Impact of Immunosuppressed Status on Prognosis of Carbapenem-Resistant Organisms Bloodstream Infections
ConclusionDespite the high mortality rate of CRO-BSI, immunosuppression did not affect the mortality. Appropriate antibiotic therapy is crucial for improving the prognosis of CRO-BSI, regardless of the immune status. (Source: Infectious Diseases and Therapy)
Source: Infectious Diseases and Therapy - March 27, 2024 Category: Infectious Diseases Source Type: research
The Y49H cytochrome c variant enhances megakaryocytic maturation of K-562 cells
Biochim Biophys Acta Mol Basis Dis. 2024 Mar 24:167134. doi: 10.1016/j.bbadis.2024.167134. Online ahead of print.ABSTRACTFive pathogenic variants in the gene encoding cytochrome c (CYCS) associated with mild autosomal dominant thrombocytopenia have been reported. Previous studies of peripheral blood CD34+ or CD45+ cells from subjects with the G42S CYCS variant showed an acceleration in megakaryopoiesis compared to wild-type (WT) cells. To determine whether this result reflects a common feature of the CYCS variants, the c.145T>C mutation (Y49H variant) was introduced into the endogenous CYCS locus in K-562 cells, which u...
Source: Biochimica et Biophysica Acta - March 26, 2024 Category: Biochemistry Authors: Zahra Shafaei Pishabad Elizabeth C Ledgerwood Source Type: research
The Y49H cytochrome c variant enhances megakaryocytic maturation of K-562 cells
Biochim Biophys Acta Mol Basis Dis. 2024 Mar 24:167134. doi: 10.1016/j.bbadis.2024.167134. Online ahead of print.ABSTRACTFive pathogenic variants in the gene encoding cytochrome c (CYCS) associated with mild autosomal dominant thrombocytopenia have been reported. Previous studies of peripheral blood CD34+ or CD45+ cells from subjects with the G42S CYCS variant showed an acceleration in megakaryopoiesis compared to wild-type (WT) cells. To determine whether this result reflects a common feature of the CYCS variants, the c.145T>C mutation (Y49H variant) was introduced into the endogenous CYCS locus in K-562 cells, which u...
Source: Biochimica et Biophysica Acta - March 26, 2024 Category: Biochemistry Authors: Zahra Shafaei Pishabad Elizabeth C Ledgerwood Source Type: research
Evaluation of childhood malignancies presenting with musculoskeletal manifestations from two different divisions: a multicenter study
CONCLUSIONS: Malignancies may present with only MSK system complaints in childhood. Therefore, malignancies should be included in the differential diagnosis of patients presenting with MSK complaints.PMID:38523382 | DOI:10.24953/turkjped.2023.446 (Source: The Turkish Journal of Pediatrics)
Source: The Turkish Journal of Pediatrics - March 25, 2024 Category: Pediatrics Authors: Şengül Çağlayan Beg üm Şirin Koç Özge Baba Esra Ba ğlan Bur çak Kurucu Deniz Gezgin Y ıldırım Aylin Canbolat Ayhan Mustafa Çakan G ülçin Otar Yener K übra Öztürk Figen Çakmak Hafize Emine S önmez Nuray Aktay Ayaz Ay şenur Paç Kısaa Source Type: research
Early neonatal outcomes in infants of mothers with organ transplantation under immunosuppressive treatment
CONCLUSION: Apart from an increased risk of prematurity, low birth weight, and cesarean delivery, no effects were observed in these infants during the early period. However, long-term follow-up is necessary to monitor for any potential morbidities.PMID:38523375 | DOI:10.24953/turkjped.2023.748 (Source: The Turkish Journal of Pediatrics)
Source: The Turkish Journal of Pediatrics - March 25, 2024 Category: Pediatrics Authors: K ıymet Çelik Sema Aray ıcı Nurten Özkan Zarif Zeynep K ıhtır Hakan Ongun B ülent Aydınlı Source Type: research
Management of pediatric hemolytic uremic syndrome
Turk J Pediatr. 2024;66(1):1-16. doi: 10.24953/turkjped.2023.596.ABSTRACTClassical clinical triad of hemolytic uremic syndrome (HUS) is microangiopathic hemolytic anemia, thrombocytopenia, and acute kidney injury associated with endothelial cell injury. Several situations, including infections, medications, malignancies, and transplantation can trigger endothelial damage. On the HUS spectrum, atypical hemolytic uremic syndrome (aHUS) deserves special attention in pediatric patients, as it can cause endstage kidney disease and mortality. A dysfunction in the alternative complement pathway, either acquired or genetic, has be...
Source: The Turkish Journal of Pediatrics - March 25, 2024 Category: Pediatrics Authors: Bora G ülhan Fatih Özaltın Kibriya Fidan Zeynep Birsin Özçakar O ğuz Söylemezoğlu Source Type: research
Long Non-coding RNA RP11-252C15.1 is a Potential Biomarker of Prognosis and Hallmark for Leukemogenesis in Children with B-cell Precursor Acute Lymphoblastic Leukemia
CONCLUSION: LncRNA RP11-252C15.1 is a potential oncogene in BCP-ALL pathogenesis and a prognostic biomarker in children with BCP-ALL.PMID:38527424 | DOI:10.1159/000535461 (Source: Acta Haematologica)
Source: Acta Haematologica - March 25, 2024 Category: Hematology Authors: Lili Pan Yongzhi Zheng Hao Zheng Source Type: research
Immune attack on megakaryocytes in immune thrombocytopenia
Res Pract Thromb Haemost. 2024 Mar 14;8(1):102345. doi: 10.1016/j.rpth.2024.102345. eCollection 2024 Jan.ABSTRACTA State of the Art lecture titled "Immune Attack on Megakaryocytes in ITP: The Role of Megakaryocyte Impairment" was presented at the International Society on Thrombosis and Haemostasis Congress in 2023. Immune thrombocytopenia (ITP) is an acquired autoimmune disorder caused by autoantibodies against platelet surface glycoproteins that provoke increased clearance of circulating platelets, leading to reduced platelet number. However, there is also evidence of a direct effect of antiplatelet autoantibodies on bone...
