Effect of Maternal Preeclampsia on Hematological Profile of Newborns in Qatar.
Abstract Background: Preeclampsia is a major cause of pregnancy-related maternal, fetal, and neonatal morbidities and mortalities. We aimed to review the effect of maternal preeclampsia on the hematological profile of newborns in the Qatari population. Methods: In this case-control study, we reviewed data and complete blood count results of neonates born to Qatari women diagnosed of preeclampsia in 2017 in comparison with data of a control group. Statistical analysis was done using unpaired t-test, chi-square test, and logistic regression analysis. Results: A total of 108 neonates of women with preeclamp...
Source: Biomed Res - April 9, 2020 Category: Research Authors: Bayoumi MAA, Ali AAH, Hamad SG, Ali AAM, Elmalik EE, Elkalaf MMIR, Moustafa BAA, Shaltout DADA, Chandra P, Langtree LJ, Olayiwola NO Tags: Biomed Res Int Source Type: research

Clinical factors related to severe enterocolitis after adjuvant CAPOX for colorectal cancer: a retrospective analysis.
Conclusion: Our data showed that adjuvant CAPOX induced severe enterocolitis in 13.1% of patients. In addition, we found that advanced age, right colectomy and concurrent use of ARB were statistically associated with these events. Awareness of these factors could be easily incorporated into the treatment decision and patient orientation. PMID: 32256697 [PubMed - as supplied by publisher] (Source: Ecancermedicalscience)
Source: Ecancermedicalscience - April 8, 2020 Category: Cancer & Oncology Tags: Ecancermedicalscience Source Type: research

Outcomes in hepatocellular carcinoma patients undergoing sorafenib treatment: toxicities, cellular oxidative stress, treatment adherence, and quality of life
This study focused on toxicities, cellular oxidative stress, adherence, and quality of life of 11 patients with HCC treated with sorafenib. Dermatotoxicity, myelotoxicity, gastro toxicity, nephrotoxicity, pain, and fatigue were investigated. For oxidative stress analysis, the peripheral blood mononuclear cells were isolated and mitochondrial superoxide anion production was measured using MitoSOX Red test. Medication adherence was evaluated based on Morisky-Green and MedTake tests. Quality of life assessment was performed using EORTC QLQ C-30 and QLQ HCC18 questionnaires. The results showed that hand-foot syndrome (45.5%), ...
Source: Anti-Cancer Drugs - April 8, 2020 Category: Cancer & Oncology Tags: Clinical Reports Source Type: research

Improvement of platelet in thrombocytopenic HCV patients after treatment with direct-acting antiviral agents and its relation to outcome.
Authors: Soliman Z, El Kassas M, Elsharkawy A, Elbadry M, Hamada Y, ElHusseiny R, M El-Nahaas S, Fouad R, Esmat G, Abdel Alem S Abstract Little is known about evolution of platelet count after treatment with direct-acting antiviral agents (DAAs). The study aimed to evaluate the changes in platelet count after treatment with DAAs among thrombocytopenic patients with HCV-related advanced fibrosis and cirrhosis. A total of 915 chronic HCV patients with advanced fibrosis and cirrhosis who were treated with different DAAs-based regimens were retrospectively enrolled in final analysis. Included patients were those with t...
Source: Platelets - April 8, 2020 Category: Hematology Tags: Platelets Source Type: research

Methotrexate-related toxicity in patients with rheumatoid arthritis and renal dysfunction
This study aimed to investigate methotrexate (MTX)-related toxicity in patients with rheumatoid arthritis (RA) and renal dysfunction. This retrospective cohort study included patients with RA and renal dysfunction. Renal dysfunction was defined as an estimated glomerular filtration rate (eGFR) of  
Source: Rheumatology International - April 8, 2020 Category: Rheumatology Source Type: research

Combinatorial Minigenome Systems for Emerging Banyangviruses Reveal Viral Reassortment Potential and Importance of a Protruding Nucleotide in Genome “Panhandle” for Promoter Activity and Reassortment
Banyangvirus is a new genus (Phenuiviridae family, Bunyavirales order) that comprises a group of emerging tick-borne viruses with severe fever with thrombocytopenia syndrome virus (SFTSV) and Heartland virus (HRTV) as virulent representatives. As segmented RNA viruses, bunyaviruses may have genome reassortment potential, increasing the concern about new life-threatening bunyavirus emergence. Using a series of combinatory minigenome reporter assays based on transfection and superinfection, we showed that replication machinery proteins of designated banyangviruses can recognize genomic untranslated regions (UTRs) of other ba...
Source: Frontiers in Microbiology - April 8, 2020 Category: Microbiology Source Type: research

