< sup > 177 < /sup > Lu-PSMA-617 Radioligand Treatment in Elderly Patients with Metastatic Castration-resistant Prostate Cancer: Therapeutic Efficacy and Safety Assessment
CONCLUSION: 177Lu-PSMA-617 treatment was a safe and effective treatment option for properly selected elderly mCRPC patients.PMID:38571351 | DOI:10.2174/0118744710284661240328094119 (Source: Current Radiopharmaceuticals)
Source: Current Radiopharmaceuticals - April 4, 2024 Category: Radiology Authors: Ertan Sahin Umut Elboga Ufuk Cimen Merve Okuyan Yusuf Burak Cayirli Source Type: research
Newborn Skin: Part I. Common Rashes and Skin Changes
Am Fam Physician. 2024 Mar;109(3):212-216.ABSTRACTRashes in the newborn period are common and most are benign. Infections should be suspected in newborns with pustules or vesicles, especially in those who are not well-appearing or have risk factors for congenital infection. Congenital cytomegalovirus infection can cause sensorineural hearing loss and neurodevelopmental delay. Skin manifestations of cytomegalovirus may include petechiae due to thrombocytopenia. The most common skin manifestations of early congenital syphilis are small, copper-red, maculopapular lesions located primarily on the hands and feet that peel and c...
Source: American Family Physician - April 4, 2024 Category: Primary Care Authors: Katherine A M Snyder Adam D Voelckers Source Type: research
A phase I study of pevonedistat, azacitidine, and venetoclax in patients with relapsed/refractory acute myeloid leukemia
Haematologica. 2024 Apr 4. doi: 10.3324/haematol.2024.285014. Online ahead of print.ABSTRACTAzacitidine/venetoclax is an active regimen in patients with newly diagnosed AML. However, primary or secondary resistance to azacitidine/venetoclax is an area of unmet need and overexpression of MCL-1 is suggested to be a potential resistance mechanism. Pevonedistat inhibits MCL-1 through activation of NOXA, and pevonedistat/azacitidine has previously shown activity in AML. To assess the tolerability and efficacy of adding pevonedistat to azacitidine/venetoclax in relapsed/refractory AML, we conducted a phase I multicenter openlabe...
Source: Haematologica - April 4, 2024 Category: Hematology Authors: Guru Subramanian Guru Murthy Antoine N Saliba Aniko Szabo Alexandra Harrington Sameem Abedin Karen Carlson Laura Michaelis Lyndsey Runaas Arielle Baim Alex Hinman Sonia Maldonado-Schmidt Annapoorna Venkatachalam Karen S Flatten Kevin L Peterson Paula A Sc Source Type: research
< sup > 177 < /sup > Lu-PSMA-617 Radioligand Treatment in Elderly Patients with Metastatic Castration-resistant Prostate Cancer: Therapeutic Efficacy and Safety Assessment
CONCLUSION: 177Lu-PSMA-617 treatment was a safe and effective treatment option for properly selected elderly mCRPC patients.PMID:38571351 | DOI:10.2174/0118744710284661240328094119 (Source: Current Radiopharmaceuticals)
Source: Current Radiopharmaceuticals - April 4, 2024 Category: Radiology Authors: Ertan Sahin Umut Elboga Ufuk Cimen Merve Okuyan Yusuf Burak Cayirli Source Type: research
Newborn Skin: Part I. Common Rashes and Skin Changes
Am Fam Physician. 2024 Mar;109(3):212-216.ABSTRACTRashes in the newborn period are common and most are benign. Infections should be suspected in newborns with pustules or vesicles, especially in those who are not well-appearing or have risk factors for congenital infection. Congenital cytomegalovirus infection can cause sensorineural hearing loss and neurodevelopmental delay. Skin manifestations of cytomegalovirus may include petechiae due to thrombocytopenia. The most common skin manifestations of early congenital syphilis are small, copper-red, maculopapular lesions located primarily on the hands and feet that peel and c...
Source: American Family Physician - April 4, 2024 Category: Primary Care Authors: Katherine A M Snyder Adam D Voelckers Source Type: research
A phase I study of pevonedistat, azacitidine, and venetoclax in patients with relapsed/refractory acute myeloid leukemia
Haematologica. 2024 Apr 4. doi: 10.3324/haematol.2024.285014. Online ahead of print.ABSTRACTAzacitidine/venetoclax is an active regimen in patients with newly diagnosed AML. However, primary or secondary resistance to azacitidine/venetoclax is an area of unmet need and overexpression of MCL-1 is suggested to be a potential resistance mechanism. Pevonedistat inhibits MCL-1 through activation of NOXA, and pevonedistat/azacitidine has previously shown activity in AML. To assess the tolerability and efficacy of adding pevonedistat to azacitidine/venetoclax in relapsed/refractory AML, we conducted a phase I multicenter openlabe...
