New Frontiers in Cardiovascular Research 2019Report from the Cardiovascular Research International Editors Symposium in Krakow, Poland
(Source: European Heart Journal)
Source: European Heart Journal - September 14, 2019 Category: Cardiology Source Type: research

Ischaemic and genetic causes of fatal arrhythmias and sudden death
(Source: European Heart Journal)
Source: European Heart Journal - September 14, 2019 Category: Cardiology Source Type: research

The British Cardiovascular Society Annual Conference 2019
(Source: European Heart Journal)
Source: European Heart Journal - September 14, 2019 Category: Cardiology Source Type: research

Gaetano Maria De Ferrari
(Source: European Heart Journal)
Source: European Heart Journal - September 14, 2019 Category: Cardiology Source Type: research

The role of advanced cardiac imaging in occupational cardiologyThe role of advanced cardiac imaging in individuals undertaking high-hazard occupations
New techniques in cardiac imaging, particularly in cardiac computed tomography (CCT) and cardiac magnetic resonance (CMR) have become increasingly accessible as their indications have broadened over the last 10 –15 years. Their ability to assess cardiac structure and function, coronary anatomy, and myocardial tissue characterization, means that they can greatly assist in the occupational cardiology assessment of those involved in high-risk activities. For those engaged in high-hazard occupations, estab lishing a definitive diagnosis or excluding significant pathology, with the highest degree of certainty, is v...
Source: European Heart Journal - September 14, 2019 Category: Cardiology Source Type: research

Causal association between adiposity and cardiovascular disease
Obesity along with smoking, poor diet, heavy alcohol use, and sedentary lifestyle are major causes of premature death. A number of observational studies have indicated that a high body mass index (BMI) is associated with an increased risk of coronary heart disease. However, the causal association between BMI and several other cardiovascular diseases, in particular aortic valve stenosis, was unknown. (Source: European Heart Journal)
Source: European Heart Journal - September 14, 2019 Category: Cardiology Source Type: research

The Sri Jayadeva Institute of Cardiovascular Sciences and Research, Bangalore, India
The Sri Jayadeva Institute of Cardiovascular Sciences and Research (SJICS&R) is a state-of-art, government-run, cardiac tertiary care centre located in Bengaluru (Bangalore), the capital city of Karnataka State of India. With a bed capacity of 1300, this centre is one of the largest exclusively cardiac care destinations in this part of the continent. (Source: European Heart Journal)
Source: European Heart Journal - September 7, 2019 Category: Cardiology Source Type: research

Fifth European Congress on eCardiology and eHealth, Moscow 2018Conclusions and Take Home Messages are discussed by Hugo Saner
(Source: European Heart Journal)
Source: European Heart Journal - September 7, 2019 Category: Cardiology Source Type: research

Konrad Emil Bloch for CholesterolKonrad E. Bloch was jointly awarded the Nobel Prize in Physiology or Medicine in 1964 with Fyodor Lynen for their discoveries surrounding cholesterol
(Source: European Heart Journal)
Source: European Heart Journal - September 7, 2019 Category: Cardiology Source Type: research

Novel insights into body fat distribution and cardiometabolic risk
(Source: European Heart Journal)
Source: European Heart Journal - September 7, 2019 Category: Cardiology Source Type: research

Occupational coronary artery disease assessment: moving beyond the stenosis paradigm
As already outlined in this series of papers on occupational cardiology, it is necessary to mitigate the risk of distraction and/or incapacitation in individuals undertaking high-hazard occupations, to ensure safety of the individual worker, co-workers, and often the general public. As a result, many organizations that employ individuals in these roles (the emergency services; the military; the transport and logistic industry, including aviation, railway, and haulage companies; and those operating in remote or physically demanding environments) screen for cardiovascular disease and make a determination of (acceptable) risk...
Source: European Heart Journal - September 7, 2019 Category: Cardiology Source Type: research

European Congress on eCardiology and eHealth 2018Hugo Saner reports on the 5th European Congress on eCardiology and eHealth held in Moscow, Russia
(Source: European Heart Journal)
Source: European Heart Journal - September 7, 2019 Category: Cardiology Source Type: research

A treadmill workstation for reading echocardiogramsCombating sedentary time in the echocardiography laboratory with a treadmill workstation. The experience of cardiologists in Minneapolis, Minnesota is discussed
(Source: European Heart Journal)
Source: European Heart Journal - September 1, 2019 Category: Cardiology Source Type: research