Contrast medium-induced severe thrombocytopenia in patient on maintenance hemodialysis: a case report and literature review
AbstractA 43-year-old male patient on maintenance hemodialysis had an enhanced computed tomography scan examination with iohexol for the first time 10  min before regular hemodialysis therapy. At the start of hemodialysis, no symptoms were observed, and the platelet count was 148,000/μl. Approximately 1 h after starting hemodialysis, dyspnea and chest discomfort appeared. Since oxygen saturation of the peripheral artery decreased to 87%, oxygen administration was immediately started while continuing hemodialysis therapy. Furthermore, gingival hemorrhage was observed, and the platelet count decreased to 5000/&m...
Source: CEN Case Reports - April 8, 2020 Category: Urology & Nephrology Source Type: research

Safety and efficacy of arsenic trioxide and all-trans retinoic acid therapy in acute promyelocytic leukemia patients with a high risk for early death
This study demonstrates the safety and efficacy profile of ATO/ATRA first-line therapy for patients with APL and high-risk features for early death. (Source: Annals of Hematology)
Source: Annals of Hematology - April 8, 2020 Category: Hematology Source Type: research

Spatial-temporal characteristics of severe fever with thrombocytopenia syndrome and the relationship with meteorological factors from 2011 to 2018 in Zhejiang Province, China
ConclusionsThe autoregressive and spatiotemporal components played an important role in driving the transmission of SFTS. Targeted preventive efforts should be made in different areas based on the main component contributing to the epidemic. For most areas, early measures several months ahead of the suitable season for the occurrence of SFTS should be implemented. The level of reporting and diagnosis of this disease should be further improved. (Source: PLoS Neglected Tropical Diseases)
Source: PLoS Neglected Tropical Diseases - April 7, 2020 Category: Tropical Medicine Authors: Haocheng Wu Source Type: research

Lung transplantation using argatroban in severe heparin-induced thrombocytopenia during extracorporeal membrane oxygenation: a case series
AbstractLung transplantation during heparin-induced thrombocytopenia (HIT) is controversial and often considered a contraindication because of the risk of increased bleeding and thrombosis in the recipient. Although lung transplantation offers the best chance for cure in end-stage lung disease, the outcome after transplantation is still controversial in patients with HIT. In our center, two patients developed HIT type II during venovenous extracorporeal membrane oxygenation (ECMO) support for acute respiratory failure. They underwent successful lung transplantation using argatroban. The subsequent clinical course was uneve...
Source: General Thoracic and Cardiovascular Surgery - April 7, 2020 Category: Cardiovascular & Thoracic Surgery Source Type: research

Immune-Mediated Thrombotic Thrombocytopenic Purpura: A Narrative Review of Diagnosis and Treatment in Adults
Semin Thromb Hemost DOI: 10.1055/s-0040-1708541Immune-mediated thrombotic thrombocytopenic purpura (iTTP) is a rare and potentially lethal disease characterized by fragmentary hemolysis, moderate-to-severe thrombocytopenia, end-organ dysfunction, and severely reduced ADAMTS13 levels (
Source: Seminars in Thrombosis and Hemostasis - April 7, 2020 Category: Hematology Authors: Blennerhassett, Richard Curnow, Jennifer Pasalic, Leonardo Tags: Review Article Source Type: research

Thrombocytopenia in Surgery and Neuraxial Anesthesia
Semin Thromb Hemost DOI: 10.1055/s-0040-1702918This is a review of the evidence for the use of different platelet count thresholds prior to invasive procedures and surgery. This review will focus on three procedures that are common in patients with thrombocytopenia—central venous catheter insertion, liver biopsy, and lumbar punctures and epidural catheters—as well as highlighting the lack of evidence for more major surgery. Tunneled or untunneled central venous catheters are low-risk procedures and can be safely performed without any intervention when the platelet count is 20 × 109/L or abov...
Source: Seminars in Thrombosis and Hemostasis - April 7, 2020 Category: Hematology Authors: Estcourt, Lise J. Tags: Review Article Source Type: research

Thrombocytopenia in Pregnancy: Approach to Diagnosis and Management
Semin Thromb Hemost DOI: 10.1055/s-0040-1708842The impact of thrombocytopenia varies widely depending on the underlying pathophysiology driving it. The biggest challenge in managing thrombocytopenia in pregnancy is accurately identifying the responsible pathophysiology—a task made difficult given the tremendous overlap in clinical and laboratory abnormalities associated with different thrombocytopenia processes. The most common etiologies of thrombocytopenia in pregnancy range from physiology deemed benign to those that are life-threatening to the mother and fetus. Even in cases in which the responsible etiology is d...
Source: Seminars in Thrombosis and Hemostasis - April 7, 2020 Category: Hematology Authors: Fogerty, Annemarie E. Tags: Review Article Source Type: research

