New targets in vascular biology and new challenges in vascular medicine
(Source: European Heart Journal)
Source: European Heart Journal - November 7, 2021 Category: Cardiology Source Type: research

Hot topics in congenital heart disease and new insight into ventricular non-compaction
(Source: European Heart Journal)
Source: European Heart Journal - November 1, 2021 Category: Cardiology Source Type: research

Maternal and neonatal complications in women with congenital heart disease: a nationwide analysis
AbstractAimsThe aim of this study was to provide population-based data on maternal and neonatal complications and outcome in the pregnancies of women with congenital heart disease (CHD).Methods and resultsBased on administrative data from one of the largest German Health Insurance Companies (BARMER GEK, ∼9 million members representative for Germany), all pregnancies in women with CHD between 2005 and 2018 were analysed. In addition, an age-matched non-CHD control group was included for comparison and the association between adult CHD (ACHD) and maternal or neonatal outcomes investigated. Overall, 7512 pregnancies occur...
Source: European Heart Journal - October 12, 2021 Category: Cardiology Source Type: research

Promising perspectives on pregnancy in women with congenital heart disease
(Source: European Heart Journal)
Source: European Heart Journal - October 12, 2021 Category: Cardiology Source Type: research

Vascular rejuvenation: a new therapeutic target?
Ministero dell ’Istruzione, Università e Ricerca Scientifica549901_2020_Madonna (Source: European Heart Journal)
Source: European Heart Journal - October 1, 2021 Category: Cardiology Source Type: research

The ‘10 commandments’ for the 2021 ESC guidelines on cardiac pacing and cardiac resynchronization therapy
The guidelines on cardiac pacing and cardiac resynchronization therapy provide an updated overview on indications for pacing, peri-operative management, and postoperative follow-up. A special emphasis is given to patient-centred care and shared decision-making. The following 10 commandments summarize main points. (Source: European Heart Journal)
Source: European Heart Journal - September 29, 2021 Category: Cardiology Source Type: research

Breaking the cycle: Succinate in aortic diseases
National Institute of HealthR01HL158801 (Source: European Heart Journal)
Source: European Heart Journal - September 26, 2021 Category: Cardiology Source Type: research

Takayasu arteritis-associated pulmonary hypertension
(Source: European Heart Journal)
Source: European Heart Journal - September 20, 2021 Category: Cardiology Source Type: research

Long-term outcomes of new-generation coronary stents in China
Yaling Han, Editor-in-Chief, reviews two highly interesting papers published inThe Chinese Journal of Cardiology. (Source: European Heart Journal)
Source: European Heart Journal - September 18, 2021 Category: Cardiology Source Type: research

Untargeted metabolomics identifies succinate as a biomarker and therapeutic target in aortic aneurysm and dissection
ConclusionPlasma succinate concentrations allow to distinguish patients with AAD from both healthy controls and patients with AMI or PE. Succinate concentrations are regulated by the p38 α–CREB–OGDH axis in macrophages. (Source: European Heart Journal)
Source: European Heart Journal - September 17, 2021 Category: Cardiology Source Type: research

The “ten commandments” for the 2021 ESC/EACTS Guidelines on valvular heart disease
Since the previous version of the guidelines on the management of patients with valvular heart disease (VHD), new data and experience have accumulated, making a revision of the document necessary. The 10 main messages of the new guidelines are: (Source: European Heart Journal)
Source: European Heart Journal - September 16, 2021 Category: Cardiology Source Type: research

Is tirzepatide in the surpass lane over GLP-1 receptor agonists for the treatment of diabetes?
The results of ‘Efficacy and Safety of a Novel Dual GIP and GLP-1 Receptor Agonist Tirzepatide in Patients with type 2 Diabetes (SURPASS-1): A Double-Blind, Randomised, Phase 3 Trial’ have been published inLancet. doi:10.1016/S0140-6736(21)01324-6. (Source: European Heart Journal)
Source: European Heart Journal - September 13, 2021 Category: Cardiology Source Type: research

LDL-cholesterol drives reversible myelomonocytic skewing in human bone marrow
(Source: European Heart Journal)
Source: European Heart Journal - September 11, 2021 Category: Cardiology Source Type: research

