The Chinese Journal of CardiologyIntroduction to the journal of the Chinese Society of Cardiology
(Source: European Heart Journal)
Source: European Heart Journal - October 14, 2019 Category: Cardiology Source Type: research

The 2019 ESC Guidelines on diabetes, pre-diabetes, and cardiovascular diseases developed in collaboration with the EASDNew features and the ‘Ten Commandments’ of the 2019 Guidelines are discussed by Professor Peter J. Grant and Professor Francesco Cosentino, the Task Force chairmen
The most clinically relevant new aspects of the 2019 version of the ESC Guidelines compared with the previous version published in 2013 relate to:Reclassification of cardiovascular (CV) risk.Individualized blood pressure (BP) targets.New lipid targets relating to severity of CV risk.Recommendations for the use of PCSK9 inhibitors in lipid management.New recommendations regarding the role of aspirin and the novel oral anticoagulants (NOACs) in diabetes.New recommendations for the duration of dual antiplatelet therapy post-ACS in diabetes mellitus (DM).The interpretation of the CV outcome trials in diabetes therapies and the...
Source: European Heart Journal - October 14, 2019 Category: Cardiology Source Type: research

Paul M. Vanhoutte (1940 –2019) MD PhD hon. mult.A pioneer of cardiovascular biology and mentor of numerous Fellows worldwide dies in Paris
(Source: European Heart Journal)
Source: European Heart Journal - October 14, 2019 Category: Cardiology Source Type: research

Introducing the 2019 ESC Guidelines on Diabetes, Pre-Diabetes, and CVDA timely document for cardio-diabetology
Six years after the previous opus, the new ESC Guidelines on Diabetes, Pre-Diabetes, and Cardiovascular Diseases (CVD) have just been released, after their presentation at the ESC 2019 Congress in Paris. The document had been prepared through collaboration between the ESC and the European Association for the Study of Diabetes (EASD), under the chairmanship of Francesco Cosentino (ESC) and Peter J. Grant (EASD). The Task Force incorporated a multidisciplinary panel of experts from both societies, including cardiologists, diabetologists, cardiac surgeons, vascular physicians, epidemiologists, methodologists, pharmacologists,...
Source: European Heart Journal - October 14, 2019 Category: Cardiology Source Type: research

Chinese Journal of Cardiology in EHJ CardioPulse
Welcome toChinese Journal of Cardiology (CJC) inEuropean Heart Journal (EHJ) CardioPulse. As the Editor-in-Chief of CJC, I will introduce two of the most remarkable papers published in the CJC from the preceding 3  months. Through this column, I would like to introduce the CJC and show the basic and clinical research for cardiovascular disease (CVD) in China. (Source: European Heart Journal)
Source: European Heart Journal - October 14, 2019 Category: Cardiology Source Type: research

Endocarditis: the Cinderella of Cardiology is back!
(Source: European Heart Journal)
Source: European Heart Journal - October 14, 2019 Category: Cardiology Source Type: research

Infective endocarditis: an ongoing global challenge
This editorial refers to ‘Clinical presentation, aetiology, and outcome of infectious endocarditis. Results of the ESC-EORP EURO-ENDO (European infectious endocarditis) registry: a prospective cohort study’††, by G. Habibet al., on page3222. (Source: European Heart Journal)
Source: European Heart Journal - October 7, 2019 Category: Cardiology Source Type: research

Endocarditis after transcatheter aortic valve implantation: a new fiend we hardly know
Abstract (Source: European Heart Journal)
Source: European Heart Journal - October 7, 2019 Category: Cardiology Source Type: research

Gustav Mahler ’s ‘Maladie Célèbre’The life of a brilliant composer cut short by endocarditis from recurrent tonsillitis
At the beginning of the 20th century, infectious diseases were still the main cause of death in the western world. The most common infection was tuberculosis, but others also killed many, among them endocarditis. However, endocarditis was not commonly known either to physicians or to the lay public, as diagnostic tools and therapeutic measures, such as imaging, antibiotics, and cardiac surgery were not yet developed. (Source: European Heart Journal)
Source: European Heart Journal - October 7, 2019 Category: Cardiology Source Type: research

TAVI is on the move! How it compares with surgery and what complications we still have to consider
(Source: European Heart Journal)
Source: European Heart Journal - October 7, 2019 Category: Cardiology Source Type: research

Alec Vahanian MDIntegrating intervention into clinical cardiology
(Source: European Heart Journal)
Source: European Heart Journal - October 7, 2019 Category: Cardiology Source Type: research