Baseline thrombocytopenia in women with coronary heart disease increases incident acute coronary syndrome: insights from national inpatient database
AbstractThere are paucity of data on gender-based differences in the effect of thrombocytopenia and coronary heart disease (CHD) towards development of acute coronary syndrome (ACS). We used National Inpatient Sample (NIS) database of the United States to assess the gender-based differences in the association of thrombocytopenia with CHD and the impact of thrombocytopenia on mortality, length of stay and hospitalization costs on ACS subgroup of CHD. Our analysis found that thrombocytopenia was associated with increased odds of CHD on univariate (odds ratio [OR] 1.31 (95% CI 1.30 –1.32) p 
Source: Journal of Thrombosis and Thrombolysis - April 6, 2020 Category: Hematology Source Type: research

Phase 1 dose escalation trial of TAS-102 (trifluridine/tipiracil) and temozolomide in the treatment of advanced neuroendocrine tumors
This study evaluated the safety of TAS-102 in combination with TMZ in patients in neuroendocrine tumors. Escalating doses of TMZ (100, 150 and 200  mg/m2) on days 8 –12 were given in combination with TAS-102 (35 mg/m2 twice a day) on days 1 –5 and 8–12 of a 28 day cycle in subjects with advanced NETs. Primary endpoints were safety and determination of maximum tolerated dose (MTD). Growth factor support was mandated starting with level 2 to avoid treatment delays. Fifteen evaluable subjects were enrolled in the phase 1 study. No d ose limiting toxicities (DLTs) were observed on level 1....
Source: Investigational New Drugs - April 6, 2020 Category: Drugs & Pharmacology Source Type: research

Dexamethasone suppresses the Th17/1 cell polarization in the CD4+ T cells from patients with primary immune thrombocytopenia
In this study, we investigated whether Th17/1 cells are involved in the pathogenesis of ITP. (Source: Thrombosis Research)
Source: Thrombosis Research - April 5, 2020 Category: Hematology Authors: Ju Li, Mingqiang Hua, Xiang Hu, Yanqi Zhang, Qi Feng, Jihua Qiu, Linlin Shao, Nailin Li, Ming Hou, Jun Peng Tags: Full Length Article Source Type: research

Apixaban therapy in a pregnant woman with heparin-induced thrombocytopenia and venous thromboembolic events caused by congenital antithrombin deficiency: A case report
Publication date: Available online 3 April 2020Source: Case Reports in Women's HealthAuthor(s): Mayuko Komori, Eijiro Hayata, Masahiko Nakata, Hitomi Yuzawa, Ayako Oji, Mineto Morita (Source: Case Reports in Womens Health)
Source: Case Reports in Womens Health - April 4, 2020 Category: OBGYN Source Type: research

Continuous lenalidomide treatment after bortezomib-melphalan-prednisolone therapy for newly diagnosed multiple myeloma
AbstractThese are the results of phase II study of bortezomib-melphalan-prednisolone (VMP) induction therapy followed by lenalidomide-dexamethasone (Rd) consolidation and lenalidomide maintenance in transplant-ineligible patients with newly diagnosed multiple myeloma (NDMM). The primary end point was progression-free survival (PFS). Secondary end points included overall survival (OS), overall response rates (ORRs), and safety. Eighty-three eligible patients were enrolled between October 2012 and August 2014. The median PFS was 28.0  months (95% CI 19.6–36.7) and the median OS was 55.3 months (95% CI 51.6&nd...
Source: Annals of Hematology - April 4, 2020 Category: Hematology Source Type: research

Molecules, Vol. 25, Pages 1667: A Pilot Study on the Effect of Anti-Thrombopoietin Antibody on Platelet Count in Patients with Type 2 Diabetes
oshima Michiaki Fukui Thrombopoietin (THPO) is a circulatory cytokine that plays an important role in platelet production. The presence of anti-THPO antibody relates to thrombocytopenia and is rarely seen in hematopoietic and autoimmune diseases. To date, there had been no reports that focused on the anti-THPO antibody in patients with type 2 diabetes mellitus (T2DM). To evaluate prevalence of the anti-THPO antibody in patients with T2DM and the relationship between anti-THPO antibody and platelet count, a cross-sectional study was performed on 82 patients with T2DM. The anti-THPO antibody was measured by ELISA using...
Source: Molecules - April 4, 2020 Category: Chemistry Authors: Takuya Fukuda Masahide Hamaguchi Takafumi Osaka Yoshitaka Hashimoto Emi Ushigome Mai Asano Masahiro Yamazaki Eriko Fukuda Kei Yamaguchi Koji Ogawa Naoki Goshima Michiaki Fukui Tags: Article Source Type: research

