Is a reduction in albuminuria associated with renal and cardiovascular protection? A post‐hoc analysis of the ALTITUDE trial
ConclusionsAddition of aliskiren to ACEi/ARB therapy shows albuminuria changes that are associated with renal and cardiovascular risk changes. This did not translate into renal or cardiovascular protection since the overall albuminuria reduction in the aliskiren arm was too small and nearly similar to placebo. (Source: Diabetes, Obesity and Metabolism)
Source: Diabetes, Obesity and Metabolism - October 30, 2015 Category: Endocrinology Authors: Hiddo J. Lambers Heerspink, Toshiharu Ninomiya, Frederik Persson, Barry M. Brenner, Patrick Brunel, Nish Chaturvedi, Akshay S. Desai, S.M. Haffner, John J.V. Mcmurray, Scott D. Solomon, Marc A. Pfeffer, Hans‐Henrik Parving, Dick de Zeeuw Tags: ORIGINAL ARTICLE Source Type: research
The Aliskiren Trial to Minimize OutcomeS in Patients with HEart failure trial (ATMOSPHERE): revised statistical analysis plan and baseline characteristics
ConclusionATMOSPHERE will determine whether patients with HF and reduced ejection fraction (particularly those without diabetes) benefit from the addition of a direct renin inhibitor to standard background therapy, including an angiotensin‐converting enzyme inhibitor, beta‐blocker, and a mineralocorticoid receptor antagonist. ATMOSPHERE will also determine whether aliskiren alone is superior to, or at least non‐inferior to, enalapril. (Source: European Journal of Heart Failure)
Source: European Journal of Heart Failure - October 28, 2015 Category: Cardiology Authors: Henry Krum, John J.V. McMurray, William T. Abraham, Kenneth Dickstein, Lars Køber, Akshay S. Desai, Scott D. Solomon, Yanntong Chiang, Claudio Gimpelewicz, Bernard Reimund, M. Atif Ali, Georgia Tarnesby, Barry M. Massie, Tags: Original Article Source Type: research
Comparative Effect of a Renin Inhibitor and a Thiazide Diuretic on Renal Tissue Oxygenation in Hypertensive Patients
Conclusion: With the classical method of evaluation using regions no difference were found between aliskiren and HCTZ on renal tissue oxygenation after 8 weeks. In contrast, with our new method that takes into account the entire kidney, within group analyses show that aliskiren slightly increases cortical and medullary renal tissue oxygenation in hypertensive patients whereas HCTZ decreases significantly renal oxygenation at trough.Kidney Blood Press Res 2015;40:542-554 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - October 27, 2015 Category: Urology & Nephrology Source Type: research
Effects of aliskiren in diabetic and non-diabetic patients with coronary artery disease: Insights from AQUARIUS
Aliskiren previously was found to have potentially harmful effects in diabetic individuals prescribed concomitant angiotensin converting enzyme inhibitors (ACEI) or angiotenisn receptor antagonists (ARB). We explored potential effects of aliskiren on coronary atheroma progression and major adverse cardiovascular events (MACE: death/non-fatal MI/non-fatal stroke/hospitalization for heart failure/hospitalization for ACS/arterial revascularization) in patients with and without diabetes mellitus (DM). (Source: Atherosclerosis)
Source: Atherosclerosis - October 21, 2015 Category: Cardiology Authors: Rishi Puri, Steven E. Nissen, Venu Menon, Mingyuan Shao, Amy Hsu, George L. Bakris, John J.P. Kastelein, Bryan Williams, Juergen Armbrecht, Patrick Brunel, Yu Kataoka, Stephen J. Nicholls Source Type: research
Suppression of murine autoimmune myocarditis achieved with direct renin inhibition.
CONCLUSION: Our results suggest that aliskiren ameliorates EAM by suppressing T-cell activation and inflammatory cytokines, and has potential as a treatment for myocarditis.
PMID: 26475067 [PubMed - as supplied by publisher] (Source: Journal of Cardiology)
Source: Journal of Cardiology - October 13, 2015 Category: Cardiology Authors: Takamura C, Suzuki JI, Ogawa M, Watanabe R, Tada Y, Maejima Y, Akazawa H, Komuro I, Isobe M Tags: J Cardiol Source Type: research
Renin inhibitor aliskiren exerts beneficial effect on trabecular bone by regulating skeletal renin-angiotensin system and kallikrein-kinin system in ovariectomized mice
Conclusions
This study revealed that renin inhibitor aliskiren exhibited the beneficial effects on trabecular bone of ovariectomy-induced osteoporotic mice, and the underlying mechanism for this action might be mediated through Ang II and BR signaling pathways in bone. (Source: Osteoporosis International)
Source: Osteoporosis International - October 6, 2015 Category: Orthopaedics Source Type: research
Direct inhibition of plasmatic renin activity with aliskiren: a promising but under-investigated therapeutic option for non-diabetic glomerulonephritis
Abstract
Non-diabetic glomerulonephritis is a frequent cause of end-stage renal disease. The use of renin–angiotensin–aldosterone system blockers is a fundamental therapeutic approach. However, converting enzyme inhibitors (ACE-is) and angiotensin receptor blockers do not always achieve the desired target of proteinuria. The induction of the prorenin and renin up-regulation is a possible explanation. Aliskiren is the first drug acting as direct inhibitor of plasmatic renin activity, also able to interfere with the prorenin and renin profibrotic escape. We aimed at reviewing the literature for the asse...
