Tradeoffs in concentration sensing in dynamic environments
Biophys J. 2024 Mar 25:S0006-3495(24)00205-4. doi: 10.1016/j.bpj.2024.03.025. Online ahead of print.ABSTRACTWhen cells measure concentrations of chemical signals, they may average multiple measurements over time in order to reduce noise in their measurements. However, when cells are in a environment that changes over time, past measurements may not reflect current conditions - creating a new source of error that trades off against noise in chemical sensing. What statistics in the cell's environment control this tradeoff? What properties of the environment make it variable enough that this tradeoff is relevant? We model a s...
Source: Biophysical Journal - March 27, 2024 Category: Physics Authors: Aparajita Kashyap Wei Wang Brian A Camley Source Type: research
Folate induces stemness and increases oxygen consumption under glucose deprivation by notch-1 pathway activation in colorectal cancer cell
Mol Cell Biochem. 2024 Mar 27. doi: 10.1007/s11010-024-04987-1. Online ahead of print.ABSTRACTEvidence for folate's protective effects on neural tube defects led the USA and Chile to start mandatory folic acid (FA) fortification programs, decreasing up to 50%. However, ∼30% of the population consuming fortified foods reach supraphysiologic serum levels. Although controversial, several epidemiological and clinical observations suggest that folate increases cancer risk, giving concern about the risks of FA supplementation. The Cancer stem cells (CSCs) model has been used to explain survival to anticancer therapies. The Not...
Source: Molecular and Cellular Biochemistry - March 27, 2024 Category: Biochemistry Authors: Juan Rodr íguez Silva Mat ías Monsalves-Álvarez Carlos Sep úlveda Camila Donoso-Barraza Rodrigo Troncoso Sandra Hirsch Source Type: research
Folate induces stemness and increases oxygen consumption under glucose deprivation by notch-1 pathway activation in colorectal cancer cell
Mol Cell Biochem. 2024 Mar 27. doi: 10.1007/s11010-024-04987-1. Online ahead of print.ABSTRACTEvidence for folate's protective effects on neural tube defects led the USA and Chile to start mandatory folic acid (FA) fortification programs, decreasing up to 50%. However, ∼30% of the population consuming fortified foods reach supraphysiologic serum levels. Although controversial, several epidemiological and clinical observations suggest that folate increases cancer risk, giving concern about the risks of FA supplementation. The Cancer stem cells (CSCs) model has been used to explain survival to anticancer therapies. The Not...
Source: Molecular and Cellular Biochemistry - March 27, 2024 Category: Biochemistry Authors: Juan Rodr íguez Silva Mat ías Monsalves-Álvarez Carlos Sep úlveda Camila Donoso-Barraza Rodrigo Troncoso Sandra Hirsch Source Type: research
Folate induces stemness and increases oxygen consumption under glucose deprivation by notch-1 pathway activation in colorectal cancer cell
Mol Cell Biochem. 2024 Mar 27. doi: 10.1007/s11010-024-04987-1. Online ahead of print.ABSTRACTEvidence for folate's protective effects on neural tube defects led the USA and Chile to start mandatory folic acid (FA) fortification programs, decreasing up to 50%. However, ∼30% of the population consuming fortified foods reach supraphysiologic serum levels. Although controversial, several epidemiological and clinical observations suggest that folate increases cancer risk, giving concern about the risks of FA supplementation. The Cancer stem cells (CSCs) model has been used to explain survival to anticancer therapies. The Not...