Successful liver transplantation for acute sickle cell intrahepatic cholestasis: A case report and review of the literature.
CONCLUSION: This case highlights the utility of LT as a viable treatment option for acute sickle cell intrahepatic cholestasis. PMID: 32231764 [PubMed] (Source: World Journal of Hepatology)
Source: World Journal of Hepatology - April 3, 2020 Category: Gastroenterology Tags: World J Hepatol Source Type: research

Expert consensus on the diagnosis and treatment of thrombocytopenia in adult critical care patients in China
AbstractThrombocytopenia is a common complication of critical care patients. The rates of bleeding events and mortality are also significantly increased in critical care patients with thrombocytopenia. Therefore, the Critical Care Medicine Committee of Chinese People ’s Liberation Army (PLA) worked with Chinese Society of Laboratory Medicine, Chinese Medical Association to develop this consensus to provide guidance for clinical practice. The consensus includes five sections and 27 items: the definition of thrombocytopenia, etiology and pathophysiology, diagnos is and differential diagnosis, treatment and prevention. ...
Source: Military Medical Research - April 3, 2020 Category: International Medicine & Public Health Source Type: research

Peripheral T cell lymphoma, NOS with aberrant αβ and γδ T cell receptor expression in a post-heart transplant patient
AbstractThree main patterns of T cell receptor (TCR) expression are identified in peripheral T cell lymphoma (PTCL): TCR- αβ type, TCR-γδ type, and TCR silent type. Cases of PTCL that express both αβ and γδ receptors are rare. Here, we report a case of PTCL-NOS (not otherwise specified) with dual αβ and γδ expression in a 61-year-old female 6 years after orthotopic cardiac transplant. The patient presented with fatigue, fever, worsening anemia, and thrombocytopenia. A chest CT showed multiple irregular lung nodules and diffuse lymphadenopathy. Cytolo...
Source: Journal of Hematopathology - April 2, 2020 Category: Pathology Source Type: research

Rare case of severe rhabdomyolysis secondary to human granulocytic anaplasmosis
Anaplasma phagocytophilum (AP) is the causative agent of human granulocytic anaplasmosis (HGA), a tick-borne illness with highest incidence in north-eastern regions of the United States. This condition presents with vague constitutional symptoms and has been associated with laboratory derangements such as leukopenia, thrombocytopenia and transaminitis [1]. Rhabdomyolysis, however, is not one of these associations. There has only been one prior case report in which a patient developed rhabdomyolysis-induced acute kidney injury (AKI) secondary to AP, that too in the setting of concomitant statin use [2]. (Source: The America...
Source: The American Journal of Emergency Medicine - April 2, 2020 Category: Emergency Medicine Authors: Jasanjeet Jawanda Source Type: research

Bilateral Pulmonary Embolism With Right Heart Strain in a Patient With Immune Thrombocytopenia—A Case Report and Review of the Literature
Conclusions The patient underwent thromboembolectomy by interventional radiology with subsequent administration of intravenous immunoglobulin, high-dose steroids, and enoxaparin therapy. There is no standard of care for patients with life-threatening pulmonary embolism in this population. Several authors suggest medical therapy options, but do not include patients with potential hemodynamic instability. (Source: Pediatric Emergency Care)
Source: Pediatric Emergency Care - April 1, 2020 Category: Emergency Medicine Tags: Illustrative Cases Source Type: research

Cangrelor with Heparin for Patients with Heparin-Induced Thrombocytopenia Undergoing Pulmonary Thromboendarterectomy
Optimal intraoperative anticoagulation strategy for patients with heparin-induced thrombocytopenia (HIT) undergoing pulmonary thromboendarterectomy (PTE) that necessitates deep hypothermic circulatory arrest (DHCA) remains controversial. Cangrelor is an intravenous direct-acting P2Y12 platelet receptor antagonist that achieves therapeutic effect and eliminates rapidly. Its antiplatelet activity is unaffected by stagnation of blood, nor is it influenced by patient's age, renal status or hepatic function. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2020 Category: Transplant Surgery Authors: Y.K. Gernhofer, C.Y. Lee, D.A. Banks, N.H. Kim, M.M. Madani, V. Pretorius Tags: (1325) Source Type: research

Multiplexed Proteomic Analysis for Diagnosis and Screening of Five Primary Immunodeficiency Disorders From Dried Blood Spots
Early detection of Primary Immunodeficiencies Disorders (PIDDs) is of paramount importance for effective treatment and disease management. Many PIDDs would be strong candidates for newborn screening (NBS) if robust screening methods could identify patients from dried blood spots (DBS) during the neonatal period. As majority of congenital PIDDs result in the reduction or absence of specific proteins, direct quantification of these target proteins represents an attractive potential screening tool. Unfortunately, detection is often limited by the extremely low protein concentrations in blood cells and limited blood volume pre...
Source: Frontiers in Immunology - April 1, 2020 Category: Allergy & Immunology Source Type: research

