Thrombopoietin Receptor Agonists and Other Second-Line Therapies for Immune Thrombocytopenia: A Narrative Review With a Focus on Drug Access in Canada
DISCUSSION: TPO-RAs are effective second-line therapies for the treatment of ITP; however, access is variable across Canada, which results in health disparities and poor uptake of international treatment guidelines.PMID:38546381 | DOI:10.3138/cim-2024-2569 (Source: Clinical and Investigative Medicine)
Source: Clinical and Investigative Medicine - March 28, 2024 Category: Biomedical Science Authors: Joanne Britto Anne Holbrook Haowei Sun Christine Cserti-Gazdewich Oksana Prokopchuk-Gauk Cyrus Hsia Karima Khamisa Paul R Yenson Michelle Sholzberg Harold J Olney Sudeep Shivakumar David Jones Hayley Merkeley Jacqueline Costello Erin Jamula Donald M Arnol Source Type: research
Thrombopoietin Receptor Agonists and Other Second-Line Therapies for Immune Thrombocytopenia: A Narrative Review With a Focus on Drug Access in Canada
DISCUSSION: TPO-RAs are effective second-line therapies for the treatment of ITP; however, access is variable across Canada, which results in health disparities and poor uptake of international treatment guidelines.PMID:38546381 | DOI:10.3138/cim-2024-2569 (Source: Clinical and Investigative Medicine)
Source: Clinical and Investigative Medicine - March 28, 2024 Category: Biomedical Science Authors: Joanne Britto Anne Holbrook Haowei Sun Christine Cserti-Gazdewich Oksana Prokopchuk-Gauk Cyrus Hsia Karima Khamisa Paul R Yenson Michelle Sholzberg Harold J Olney Sudeep Shivakumar David Jones Hayley Merkeley Jacqueline Costello Erin Jamula Donald M Arnol Source Type: research
A woman with eptifibatide (integrilin) ‐induced thrombocytopenia following treatment of a clot in her coronary artery: A case report and literature review
AbstractEptifibatide, a GPIIb/IIIa receptor inhibitor, has shown its efficacy and safety in patients with high clot burden in their coronary vessels. It is widely used in patients with this condition. However, this medication use is accompanied by complications in some cases. Thrombocytopenia which is a relatively common condition in patients admitted to the hospital, especially in the acute setting, can be caused by medications. This condition can occur as an antibody or non-antibody-mediated process, caused by medications, such as heparin, clopidogrel, and eptifibatide. In this case, we present a woman with acute coronar...
Source: Clinical Case Reports - March 28, 2024 Category: General Medicine Authors: Morteza Safi,
Roozbeh Nazari,
Nahid Senobari,
Homa Taheri,
Pouya Ebrahimi Tags: CASE REPORT Source Type: research
A case of hypertensive emergency with alveolar hemorrhage and thrombotic microangiopathy
AbstractA 28-year-old woman with a 5-year history of untreated hypertension was admitted for respiratory distress, hemoptysis, and retinopathy. Computed tomography showed diffuse plaques in both lung fields. Acute kidney injury, hemolytic anemia, and thrombocytopenia were noted. Kidney biopsy showed thrombosis with fibrinoid necrosis and edematous intimal thickening and luminal narrowing of the small renal artery, indicating thrombotic microangiopathy; the majority of glomeruli were collapsed. After 8 weeks of treatment with antihypertensive drugs, serum creatinine decreased to 1.0 mg/dL, and the patient recovered. In t...
Source: CEN Case Reports - March 28, 2024 Category: Urology & Nephrology Source Type: research
Short-term chemotherapy-related complications and undernutrition in children diagnosed with cancer at Korle Bu Teaching Hospital, Accra, Ghana: A prospective cohort study
by Nihad Salifu, Catherine I. Segbefia, Yakubu Alhassan, Lorna A. Renner, Edem M. A. Tette
Undernutrition in children with cancer is associated with complications during cancer therapy. The study objective was to determine the association between specific anthropometric parameters and short-term chemotherapy-related complications and mortality. This was a hospital-based, prospective coh ort study of children, age ≤12 years, with a new cancer diagnosis at the Paediatric Oncology Unit, Korle Bu Teaching Hospital, Ghana. Socio-demographic information, cancer characteristics and anthropometric measurements were obtained at ...
