Feline infectious peritonitis: A comprehensive evaluation of clinical manifestations, laboratory diagnosis, and therapeutic approaches
CONCLUSION: Confirming FIP cases can be challenging; therefore, a tentative diagnosis of FIP must be made with care. This study provided practical diagnostic tools to diagnose FIP based on clinical signs and multiple abnormalities, which allowed for more efficient and rapid detection.PMID:38680809 | PMC:PMC11055576 | DOI:10.5455/javar.2024.k742 (Source: Adv Data)
Source: Adv Data - April 29, 2024 Category: Epidemiology Authors: Wassamon Moyadee Supita Sunpongsri Kiattawee Choowongkomon Sittiruk Roytrakul Amonpun Rattanasrisomporn Natthasit Tansakul Jatuporn Rattanasrisomporn Source Type: research
CRKL but not CRKII contributes to hemin-induced erythroid differentiation of CML
J Cell Mol Med. 2024 May;28(9):e18308. doi: 10.1111/jcmm.18308.ABSTRACTDestruction of erythropoiesis process leads to various diseases, including thrombocytopenia, anaemia, and leukaemia. miR-429-CT10 regulation of kinase-like (CRKL) axis involved in development, progression and metastasis of cancers. However, the exact role of miR-429-CRKL axis in leukaemic cell differentiation are still unknown. The current work aimed to uncover the effect of miR-429-CRKL axis on erythropoiesis. In the present study, CRKL upregulation was negatively correlated with miR-429 downregulation in both chronic myeloid leukaemia (CML) patient an...
Source: J Cell Mol Med - April 29, 2024 Category: Molecular Biology Authors: Chunmei Guo Xinxin Lv Qiuling Zhang Lina Yi Yingying Ren Zhaopeng Li Jinsong Yan Shanliang Zheng Ming-Zhong Sun Shuqing Liu Source Type: research
Distinctive patterns of sequential platelet counts following blunt traumatic brain injury predict outcomes
CONCLUSION: NCNS-bTBI, thrombocytosis was correlated with better outcomes and was not associated with an increased risk for developing thromboembolism or hemorrhage, precluding the immediate need for any additional antiaggregates.PMID:38679938 | DOI:10.1080/02699052.2024.2347571 (Source: Brain Injury)
Source: Brain Injury - April 29, 2024 Category: Neurology Authors: Mikael Levy Esther Arfi Levy Neelan J Marianayagama Vladimir Frolov Shimon Maimon Ophira Salomon Source Type: research
CRKL but not CRKII contributes to hemin-induced erythroid differentiation of CML
J Cell Mol Med. 2024 May;28(9):e18308. doi: 10.1111/jcmm.18308.ABSTRACTDestruction of erythropoiesis process leads to various diseases, including thrombocytopenia, anaemia, and leukaemia. miR-429-CT10 regulation of kinase-like (CRKL) axis involved in development, progression and metastasis of cancers. However, the exact role of miR-429-CRKL axis in leukaemic cell differentiation are still unknown. The current work aimed to uncover the effect of miR-429-CRKL axis on erythropoiesis. In the present study, CRKL upregulation was negatively correlated with miR-429 downregulation in both chronic myeloid leukaemia (CML) patient an...
Source: Molecular Medicine - April 29, 2024 Category: Molecular Biology Authors: Chunmei Guo Xinxin Lv Qiuling Zhang Lina Yi Yingying Ren Zhaopeng Li Jinsong Yan Shanliang Zheng Ming-Zhong Sun Shuqing Liu Source Type: research
Post-transfusion purpura and adult primary thrombocytopenia
Int J Hematol. 2024 Apr 29. doi: 10.1007/s12185-024-03784-2. Online ahead of print.NO ABSTRACTPMID:38684587 | DOI:10.1007/s12185-024-03784-2 (Source: International Journal of Hematology)
Source: International Journal of Hematology - April 29, 2024 Category: Hematology Authors: Philip Murphy Source Type: research
Feline infectious peritonitis: A comprehensive evaluation of clinical manifestations, laboratory diagnosis, and therapeutic approaches
CONCLUSION: Confirming FIP cases can be challenging; therefore, a tentative diagnosis of FIP must be made with care. This study provided practical diagnostic tools to diagnose FIP based on clinical signs and multiple abnormalities, which allowed for more efficient and rapid detection.PMID:38680809 | PMC:PMC11055576 | DOI:10.5455/javar.2024.k742 (Source: Adv Data)
Source: Adv Data - April 29, 2024 Category: Epidemiology Authors: Wassamon Moyadee Supita Sunpongsri Kiattawee Choowongkomon Sittiruk Roytrakul Amonpun Rattanasrisomporn Natthasit Tansakul Jatuporn Rattanasrisomporn Source Type: research
Distinctive patterns of sequential platelet counts following blunt traumatic brain injury predict outcomes
CONCLUSION: NCNS-bTBI, thrombocytosis was correlated with better outcomes and was not associated with an increased risk for developing thromboembolism or hemorrhage, precluding the immediate need for any additional antiaggregates.PMID:38679938 | DOI:10.1080/02699052.2024.2347571 (Source: Brain Injury)
Source: Brain Injury - April 29, 2024 Category: Neurology Authors: Mikael Levy Esther Arfi Levy Neelan J Marianayagama Vladimir Frolov Shimon Maimon Ophira Salomon Source Type: research
Viruses, Vol. 16, Pages 700: Correlation between the Cycle Threshold Values in Detection of Severe Fever with Thrombocytopenia Syndrome Virus Using PowerChekTM SFTSV Real-Time PCR Kit and Viral Load: Prognostic Implications
