Risk factors associated with congenital central nervous system abnormalities in the National Hospital of Zinder, Niger
CONCLUSION: Risk factors such as family malformation history and consanguine marriage increased the risk of developing congenital malformations of the central nervous system. In contrast, folic acid supplementation in the index period and multiparity had a significant protective effect.PMID:38458060 | DOI:10.1016/j.neuchi.2024.101547 (Source: Neurochirurgie)
Source: Neurochirurgie - March 8, 2024 Category: Neurosurgery Authors: Rabiou Mahaman Sani Hamissou Moussa Maman Roufai George Thomas Ibrahim Hassane Ali Amadou Hounkpatin Seton Stachys Beranger Source Type: research
Risk factors associated with congenital central nervous system abnormalities in the National Hospital of Zinder, Niger
CONCLUSION: Risk factors such as family malformation history and consanguine marriage increased the risk of developing congenital malformations of the central nervous system. In contrast, folic acid supplementation in the index period and multiparity had a significant protective effect.PMID:38458060 | DOI:10.1016/j.neuchi.2024.101547 (Source: Neuro-Chirurgie)
Source: Neuro-Chirurgie - March 8, 2024 Category: Neurosurgery Authors: Rabiou Mahaman Sani Hamissou Moussa Maman Roufai George Thomas Ibrahim Hassane Ali Amadou Hounkpatin Seton Stachys Beranger Source Type: research
Risk factors associated with congenital central nervous system abnormalities in the National Hospital of Zinder, Niger
CONCLUSION: Risk factors such as family malformation history and consanguine marriage increased the risk of developing congenital malformations of the central nervous system. In contrast, folic acid supplementation in the index period and multiparity had a significant protective effect.PMID:38458060 | DOI:10.1016/j.neuchi.2024.101547 (Source: Neurochirurgie)
Source: Neurochirurgie - March 8, 2024 Category: Neurosurgery Authors: Rabiou Mahaman Sani Hamissou Moussa Maman Roufai George Thomas Ibrahim Hassane Ali Amadou Hounkpatin Seton Stachys Beranger Source Type: research
Risk factors associated with congenital central nervous system abnormalities in the National Hospital of Zinder, Niger
CONCLUSION: Risk factors such as family malformation history and consanguine marriage increased the risk of developing congenital malformations of the central nervous system. In contrast, folic acid supplementation in the index period and multiparity had a significant protective effect.PMID:38458060 | DOI:10.1016/j.neuchi.2024.101547 (Source: Neuro-Chirurgie)
Source: Neuro-Chirurgie - March 8, 2024 Category: Neurosurgery Authors: Rabiou Mahaman Sani Hamissou Moussa Maman Roufai George Thomas Ibrahim Hassane Ali Amadou Hounkpatin Seton Stachys Beranger Source Type: research
Risk factors associated with congenital central nervous system abnormalities in the National Hospital of Zinder, Niger
CONCLUSION: Risk factors such as family malformation history and consanguine marriage increased the risk of developing congenital malformations of the central nervous system. In contrast, folic acid supplementation in the index period and multiparity had a significant protective effect.PMID:38458060 | DOI:10.1016/j.neuchi.2024.101547 (Source: Neurochirurgie)
Source: Neurochirurgie - March 8, 2024 Category: Neurosurgery Authors: Rabiou Mahaman Sani Hamissou Moussa Maman Roufai George Thomas Ibrahim Hassane Ali Amadou Hounkpatin Seton Stachys Beranger Source Type: research
Risk factors associated with congenital central nervous system abnormalities in the National Hospital of Zinder, Niger
CONCLUSION: Risk factors such as family malformation history and consanguine marriage increased the risk of developing congenital malformations of the central nervous system. In contrast, folic acid supplementation in the index period and multiparity had a significant protective effect.PMID:38458060 | DOI:10.1016/j.neuchi.2024.101547 (Source: Neuro-Chirurgie)
Source: Neuro-Chirurgie - March 8, 2024 Category: Neurosurgery Authors: Rabiou Mahaman Sani Hamissou Moussa Maman Roufai George Thomas Ibrahim Hassane Ali Amadou Hounkpatin Seton Stachys Beranger Source Type: research
Risk factors associated with congenital central nervous system abnormalities in the National Hospital of Zinder, Niger
CONCLUSION: Risk factors such as family malformation history and consanguine marriage increased the risk of developing congenital malformations of the central nervous system. In contrast, folic acid supplementation in the index period and multiparity had a significant protective effect.PMID:38458060 | DOI:10.1016/j.neuchi.2024.101547 (Source: Neurochirurgie)
Source: Neurochirurgie - March 8, 2024 Category: Neurosurgery Authors: Rabiou Mahaman Sani Hamissou Moussa Maman Roufai George Thomas Ibrahim Hassane Ali Amadou Hounkpatin Seton Stachys Beranger Source Type: research
Synthesis and biological evaluation of folic acid-rotenol conjugate as a potent targeted anticancer prodrug
Eur J Pharmacol. 2024 Mar 5:176482. doi: 10.1016/j.ejphar.2024.176482. Online ahead of print.ABSTRACTRotenone, a plant-based agricultural insecticide, has been shown to have anti-tumor activity through targeting mitochondrial complex I in cancer cells. However, off-target toxic side effect on nervous systems have greatly restricted the application of rotenone as anticancer drugs. Here, a folic acid-rotenol (FA-rotenol) conjugate was prepared by covalent coupling of the tumor-targeting ligand folic acid with rotenone derivative-rotenol to enhance its accumulation at tumor site. FA-rotenol conjugates presents high in vitro c...