An inflammatory ageing clock to detect cardiovascular and other age-related diseases: a new approach to preventive medicine
Key PointsThe Stanford 1000 Immunomes Project consists of 1001 individuals aged 8 –96 (66% females) recruited between 2007 and 2016 for studies of ageing, vaccination, and chronic fatigue syndrome.1 Peripheral blood samples were analysed for gene expression; serum cytokines, chemokines, and growth factors; cell subset composition; cellular responses to multiple stimuli; and seropositivity to cytomegalovirus infection. A comprehensive health assessment using a 53-feature clinical questionnaire was performed in 902 individuals. Cardiovascular screening was conducted in 97 extremely healthy adults.A deep-learning method...
Source: European Heart Journal - September 11, 2021 Category: Cardiology Source Type: research

Clinical features and survival in Takayasu ’s arteritis-associated pulmonary hypertension: a nationwide study
This study aimed to assess the clinical characteristics and long-term survival outcome in patients with Takayasu ’s arteritis-associated pulmonary hypertension (TA-PH).Methods and resultsWe conducted a nationally representative cohort study of TA-PH using data from the National Rare Diseases Registry System of China. Patients with pulmonary artery involvement who fulfilled the diagnostic criteria of Takayasu ’s arteritis and pulmonary hypertension were included. The primary outcome was the time from diagnosis of TA-PH to the occurrence of all-cause death. Between January 2007 and January 2019, a total of 140 pa...
Source: European Heart Journal - September 10, 2021 Category: Cardiology Source Type: research

Big cohort studies offer insights into preventable risk factors
Alzheimer ’s Society10.13039/501100017506450-AS-PG-18-018Wellcome Trust Clinical Research Career Development Fellowship206589/Z/17/Z (Source: European Heart Journal)
Source: European Heart Journal - September 4, 2021 Category: Cardiology Source Type: research

Cerebrotoxicity of antihypertensive therapy in the UK Biobank Cohort Study
This commentary refers to ‘On cerebrotoxicity of antihypertensive therapy and risk factor cosmetics’, by F.H. Messerliet al.,https://doi.org/10.1093/eurheartj/ehaa971; ‘Midlife blood pressure is associated with the severity of white matter hyperintensities: analysis of the UK Biobank Cohort Study’, by K.A. Wartolowska and A.J.S. Webb,https://doi.org/10.1093/eurheartj/ehaa756; and the discussion piece ‘Big cohort studies offer insights into preventable risk factors’, by K.A. Wartolowska and A.J.S. Webb,https://doi.org/10.1093/eurheartj/ehab566. (Source: European Heart Journal)
Source: European Heart Journal - September 4, 2021 Category: Cardiology Source Type: research

Management of acute cardiovascular complications in pregnancy
This article covers the diagnosis, risk stratification, and therapy and is organized according to the clinical presentation and the type of complication, providing a reference for the practicing cardiologist, obstetrician, and acute medicine specialist, while highlighting areas of need and potential future research. (Source: European Heart Journal)
Source: European Heart Journal - August 18, 2021 Category: Cardiology Source Type: research

The endothelial niche in heart failure: from development to regeneration
(Source: European Heart Journal)
Source: European Heart Journal - August 15, 2021 Category: Cardiology Source Type: research

Telomerase therapy reverses vascular senescence and extends lifespan in progeria mice
ConclusionVascular rejuvenation using telomerase mRNA is a promising approach for progeria and other age-related diseases. (Source: European Heart Journal)
Source: European Heart Journal - August 14, 2021 Category: Cardiology Source Type: research

Keeping remnants in perspective
(Source: European Heart Journal)
Source: European Heart Journal - August 5, 2021 Category: Cardiology Source Type: research

The JAK –STAT pathway: an emerging target for cardiovascular disease in rheumatoid arthritis and myeloproliferative neoplasms
AbstractInflammation contributes centrally to cardiovascular diseases, and anti-inflammatory treatments can reduce cardiovascular events. The JAK –STAT pathway is an emerging target in inflammation, mainly in rheumatoid arthritis (RA) and chronic myeloproliferative neoplasms (MPNs), disorders that heighten cardiovascular risk. The aim of this study was to review the international literature on the relationship between dysregulation of the J AK–STAT pathway in RA/MPNs and cardiovascular risk and on the potential cardiovascular effects of JAK–STAT inhibitors. The JAK–STAT pathway sustains inflammatory...
Source: European Heart Journal - August 3, 2021 Category: Cardiology Source Type: research