Conclusion: In this study, we established a correlation between SFTS viral load and Ct values for estimating the initial viral load and early predicting prognosis. These results are expected to offer valuable insights for SFTS patient treatment and prognosis prediction. (Source: Viruses)
Source: Viruses - April 29, 2024 Category: Virology Authors: Misun Kim Sang Taek Heo Hee Cheol Kim Myeong Jin Kang Sora Kim Keun Hwa Lee Jeong Rae Yoo Tags: Brief Report Source Type: research
ASCT2-Targeting Antibody-Drug Conjugate MEDI7247 in Adult Patients with Relapsed/Refractory Hematological Malignancies: A First-in-Human, Phase 1 Study
ConclusionsThrombocytopenia and neutropenia limited repeat dosing. Although limited clinical activity was detected, the dose-escalation phase was stopped early without establishing an MTD.The study was registered with ClinicalTrials.gov (NCT03106428). (Source: Targeted Oncology)
Source: Targeted Oncology - April 29, 2024 Category: Cancer & Oncology Source Type: research
Prediction Model for Severe Thrombocytopenia Induced by Gemcitabine Plus Cisplatin Combination Therapy in Patients with Urothelial Cancer
ConclusionsPlatelet count, hemoglobin level, lymphocyte count, and gemcitabine dose contributed to the development of a novel prediction model to identify the incidence of GC-induced severe thrombocytopenia. (Source: Clinical Drug Investigation)
Source: Clinical Drug Investigation - April 29, 2024 Category: Drugs & Pharmacology Source Type: research
FOXO1 Single-Nucleotide Polymorphisms Are Associated with Bleeding Severity and Sensitivity of Glucocorticoid Treatment of Pediatric Immune Thrombocytopenia
DNA and Cell Biology, Ahead of Print. (Source: DNA and Cell Biology)
Source: DNA and Cell Biology - April 29, 2024 Category: Cytology Authors: Xingjuan Xie Hao Gu Jingyao Ma Lingling Fu Jie Ma Jialu Zhang Runhui Wu Zhenping Chen Source Type: research
A 11-year-old boy with Blastocystis hominis infection, presents as immune thrombocytopenia
Some causes of first-line treatment failure for ITP are often closely related to infections. But parasitic infections are rarely mentioned and easily overlooked. The case is the first to describe a boy with im... (Source: Thrombosis Journal)
Source: Thrombosis Journal - April 29, 2024 Category: Hematology Authors: Fajuan Tang, Dongqiong Xiao, Lin Chen, Xihong Li and Lina Qiao Tags: Case Report Source Type: research
Long non-coding RNA NORAD regulates megakaryocyte differentiation and proplatelet formation via the DUSP6/ERK signaling pathway
In this study, we demonstrate NORAD RNA is highly expressed in the cytoplasm during megakaryocyte differentiation. Interestingly, we identified for the first time that NORAD has a strong inhibitory effect on megakaryocyte differentiation and proplatelet formation from cultured megakaryocytes. DUSP6/ERK1/2 pathway is activated in response to NORAD knockdown during megakaryocytopoiesis, which is achieved by sequestering PUM2 proteins. Finally, compared with the wild-type control mice, NORAD knockout mice show a faster platelet recovery after severe thrombocytopenia induced by 6 Gy total body irradiation. These findings demon...
Source: Biochemical and Biophysical Research communications - April 28, 2024 Category: Biochemistry Authors: Yong Wang Yan Lv Xiaoli Jiang Xin Yu Delong Wang Desheng Liu Xiangyong Liu Yeying Sun Source Type: research
Adverse reactions caused by high serum concentration of linezolid: Two case reports and literature review
The relationship between drug concentrations and adverse drug reactions in patients. Key Clinical MessageLinezolid is a potent oxazolidinone for the treatment of various gram-positive bacterial infections. However, the drug can cause potential adverse reactions such as thrombocytopenia, hyperlactacidemia and serotonin syndrome, which warrant consideration by the medical team when planning treatment. The existing literature has reported some adverse reactions caused by linezolid, but most of these are based on clinical characteristics and simple treatment measures. Two cases of linezolid overdose resulting in thrombocytopen...
Source: Clinical Case Reports - April 27, 2024 Category: General Medicine Authors: Renzhu Liu,
Lu Xiao,
Can Xiao,
Wencan Li,
Xiang Liu Tags: CASE REPORT Source Type: research
Fewer severe infections with tranexamic acid in patients with hematologic malignancies
CONCLUSION: Patients with hematologic malignancies who received TXA had less severe infections than those who received placebo with no difference in overall rate of infection or other inflammatory outcomes. Further investigation is needed on the impact of TXA on infections in this population.PMID:38666065 | PMC:PMC11043644 | DOI:10.1016/j.rpth.2024.102358 (Source: Cell Research)
Source: Cell Research - April 26, 2024 Category: Cytology Authors: Jacqueline N Poston Siobhan P Brown Anton Ilich Amy Sarah Ginsburg Heather Herren Nahed El Kassar Christopher E Jensen Darrell J Triulzi Nigel S Key Susanne May Terry B Gernsheimer Source Type: research