Source: International Urology and Nephrology - October 5, 2015 Category: Urology & Nephrology Source Type: research
Mortality following a cardiovascular or renal event in patients with type 2 diabetes in the ALTITUDE trial
Conclusion
The majority of deaths occurred in patients who did not experience a non-fatal CV or renal event, although the risk of death was higher following an event. Our findings illustrate continuing opportunities to reduce morbidity and mortality in patients with type 2 diabetes. (Source: European Heart Journal)
Source: European Heart Journal - September 21, 2015 Category: Cardiology Authors: Jhund, P. S., McMurray, J. J. V., Chaturvedi, N., Brunel, P., Desai, A. S., Finn, P. V., Haffner, S. M., Solomon, S. D., Weinrauch, L. A., Claggett, B. L., Pfeffer, M. A. Tags: Prevention and epidemiology Source Type: research
Central integration and neural control of blood pressure during the cold pressor test: a comparison between hydrochlorothiazide and aliskiren
Abstract
Individuals with hypertension and sympathetic overactivity are at risk for cardiovascular events. Renin inhibitors are new while thiazide diuretics are first‐class drugs used for treatment of hypertension. The purpose of this study was to determine whether 6 months of treatment with aliskiren (ALSK) or hydrochlorothiazide (HCTZ) would alter blood pressure (BP) and muscle sympathetic nerve activity (MSNA) indices in older mild hypertensives during a cold pressor test (CPT). We hypothesized that the ALSK group would demonstrate a blunted response compared to HCTZ. Nineteen (9 men, 10 women) subjects performed a C...
Source: Physiological Reports - September 14, 2015 Category: Physiology Authors: Sara S. Jarvis, Yoshiyuki Okada, Benjamin D. Levine, Qi Fu Tags: Original Research Source Type: research
Spironolactone enhances the beneficial effect of aliskiren on cardiac structural and electrical remodeling in TGR(mRen2)27 rats
Conclusion:
The combination of an aldosterone inhibitor with a direct renin inhibitor proved to be of greater benefit for cardiac structural and electrical remodeling in this experimental model of hypertension than aliskiren alone. (Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS)
Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS - September 7, 2015 Category: Biomedical Science Authors: De Mello, W. C. Tags: Original Articles Source Type: research
Aliskiren in early postnatal life prevents hypertension and reduces asymmetric dimethylarginine in offspring exposed to maternal caloric restriction
Conclusions:
Early aliskiren therapy prevents CR-induced hypertension via ADMA reduction, decreases angiotensinogen expression, and increases renal angiotensin II type 2 receptor and Mas protein. (Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS)
Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS - September 7, 2015 Category: Biomedical Science Authors: Hsu, C.-N., Lee, C.-T., Huang, L.-T., Tain, Y.-L. Tags: Original Articles Source Type: research
Effects of treatment withdrawal on brachial and central aortic pressure after direct renin inhibition or angiotensin receptor blockade
Conclusions:
Following treatment withdrawal, aliskiren demonstrated more sustained control of both brachial and central SBP than telmisartan. (Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS)
Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS - September 7, 2015 Category: Biomedical Science Authors: Lacy, P. S., Brunel, P., Bader, G., Jones, A., Baschiera, F., Dusing, R., Williams, B. Tags: Original Articles Source Type: research
Discovery of highly potent renin inhibitors potentially interacting with the S3' subsite of renin.
Abstract
To exploit the S3' subsite of renin active site for renin inhibitor design, 42 aliskiren derivatives with modified P2' portion were designed, synthesized and biologically evaluated. Some highly potent renin inhibitors (IC50 < 3 nM) were identified, among which compounds 38 (IC50 = 0.9 nM) and 39 (IC50 = 0.7 nM) were over 2.5-fold more potent than aliskiren (IC50 = 2.3 nM). SAR analysis indicated that incorporation of polar hydrophilic moieties into the P2' portion of renin inhibitors generally enhanced the potency. Consistently with this, molecular modeling study revealed that the t...
Source: European Journal of Medicinal Chemistry - September 2, 2015 Category: Chemistry Authors: Sun X, Wen X, Chen YY, Shi C, Gao C, Wu Y, Wang LJ, Yang XH, Sun H Tags: Eur J Med Chem Source Type: research
The Role of RAAS Inhibition by Aliskiren on Paracetamol‐Induced Hepatotoxicity Model in Rats
This article is protected by copyright. All rights reserved (Source: Journal of Cellular Biochemistry)
Source: Journal of Cellular Biochemistry - August 18, 2015 Category: Biochemistry Authors: Saliha Sena Karcioglu, Saziye Sezin Palabiyik, Yasin Bayir, Emre Karakus, Tolga Mercantepe, Zekai Halici, Abdulmecit Albayrak Tags: Article Source Type: research
