Sirenomelia or mermaid syndrome with a cleft lip in a Tanzanian newborn: a case report
ConclusionSirenomelia is a rare congenital malformation with very poor prognosis. Specific interventions during pre-conception and early prenatal care are critical in the prevention of specific congenital anomalies. Early obstetric ultrasonography is invaluable for diagnosis of sirenomelia as well as counseling for possible termination of pregnancy. (Source: Journal of Medical Case Reports)
Source: Journal of Medical Case Reports - May 6, 2024 Category: General Medicine Source Type: research
A quality of care assessment for women of childbearing potential with epilepsy in Bhutan: An observational study
CONCLUSIONS: Based on data about WWE participants' ASM, supplement, and substance use, our study identified the high use of first generation ASMs (including valproate), frequently in polytherapy, and betel nut use as treatment gaps in women of childbearing potential age with active epilepsy in Bhutan. To address these gaps for locations such as Bhutan, we propose modifications to the QUIET tool's "Chronic Epilepsy Care for Women" section.PMID:38704988 | DOI:10.1016/j.yebeh.2024.109819 (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - May 5, 2024 Category: Neurology Authors: Maya L Mastick Lhab Tshering Ugyen Dema Bikram Chhetri Chencho Dorji Damber K Nirola Puja Subedi Sonam Lhamo Kiran Diyali Sonam R Chodden Andrew S Ham Farrah J Mateen Bhutan Epilepsy Project Source Type: research
A quality of care assessment for women of childbearing potential with epilepsy in Bhutan: An observational study
CONCLUSIONS: Based on data about WWE participants' ASM, supplement, and substance use, our study identified the high use of first generation ASMs (including valproate), frequently in polytherapy, and betel nut use as treatment gaps in women of childbearing potential age with active epilepsy in Bhutan. To address these gaps for locations such as Bhutan, we propose modifications to the QUIET tool's "Chronic Epilepsy Care for Women" section.PMID:38704988 | DOI:10.1016/j.yebeh.2024.109819 (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - May 5, 2024 Category: Neurology Authors: Maya L Mastick Lhab Tshering Ugyen Dema Bikram Chhetri Chencho Dorji Damber K Nirola Puja Subedi Sonam Lhamo Kiran Diyali Sonam R Chodden Andrew S Ham Farrah J Mateen Bhutan Epilepsy Project Source Type: research
The role of singlet oxygen and hydroxyl radical in the photobleaching of meso-substituted cationic pyridyl porphyrins in the presence of folic acid
Journal of Innovative Optical Health Sciences, Ahead of Print. Using a photosensitizer (PS), light, and oxygen, photodynamic therapy creates cytotoxic reactive oxygen species, such as singlet oxygen (1O2), that kill cancer cells. Many cancer cell lines have up to 300 times more folic acid receptors than healthy cells. Therefore, folic acid is often used to improve selectivity of PSs. Photobleaching poses a disadvantage for PSs. In this paper, we have studied the photoinduced changes of meso-substituted cationic pyridyl porphyrins in the presence of folic acid using fluorescence and absorption spectroscopy. In this work, it...
Source: Journal of Innovative Optical Health Sciences - May 4, 2024 Category: Biomedical Science Authors: Lusine Mkrtchyan Torgom Seferyan Marina Parkhats Sergei Lepeshkevich Boris Dzhagarov Gagik Shmavonyan Elena Tuchina Valery Tuchin Grigor Gyulkhandanyan Source Type: research
Role of vitamin B12 and folic acid in treatment of Alzheimer's disease: a meta-analysis of randomized control trials
Aging (Albany NY). 2024 May 2;16. doi: 10.18632/aging.205788. Online ahead of print.ABSTRACTVitamin B12 and folic acid could reduce blood homocysteine levels, which was thought to slow down the progression of Alzheimer's disease (AD), but previous studies regarding the effect of vitamin B12 and folic acid in treatment of AD have not reached conclusive results. We searched PubMed and Embase until January 12, 2023. Only randomized control trials involving participants clearly diagnosed with AD and who received vitamin B12 and folic acid were enrolled. Five studies that met the criteria were selected for inclusion in the meta...