Activated platelets kill Staphylococcus aureus, but not Streptococcus pneumoniae - The role of Fc γRIIa and platelet factor 4/heparin-antibodies.
CONCLUSIONS: Anti-PF4/H antibodies seem to have only a minor role for direct killing of Gram-positive bacteria by platelets. S.aureus is killed by platelets or platelet releasate. In contrast, S.pneumoniae affect platelet viability. PMID: 32237268 [PubMed - as supplied by publisher] (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - April 1, 2020 Category: Hematology Authors: Wolff M, Handtke S, Palankar R, Wesche J, Kohler TP, Kohler C, Gruel Y, Hammerschmidt S, Greinacher A Tags: J Thromb Haemost Source Type: research

Verotoxin Receptor-Based Pathology and Therapies
Verotoxin, VT (aka Shiga toxin,Stx) is produced by enterohemorrhagic E. coli (EHEC) and is the key pathogenic factor in EHEC-induced hemolytic uremic syndrome (eHUS-hemolytic anemia/thrombocytopenia/glomerular infarct) which can follow gastrointestinal EHEC infection, particularly in children. This AB5 subunit toxin family bind target cell globotriaosyl ceramide (Gb3), a glycosphingolipid (GSL) (aka CD77, pk blood group antigen) of the globoseries of neutral GSLs, initiating lipid raft-dependent plasma membrane Gb3 clustering, membrane curvature, invagination, scission, endosomal trafficking, and retrograde traffic via the...
Source: Frontiers in cellular and infection microbiology - March 31, 2020 Category: Microbiology Source Type: research

New thrombopoietin receptor agonist (Lusutrombopag) is more effective in impaired renal function patients with chronic liver disease.
CONCLUSION: This study revealed that Lusutrombopag was more sufficiently effective in CLD patients compared with platelet transfusion and that renal function is independent predictor of increase. Factors indicative of renal function significantly and negatively correlated with increase in platelets. PMID: 32238734 [PubMed - as supplied by publisher] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - March 31, 2020 Category: Universities & Medical Training Authors: Takeuchi H, Furuichi Y, Yoshimasu Y, Kasai Y, Abe M, Sugimoto K, Itoi T Tags: J Nippon Med Sch Source Type: research

Clinical and laboratory characteristics in juvenile-onset systemic lupus erythematosus across age groups.
CONCLUSIONS: Disease presentations and laboratory findings vary significantly between age groups within a national cohort of JSLE patients. Patients diagnosed during adolescence exhibit greater disease activity and "classic" autoantibody, immune cell and complement patterns when compared with younger patients. This supports the hypothesis that pathomechanisms may vary between patient age groups. PMID: 32233733 [PubMed - as supplied by publisher] (Source: Lupus)
Source: Lupus - March 31, 2020 Category: Rheumatology Authors: Massias JS, Smith EMD, Al-Abadi E, Armon K, Bailey K, Ciurtin C, Davidson J, Gardner-Medwin J, Haslam K, Hawley DP, Leahy A, Leone V, McErlane F, Mewar D, Modgil G, Moots R, Pilkington C, Ramanan AV, Rangaraj S, Riley P, Sridhar A, Wilkinson N, Beresford Tags: Lupus Source Type: research

A child with complementary mosaic trisomy 8 and mosaic trisomy 21; clinical description of warkany-down syndrome and mechanism of origin.
Abstract Aneuploidy mosaicism involving two complementary different autosomal trisomy cell lines is extremely rare. Although a mosaic double trisomy 8/trisomy 21 has been described in literature, this is the first report of Warkany (+8)-Down (+21) syndrome due to two complementary mosaic trisomy cell lines. The phenotype of the male patient with Warkany-Down syndrome includes upslanting palpebral fissures, hypertelorism, small low-set ears with unilateral aural stenosis, large and broad hands and feet with deep palmar and plantar creases, bilateral cryptorchidism, generalized mild hypotonia and transient neonatal ...
Source: European Journal of Medical Genetics - March 30, 2020 Category: Genetics & Stem Cells Authors: McGregor-Schuerman M, Sang ALF, Bihari S, Ramdajal N, Suijkerbuijk RF, van Ravenswaaij-Arts CM Tags: Eur J Med Genet Source Type: research

The paradox of heparin induced thrombocytopenia-thrombosis, the role of fondaparinux and the need for new therapeutic strategies.
Authors: Kounis NG, Koniari I, Soufras GD, Tsigkas G, Plotas P, Davlouros P, Hahalis G PMID: 32214073 [PubMed - as supplied by publisher] (Source: International Angiology)
Source: International Angiology - March 28, 2020 Category: Cardiology Tags: Int Angiol Source Type: research

