic tomography of the finger joints
We present a systematical study on comparison between water and dry coupling in photoacoustic tomography of the human finger joints. Compared to the direct water immersion of the finger for water coupling, the dry coupling is realized through a transparent PDMS film-based water bag, which ensures water-free contact with the skin. The results obtained suggest that the dry coupling provides image quality comparable to that by water coupling while eliminating the wrinkling of the finger joint caused by the water immersion. In addition, the dry coupling offers more stable hemodynamic images than the water coupling as the water...
Source: Journal of Innovative Optical Health Sciences - April 17, 2020 Category: Biomedical Science Authors: Qiquan Shang Man Wu Jinge Yang Ten Pan Guang Zhang Dan Wu Huabei Jiang Source Type: research

Combating acoustic heterogeneity in photoacoustic computed tomography: A review
Journal of Innovative Optical Health Sciences, Ahead of Print. Based on the energy conversion of light into sound, photoacoustic computed tomography (PACT) is an emerging biomedical imaging modality and has unique applications in a range of biomedical fields. In PACT, image formation relies on a process called acoustic inversion from received photoacoustic signals. While most PACT systems perform this inversion with a basic assumption that biological tissues are acoustically homogeneous, the community gradually realizes that the intrinsic acoustic heterogeneity of tissues could pose distortions and artifacts to finally for...
Source: Journal of Innovative Optical Health Sciences - March 4, 2020 Category: Biomedical Science Authors: Tong Wang Wen Liu Chao Tian Source Type: research

Interaction between Bax and Bcl-XL proteins confirmed by partial acceptor photobleaching-based FRET imaging
In this report, we implemented pixel-to-pixel PbFRET imaging on a wide-field microscope to map the FRET efficiency ([math] images of single living HepG2 cells co-expressing CFP-Bax and YFP-Bcl-XL. The [math] value between CFP-Bax and YFP-Bcl-XL was 4.59% in cytosol and 11.31% on mitochondria, conclusively indicating the direct interaction of the two proteins, and the interaction of the two proteins was strong on mitochondria and modest in cytosol. (Source: Journal of Innovative Optical Health Sciences)
Source: Journal of Innovative Optical Health Sciences - February 26, 2020 Category: Biomedical Science Authors: Fangfang Yang Mengyan Du Xiaoping Wang Tongsheng Chen Source Type: research

Time-gated fluorescence imaging: Advances in technology and biological applications
Journal of Innovative Optical Health Sciences, Ahead of Print. Time-gated (TG) fluorescence imaging (TGFI) has attracted increasing attention within the biological imaging community, especially during the past decade. With rapid development of light sources, image devices, and a variety of approaches for TG implementation, TGFI has demonstrated numerous biological applications ranging from molecules to tissues. The paper presents inclusive TG implementation mainly based on optical choppers and electronic units for synchronization of fluorescence excitation and emission, which also serves as guidelines for researchers to bu...
Source: Journal of Innovative Optical Health Sciences - February 14, 2020 Category: Biomedical Science Authors: Wenzhao Yang Sung-Liang Chen Source Type: research

Development of calibration models for rapid determination of moisture content in rubber sheets using portable near-infrared spectrometers
Journal of Innovative Optical Health Sciences, Ahead of Print. Rubber sheets are one of the primary products of natural rubber and are the main raw material in various rubber industries. The quality of a rubber sheet can be visually examined by holding it against clear light to inspect for any specks and impurities inside, but its moisture content is difficult to evaluate based on a visual inspection and this might lead to unfair trading. Herein, we developed a rapid, robust and nondestructive near-infrared spectroscopy (NIRS)-based method for moisture content determination in rubber sheets. A set of 300 rubber sheets were...
Source: Journal of Innovative Optical Health Sciences - February 6, 2020 Category: Biomedical Science Authors: Amorndej Puttipipatkajorn Amornrit Puttipipatkajorn Source Type: research