Source: European Journal of Pharmacology - March 7, 2024 Category: Drugs & Pharmacology Authors: Min Hong Juan Wang Haobin Chen Jiayu Qi Qinghong Ji Xiaoyan Liu Qiaoli Yue Lei Li Shuang Cheng Source Type: research
Synthesis and biological evaluation of folic acid-rotenol conjugate as a potent targeted anticancer prodrug
Eur J Pharmacol. 2024 Mar 5:176482. doi: 10.1016/j.ejphar.2024.176482. Online ahead of print.ABSTRACTRotenone, a plant-based agricultural insecticide, has been shown to have anti-tumor activity through targeting mitochondrial complex I in cancer cells. However, off-target toxic side effect on nervous systems have greatly restricted the application of rotenone as anticancer drugs. Here, a folic acid-rotenol (FA-rotenol) conjugate was prepared by covalent coupling of the tumor-targeting ligand folic acid with rotenone derivative-rotenol to enhance its accumulation at tumor site. FA-rotenol conjugates presents high in vitro c...
Source: European Journal of Pharmacology - March 7, 2024 Category: Drugs & Pharmacology Authors: Min Hong Juan Wang Haobin Chen Jiayu Qi Qinghong Ji Xiaoyan Liu Qiaoli Yue Lei Li Shuang Cheng Source Type: research
Nanoparticles alleviate non-alcoholic steatohepatitis via ER stress sensor-mediated intestinal barrier damage and gut dysbiosis
DiscussionRegulation of the key transcription factor XBP1s can partially restore the intestinal microbiota structure, maintain the integrity of intestinal mucosal barrier, and prevent the progression of NASH, providing new evidence for treating NASH. (Source: Frontiers in Microbiology)
Source: Frontiers in Microbiology - March 7, 2024 Category: Microbiology Source Type: research
The effect of UNIMMAP multiple micronutrient supplements versus iron-folic acid and placebo in anemia reduction among women of reproductive age in Kebribeyah Woreda, Somali Regional State, Ethiopia: a study protocol for a community-based individual RCT
Women of reproductive age (WRA) in developing countries are often at risk of micronutrient deficiencies due to inadequate intakes and excessive losses. (Source: Trials)
Source: Trials - March 6, 2024 Category: General Medicine Authors: Desalegn Kuche, Zeweter Abebe, Masresha Tessema, Meron Girma, Alemayehu Hussen, Kaleab Baye and Barbara J. Stoecker Tags: Study protocol Source Type: research
Long-Term Low-Dose Pyrimethamine Use for the Prevention of Ocular Toxoplasmosis Recurrences: A Cohort Study
CONCLUSION: Long-term, low-dose pyrimethamine can be considered as a treatment option for the prevention of ocular toxoplasmosis recurrence in selected patients, with only a few, mild and reversible systemic adverse events.PMID:38441575 | DOI:10.1080/09273948.2024.2321270 (Source: Ocular Immunology and Inflammation)
Source: Ocular Immunology and Inflammation - March 5, 2024 Category: Allergy & Immunology Authors: Yuslay Fern ández Zamora Paula M Marinho Jo ão Rafael Oliveira Dias Thiago Silva Julio Casoy Cristina Muccioli Heloisa Nascimento Rubens Belfort Source Type: research