Source: Molecular and Cellular Biochemistry - March 27, 2024 Category: Biochemistry Authors: Juan Rodr íguez Silva Mat ías Monsalves-Álvarez Carlos Sep úlveda Camila Donoso-Barraza Rodrigo Troncoso Sandra Hirsch Source Type: research
Folic acid in women with epilepsy: prescribing advice
Pract Neurol. 2024 Mar 25:pn-2023-003829. doi: 10.1136/pn-2023-003829. Online ahead of print.NO ABSTRACTPMID:38527794 | DOI:10.1136/pn-2023-003829 (Source: Practical Neurology)
Source: Practical Neurology - March 25, 2024 Category: Neurology Authors: Michael Owen Kinney John J Craig Norman Delanty Source Type: research
Folic acid in women with epilepsy: prescribing advice
Pract Neurol. 2024 Mar 25:pn-2023-003829. doi: 10.1136/pn-2023-003829. Online ahead of print.NO ABSTRACTPMID:38527794 | DOI:10.1136/pn-2023-003829 (Source: Practical Neurology)
Source: Practical Neurology - March 25, 2024 Category: Neurology Authors: Michael Owen Kinney John J Craig Norman Delanty Source Type: research
Folic acid in women with epilepsy: prescribing advice
Pract Neurol. 2024 Mar 25:pn-2023-003829. doi: 10.1136/pn-2023-003829. Online ahead of print.NO ABSTRACTPMID:38527794 | DOI:10.1136/pn-2023-003829 (Source: Practical Neurology)
Source: Practical Neurology - March 25, 2024 Category: Neurology Authors: Michael Owen Kinney John J Craig Norman Delanty Source Type: research
Folic acid and plasma lipids: interactions and effect of folate supplementation
Curr Probl Cardiol. 2024 Mar 21:102539. doi: 10.1016/j.cpcardiol.2024.102539. Online ahead of print.ABSTRACTDyslipidaemia and hyperhomocysteinemia are known risk factors for cardiovascular disease. While it is evident that optimization of plasma lipid is associated with low risk of cardiovascular disease in the general population, it is not yet fully clear whether reduction of homocysteinemia is associated with an improvement in risk in all subjects. The aim of our narrative review is to highlight eventual effects of folate supplementation on LDL-C levels, LDL-C oxidation and atherosclerosis-related complications. A compre...
Source: Atherosclerosis - March 23, 2024 Category: Cardiology Authors: Federica Fogacci Carmine Pizzi Luca Bergamaschi Valentina Di Micoli Arrigo F G Cicero Source Type: research
Potential Micronutrient Deficiencies in the First 1000 Days of Life: The Pediatrician on the Side of the Weakest
This study is to examine potential micronutrient deficiencies and any need for supplementation in children following specific diet plans in the first 1000 days of life.RECENT FINDINGS: Optimal nutrition in the first 1000 days of life has a lifelong positive impact on child development. Specific intrauterine and perinatal factors, pathological conditions, and dietary restrictions can represent potential risk factors for micronutrient deficiencies in the first 1000 days of life, which can have negative systemic consequences. Preterm and low-birth-weight infants are intrinsically at risk because of immature body systems. Chil...
Source: Epilepsy Curr - March 21, 2024 Category: Neurology Authors: Carol à Panzeri Luca Pecoraro Alice Dianin Andrea Sboarina Olivia C Arnone Giorgio Piacentini Angelo Pietrobelli Source Type: research
Potential Micronutrient Deficiencies in the First 1000 Days of Life: The Pediatrician on the Side of the Weakest
This study is to examine potential micronutrient deficiencies and any need for supplementation in children following specific diet plans in the first 1000 days of life.RECENT FINDINGS: Optimal nutrition in the first 1000 days of life has a lifelong positive impact on child development. Specific intrauterine and perinatal factors, pathological conditions, and dietary restrictions can represent potential risk factors for micronutrient deficiencies in the first 1000 days of life, which can have negative systemic consequences. Preterm and low-birth-weight infants are intrinsically at risk because of immature body systems. Chil...
Source: Epilepsy Curr - March 21, 2024 Category: Neurology Authors: Carol à Panzeri Luca Pecoraro Alice Dianin Andrea Sboarina Olivia C Arnone Giorgio Piacentini Angelo Pietrobelli Source Type: research
Potential Micronutrient Deficiencies in the First 1000 Days of Life: The Pediatrician on the Side of the Weakest
This study is to examine potential micronutrient deficiencies and any need for supplementation in children following specific diet plans in the first 1000 days of life.RECENT FINDINGS: Optimal nutrition in the first 1000 days of life has a lifelong positive impact on child development. Specific intrauterine and perinatal factors, pathological conditions, and dietary restrictions can represent potential risk factors for micronutrient deficiencies in the first 1000 days of life, which can have negative systemic consequences. Preterm and low-birth-weight infants are intrinsically at risk because of immature body systems. Chil...