Intraoperative imaging of oral-maxillofacial lesions using optical coherence tomography
In this study, in order to assess the feasibility of OCT in oral clinical application, fresh excised tissue specimens from 59 patients undergoing oral-maxillofacial surgery were imaged in detail by using a benchtop swept-source OCT system. It is shown that different lesions or tissues can be obviously distinguished based on their different microstructural features in OCT images, and the features are similar to those of their corresponding histopathological images. It is proven that OCT has great feasibility and potential as a diagnostic aid for surgeons in oral medicine. (Source: Journal of Innovative Optical Health Sciences)
Source: Journal of Innovative Optical Health Sciences - February 5, 2020 Category: Biomedical Science Authors: Zihan Yang Jianwei Shang Chenlu Liu Jun Zhang Fang Hou Yanmei Liang Source Type: research

Photoacoustic reporter genes for noninvasive molecular imaging and theranostics
Journal of Innovative Optical Health Sciences, Ahead of Print. Noninvasive molecular imaging makes the observation and comprehensive understanding of complex biological processes possible. Photoacoustic imaging (PAI) is a fast evolving hybrid imaging technology enabling in vivo imaging with high sensitivity and spatial resolution in deep tissue. Among the various probes developed for PAI, genetically encoded reporters attracted increasing attention of researchers, which provide improved performance by acquiring images of a PAI reporter gene ’s expression driven by disease-specific enhancers/promoters. Here, we presen...
Source: Journal of Innovative Optical Health Sciences - January 31, 2020 Category: Biomedical Science Authors: Zhao Lei Yun Zeng Xiaofen Zhang Xiaoyong Wang Gang Liu Source Type: research

Photodynamic therapy of brain tumors and novel optical coherence tomography strategies for in vivo monitoring of cerebral fluid dynamics
Journal of Innovative Optical Health Sciences, Ahead of Print. Photodynamic therapy (PDT) is a promising tool for least-invasive alternative methods for the treatment of brain tumors. The newly discovered PDT-induced opening of the blood –brain barrier (BBB) permeability open novel strategies for drug-brain delivery during post-surgical treatment of glioblastoma GBM. Here we discuss mechanisms of PDT-mediated opening of the BBB and age differences in PDT-related increase in BBB permeability, including with formation of brain edem a. The meningeal lymphatic system plays a crucial role in the mechanism of brain dr...
Source: Journal of Innovative Optical Health Sciences - January 21, 2020 Category: Biomedical Science Authors: A. Abdurashitov V. Tuchin O. Semyachkina-Glushkovskaya Source Type: research

Video-rate multimodal multiphoton imaging and three-dimensional characterization of cellular dynamics in wounded skin
Journal of Innovative Optical Health Sciences, Ahead of Print. To date, numerous studies have been performed to elucidate the complex cellular dynamics in skin diseases, but few have attempted to characterize these cellular events under conditions similar to the native environment. To address this challenge, a three-dimensional (3D) multimodal analysis platform was developed for characterizing in vivo cellular dynamics in skin, which was then utilized to process in vivo wound healing data to demonstrate its applicability. Special attention is focused on in vivo biological parameters that are difficult to study with ex vivo...
Source: Journal of Innovative Optical Health Sciences - January 15, 2020 Category: Biomedical Science Authors: Joanne Li Madison N. Wilson Andrew J. Bower Marina Marjanovic Eric J. Chaney Ronit Barkalifa Stephen A. Boppart Source Type: research

Spatial-spectral identification of abnormal leukocytes based on microscopic hyperspectral imaging technology
Journal of Innovative Optical Health Sciences, Ahead of Print. Screening and diagnosing of abnormal Leukocytes are crucial for the diagnosis of immune diseases and Acute Lymphoblastic Leukemia (ALL). As the deterioration of abnormal leukocytes is mainly due to the changes in the chromatin distribution, which significantly affects the absorption and reflection of light, the spectral feature is proved to be important for leukocytes classification and identification. This paper proposes an accurate identification method for healthy and abnormal leukocytes based on microscopic hyperspectral imaging (HSI) technology which combi...
Source: Journal of Innovative Optical Health Sciences - January 15, 2020 Category: Biomedical Science Authors: Xueqi Hu Jiahua Ou Mei Zhou Menghan Hu Li Sun Song Qiu Qingli Li Junhao Chu Source Type: research