Source: Haematologica - April 4, 2024 Category: Hematology Authors: Guru Subramanian Guru Murthy Antoine N Saliba Aniko Szabo Alexandra Harrington Sameem Abedin Karen Carlson Laura Michaelis Lyndsey Runaas Arielle Baim Alex Hinman Sonia Maldonado-Schmidt Annapoorna Venkatachalam Karen S Flatten Kevin L Peterson Paula A Sc Source Type: research
< sup > 177 < /sup > Lu-PSMA-617 Radioligand Treatment in Elderly Patients with Metastatic Castration-resistant Prostate Cancer: Therapeutic Efficacy and Safety Assessment
CONCLUSION: 177Lu-PSMA-617 treatment was a safe and effective treatment option for properly selected elderly mCRPC patients.PMID:38571351 | DOI:10.2174/0118744710284661240328094119 (Source: Current Radiopharmaceuticals)
Source: Current Radiopharmaceuticals - April 4, 2024 Category: Radiology Authors: Ertan Sahin Umut Elboga Ufuk Cimen Merve Okuyan Yusuf Burak Cayirli Source Type: research
Newborn Skin: Part I. Common Rashes and Skin Changes
Am Fam Physician. 2024 Mar;109(3):212-216.ABSTRACTRashes in the newborn period are common and most are benign. Infections should be suspected in newborns with pustules or vesicles, especially in those who are not well-appearing or have risk factors for congenital infection. Congenital cytomegalovirus infection can cause sensorineural hearing loss and neurodevelopmental delay. Skin manifestations of cytomegalovirus may include petechiae due to thrombocytopenia. The most common skin manifestations of early congenital syphilis are small, copper-red, maculopapular lesions located primarily on the hands and feet that peel and c...
Source: American Family Physician - April 4, 2024 Category: Primary Care Authors: Katherine A M Snyder Adam D Voelckers Source Type: research
A phase I study of pevonedistat, azacitidine, and venetoclax in patients with relapsed/refractory acute myeloid leukemia
Haematologica. 2024 Apr 4. doi: 10.3324/haematol.2024.285014. Online ahead of print.ABSTRACTAzacitidine/venetoclax is an active regimen in patients with newly diagnosed AML. However, primary or secondary resistance to azacitidine/venetoclax is an area of unmet need and overexpression of MCL-1 is suggested to be a potential resistance mechanism. Pevonedistat inhibits MCL-1 through activation of NOXA, and pevonedistat/azacitidine has previously shown activity in AML. To assess the tolerability and efficacy of adding pevonedistat to azacitidine/venetoclax in relapsed/refractory AML, we conducted a phase I multicenter openlabe...
Source: Haematologica - April 4, 2024 Category: Hematology Authors: Guru Subramanian Guru Murthy Antoine N Saliba Aniko Szabo Alexandra Harrington Sameem Abedin Karen Carlson Laura Michaelis Lyndsey Runaas Arielle Baim Alex Hinman Sonia Maldonado-Schmidt Annapoorna Venkatachalam Karen S Flatten Kevin L Peterson Paula A Sc Source Type: research
< sup > 177 < /sup > Lu-PSMA-617 Radioligand Treatment in Elderly Patients with Metastatic Castration-resistant Prostate Cancer: Therapeutic Efficacy and Safety Assessment
CONCLUSION: 177Lu-PSMA-617 treatment was a safe and effective treatment option for properly selected elderly mCRPC patients.PMID:38571351 | DOI:10.2174/0118744710284661240328094119 (Source: Current Radiopharmaceuticals)
Source: Current Radiopharmaceuticals - April 4, 2024 Category: Radiology Authors: Ertan Sahin Umut Elboga Ufuk Cimen Merve Okuyan Yusuf Burak Cayirli Source Type: research
Newborn Skin: Part I. Common Rashes and Skin Changes
Am Fam Physician. 2024 Mar;109(3):212-216.ABSTRACTRashes in the newborn period are common and most are benign. Infections should be suspected in newborns with pustules or vesicles, especially in those who are not well-appearing or have risk factors for congenital infection. Congenital cytomegalovirus infection can cause sensorineural hearing loss and neurodevelopmental delay. Skin manifestations of cytomegalovirus may include petechiae due to thrombocytopenia. The most common skin manifestations of early congenital syphilis are small, copper-red, maculopapular lesions located primarily on the hands and feet that peel and c...