Source: PLoS One - March 28, 2024 Category: Biomedical Science Authors: Nihad Salifu Source Type: research
Hereditary TTP/Upshaw-Schulman syndrome: the ductus arteriosus controls newborn survival
Int J Hematol. 2024 Mar 27. doi: 10.1007/s12185-024-03731-1. Online ahead of print.ABSTRACTHereditary TTP (hTTP), termed Upshaw-Schulman syndrome, is an ultra-rare disorder caused by a severe deficiency of plasma ADAMTS13 activity that allows circulation of ultra-large von Willebrand factor (UL-VWF) multimers. The greatest risk for hTTP is in their first days after birth, when 35-50% of patients will have severe hemolysis, jaundice, and thrombocytopenia. It is often fatal without effective treatment. In utero, fetal blood flowing from the pulmonary artery through the ductus arteriosus (DA) to the aorta is under low-shear-f...
Source: International Journal of Hematology - March 27, 2024 Category: Hematology Authors: Yoshihiro Fujimura Source Type: research
Hereditary TTP/Upshaw-Schulman syndrome: the ductus arteriosus controls newborn survival
Int J Hematol. 2024 Mar 27. doi: 10.1007/s12185-024-03731-1. Online ahead of print.ABSTRACTHereditary TTP (hTTP), termed Upshaw-Schulman syndrome, is an ultra-rare disorder caused by a severe deficiency of plasma ADAMTS13 activity that allows circulation of ultra-large von Willebrand factor (UL-VWF) multimers. The greatest risk for hTTP is in their first days after birth, when 35-50% of patients will have severe hemolysis, jaundice, and thrombocytopenia. It is often fatal without effective treatment. In utero, fetal blood flowing from the pulmonary artery through the ductus arteriosus (DA) to the aorta is under low-shear-f...
Source: International Journal of Hematology - March 27, 2024 Category: Hematology Authors: Yoshihiro Fujimura Source Type: research
Cancers, Vol. 16, Pages 1293: Impact of Thrombocytopenia on Survival in Patients with Hepatocellular Carcinoma: Updated Meta-Analysis and Systematic Review
Conclusion: Our meta-analysis confirmed that PLT count could act as a prognostic marker in HCC, especially with a PLT count cut off <100 × 103/mm3. Further prospective studies focusing on the role of PLT in clearly defined subgroups are necessary. (Source: Cancers)
Source: Cancers - March 27, 2024 Category: Cancer & Oncology Authors: Leszek Kraj Paulina Chmiel Maciej Gryziak Laretta Grabowska-Derlatka Łukasz Szymański Ewa Wysoki ńska Tags: Systematic Review Source Type: research
Impact of Immunosuppressed Status on Prognosis of Carbapenem-Resistant Organisms Bloodstream Infections
ConclusionDespite the high mortality rate of CRO-BSI, immunosuppression did not affect the mortality. Appropriate antibiotic therapy is crucial for improving the prognosis of CRO-BSI, regardless of the immune status. (Source: Infectious Diseases and Therapy)
Source: Infectious Diseases and Therapy - March 27, 2024 Category: Infectious Diseases Source Type: research
The Y49H cytochrome c variant enhances megakaryocytic maturation of K-562 cells
Biochim Biophys Acta Mol Basis Dis. 2024 Mar 24:167134. doi: 10.1016/j.bbadis.2024.167134. Online ahead of print.ABSTRACTFive pathogenic variants in the gene encoding cytochrome c (CYCS) associated with mild autosomal dominant thrombocytopenia have been reported. Previous studies of peripheral blood CD34+ or CD45+ cells from subjects with the G42S CYCS variant showed an acceleration in megakaryopoiesis compared to wild-type (WT) cells. To determine whether this result reflects a common feature of the CYCS variants, the c.145T>C mutation (Y49H variant) was introduced into the endogenous CYCS locus in K-562 cells, which u...
