Myelotoxicity and kidney dysfunction related to the use of trimethoprim-sulfamethoxazole for the treatment of Pneumocystis jirovecii pneumonia: a case report of severe adverse events with a common drug
We present the case of a male patient with hypertension and a recent diagnosis of non-Hodgkin lymphoma, undergoing rituximab treatment for two months. He was admitted to the intensive care unit due to dyspnea, tachypnea, and pleuritic pain, requiring mechanical ventilation. Chest computed tomography showed bilateral and multilobed ground-glass opacities, compromising more than 80% of the lung parenchyma. Pulmonary tuberculosis and COVID-19 were ruled out. An angiotomography and Doppler ultrasound revealed an extensive pulmonary thrombus and deep venous thrombosis. Empiric treatment with TMP-SMX for PCP was initiated, but w...
Source: Revista do Instituto de Medicina Tropical de Sao Paulo - March 21, 2024 Category: Tropical Medicine Authors: Isabel Cristina Melo Mendes Roxana Flores Mamani David Richer Araujo Coelho Clarisse Pimentel Source Type: research
Myelotoxicity and kidney dysfunction related to the use of trimethoprim-sulfamethoxazole for the treatment of Pneumocystis jirovecii pneumonia: a case report of severe adverse events with a common drug
We present the case of a male patient with hypertension and a recent diagnosis of non-Hodgkin lymphoma, undergoing rituximab treatment for two months. He was admitted to the intensive care unit due to dyspnea, tachypnea, and pleuritic pain, requiring mechanical ventilation. Chest computed tomography showed bilateral and multilobed ground-glass opacities, compromising more than 80% of the lung parenchyma. Pulmonary tuberculosis and COVID-19 were ruled out. An angiotomography and Doppler ultrasound revealed an extensive pulmonary thrombus and deep venous thrombosis. Empiric treatment with TMP-SMX for PCP was initiated, but w...
Source: Revista do Instituto de Medicina Tropical de Sao Paulo - March 21, 2024 Category: Tropical Medicine Authors: Isabel Cristina Melo Mendes Roxana Flores Mamani David Richer Araujo Coelho Clarisse Pimentel Source Type: research
Myelotoxicity and kidney dysfunction related to the use of trimethoprim-sulfamethoxazole for the treatment of Pneumocystis jirovecii pneumonia: a case report of severe adverse events with a common drug
We present the case of a male patient with hypertension and a recent diagnosis of non-Hodgkin lymphoma, undergoing rituximab treatment for two months. He was admitted to the intensive care unit due to dyspnea, tachypnea, and pleuritic pain, requiring mechanical ventilation. Chest computed tomography showed bilateral and multilobed ground-glass opacities, compromising more than 80% of the lung parenchyma. Pulmonary tuberculosis and COVID-19 were ruled out. An angiotomography and Doppler ultrasound revealed an extensive pulmonary thrombus and deep venous thrombosis. Empiric treatment with TMP-SMX for PCP was initiated, but w...
Source: Revista do Instituto de Medicina Tropical de Sao Paulo - March 21, 2024 Category: Tropical Medicine Authors: Isabel Cristina Melo Mendes Roxana Flores Mamani David Richer Araujo Coelho Clarisse Pimentel Source Type: research
Myelotoxicity and kidney dysfunction related to the use of trimethoprim-sulfamethoxazole for the treatment of Pneumocystis jirovecii pneumonia: a case report of severe adverse events with a common drug
We present the case of a male patient with hypertension and a recent diagnosis of non-Hodgkin lymphoma, undergoing rituximab treatment for two months. He was admitted to the intensive care unit due to dyspnea, tachypnea, and pleuritic pain, requiring mechanical ventilation. Chest computed tomography showed bilateral and multilobed ground-glass opacities, compromising more than 80% of the lung parenchyma. Pulmonary tuberculosis and COVID-19 were ruled out. An angiotomography and Doppler ultrasound revealed an extensive pulmonary thrombus and deep venous thrombosis. Empiric treatment with TMP-SMX for PCP was initiated, but w...