A case of recurrent thrombocytopenia involving divergent immune-related mechanisms associated with pembrolizumab
Immune checkpoint inhibitors (ICIs) have been extensively investigated as a novel form of cancer therapy against a range of malignancies including urothelial carcinoma [1]. Notably however, they have also been associated with unique toxicities known as immune-related adverse events (irAEs) which may involve any organs, including haematologic systems [2]. The precise mechanisms involved in different irAEs are largely unknown, but they are believed to be associated with aberrant activation of immune systems induced by ICIs. (Source: European Journal of Cancer)
Source: European Journal of Cancer - March 28, 2020 Category: Cancer & Oncology Authors: Shunya Matsumoto, Toshiki Kijima, Yoh Matsuoka, Masahide Yamamoto, Yasuhisa Fujii Tags: Letter to the Editor Source Type: research

When to consider targeted therapies in thrombotic microangiopathies in the modern era: walking the tightrope between cost, safety, and efficacy
AbstractThrombotic Microangiopathy (TMA) is a heterogeneous collection of syndromes that encompasses TTP, HUS, and other processes characterized by thrombocytopenia, microangiopathic hemolytic anemia, and, if untreated, organ failure and death. Novel therapies have recently been approved for the management of certain thrombotic microangiopathies, including caplacizumab for immune-mediated TTP, and eculizumab for atypical HUS. These options have complicated the standard workflow, which includes initiation of plasma exchange until ADAMTS13 testing can be resulted. Given such results may take several days, there is indecision...
Source: Journal of Thrombosis and Thrombolysis - March 26, 2020 Category: Hematology Source Type: research

FDA Approval Summary: Ado-trastuzumab emtansine for the adjuvant treatment of HER2-positive early breast cancer.
This article summarizes the FDA review and the data supporting the approval of ado-trastuzumab emtansine as a component of treatment for patients with HER2-positive EBC with residual disease. PMID: 32217612 [PubMed - as supplied by publisher] (Source: Clinical Cancer Research)
Source: Clinical Cancer Research - March 26, 2020 Category: Cancer & Oncology Authors: Wedam S, Fashoyin-Aje L, Gao X, Bloomquist E, Tang S, Sridhara R, Goldberg KB, King-Kallimanis BL, Theoret MR, Ibrahim A, Amiri-Kordestani L, Pazdur R, Beaver JA Tags: Clin Cancer Res Source Type: research

Management of Major Bleeds in Patients with Immune Thrombocytopenia.
Abstract BACKGROUND: A standard approach to the recognition and management of major bleeding in immune thrombocytopenia (ITP) is lacking. METHODS: Retrospective cohort study of ITP patients presenting to the ED with severe thrombocytopenia (platelet count
Source: Thrombosis and Haemostasis - March 26, 2020 Category: Hematology Authors: Mithoowani S, Cervi A, Shah N, Ejaz R, Sirotich E, Barty R, Li N, Nazy I, Arnold DM Tags: J Thromb Haemost Source Type: research

Identification of a Novel MYH9 Mutation in a Young Adult With Inherited Thrombocytopenia and Recurrent Seizures by Targeted Exome Sequencing
We describe a 25-year-old man with isolated thrombocytopenia initially. He experienced recurrent seizures with stable thrombocytopenia after the first seizures related to intracranial hemorrhage. He was identified a novel c.3452C>T mutation by targeted exome sequencing. If a patient with thrombocytopenia shows recurrent seizures as well as renal, hearing, visual symptoms, MHA should be suspected and the targeted exome sequencing is considered an effective diagnostic tool. (Source: Journal of Pediatric Hematology Oncology)
Source: Journal of Pediatric Hematology Oncology - March 25, 2020 Category: Hematology Tags: Online Articles: Clinical and Laboratory Observations Source Type: research

Engineering of Fc Multimers as a Protein Therapy for Autoimmune Disease
The success of Intravenous Immunoglobulin in treating autoimmune and inflammatory processes such as immune thrombocytopenia purpura and Kawasaki disease has led to renewed interest in developing recombinant molecules capable of recapitulating these therapeutic effects. The anti-inflammatory properties of IVIG are, in part, due to the Fc region of the IgG molecule, which interacts with activating or inhibitory Fcγ receptors (FcγRs), the neonatal Fc Receptor, non-canonical FcRs expressed by immune cells and complement proteins. In most cases, Fc interactions with these cognate receptors are dependent upon avidity...
Source: Frontiers in Immunology - March 25, 2020 Category: Allergy & Immunology Source Type: research