EuroHeart: European Unified Registries On Heart Care Evaluation and Randomized TrialsAn ESC project to develop a new IT registry system which will encompass multiple features of cardiovascular medicine
In July 2019, the ESC Board agreed to co-ordinate and sponsor the development of the European Unified Registries On Heart care Evaluation And Randomized Trials (EuroHeart) for supporting assessment and improvement of quality of cardiovascular care in Europe based on continuous recording of individual patient data. EuroHeart will offer a common IT- and dataset infrastructure, which will allow participating countries to undertake continuous quality improvement, with the added value of providing a platform for observational and randomized research and post-marketing surveillance of new devices and pharmacotherapies. The natio...
Source: European Heart Journal - September 1, 2019 Category: Cardiology Source Type: research

The assessment of asymptomatic inherited QT prolongation for high-hazard occupations
Individuals undertaking high-hazard professions such as aircrew, commercial divers, firefighters, policemen, and professional drivers typically undergo more intensive medical screening than in other occupations. Conditions with a risk of life-threatening cardiac events, either directly, or as a result of incapacitation or distraction, should, as far as possible be excluded. (Source: European Heart Journal)
Source: European Heart Journal - September 1, 2019 Category: Cardiology Source Type: research

The Story of AmiodaroneDiscovery of an anti-arrhythmic drug by exploring a medicinal plant, from history to clinical practice
Medicinal plants have been targets for the development of new drugs since ancient times.1 Several common cardiovascular agents —including digoxin, quinidine, atropine, and amiodarone—have originated from plants. Among these, amiodarone is the most recently discovered. It was derived from the plantAmmi visnaga (L.) Lam., a medicinal herb traditionally and historically prescribed for a variety of conditions, including, but not limited to, urinary stones, asthma, chest pain, and menstrual disorders in different civilizations since ancient times.2 It was prescribed for such clinical use at least more than 1000 &thi...
Source: European Heart Journal - September 1, 2019 Category: Cardiology Source Type: research

Frontiers in lipid research: lipoprotein(a), apolipoprotein C-III and E, and PCSK9 and inflammation
(Source: European Heart Journal)
Source: European Heart Journal - September 1, 2019 Category: Cardiology Source Type: research

SUNecho 2019Promoting echocardiographic excellence in Africa for 10  years
There has been a major increase in cardiovascular disease and thus the utility and demand for echocardiographic services have increased significantly worldwide.1,2 Echocardiography as a tool, provides accurate haemodynamic and anatomical information non-invasively. Previously what was considered a cardiology-driven diagnostic modality has now found wider uptake and applicability in other fields including anaesthesia, intensive care and emergency medicine.3 (Source: European Heart Journal)
Source: European Heart Journal - September 1, 2019 Category: Cardiology Source Type: research

ECG interpretationInterpretation of the ECG in young, fit, asymptomatic individuals undertaking high-hazard occupations is the topic of the fourth article in the occupational cardiology series
An electrocardiogram (ECG) is a well-tolerated, non-invasive, and inexpensive test for overt electrical signs of cardiac pathology, including conduction disease, accessory pathways, and channelopathies; structural heart disease and previous ischaemic injury. Resting ECGs are widely used in screening of individuals applying for, or engaged in, high-hazard employment to exclude cardiac conditions incompatible with high-risk work. The use of screening ECGs is commonplace in law-enforcement, commercial diving operations, offshore working, and aviation. In an asymptomatic, often young and fit population, there are several consi...
Source: European Heart Journal - August 21, 2019 Category: Cardiology Source Type: research

Adolf Otto Reinhold WindausGerman chemist Adolf Otto Reinhold Windaus received the 1928 Nobel Prize in Chemistry for his contribution to research into the structure of sterols and their connections with vitamins
(Source: European Heart Journal)
Source: European Heart Journal - August 21, 2019 Category: Cardiology Source Type: research

Call to action from the cardiovascular reparative medicine communityA Report of the Sixteenth International Symposium on Cardiovascular Regeneration and Repair
(Source: European Heart Journal)
Source: European Heart Journal - August 21, 2019 Category: Cardiology Source Type: research

Kyrgyz Society of Cardiology Annual Congress 2019The participation of the European Society of Cardiology in the work of the Congress of the Kyrgyz Society of Cardiology has become the traditional and most important medical event
(Source: European Heart Journal)
Source: European Heart Journal - August 21, 2019 Category: Cardiology Source Type: research