Source: Biochimica et Biophysica Acta - March 26, 2024 Category: Biochemistry Authors: Zahra Shafaei Pishabad Elizabeth C Ledgerwood Source Type: research
The Y49H cytochrome c variant enhances megakaryocytic maturation of K-562 cells
Biochim Biophys Acta Mol Basis Dis. 2024 Mar 24:167134. doi: 10.1016/j.bbadis.2024.167134. Online ahead of print.ABSTRACTFive pathogenic variants in the gene encoding cytochrome c (CYCS) associated with mild autosomal dominant thrombocytopenia have been reported. Previous studies of peripheral blood CD34+ or CD45+ cells from subjects with the G42S CYCS variant showed an acceleration in megakaryopoiesis compared to wild-type (WT) cells. To determine whether this result reflects a common feature of the CYCS variants, the c.145T>C mutation (Y49H variant) was introduced into the endogenous CYCS locus in K-562 cells, which u...
Source: Biochimica et Biophysica Acta - March 26, 2024 Category: Biochemistry Authors: Zahra Shafaei Pishabad Elizabeth C Ledgerwood Source Type: research
Evaluation of childhood malignancies presenting with musculoskeletal manifestations from two different divisions: a multicenter study
CONCLUSIONS: Malignancies may present with only MSK system complaints in childhood. Therefore, malignancies should be included in the differential diagnosis of patients presenting with MSK complaints.PMID:38523382 | DOI:10.24953/turkjped.2023.446 (Source: The Turkish Journal of Pediatrics)
Source: The Turkish Journal of Pediatrics - March 25, 2024 Category: Pediatrics Authors: Şengül Çağlayan Beg üm Şirin Koç Özge Baba Esra Ba ğlan Bur çak Kurucu Deniz Gezgin Y ıldırım Aylin Canbolat Ayhan Mustafa Çakan G ülçin Otar Yener K übra Öztürk Figen Çakmak Hafize Emine S önmez Nuray Aktay Ayaz Ay şenur Paç Kısaa Source Type: research
Early neonatal outcomes in infants of mothers with organ transplantation under immunosuppressive treatment
CONCLUSION: Apart from an increased risk of prematurity, low birth weight, and cesarean delivery, no effects were observed in these infants during the early period. However, long-term follow-up is necessary to monitor for any potential morbidities.PMID:38523375 | DOI:10.24953/turkjped.2023.748 (Source: The Turkish Journal of Pediatrics)
Source: The Turkish Journal of Pediatrics - March 25, 2024 Category: Pediatrics Authors: K ıymet Çelik Sema Aray ıcı Nurten Özkan Zarif Zeynep K ıhtır Hakan Ongun B ülent Aydınlı Source Type: research
Management of pediatric hemolytic uremic syndrome
Turk J Pediatr. 2024;66(1):1-16. doi: 10.24953/turkjped.2023.596.ABSTRACTClassical clinical triad of hemolytic uremic syndrome (HUS) is microangiopathic hemolytic anemia, thrombocytopenia, and acute kidney injury associated with endothelial cell injury. Several situations, including infections, medications, malignancies, and transplantation can trigger endothelial damage. On the HUS spectrum, atypical hemolytic uremic syndrome (aHUS) deserves special attention in pediatric patients, as it can cause endstage kidney disease and mortality. A dysfunction in the alternative complement pathway, either acquired or genetic, has be...
Source: The Turkish Journal of Pediatrics - March 25, 2024 Category: Pediatrics Authors: Bora G ülhan Fatih Özaltın Kibriya Fidan Zeynep Birsin Özçakar O ğuz Söylemezoğlu Source Type: research