Apatinib in recurrent anaplastic meningioma: a retrospective case series and systematic literature review.
Conclusion: Apatinib is actively used in treating patients with recurrent AM. A randomized trial and phase II clinical trial of this inhibitor should be performed to further evaluate its efficacy in treating malignant meningioma. PMID: 32212907 [PubMed - as supplied by publisher] (Source: Cancer Biology and Therapy)
Source: Cancer Biology and Therapy - March 25, 2020 Category: Cancer & Oncology Authors: Wang Y, Li W, Jing N, Meng X, Zhou S, Zhu Y, Xu J, Tao R Tags: Cancer Biol Ther Source Type: research

Changes in megakaryopoiesis over ontogeny and their implications in health and disease.
Authors: Davenport P, Liu ZJ, Sola-Visner M Abstract A growing body of research has made it increasingly clear that there are substantial biological differences between fetal/neonatal and adult megakaryopoiesis. Over the last decade, studies revealed a developmentally unique uncoupling of proliferation, polyploidization, and cytoplasmic maturation in neonatal MKs that results in the production of large numbers of small, low ploidy, but mature MKs during this period of development, and identified substantial molecular differences between fetal/neonatal and adult MKs. This review will summarize our current knowledge ...
Source: Platelets - March 24, 2020 Category: Hematology Tags: Platelets Source Type: research

Isolated thrombotic microangiopathy of the small intestine in a patient with atypical hemolytic uremic syndrome – a case report
Atypical hemolytic uremic syndrome (aHUS) is a rare disease characterized by systemic thrombotic microangiopathy (TMA) reflected by hemolysis, anemia, thrombocytopenia and systemic organ injury. The optimal ma... (Source: BMC Nephrology)
Source: BMC Nephrology - March 24, 2020 Category: Urology & Nephrology Authors: Christoph Nunius, Maike B üttner-Herold, Simone Bertz, Mario Schiffer and Bjoern Buchholz Tags: Case report Source Type: research

Association of Oxidative Stress with Disease Activity and Damage in Systemic Lupus Erythematosus: A Cross Sectional Study from a Tertiary Care Centre in Southern India
AbstractTo study oxidative stress in systemic lupus erythematosus (SLE) by estimating serum oxidised LDL (OxLDL), 8-hydroxy-2 ′-deoxyguanosine (8-OHdG), malondialdehyde (MDA), and total anti-oxidant status and to correlate with SLE disease activity and disease damage. Eighty SLE patients satisfying the Systemic Lupus International Collaborating Clinics/American College of Rheumatology (SLICC/ACR) 2012 criteria and 80 hea lthy controls were studied. Exclusion criteria were infections, renal insufficiency, other connective tissue diseases, drug-induced lupus, smoking, alcohol consumption. Disease activity was measured ...
Source: Indian Journal of Clinical Biochemistry - March 24, 2020 Category: Biochemistry Source Type: research

Effects of Interleukin-1 β Inhibition on Incident Anemia: Exploratory Analyses From a Randomized Trial.
Effects of Interleukin-1β Inhibition on Incident Anemia: Exploratory Analyses From a Randomized Trial. Ann Intern Med. 2020 Mar 24;: Authors: Vallurupalli M, MacFadyen JG, Glynn RJ, Thuren T, Libby P, Berliner N, Ridker PM Abstract Background: Inflammatory cytokines, such as interleukin (IL)-1β, alter iron homeostasis and erythropoiesis, resulting in anemia, but whether inhibition of IL-1β can reverse these effects is unclear. Objective: To determine whether IL-1β inhibition with canakinumab reduces incident anemia and improves hemoglobin levels among those with prevalent anem...
Source: Annals of Internal Medicine - March 24, 2020 Category: Internal Medicine Authors: Vallurupalli M, MacFadyen JG, Glynn RJ, Thuren T, Libby P, Berliner N, Ridker PM Tags: Ann Intern Med Source Type: research

Role of Antenatal Intervention and Pregnancy Outcome in Large Chorioangiomas
AbstractChorioangioma is a non-trophoblastic  benign vascular tumour of the placenta affecting fetal outcome. It has no malignant potential. It is usually diagnosed during the 2nd trimester. These are usually found on the fetal side of the placenta, close to the umbilical cord insertion site protruding into the amniotic cavity. Chorioangi omas can be small or large. Small tumours (less than 5 cm) usually have favourable outcome. Large chorioangiomas (more than 5 cm) usually have an unfavourable outcome and may cause maternal complications like pre-eclampsia, ...
Source: Journal of Fetal Medicine - March 23, 2020 Category: Perinatology & Neonatology Source Type: research