The GREAT research networkA network that places young physician research scientists first, had its 12th annual meeting in the legendary Edinburgh Castle in Scotland
Addressing the major unmet need of interdisciplinary international clinical research in acute conditions, the GREAT research network was founded 12  years ago by Professor Alexandre Mebazaa (Paris), Professor Salvatore Di Somma (Rome), and Professor Christian Müller (Basel). While initially focused on the diagnosis and management of patients with acute heart failure, the research topics of the GREAT research network have meanwhile expanded t o include the diagnosis and management of patients with acute myocardial infarction, syncope, sepsis, and acute abdominal pain. (Source: European Heart Journal)
Source: European Heart Journal - August 21, 2019 Category: Cardiology Source Type: research

Frontiers of acute coronary and aortic syndromes: outcomes, novel prognostic markers, and cardiogenic shock
(Source: European Heart Journal)
Source: European Heart Journal - August 21, 2019 Category: Cardiology Source Type: research

Announcing Global Heart ’s activities for 2019
(Source: European Heart Journal)
Source: European Heart Journal - August 21, 2019 Category: Cardiology Source Type: research

Pedro Brugada and Peter Schwartz share the Lefoulon-Delalande Foundation Scientific Prize 2019
(Source: European Heart Journal)
Source: European Heart Journal - August 21, 2019 Category: Cardiology Source Type: research

Prolapse of left atrial appendage during transcatheter left atrial appendage closure
We present the case of an 89-year-old gentleman referred for transcatheter left atrial appendage (LAA) closure (LAAC). Intra-procedural transoesophageal echocardiogram (TOE) was used to size the LAA and a 27  mm Watchman (Boston Scientific, Marlborough, MA, USA) LAAC device was selected (Panel A). The LAAC device was placed but needed to be repositioned. As the device was recaptured for repositioning, it was noted on TOE as well as fluoroscopy that the LAA had prolapsed and was essentially inverted into the left atrium (LA) (Panels B andC, Supplementary material onlineSupplementary material online,Video S1). The LAA...
Source: European Heart Journal - August 1, 2019 Category: Cardiology Source Type: research

Reply to letter by Frey et al. regarding the article: Reduction in mortality from implantable cardioverter-defibrillators in non-ischaemic cardiomyopathy patients is dependent on the presence of left ventricular scar
This commentary refers to ‘Comment to: Reduction in mortality from implantable cardioverter-defibrillators in non-ischaemic cardiomyopathy patients is dependent on the presence of left ventricular scar’, by S.M. Freyet al., on page2996. (Source: European Heart Journal)
Source: European Heart Journal - July 30, 2019 Category: Cardiology Source Type: research

Comment to: Reduction in mortality from implantable cardioverter-defibrillators in non-ischaemic cardiomyopathy patients is dependent on the presence of left ventricular scar
This commentary refers to ‘Reduction in mortality from implantable cardioverter-defibrillators in non-ischaemic cardiomyopathy patients is dependent on the presence of left ventricular scar’, by S. Gutmanet al.,Eur Heart J 2019;40:542 –550. (Source: European Heart Journal)
Source: European Heart Journal - July 30, 2019 Category: Cardiology Source Type: research

Predicting outcomes in cardiogenic shock: are we at risk of having too many scores but too little information?
This editorial refers to ‘Protein-based cardiogenic shock patient classifier’††, by F. Ruedaet al., on page2684. (Source: European Heart Journal)
Source: European Heart Journal - July 25, 2019 Category: Cardiology Source Type: research

S100A8/A9 as a therapeutic target in myocardial infarction: cellular mechanisms, molecular interactions, and translational challenges
This editorial refers to ‘Inhibition of pro-inflammatory myeloid cell responses by short-term S100A9 blockade improves cardiac function after myocardial infarction’††, by G. Marinkovi ćet al., on page2713. (Source: European Heart Journal)
Source: European Heart Journal - July 23, 2019 Category: Cardiology Source Type: research

Four-dimensional flow cardiac magnetic resonance visualization and quantification of a large coronary fistula
A 71-year-old man with an unremarkable medical history was referred to our centre for right heart failure with atrial fibrillation. Transthoracic echocardiography showed dilation of both atria (left 44.8 cm2 and right 49.6 cm2) and ventricles (end diastole: right 48  mm and left 69 mm) with tricuspid and mitral regurgitation (Supplementary material onlineSupplementary material online,Video SA). Systolic function was moderately impaired (left ejection fraction 40%). The left coronary artery was dilated (15  mm) with continuous flow in a markedly dilated coronary sinus (CS) (Supplementary material online...
Source: European Heart Journal - July 10, 2019 Category: Cardiology Source Type: research