Impact of cholesterol on proinflammatory monocyte production by the bone marrow
In this study, we aim to unravel the impact of LDL-C on monocyte production in the BM compartment in human subjects.Methods and resultsA multivariable linear regression analysis in 12 304 individuals of the EPIC-Norfolk prospective population study showed that LDL-C is associated with monocyte percentage ( β = 0.131 [95% CI: 0.036–0.225];P = 0.007), at the expense of granulocytes ( β = −0.876 [95% CI: −1.046 to −0.705];P
Source: European Heart Journal - August 3, 2021 Category: Cardiology Source Type: research

Remnant cholesterol predicts cardiovascular disease beyond LDL and ApoB: a primary prevention study
ConclusionsIn ASCVD-free individuals, elevated RC levels were associated with ASCVD independent of traditional risk factors, LDL-C, and apoB levels. The mechanisms of RC association with ASCVD, surprisingly beyond apoB, and the potential value of targeted RC-lowering in primary prevention need to be further investigated. (Source: European Heart Journal)
Source: European Heart Journal - July 19, 2021 Category: Cardiology Source Type: research

Endocardial/endothelial angiocrines regulate cardiomyocyte development and maturation and induce features of ventricular non-compaction
ConclusionsThese findings support a model where coronary endothelial cells normally promote myocardial compaction through secreted factors, but that endocardial and endothelial cells can secrete factors that contribute to non-compaction under pathological conditions. (Source: European Heart Journal)
Source: European Heart Journal - July 19, 2021 Category: Cardiology Source Type: research

Lack of specialist care is associated with increased morbidity and mortality in adult congenital heart disease: a population-based study
AbstractAimsThe aim of this study was to provide population-based data on the healthcare provision for adults with congenital heart disease (ACHD) and the impact of cardiology care on morbidity and mortality in this vulnerable population.Methods and resultsBased on administrative data from one of the largest German Health Insurance Companies, all insured ACHD patients (
Source: European Heart Journal - July 16, 2021 Category: Cardiology Source Type: research

STING, a cytosolic DNA sensor, plays a critical role in atherogenesis: a link between innate immunity and chronic inflammation caused by lifestyle-related diseases
ConclusionStimulator of interferon genes stimulates pro-inflammatory activation of macrophages, leading to the development of atherosclerosis. Stimulator of interferon genes signalling may serve as a potential therapeutic target for atherosclerosis. (Source: European Heart Journal)
Source: European Heart Journal - July 6, 2021 Category: Cardiology Source Type: research

DNA damage and extranuclear DNA sensors: a dangerous duo in atherosclerosis
(Source: European Heart Journal)
Source: European Heart Journal - July 6, 2021 Category: Cardiology Source Type: research

Transition to adulthood and transfer to adult care of adolescents with congenital heart disease: a global consensus statement of the ESC Association of Cardiovascular Nursing and Allied Professions (ACNAP), the ESC Working Group on Adult Congenital Heart Disease (WG ACHD), the Association for European Paediatric and Congenital Cardiology (AEPC), the Pan-African Society of Cardiology (PASCAR), the Asia-Pacific Pediatric Cardiac Society (APPCS), the Inter-American Society of Cardiology (IASC), the Cardiac Society of Australia and New Zealand (CSANZ), the International Society for Adult Congenital Heart Disease (ISACHD), the World Heart Federation (WHF), the European Congenital Heart Disease Organisation (ECHDO), and the Global Alliance for Rheumatic and Congenital Hearts (Global ARCH)
AbstractThe vast majority of children with congenital heart disease (CHD) in high-income countries survive into adulthood. Further, paediatric cardiac services have expanded in middle-income countries. Both evolutions have resulted in an increasing number of CHD survivors. Expert care across the life span is necessitated. In adolescence, patients transition from being a dependent child to an independent adult. They are also advised to transfer from paediatrics to adult care. There is no universal consensus regarding how transitional care should be provided and how the transfer should be organized. This is even more challen...
Source: European Heart Journal - July 1, 2021 Category: Cardiology Source Type: research