Comparison of clinical presentation and out-comes of Chikungunya and Dengue virus infections in patients with acute undifferentiated febrile illness from the Sindh region of Pakistan
ConclusionCHIKV is an important cause of illness amongst patients presenting with acute febrile illness in Sindh region of Pakistan. Arthralgia and encephalitis at time of presentation among patients with dengue-like illness should prompt suspicion of CHIKV infection, and laboratory confirmation must be sought. (Source: PLoS Neglected Tropical Diseases)
Source: PLoS Neglected Tropical Diseases - March 23, 2020 Category: Tropical Medicine Authors: Uzma Shahid Source Type: research

Treatment of newly diagnosed glioblastoma in the elderly: a network meta-analysis.
CONCLUSIONS: For elderly people with glioblastoma who are self-caring, evidence suggests that CRT prolongs survival compared with RT and may prolong overall survival compared with TMZ alone. For those undergoing RT or TMZ therapy, there is probably little difference in QoL overall. Systemic anti-cancer treatments TMZ and BEV carry a higher risk of severe haematological and thromboembolic events and CRT is probably associated with a higher risk of these events. Current evidence provides little justification for using BEV in elderly patients outside a clinical trial setting. Whilst the novel TTF device appears prom...
Source: Cochrane Database of Systematic Reviews - March 23, 2020 Category: General Medicine Authors: Hanna C, Lawrie TA, Rogozińska E, Kernohan A, Jefferies S, Bulbeck H, Ali UM, Robinson T, Grant R Tags: Cochrane Database Syst Rev Source Type: research

Clinical course of primary immune thrombocytopenia with positive antiphospholipid antibodies: Author ´s reply.
Clinical course of primary immune thrombocytopenia with positive antiphospholipid antibodies: Author´s reply. Eur J Intern Med. 2020 Mar 23;: Authors: Cruz ACL, Colella MP, De Paula EV, Annichinno-Bizzachi J, Orsi FA PMID: 32216995 [PubMed - as supplied by publisher] (Source: European Journal of Internal Medicine)
Source: European Journal of Internal Medicine - March 23, 2020 Category: Internal Medicine Authors: Cruz ACL, Colella MP, De Paula EV, Annichinno-Bizzachi J, Orsi FA Tags: Eur J Intern Med Source Type: research

Influenza Vaccination-associated Acute Thrombocytopenia and Diffuse Alveolar Hemorrhage: A Case Report.
Authors: Yamamoto Y, Ohara Y, Iwai A, Hara R, Matsuki T, Fukushima K, Oshitani Y, Kagawa H, Tsujino K, Yoshimura K, Miki M, Miki K, Mori M, Kida H Abstract Influenza vaccination can trigger various adverse reactions, and thrombocytopenia is also rarely reported. Although patients with mild thrombocytopenia are sometimes asymptomatic, severe thrombocytopenia can cause severe bleeding. We herein report a rare case of severe thrombocytopenia that occurred within one day of influenza vaccination and diffuse alveolar hemorrhage (DAH) leading to acute respiratory failure. The patient was treated with glucocorticoid pulse...
Source: Internal Medicine - March 21, 2020 Category: Internal Medicine Tags: Intern Med Source Type: research

Clinical Score System to Differentiate Severe Fever with Thrombocytopenia Syndrome Patients from Patients with Scrub Typhus or Hemorrhagic Fever with Renal Syndrome in Korea.
This study aimed to develop, for primary care providers, a prediction score using initial symptoms and basic laboratory blood tests to differentiate between SFTS and other endemic zoonoses in Korea. METHODS: Patients aged ≥ 18 years diagnosed with endemic zoonoses during a 3-year period (between January 2015 and December 2017) were retrospectively enrolled from 4 tertiary university hospitals. A prediction score was built based on multivariate logistic regression analyses. RESULTS: Of 84 patients, 35 with SFTS and 49 with other endemic zoonoses were enrolled. In multivariate logistic regression analysis, indep...
Source: J Korean Med Sci - March 21, 2020 Category: General Medicine Authors: Heo DH, Kang YM, Song KH, Seo JW, Kim JH, Chun JY, Jun KI, Kang CK, Moon SM, Choe PG, Park WB, Bang JH, Kim ES, Kim HB, Park SW, Oh WS, Kim NJ, Oh MD Tags: J Korean Med Sci Source Type: research

Erythrocyte deformability reduction in various pediatric hematologic diseases.
CONCLUSIONS: This study showed that erythrocyte deformability differed among various hematologic diseases. Further study concerning correlation in relation to the diagnostic and prognostic significance of erythrocyte deformability in hematologic disease is needed. PMID: 32224530 [PubMed - as supplied by publisher] (Source: Clinical Hemorheology and Microcirculation)
Source: Clinical Hemorheology and Microcirculation - March 21, 2020 Category: Hematology Authors: Kim YK, Lim YT, Suh JS, Hah JO, Lee JM Tags: Clin Hemorheol Microcirc Source Type: research