Source: American Family Physician - April 4, 2024 Category: Primary Care Authors: Katherine A M Snyder Adam D Voelckers Source Type: research
A phase I study of pevonedistat, azacitidine, and venetoclax in patients with relapsed/refractory acute myeloid leukemia
Haematologica. 2024 Apr 4. doi: 10.3324/haematol.2024.285014. Online ahead of print.ABSTRACTAzacitidine/venetoclax is an active regimen in patients with newly diagnosed AML. However, primary or secondary resistance to azacitidine/venetoclax is an area of unmet need and overexpression of MCL-1 is suggested to be a potential resistance mechanism. Pevonedistat inhibits MCL-1 through activation of NOXA, and pevonedistat/azacitidine has previously shown activity in AML. To assess the tolerability and efficacy of adding pevonedistat to azacitidine/venetoclax in relapsed/refractory AML, we conducted a phase I multicenter openlabe...
Source: Haematologica - April 4, 2024 Category: Hematology Authors: Guru Subramanian Guru Murthy Antoine N Saliba Aniko Szabo Alexandra Harrington Sameem Abedin Karen Carlson Laura Michaelis Lyndsey Runaas Arielle Baim Alex Hinman Sonia Maldonado-Schmidt Annapoorna Venkatachalam Karen S Flatten Kevin L Peterson Paula A Sc Source Type: research
Newborn Skin: Part I. Common Rashes and Skin Changes
Am Fam Physician. 2024 Mar;109(3):212-216.ABSTRACTRashes in the newborn period are common and most are benign. Infections should be suspected in newborns with pustules or vesicles, especially in those who are not well-appearing or have risk factors for congenital infection. Congenital cytomegalovirus infection can cause sensorineural hearing loss and neurodevelopmental delay. Skin manifestations of cytomegalovirus may include petechiae due to thrombocytopenia. The most common skin manifestations of early congenital syphilis are small, copper-red, maculopapular lesions located primarily on the hands and feet that peel and c...
Source: American Family Physician - April 4, 2024 Category: Primary Care Authors: Katherine A M Snyder Adam D Voelckers Source Type: research
A phase I study of pevonedistat, azacitidine, and venetoclax in patients with relapsed/refractory acute myeloid leukemia
Haematologica. 2024 Apr 4. doi: 10.3324/haematol.2024.285014. Online ahead of print.ABSTRACTAzacitidine/venetoclax is an active regimen in patients with newly diagnosed AML. However, primary or secondary resistance to azacitidine/venetoclax is an area of unmet need and overexpression of MCL-1 is suggested to be a potential resistance mechanism. Pevonedistat inhibits MCL-1 through activation of NOXA, and pevonedistat/azacitidine has previously shown activity in AML. To assess the tolerability and efficacy of adding pevonedistat to azacitidine/venetoclax in relapsed/refractory AML, we conducted a phase I multicenter openlabe...
Source: Haematologica - April 4, 2024 Category: Hematology Authors: Guru Subramanian Guru Murthy Antoine N Saliba Aniko Szabo Alexandra Harrington Sameem Abedin Karen Carlson Laura Michaelis Lyndsey Runaas Arielle Baim Alex Hinman Sonia Maldonado-Schmidt Annapoorna Venkatachalam Karen S Flatten Kevin L Peterson Paula A Sc Source Type: research
Newborn Skin: Part I. Common Rashes and Skin Changes
Am Fam Physician. 2024 Mar;109(3):212-216.ABSTRACTRashes in the newborn period are common and most are benign. Infections should be suspected in newborns with pustules or vesicles, especially in those who are not well-appearing or have risk factors for congenital infection. Congenital cytomegalovirus infection can cause sensorineural hearing loss and neurodevelopmental delay. Skin manifestations of cytomegalovirus may include petechiae due to thrombocytopenia. The most common skin manifestations of early congenital syphilis are small, copper-red, maculopapular lesions located primarily on the hands and feet that peel and c...
Source: American Family Physician - April 4, 2024 Category: Primary Care Authors: Katherine A M Snyder Adam D Voelckers Source Type: research