Retractions in medicine: the tip of the iceberg
In 1983, in the aftermath of what was then considered one of the most significant cases of scientific fraud ever,The New York Times reported that 82 papers by John Darsee, formerly of Harvard and Emory, had been retracted (available athttps://www.nytimes.com/1983/06/14/science/notorious-darsee-case-shakes-assumptions-about-science.html). That idea persisted: ∼30 years later,Nature said that>80 of Darsee ’s papers had been withdrawn.1 (Source: European Heart Journal)
Source: European Heart Journal - June 28, 2021 Category: Cardiology Source Type: research

Maintaining high standards of clinical research during the Covid-19 pandemic: insights from an excellence clinical research centre
Science Foundation Ireland InfrastructureRSF 1413 (Source: European Heart Journal)
Source: European Heart Journal - June 28, 2021 Category: Cardiology Source Type: research

Selecting the right cohorts and endpoints for the validation of pre-test probability models for obstructive coronary artery disease
This commentary refers to ‘Validation of the European Society of Cardiology pre-test probability model for obstructive coronary artery disease’, by S. Wintheret al.,https://doi.org/10.1093/eurheartj/ehaa755. and the discussion piece ‘Coronary artery stenosis prediction does not mean coronary artery stenosis obstruction’, by F. Derimayet al.,https://doi.org/10.1093/eurheartj/ehab332. (Source: European Heart Journal)
Source: European Heart Journal - June 20, 2021 Category: Cardiology Source Type: research

Coronary artery stenosis prediction does not mean coronary artery stenosis obstruction
This commentary refers to ‘Validation of the European Society of Cardiology pre-test probability model for obstructive coronary artery disease’, by S. Wintheret al.,https://doi.org/10.1093/eurheartj/ehaa755 and the discussion piece ‘Selecting the right cohorts and endpoints for the validation of pre-test probability models for obstructive coronary artery disease’, by S. Wintheret al.,https://doi.org/10.1093/eurheartj/ehab336. (Source: European Heart Journal)
Source: European Heart Journal - June 20, 2021 Category: Cardiology Source Type: research

Spontaneous true lumen expansion in chronic type B aortic dissection
A 32-year-old man presented to a hospital with severe back pain and contrast-enhanced computed tomography (CT) revealed acute type B aortic dissection (Panel A, Supplementary material online, Video  S1Supplementary material online,Video S1). The patient was transferred to our hospital for further management. Physical examination did not indicate any evidence of connective tissue disorders. CT revealed that the aortic dissection extended from the left subclavian artery to both external iliac arteries without any organ malperfusion. His blood pressure was well controlled with multiple oral antihypertensive drugs in...
Source: European Heart Journal - June 20, 2021 Category: Cardiology Source Type: research

Don ’t be alarmed: the need for enhanced partnerships between medical communities to improve outcomes for adults living with congenital heart disease
(Source: European Heart Journal)
Source: European Heart Journal - June 3, 2021 Category: Cardiology Source Type: research

Backup natural pacemaker found in the heart
A UK-based team has discovered a backup natural pacemaker in the heart, which they believe will change understanding of the anatomy of the cardiac pacemaker tissues. The findings by researchers from the University of Manchester and Manchester University NHS Foundation Trust show the ‘subsidiary atrial pacemaker’, which is able to generate a pulse and, in time, control the heart rate, has implications on the work of cardiologists and for heart surgery and may advance the testing of treatments for sinus node disease that could reduce the dependence on pacemakers. (Source: European Heart Journal)
Source: European Heart Journal - May 29, 2021 Category: Cardiology Source Type: research

Cardiovascular Genetics in the European Heart Journal
The team of Deputy and Associate Editors Heribert Schunkert, Sharlene Day and Peter Schwartz (Source: European Heart Journal)
Source: European Heart Journal - May 22, 2021 Category: Cardiology Source Type: research

The growing role of genetics in the understanding of cardiovascular diseases: towards personalized medicine
With thanks to Amelia Meier-Batschelet, Johanna Huggler, and Martin Meyer for help with compilation of this article. (Source: European Heart Journal)
Source: European Heart Journal - May 21, 2021 Category: Cardiology Source Type: research