Source: Thrombosis and Haemostasis - March 25, 2024 Category: Hematology Authors: Eleonora Petito Paolo Gresele Source Type: research
Evaluation of childhood malignancies presenting with musculoskeletal manifestations from two different divisions: a multicenter study
CONCLUSIONS: Malignancies may present with only MSK system complaints in childhood. Therefore, malignancies should be included in the differential diagnosis of patients presenting with MSK complaints.PMID:38523382 | DOI:10.24953/turkjped.2023.446 (Source: The Turkish Journal of Pediatrics)
Source: The Turkish Journal of Pediatrics - March 25, 2024 Category: Pediatrics Authors: Şengül Çağlayan Beg üm Şirin Koç Özge Baba Esra Ba ğlan Bur çak Kurucu Deniz Gezgin Y ıldırım Aylin Canbolat Ayhan Mustafa Çakan G ülçin Otar Yener K übra Öztürk Figen Çakmak Hafize Emine S önmez Nuray Aktay Ayaz Ay şenur Paç Kısaa Source Type: research
Early neonatal outcomes in infants of mothers with organ transplantation under immunosuppressive treatment
CONCLUSION: Apart from an increased risk of prematurity, low birth weight, and cesarean delivery, no effects were observed in these infants during the early period. However, long-term follow-up is necessary to monitor for any potential morbidities.PMID:38523375 | DOI:10.24953/turkjped.2023.748 (Source: The Turkish Journal of Pediatrics)
Source: The Turkish Journal of Pediatrics - March 25, 2024 Category: Pediatrics Authors: K ıymet Çelik Sema Aray ıcı Nurten Özkan Zarif Zeynep K ıhtır Hakan Ongun B ülent Aydınlı Source Type: research
Management of pediatric hemolytic uremic syndrome
Turk J Pediatr. 2024;66(1):1-16. doi: 10.24953/turkjped.2023.596.ABSTRACTClassical clinical triad of hemolytic uremic syndrome (HUS) is microangiopathic hemolytic anemia, thrombocytopenia, and acute kidney injury associated with endothelial cell injury. Several situations, including infections, medications, malignancies, and transplantation can trigger endothelial damage. On the HUS spectrum, atypical hemolytic uremic syndrome (aHUS) deserves special attention in pediatric patients, as it can cause endstage kidney disease and mortality. A dysfunction in the alternative complement pathway, either acquired or genetic, has be...
Source: The Turkish Journal of Pediatrics - March 25, 2024 Category: Pediatrics Authors: Bora G ülhan Fatih Özaltın Kibriya Fidan Zeynep Birsin Özçakar O ğuz Söylemezoğlu Source Type: research
Long Non-coding RNA RP11-252C15.1 is a Potential Biomarker of Prognosis and Hallmark for Leukemogenesis in Children with B-cell Precursor Acute Lymphoblastic Leukemia
CONCLUSION: LncRNA RP11-252C15.1 is a potential oncogene in BCP-ALL pathogenesis and a prognostic biomarker in children with BCP-ALL.PMID:38527424 | DOI:10.1159/000535461 (Source: Acta Haematologica)
Source: Acta Haematologica - March 25, 2024 Category: Hematology Authors: Lili Pan Yongzhi Zheng Hao Zheng Source Type: research
Immune attack on megakaryocytes in immune thrombocytopenia
Res Pract Thromb Haemost. 2024 Mar 14;8(1):102345. doi: 10.1016/j.rpth.2024.102345. eCollection 2024 Jan.ABSTRACTA State of the Art lecture titled "Immune Attack on Megakaryocytes in ITP: The Role of Megakaryocyte Impairment" was presented at the International Society on Thrombosis and Haemostasis Congress in 2023. Immune thrombocytopenia (ITP) is an acquired autoimmune disorder caused by autoantibodies against platelet surface glycoproteins that provoke increased clearance of circulating platelets, leading to reduced platelet number. However, there is also evidence of a direct effect of antiplatelet autoantibodies on bone...
Source: Thrombosis and Haemostasis - March 25, 2024 Category: Hematology Authors: Eleonora Petito Paolo Gresele Source Type: research
Evaluation of childhood malignancies presenting with musculoskeletal manifestations from two different divisions: a multicenter study
CONCLUSIONS: Malignancies may present with only MSK system complaints in childhood. Therefore, malignancies should be included in the differential diagnosis of patients presenting with MSK complaints.PMID:38523382 | DOI:10.24953/turkjped.2023.446 (Source: The Turkish Journal of Pediatrics)
Source: The Turkish Journal of Pediatrics - March 25, 2024 Category: Pediatrics Authors: Şengül Çağlayan Beg üm Şirin Koç Özge Baba Esra Ba ğlan Bur çak Kurucu Deniz Gezgin Y ıldırım Aylin Canbolat Ayhan Mustafa Çakan G ülçin Otar Yener K übra Öztürk Figen Çakmak Hafize Emine S önmez Nuray Aktay Ayaz Ay şenur Paç Kısaa Source Type: research