Source: Revista do Instituto de Medicina Tropical de Sao Paulo - March 21, 2024 Category: Tropical Medicine Authors: Isabel Cristina Melo Mendes Roxana Flores Mamani David Richer Araujo Coelho Clarisse Pimentel Source Type: research
Scoring systems for prediction of malaria and dengue fever in non-endemic areas among travellers arriving from tropical and subtropical areas
Conclusion
The presented scoring systems provide novel tools for structured assessment of patients with tropical fever in a non-endemic area and highlight clinical signs associated with a potential severe aetiology to direct the need for microbial investigation. (Source: Emergency Medicine Journal)
Source: Emergency Medicine Journal - March 21, 2024 Category: Emergency Medicine Authors: Satarvandi, D., van der Werff, S. D., Naucler, P., Hildenwall, H., Sonden, K. Tags: Open access Original research Source Type: research
Can low-dose intravenous immunoglobulin be an alternative to high-dose intravenous immunoglobulin in the treatment of children with newly diagnosed immune thrombocytopenia: a systematic review and meta-analysis
Intravenous immunoglobulin (IVIg) is a first-line treatment for children with newly diagnosed immune thrombocytopenia (ITP). Higher doses of IVIg are associated with a more insupportable financial burden to pe... (Source: BMC Pediatrics)
Source: BMC Pediatrics - March 21, 2024 Category: Pediatrics Authors: Xiangge Ren, Miaomiao Zhang, Xiaohan Zhang, Peidong Zhao and Wensheng Zhai Tags: Research Source Type: research
Congenital cytomegalovirus infection in a preterm infant with 22q11.2 deletion syndrome and immunological abnormalities
We report a case of a preterm infant with congenital cytomegalovirus infection complicated with 22q11.2 deletion syndrome and immunological abnormalities. Ultrasonography revealed pulmonary atresia, ventricular septal defect, major aortopulmonary collateral artery, and thymic hypoplasia. His serum chemistry tests on admission revealed immunoglobulin G, A, and M levels of 1,547 mg/dL, 70 mg/dL, and 274 mg/dL, respectively. A surface antigen analysis of the peripheral lymphocytes using flow cytometry revealed the following: relatively low CD4-positive T-cell levels (18.1%; 1,767/μL), very high CD8-positive T-cell levels (58...
Source: Nagoya Journal of Medical Science - March 20, 2024 Category: International Medicine & Public Health Authors: Yoshihiko Shitara Etsushi Toyofuku Hideki Doi Takeo Mukai Kohei Kashima Satsuki Kakiuchi Motohiro Kato Naoto Takahashi Source Type: research
Antagonism of the Platelet-Activating Factor Pathway Mitigates Inflammatory Adverse Events Driven by Anti-erythrocyte Antibody Therapy in Mice
J Immunol. 2024 Mar 20:ji2300638. doi: 10.4049/jimmunol.2300638. Online ahead of print.ABSTRACTImmune thrombocytopenia (ITP) is an autoimmune disease characterized by low platelet counts primarily due to antiplatelet autoantibodies. Anti-D is a donor-derived polyclonal Ab against the rhesus D Ag on erythrocytes used to treat ITP. Unfortunately, adverse inflammatory/hypersensitivity reactions and a Food and Drug Administration-issued black box warning have limited its clinical use. This underscores the imperative to understand the inflammatory pathway associated with anti-erythrocyte Ab-based therapies. TER119 is an erythro...
Source: Journal of Immunology - March 20, 2024 Category: Allergy & Immunology Authors: Kevin Doyoon Won Lazaro Gil Gonzalez Yoelys Cruz-Leal Alequis Pavon Oro Alan H Lazarus Source Type: research
Congenital cytomegalovirus infection in a preterm infant with 22q11.2 deletion syndrome and immunological abnormalities
We report a case of a preterm infant with congenital cytomegalovirus infection complicated with 22q11.2 deletion syndrome and immunological abnormalities. Ultrasonography revealed pulmonary atresia, ventricular septal defect, major aortopulmonary collateral artery, and thymic hypoplasia. His serum chemistry tests on admission revealed immunoglobulin G, A, and M levels of 1,547 mg/dL, 70 mg/dL, and 274 mg/dL, respectively. A surface antigen analysis of the peripheral lymphocytes using flow cytometry revealed the following: relatively low CD4-positive T-cell levels (18.1%; 1,767/μL), very high CD8-positive T-cell levels (58...