Inhibition of pro-inflammatory myeloid cell responses by short-term S100A9 blockade improves cardiac function after myocardial infarction
ConclusionShort-term S100A9 blockade inhibits inflammation and improves cardiac function in murine models of MI. As an excessive S100A8/A9 release is linked to incident HF, S100A9 blockade might represent a feasible strategy to improve prognosis in ACS patients. (Source: European Heart Journal)
Source: European Heart Journal - July 10, 2019 Category: Cardiology Source Type: research

No time to weight: obesity through life and AF risk
Abstract (Source: European Heart Journal)
Source: European Heart Journal - July 6, 2019 Category: Cardiology Source Type: research

The International Calmodulinopathy Registry: recording the diverse phenotypic spectrum of un-CALM hearts
Abstract (Source: European Heart Journal)
Source: European Heart Journal - July 5, 2019 Category: Cardiology Source Type: research

Management of cardiogenic shock complicating myocardial infarction: an update 2019
AbstractCardiogenic shock (CS) remains the most common cause of death in patients admitted with acute myocardial infarction (AMI) and mortality remained nearly unchanged in the range of 40 –50% during the last two decades. Early revascularization, vasopressors and inotropes, fluids, mechanical circulatory support, and general intensive care measures are widely used for CS management. However, there is only limited evidence for any of the above treatment strategies except for revascu larization and the relative ineffectiveness of intra-aortic balloon pumping. This updated review will outline the management of CS compl...
Source: European Heart Journal - July 4, 2019 Category: Cardiology Source Type: research

New concepts for body shape-related cardiovascular risk: role of fat distribution and adipose tissue function
This editorial refers to ‘Association between regional body fat and cardiovascular disease risk among postmenopausal women with normal body mass index’††, by G.-C. Chenet al., on page 2849. (Source: European Heart Journal)
Source: European Heart Journal - June 30, 2019 Category: Cardiology Source Type: research

Association between regional body fat and cardiovascular disease risk among postmenopausal women with normal body mass index
AbstractAimsCentral adiposity is associated with increased cardiovascular disease (CVD) risk, even among people with normal body mass index (BMI). We tested the hypothesis that regional body fat deposits (trunk or leg fat) are associated with altered risk of CVD among postmenopausal women with normal BMI.Methods and resultsWe included 2683 postmenopausal women with normal BMI (18.5 to
Source: European Heart Journal - June 30, 2019 Category: Cardiology Source Type: research

Should myocardial infarction type 2 be regarded as two separate entities?
Abstract (Source: European Heart Journal)
Source: European Heart Journal - June 26, 2019 Category: Cardiology Source Type: research

Multimodality advanced cardiac imaging for diagnosis and treatment monitoring in cardiac lymphoma
A 76-year-old man presented with progressive breathlessness, orthopnoea, and peripheral oedema over 2 weeks, without weight loss, fever, or night sweats. Bedside echocardiography revealed a large pericardial effusion with signs of tamponade and a right ventricular mass (Panel A). Ultrasound and fluoroscopy guided pericardiocentesis removed 1800 mL of blood-stained fluid. Cardiovascular magnetic resonance (CMR) imaging confirmed a large (9.1 × 6.5 cm) mass (Panel B, Supplementary material onlineSupplementary material online,Video S1) infiltrating the pericardium, and encroaching into the right atrium and ventricle but...
Source: European Heart Journal - June 25, 2019 Category: Cardiology Source Type: research

Plasma levels of apolipoprotein E, APOE genotype, and all-cause and cause-specific mortality in 105  949 individuals from a white general population cohort
ConclusionHigh plasma levels of apoE were associated with increased all-cause, cardiovascular, and cancer mortality, however of a non-causal nature, while low levels were causally associated with increased dementia-associated mortality. (Source: European Heart Journal)
Source: European Heart Journal - June 24, 2019 Category: Cardiology Source Type: research

