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GSE256085 Histone modifications of Monocytes in the context of thrombocytopenia
Contributors : Craig Morrell ; Chen LiSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusWe sought to define changes in open and closed chromatin in monocytes isolated from control and thrombocytopenic mice (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - April 12, 2024 Category: Genetics & Stem Cells Tags: Genome binding/occupancy profiling by high throughput sequencing Mus musculus Source Type: research

GSE256083 RNA expression in Monocytes from thrombocytopenic mice
Contributors : Craig Morrell ; Chen LiSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusWe sought to define changes in gene expression in monocytes in the context of thrombocytopenia (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - April 12, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research

Viruses, Vol. 16, Pages 594: Molecular and Entomological Characterization of 2023 Dengue Outbreak in Dhading District, Central Nepal
hrestha Stefan Fernandez Gathsaurie Neelika Malavige Basu Dev Pandey Takeshi Urano Kouichi Morita Mya Myat Ngwe Tun Shyam Prakash Dumre In 2023, Nepal faced its second largest dengue outbreak ever, following a record-breaking number of dengue cases in 2022, characterized by the expansion of infections into areas of higher altitudes. However, the characteristics of the 2023 circulating dengue virus (DENV) and the vector density remain poorly understood. Therefore, we performed DENV serotyping, clinical and laboratory assessment, and entomological analysis of the 2023 outbreak in central Nepal. A total of 3...
Source: Viruses - April 12, 2024 Category: Virology Authors: Sandesh Rimal Sabin Shrestha Sunita Wagle Paudel Yogendra Shah Govinda Bhandari Kishor Pandey Anjana Kharbuja Merveille Kapandji Ishan Gautam Rajshree Bhujel Yuki Takamatsu Rudramani Bhandari Chonticha Klungthong Sanjaya Kumar Shrestha Stefan Fernandez Ga Tags: Article Source Type: research

Analysis of mild and severe neonatal enterovirus infections in a Chinese neonatal tertiary center: a retrospective case-control study
ConclusionWe found significant differences between mild and severe cases of neonatal enterovirus infection with respect to complications, laboratory findings, and enterovirus serotypes. It is crucial to exercise caution when newborns exhibit symptoms of sepsis, during an enterovirus outbreak. Anemia, thrombocytopenia, abnormal liver function, and coagulation dysfunction should be monitored closely as they could indicate the presence of a severe enteroviral infection. (Source: European Journal of Clinical Microbiology and Infectious Diseases)
Source: European Journal of Clinical Microbiology and Infectious Diseases - April 12, 2024 Category: Microbiology Source Type: research

Thrombocytopenia After Dupilumab for the Treatment of Atopic Dermatitis
Dermatitis. 2024 Apr 11. doi: 10.1089/derm.2024.0015. Online ahead of print.NO ABSTRACTPMID:38603575 | DOI:10.1089/derm.2024.0015 (Source: Dermatitis)
Source: Dermatitis - April 11, 2024 Category: Dermatology Authors: Aline Lopes Bressan Nat ália Torres Troncoso Nathalie Andrade Sousa Source Type: research

Cancers, Vol. 16, Pages 1462: The Challenge for a Correct Diagnosis of Refractory Thrombocytopenia: ITP or MDS with Isolated Thrombocytopenia?
nidis Immune thrombocytopenia (ITP) is an autoimmune disease characterized by isolated thrombocytopenia. It is diagnosed in patients with a platelet count below 100,000 per cubic millimeter in whom other causes of thrombocytopenia have been ruled out, and its diagnosis is generally one of exclusion. Clinical manifestations of patients may vary from asymptomatic disease to mild mucocutaneous or life-threatening bleeding. Glucocorticoids are used as first-line treatment for ITP, while other second-line medications, mainly thrombopoietin-receptor agonists (TPO-RA) and rituximab, are given to patients in whom ITP does not ...
Source: Cancers - April 11, 2024 Category: Cancer & Oncology Authors: Aikaterini Kosmidou Eleni Gavriilaki Athanasios Tragiannidis Tags: Review Source Type: research

Symptomatic corpus luteum hemorrhage in adolescent females with ITP
Conclusion: CLH could potentially pose a significant complication in the context of adolescent females with ITP, requiring a strong index of suspicion to direct expedient therapy.What is Known:• Immune thrombocytopenia is typically associated with minor bleeding tendency.• Corpus luteum hemorrhage is generally asymptomatic; however, in women with bleeding disorders, it has the potential to result in substantial intra-abdominal bleeding.What is New:• Corpus luteum hemorrhage leading to intra-abdominal bleeding is a potential severe complication of immune thrombocytopenia in adolescent females. (Source: European Journal of Pediatrics)
Source: European Journal of Pediatrics - April 11, 2024 Category: Pediatrics Source Type: research

Heterozygous ITGA2B Phe1024 Deletion Associated with Abnormal αIIbβ3 Function in a Patient with Congenital Thrombocytopenia
Semin Thromb Hemost DOI: 10.1055/s-0044-1785655 Thieme Medical Publishers, Inc. 333 Seventh Avenue, 18th Floor, New York, NY 10001, USAArticle in Thieme eJournals: Table of contents | Full text (Source: Seminars in Thrombosis and Hemostasis)
Source: Seminars in Thrombosis and Hemostasis - April 11, 2024 Category: Hematology Authors: Wang, Bin Tang, Ning Hou, Hongyan Chen, Junkun Wang, Xiong Li, Jiaoyuan Tags: Letter to the Editor Source Type: research

An anti-PF4 antibody-related disorder with cerebral venous sinus thrombosis and thrombocytopenia initially presenting as intracranial hemorrhage
(Source: Journal of Neurology)
Source: Journal of Neurology - April 10, 2024 Category: Neurology Source Type: research

Phase II Study of Osimertinib in Patients With Epidermal Growth Factor Receptor Mutations: Results From the NCI-MATCH ECOG-ACRIN (EAY131) Trial Subprotocol E
CONCLUSION: In this pretreated cohort, osimertinib did not meet the prespecified end point threshold for efficacy, but responses were seen in a neuroendocrine carcinoma with an EGFR exon 20 S768T and exon 18 G719C mutation and an epithelial carcinoma with an EGFR D770_N771insSVD mutation. Osimertinib was well tolerated and had a safety profile consistent with previous studies.PMID:38591867 | DOI:10.1200/PO.23.00454 (Source: Ann Oncol)
Source: Ann Oncol - April 9, 2024 Category: Cancer & Oncology Authors: Monica F Chen Zihe Song Helena A Yu Lecia V Sequist Christine M Lovly Edith P Mitchell Jeffrey A Moscow Robert J Gray Victoria Wang Lisa M McShane Larry V Rubinstein David R Patton P Mickey Williams Stanley R Hamilton Yoshie Umemura James V Tricoli Barbar Source Type: research