Source: Nagoya Journal of Medical Science - March 20, 2024 Category: International Medicine & Public Health Authors: Yoshihiko Shitara Etsushi Toyofuku Hideki Doi Takeo Mukai Kohei Kashima Satsuki Kakiuchi Motohiro Kato Naoto Takahashi Source Type: research
Antagonism of the Platelet-Activating Factor Pathway Mitigates Inflammatory Adverse Events Driven by Anti-erythrocyte Antibody Therapy in Mice
J Immunol. 2024 Mar 20:ji2300638. doi: 10.4049/jimmunol.2300638. Online ahead of print.ABSTRACTImmune thrombocytopenia (ITP) is an autoimmune disease characterized by low platelet counts primarily due to antiplatelet autoantibodies. Anti-D is a donor-derived polyclonal Ab against the rhesus D Ag on erythrocytes used to treat ITP. Unfortunately, adverse inflammatory/hypersensitivity reactions and a Food and Drug Administration-issued black box warning have limited its clinical use. This underscores the imperative to understand the inflammatory pathway associated with anti-erythrocyte Ab-based therapies. TER119 is an erythro...
Source: Journal of Immunology - March 20, 2024 Category: Allergy & Immunology Authors: Kevin Doyoon Won Lazaro Gil Gonzalez Yoelys Cruz-Leal Alequis Pavon Oro Alan H Lazarus Source Type: research
Congenital cytomegalovirus infection in a preterm infant with 22q11.2 deletion syndrome and immunological abnormalities
We report a case of a preterm infant with congenital cytomegalovirus infection complicated with 22q11.2 deletion syndrome and immunological abnormalities. Ultrasonography revealed pulmonary atresia, ventricular septal defect, major aortopulmonary collateral artery, and thymic hypoplasia. His serum chemistry tests on admission revealed immunoglobulin G, A, and M levels of 1,547 mg/dL, 70 mg/dL, and 274 mg/dL, respectively. A surface antigen analysis of the peripheral lymphocytes using flow cytometry revealed the following: relatively low CD4-positive T-cell levels (18.1%; 1,767/μL), very high CD8-positive T-cell levels (58...
Source: Nagoya Journal of Medical Science - March 20, 2024 Category: International Medicine & Public Health Authors: Yoshihiko Shitara Etsushi Toyofuku Hideki Doi Takeo Mukai Kohei Kashima Satsuki Kakiuchi Motohiro Kato Naoto Takahashi Source Type: research
Antagonism of the Platelet-Activating Factor Pathway Mitigates Inflammatory Adverse Events Driven by Anti-erythrocyte Antibody Therapy in Mice
J Immunol. 2024 Mar 20:ji2300638. doi: 10.4049/jimmunol.2300638. Online ahead of print.ABSTRACTImmune thrombocytopenia (ITP) is an autoimmune disease characterized by low platelet counts primarily due to antiplatelet autoantibodies. Anti-D is a donor-derived polyclonal Ab against the rhesus D Ag on erythrocytes used to treat ITP. Unfortunately, adverse inflammatory/hypersensitivity reactions and a Food and Drug Administration-issued black box warning have limited its clinical use. This underscores the imperative to understand the inflammatory pathway associated with anti-erythrocyte Ab-based therapies. TER119 is an erythro...
Source: Journal of Immunology - March 20, 2024 Category: Allergy & Immunology Authors: Kevin Doyoon Won Lazaro Gil Gonzalez Yoelys Cruz-Leal Alequis Pavon Oro Alan H Lazarus Source Type: research
Congenital cytomegalovirus infection in a preterm infant with 22q11.2 deletion syndrome and immunological abnormalities
We report a case of a preterm infant with congenital cytomegalovirus infection complicated with 22q11.2 deletion syndrome and immunological abnormalities. Ultrasonography revealed pulmonary atresia, ventricular septal defect, major aortopulmonary collateral artery, and thymic hypoplasia. His serum chemistry tests on admission revealed immunoglobulin G, A, and M levels of 1,547 mg/dL, 70 mg/dL, and 274 mg/dL, respectively. A surface antigen analysis of the peripheral lymphocytes using flow cytometry revealed the following: relatively low CD4-positive T-cell levels (18.1%; 1,767/μL), very high CD8-positive T-cell levels (58...
Source: Nagoya Journal of Medical Science - March 20, 2024 Category: International Medicine & Public Health Authors: Yoshihiko Shitara Etsushi Toyofuku Hideki Doi Takeo Mukai Kohei Kashima Satsuki Kakiuchi Motohiro Kato Naoto Takahashi Source Type: research