Risk stratification for sudden cardiac death: show me the money!
This editorial refers to ‘Arrhythmic risk stratification in post-myocardial infarction patients with preserved ejection fraction: the PRESERVE EF study’††, by K.A. Gatzouliset al., on page2940. (Source: European Heart Journal)
Source: European Heart Journal - June 23, 2019 Category: Cardiology Source Type: research

Should we do ‘whatever it takes’ or ‘whatever is best’ to prevent cardiac arrest in high-risk patients?
This editorial refers to ‘Implantable cardioverter-defibrillators in previously undiagnosed patients with catecholaminergic polymorphic ventricular tachycardia resuscitated from sudden cardiac arrest’††, by C. van der Werfet al., on page2953. (Source: European Heart Journal)
Source: European Heart Journal - June 20, 2019 Category: Cardiology Source Type: research

Weight and weight change and risk of atrial fibrillation: the HUNT study
ConclusionLong-term obesity and BMI change are associated with AF risk. Obesity earlier in life and weight gain over time exert cumulative effects on AF development even after accounting for most recent BMI. (Source: European Heart Journal)
Source: European Heart Journal - June 17, 2019 Category: Cardiology Source Type: research

Protein-based cardiogenic shock patient classifier
ConclusionA new protein-based CS patient classifier, the CS4P, was developed for short-term mortality risk stratification. CS4P improved predictive metrics in combination with contemporary risk scores, which may guide clinicians in selecting patients for advanced therapies. (Source: European Heart Journal)
Source: European Heart Journal - June 17, 2019 Category: Cardiology Source Type: research

Calmodulin mutations and life-threatening cardiac arrhythmias: insights from the International Calmodulinopathy Registry
ConclusionCalmodulinopathies are largely characterized by adrenergically-induced life-threatening arrhythmias. Available therapies are disquietingly insufficient, especially inCALM-LQTS. Combination therapy with drugs, sympathectomy, and devices should be considered. (Source: European Heart Journal)
Source: European Heart Journal - June 6, 2019 Category: Cardiology Source Type: research

Microbial metabolites as predictive biomarkers: a paradigm shift for cardiovascular risk stratification
This editorial refers to ‘Trimethyllysine, a trimethylamine N-oxide precursor, provides near- and long-term prognostic value in patients presenting with acute coronary syndrome’††, by X.S. Liet al., on page2700. (Source: European Heart Journal)
Source: European Heart Journal - June 5, 2019 Category: Cardiology Source Type: research

When winter comes with all its might, so does the fright
A 57-year-old man with a personal history of arterial hypertension and overweight was referred from his primary care medical centre to our tertiary hospital reporting refractory typical chest pain lasting 3  h with persistent electrocardiogram (ECG) changes. The initial ECG (Panel A) showed: (i) atrial fibrillation with marked upsloping ST-segment depression; (ii) hyperacute T waves from leads V2 through V5, with a millimetric J point rise at lead aVR (De Winter sign, which was recently recognized as a ST-segment elevation equivalent). TheST ‐segment-elevation myocardial infarction network was activated and the pa...
Source: European Heart Journal - June 4, 2019 Category: Cardiology Source Type: research

Implantable cardioverter-defibrillators in previously undiagnosed patients with catecholaminergic polymorphic ventricular tachycardia resuscitated from sudden cardiac arrest
AbstractAimsIn patients with catecholaminergic polymorphic ventricular tachycardia (CPVT), implantable cardioverter-defibrillator (ICD) shocks are sometimes ineffective and may even trigger fatal electrical storms. We assessed the efficacy and complications of ICDs placed in patients with CPVT who presented with a sentinel event of sudden cardiac arrest (SCA) while undiagnosed and therefore untreated.Methods and resultsWe analysed 136 patients who presented with SCA and in whom CPVT was diagnosed subsequently, leading to the initiation of guideline-directed therapy, including β-blockers, flecainide, and/or left cardia...
Source: European Heart Journal - May 30, 2019 Category: Cardiology Source Type: research

Left ventricular unloading by percutaneous mechanical circulatory support in takotsubo syndrome with severe cardiogenic shock
A 76-year-old woman was admitted to our intensive care unit in severe cardiogenic shock due to takotsubo syndrome related to both emotional and physical triggers (cancer diagnosis of a beloved one and conus cauda syndrome, respectively). Eight months before she had undergone reconstruction of the mitral and tricuspid valve due to severe regurgitations after invasive exclusion of significant coronary artery disease. (Source: European Heart Journal)
Source: European Heart Journal - May 27, 2019 Category: Cardiology Source Type: research