Source: Epilepsy Curr - March 21, 2024 Category: Neurology Authors: Carol à Panzeri Luca Pecoraro Alice Dianin Andrea Sboarina Olivia C Arnone Giorgio Piacentini Angelo Pietrobelli Source Type: research
Potential Micronutrient Deficiencies in the First 1000 Days of Life: The Pediatrician on the Side of the Weakest
This study is to examine potential micronutrient deficiencies and any need for supplementation in children following specific diet plans in the first 1000 days of life.RECENT FINDINGS: Optimal nutrition in the first 1000 days of life has a lifelong positive impact on child development. Specific intrauterine and perinatal factors, pathological conditions, and dietary restrictions can represent potential risk factors for micronutrient deficiencies in the first 1000 days of life, which can have negative systemic consequences. Preterm and low-birth-weight infants are intrinsically at risk because of immature body systems. Chil...
Source: Epilepsy Curr - March 21, 2024 Category: Neurology Authors: Carol à Panzeri Luca Pecoraro Alice Dianin Andrea Sboarina Olivia C Arnone Giorgio Piacentini Angelo Pietrobelli Source Type: research
Relevant Aspects of Combined Protocols for Prevention of N(M)AFLD and Other Non ‐Communicable Diseases
Risk factors for metabolic dysfunction-associated fatty liver disease (MAFLD) development and main characteristics of the monotherapies and combined protocols preventing or treating the disease. AbstractObesity is a global health issue characterized by the excessive fat accumulation, leading to an increased risk of chronic noncommunicable diseases (NCDs), including metabolic dysfunction-associated fatty liver disease (MAFLD), which can progress from simple steatosis to steatohepatitis, fibrosis, cirrhosis, and hepatocellular carcinoma. Currently, there are no approved pharmacological protocols for prevention/treatment of M...
Source: Molecular Nutrition and Food Research - March 21, 2024 Category: Food Science Authors: Luis A. Videla,
Rodrigo Valenzuela,
Jessica Z úñiga‐Hernández,
Andrea del Campo Tags: Review Source Type: research
Potential Micronutrient Deficiencies in the First 1000 Days of Life: The Pediatrician on the Side of the Weakest
This study is to examine potential micronutrient deficiencies and any need for supplementation in children following specific diet plans in the first 1000 days of life.Recent FindingsOptimal nutrition in the first 1000 days of life has a lifelong positive impact on child development. Specific intrauterine and perinatal factors, pathological conditions, and dietary restrictions can represent potential risk factors for micronutrient deficiencies in the first 1000 days of life, which can have negative systemic con sequences. Preterm and low-birth-weight infants are intrinsically at risk because of immature body systems. ...
Source: Current Obesity Reports - March 21, 2024 Category: Eating Disorders & Weight Management Source Type: research
Effect of Unmetabolized Folic Acid on Immunoinflammatory Markers in Sickle Cell Disease Patients Taking Folic Acid Supplementation
AbstractFolic acid (FA) supplementation in sickle cell disease (SCD) patients lead to accumulation of unmetabolized folic acid (UMFA) which might influence the level of cytokines and NK cell activity and thus trigger the crisis event. The aim of the study was to investigate the effect of UMFA levels on immuno-inflammatory markers in SCD patients taking FA supplementation. The cross-sectional study was conducted on 60 HbSS confirmed SCD cases with 22 crisis and 38 cases at steady state of 15 –40 years age group. Serum FA, 5-Methyl Tetrahydrofolate (5-MTHF), Dihydrofolate reductase, Interleukin-6 (IL-6), Highly sensitive ...
Source: Indian Journal of Clinical Biochemistry - March 20, 2024 Category: Biochemistry Source Type: research