Video-rate multimodal multiphoton imaging and three-dimensional characterization of cellular dynamics in wounded skin
Journal of Innovative Optical Health Sciences, Ahead of Print. To date, numerous studies have been performed to elucidate the complex cellular dynamics in skin diseases, but few have attempted to characterize these cellular events under conditions similar to the native environment. To address this challenge, a three-dimensional (3D) multimodal analysis platform was developed for characterizing in vivo cellular dynamics in skin, which was then utilized to process in vivo wound healing data to demonstrate its applicability. Special attention is focused on in vivo biological parameters that are difficult to study with ex vivo...
Source: Journal of Innovative Optical Health Sciences - January 15, 2020 Category: Biomedical Science Authors: Joanne Li Madison N. Wilson Andrew J. Bower Marina Marjanovic Eric J. Chaney Ronit Barkalifa Stephen A. Boppart Source Type: research

Spatial-spectral identification of abnormal leukocytes based on microscopic hyperspectral imaging technology
Journal of Innovative Optical Health Sciences, Ahead of Print. Screening and diagnosing of abnormal Leukocytes are crucial for the diagnosis of immune diseases and Acute Lymphoblastic Leukemia (ALL). As the deterioration of abnormal leukocytes is mainly due to the changes in the chromatin distribution, which significantly affects the absorption and reflection of light, the spectral feature is proved to be important for leukocytes classification and identification. This paper proposes an accurate identification method for healthy and abnormal leukocytes based on microscopic hyperspectral imaging (HSI) technology which combi...
Source: Journal of Innovative Optical Health Sciences - January 15, 2020 Category: Biomedical Science Authors: Xueqi Hu Jiahua Ou Mei Zhou Menghan Hu Li Sun Song Qiu Qingli Li Junhao Chu Source Type: research

Video-rate multimodal multiphoton imaging and three-dimensional characterization of cellular dynamics in wounded skin
Journal of Innovative Optical Health Sciences, Ahead of Print. To date, numerous studies have been performed to elucidate the complex cellular dynamics in skin diseases, but few have attempted to characterize these cellular events under conditions similar to the native environment. To address this challenge, a three-dimensional (3D) multimodal analysis platform was developed for characterizing in vivo cellular dynamics in skin, which was then utilized to process in vivo wound healing data to demonstrate its applicability. Special attention is focused on in vivo biological parameters that are difficult to study with ex vivo...
Source: Journal of Innovative Optical Health Sciences - January 15, 2020 Category: Biomedical Science Authors: Joanne Li Madison N. Wilson Andrew J. Bower Marina Marjanovic Eric J. Chaney Ronit Barkalifa Stephen A. Boppart Source Type: research

Spatial-spectral identification of abnormal leukocytes based on microscopic hyperspectral imaging technology
Journal of Innovative Optical Health Sciences, Ahead of Print. Screening and diagnosing of abnormal Leukocytes are crucial for the diagnosis of immune diseases and Acute Lymphoblastic Leukemia (ALL). As the deterioration of abnormal leukocytes is mainly due to the changes in the chromatin distribution, which significantly affects the absorption and reflection of light, the spectral feature is proved to be important for leukocytes classification and identification. This paper proposes an accurate identification method for healthy and abnormal leukocytes based on microscopic hyperspectral imaging (HSI) technology which combi...
Source: Journal of Innovative Optical Health Sciences - January 15, 2020 Category: Biomedical Science Authors: Xueqi Hu Jiahua Ou Mei Zhou Menghan Hu Li Sun Song Qiu Qingli Li Junhao Chu Source Type: research