Broaden your horizons with the latest addition to the journal family, EHJ Open
(Source: European Heart Journal)
Source: European Heart Journal - May 14, 2021 Category: Cardiology Source Type: research

The central role of amygdala in stress-related cardiac diseases and an update on long-COVID
(Source: European Heart Journal)
Source: European Heart Journal - May 14, 2021 Category: Cardiology Source Type: research

The ongoing impact of COVID-19 on cardiovascular care
Last Spring, CardioPulse spoke to leading cardiologists from four continents to assess their views of the COVID-19 crisis and its impact on the fight against cardiovascular disease.1 One year on, we return to them for their updated assessment and thoughts. (Source: European Heart Journal)
Source: European Heart Journal - May 8, 2021 Category: Cardiology Source Type: research

StatinWISE sheds new light on statin-related muscle symptoms
Comment on ‘Statin treatment and muscle symptoms: series of randomised, placebo controlled n-of-1 trials’ published in theBritish Medical Journal (DOI:http://dx.doi.org/10.1136/bmj.n135). (Source: European Heart Journal)
Source: European Heart Journal - May 7, 2021 Category: Cardiology Source Type: research

New challenges in vascular biology and medicine: from unravelling the mechanisms of neointima formation to the prevention of amputations and of ischaemic stroke
(Source: European Heart Journal)
Source: European Heart Journal - May 7, 2021 Category: Cardiology Source Type: research

Leveraging clinical epigenetics in heart failure with preserved ejection fraction: a call for individualized therapies
AbstractDescribed as the ‘single largest unmet need in cardiovascular medicine’, heart failure with preserved ejection fraction (HFpEF) remains an untreatable disease currently representing 65% of new heart failure diagnoses. HFpEF is more frequent among women and associates with a poor prognosis and unsustainable healt hcare costs. Moreover, the variability in HFpEF phenotypes amplifies complexity and difficulties in the approach. In this perspective, unveiling novel molecular targets is imperative. Epigenetic modifications—defined as changes of DNA, histones, and non-coding RNAs (ncRNAs)—represent...
Source: European Heart Journal - May 5, 2021 Category: Cardiology Source Type: research

Dr John Joseph Gallagher (1943 –2020)
Last November, my mentor in clinical electrophysiology Dr Eric Prystowsky, informed me about the decease of his mentor, our good friend John Gallagher (seeFigure 1). John passed away from complications of Covid-19, 21 November 2020. This was such a shock to us all. John was a giant in our field of clinical electrophysiology. His contributions, particularly in understanding and treatment of the WPW syndrome was pivotal. He offered hope and cure to so many patients. Since he was also an outstanding teacher and trained so many fellows, he not only helped his own patients but innumerable patients worldwide. (Source: European Heart Journal)
Source: European Heart Journal - May 1, 2021 Category: Cardiology Source Type: research

Prediction of sudden death in the era of personalized medicine
(Source: European Heart Journal)
Source: European Heart Journal - May 1, 2021 Category: Cardiology Source Type: research

Corrigendum to: Genome-wide association analysis in dilated cardiomyopathy reveals two new players in systolic heart failure on chromosomes 3p25.1 and 22q11.23
Eur Heart J 2021; doi:10.1093/eurheartj/ehab030 (Source: European Heart Journal)
Source: European Heart Journal - April 24, 2021 Category: Cardiology Source Type: research

Genome-wide association for heart failure: from discovery to clinical use
(Source: European Heart Journal)
Source: European Heart Journal - April 21, 2021 Category: Cardiology Source Type: research

The Year in Cardiovascular Medicine 2020: Valvular Heart Disease
Discussing the Year in Cardiovascular Medicine for 2020 in the field of valvular heart disease is Professor Helmut Baumgartner and Dr Javier Bermejo. Mark Nicholls reports (Source: European Heart Journal)
Source: European Heart Journal - April 21, 2021 Category: Cardiology Source Type: research

Music of the cosmos and the heart
Cardiologists and a musician join to discuss similarities between the non-linear arrangement of micro- and macro-cosmos phenomena, and their relation to philosophy (Pythagoras, Fibonacci), art, music (J.S. Bach and others), and analogies to the functional anatomy of cardiomyocytes (Source: European Heart Journal)
Source: European Heart Journal - April 21, 2021 Category: Cardiology Source Type: research