Source: Aging - May 3, 2024 Category: Biomedical Science Authors: Chih-Ying Lee Lung Chan Chaur-Jong Hu Chien-Tai Hong Jia-Hung Chen Source Type: research
Role of vitamin B12 and folic acid in treatment of Alzheimer's disease: a meta-analysis of randomized control trials
Aging (Albany NY). 2024 May 2;16. doi: 10.18632/aging.205788. Online ahead of print.ABSTRACTVitamin B12 and folic acid could reduce blood homocysteine levels, which was thought to slow down the progression of Alzheimer's disease (AD), but previous studies regarding the effect of vitamin B12 and folic acid in treatment of AD have not reached conclusive results. We searched PubMed and Embase until January 12, 2023. Only randomized control trials involving participants clearly diagnosed with AD and who received vitamin B12 and folic acid were enrolled. Five studies that met the criteria were selected for inclusion in the meta...
Source: Aging - May 3, 2024 Category: Biomedical Science Authors: Chih-Ying Lee Lung Chan Chaur-Jong Hu Chien-Tai Hong Jia-Hung Chen Source Type: research
Role of vitamin B12 and folic acid in treatment of Alzheimer's disease: a meta-analysis of randomized control trials
Aging (Albany NY). 2024 May 2;16. doi: 10.18632/aging.205788. Online ahead of print.ABSTRACTVitamin B12 and folic acid could reduce blood homocysteine levels, which was thought to slow down the progression of Alzheimer's disease (AD), but previous studies regarding the effect of vitamin B12 and folic acid in treatment of AD have not reached conclusive results. We searched PubMed and Embase until January 12, 2023. Only randomized control trials involving participants clearly diagnosed with AD and who received vitamin B12 and folic acid were enrolled. Five studies that met the criteria were selected for inclusion in the meta...
Source: Aging - May 3, 2024 Category: Biomedical Science Authors: Chih-Ying Lee Lung Chan Chaur-Jong Hu Chien-Tai Hong Jia-Hung Chen Source Type: research
Role of vitamin B12 and folic acid in treatment of Alzheimer's disease: a meta-analysis of randomized control trials
Aging (Albany NY). 2024 May 2;16. doi: 10.18632/aging.205788. Online ahead of print.ABSTRACTVitamin B12 and folic acid could reduce blood homocysteine levels, which was thought to slow down the progression of Alzheimer's disease (AD), but previous studies regarding the effect of vitamin B12 and folic acid in treatment of AD have not reached conclusive results. We searched PubMed and Embase until January 12, 2023. Only randomized control trials involving participants clearly diagnosed with AD and who received vitamin B12 and folic acid were enrolled. Five studies that met the criteria were selected for inclusion in the meta...
Source: Aging - May 3, 2024 Category: Biomedical Science Authors: Chih-Ying Lee Lung Chan Chaur-Jong Hu Chien-Tai Hong Jia-Hung Chen Source Type: research
Targeted photodynamic therapy technique of Janus nanoparticles on breast cancer
Artif Cells Nanomed Biotechnol. 2024 Dec;52(1):270-277. doi: 10.1080/21691401.2024.2347369. Epub 2024 May 2.ABSTRACTSpherical gold/polyacrylic acid (Au/PAA) polymer-inorganic Janus nanoparticles (JNPs) with simultaneous therapeutic and targeting functions were fabricated. The obtained Au/PAA JNPs were further selectively functionalized with folic acid (FA) and thiol PEG amine (SH-PEG-NH2) on Au sides to provide superior biocompatibility and active targeting, while the other PAA sides were loaded with 5-aminolevulinic acid (5-ALA) to serve as a photosensitizer (PS) for photodynamic therapeutic (PDT) effects on MCF-7 cancer ...
Source: Artificial Cells, Nanomedicine and Biotechnology - May 2, 2024 Category: Biotechnology Authors: Hanieh Montaseri Heidi Abrahamse Source Type: research
Functionalized liposomes as a potential drug delivery systems for colon cancer treatment: A systematic review
Int J Biol Macromol. 2024 Apr 30:132023. doi: 10.1016/j.ijbiomac.2024.132023. Online ahead of print.ABSTRACTColon cancer is one of the lethal diseases in the world with approximately 700,000 fatalities annually (Abdulzehra et al., 2023 [1]). Nowadays, due to the side effects of existing methods in the treatment of colon cancer such as radiotherapy and chemotherapy, the use of targeted nanocarriers in cancer treatment has received wide attention, and among them, especially liposomes have been studied a lot. Based on this, anti-tumor drugs hidden in targeted active liposomes can selectively act on cancer cells. In this syste...
Source: International Journal of Biological Macromolecules - May 2, 2024 Category: Biochemistry Authors: Eskandar Moghimipour Somayeh Handali Source Type: research
Targeted photodynamic therapy technique of Janus nanoparticles on breast cancer
Artif Cells Nanomed Biotechnol. 2024 Dec;52(1):270-277. doi: 10.1080/21691401.2024.2347369. Epub 2024 May 2.ABSTRACTSpherical gold/polyacrylic acid (Au/PAA) polymer-inorganic Janus nanoparticles (JNPs) with simultaneous therapeutic and targeting functions were fabricated. The obtained Au/PAA JNPs were further selectively functionalized with folic acid (FA) and thiol PEG amine (SH-PEG-NH2) on Au sides to provide superior biocompatibility and active targeting, while the other PAA sides were loaded with 5-aminolevulinic acid (5-ALA) to serve as a photosensitizer (PS) for photodynamic therapeutic (PDT) effects on MCF-7 cancer ...
Source: Artificial Cells, Nanomedicine and Biotechnology - May 2, 2024 Category: Biotechnology Authors: Hanieh Montaseri Heidi Abrahamse Source Type: research
Functionalized liposomes as a potential drug delivery systems for colon cancer treatment: A systematic review
Int J Biol Macromol. 2024 Apr 30;269(Pt 1):132023. doi: 10.1016/j.ijbiomac.2024.132023. Online ahead of print.ABSTRACTColon cancer is one of the lethal diseases in the world with approximately 700,000 fatalities annually. Nowadays, due to the side effects of existing methods in the treatment of colon cancer such as radiotherapy and chemotherapy, the use of targeted nanocarriers in cancer treatment has received wide attention, and among them, especially liposomes have been studied a lot. Based on this, anti-tumor drugs hidden in targeted active liposomes can selectively act on cancer cells. In this systematic review, the us...
Source: International Journal of Biological Macromolecules - May 2, 2024 Category: Biochemistry Authors: Eskandar Moghimipour Somayeh Handali Source Type: research
Targeted photodynamic therapy technique of Janus nanoparticles on breast cancer
Artif Cells Nanomed Biotechnol. 2024 Dec;52(1):270-277. doi: 10.1080/21691401.2024.2347369. Epub 2024 May 2.ABSTRACTSpherical gold/polyacrylic acid (Au/PAA) polymer-inorganic Janus nanoparticles (JNPs) with simultaneous therapeutic and targeting functions were fabricated. The obtained Au/PAA JNPs were further selectively functionalized with folic acid (FA) and thiol PEG amine (SH-PEG-NH2) on Au sides to provide superior biocompatibility and active targeting, while the other PAA sides were loaded with 5-aminolevulinic acid (5-ALA) to serve as a photosensitizer (PS) for photodynamic therapeutic (PDT) effects on MCF-7 cancer ...
Source: Artificial Cells, Nanomedicine and Biotechnology - May 2, 2024 Category: Biotechnology Authors: Hanieh Montaseri Heidi Abrahamse Source Type: research