Screening for RHD in BotswanaA young Czech team introduces echocardiography screening for rheumatic heart disease (RHD) in Botswana
(Source: European Heart Journal)
Source: European Heart Journal - October 7, 2019 Category: Cardiology Source Type: research

1000 MitraClip ™ proceduresLessons learnt from the largest single-centre experience worldwide
(Source: European Heart Journal)
Source: European Heart Journal - October 7, 2019 Category: Cardiology Source Type: research

The final meta-analysis?
This editorial refers to ‘Transcatheter aortic valve implantation vs. surgical aortic valve replacement for treatment of symptomatic severe aortic stenosis: an updated meta-analysis’††, by G.C.M. Siontiset al., on page 3143. (Source: European Heart Journal)
Source: European Heart Journal - October 1, 2019 Category: Cardiology Source Type: research

Advocacy and AccessHow the European Society of Cardiology is Building Healthy Relationships with Brussels
New drugs and devices are keenly anticipated by doctors and patients in search of new remedies. But the speed of biomedical progress is highly dependent on rules and procedures to make innovations available to those in need. Ensuring that appropriate regulation and legislation are in place so that European patients and healthcare professionals have timely access to innovative, safe and effective health technologies has been an ESC priority for some time. The ESC Regulatory Affairs Committee is ESC ’s main contact with EU regulators in Brussels. The group represents another strand of ESC advocacy and is part of a long...
Source: European Heart Journal - October 1, 2019 Category: Cardiology Source Type: research

Brexit: What ’s the Deal for Medicine in the United Kingdom?
In June 2016, the UK voted to leave the European Union —a decision that sparked heated and passionate debate on the referendum result. The process of leaving the European Union (EU) became known as ‘Brexit’ and went on to dominate the UK’s political agenda and ultimately led to the resignation of two prime ministers. Following a flurry of negoti ations between London and Brussels, the original leaving date in March 2019 was pushed back, bringing about the resignation of Prime Minister Theresa May. New leader of the governing Conservative party Boris Johnson stands poised to take the UK out of the EU...
Source: European Heart Journal - October 1, 2019 Category: Cardiology Source Type: research

Channelopathies and sudden cardiac death: genetics and pharmacological triggers
(Source: European Heart Journal)
Source: European Heart Journal - October 1, 2019 Category: Cardiology Source Type: research

The importance of exercise testing in occupational cardiovascular assessment for high-hazard professions
In the setting of high-hazard work, occupational medicine is principally concerned with risk assessment. Cardiovascular risk assessment must consider interactions of the body with the environment of the work in order to accurately estimate event rates. Aircrew, emergency service workers, and miners, for example, face heterogeneous physiological and psychological challenges including hypoxia, sustained acceleration, thermal stress, high physical workload, disorientation, fear and sensory overload. One can readily appreciate how these environmental factors might influence cardiac output, increase myocardial oxygen demand, le...
Source: European Heart Journal - October 1, 2019 Category: Cardiology Source Type: research

Willem EinthovenAs part of our ongoing series of Nobel Prize winners that have contributed to cardiovascular medicine, Mark Nicholls focuses on the work of Willem Einthoven who was awarded the 1924 Nobel Prize in Physiology or Medicine “for his discovery of the mechanism of the electrocardiogram”
(Source: European Heart Journal)
Source: European Heart Journal - October 1, 2019 Category: Cardiology Source Type: research

Risks and management of cardioversion and catheter ablation in atrial fibrillation
(Source: European Heart Journal)
Source: European Heart Journal - September 21, 2019 Category: Cardiology Source Type: research

Oral Anticoagulation in patients with non-valvular atrial fibrillation and a CHA2DS2-VASc score of 1A current opinion of the European Society of Cardiology Working Group on Cardiovascular Pharmacotherapy and European Society of Cardiology Council on Stroke
(Source: European Heart Journal)
Source: European Heart Journal - September 21, 2019 Category: Cardiology Source Type: research

KODEX-EPD mapping for AF ablationCardiologists in the UK are trialling a new system they believe could be a game-changer in the treatment of Atrial Fibrillation (AF)
(Source: European Heart Journal)
Source: European Heart Journal - September 21, 2019 Category: Cardiology Source Type: research

The National Institute for Health Research (NIHR) Global Health Research Group on Atrial Fibrillation management
(Source: European Heart Journal)
Source: European Heart Journal - September 21, 2019 Category: Cardiology Source Type: research

Atrial Fibrillation in the Era of Emerging Cancer Therapies
Atrial fibrillation (AF) is becoming a global epidemic and is predicted to affect 6 –12 million people in the USA by 2050 and 17.9 million in Europe by 2060.1–4 Concurrently, with the advent of newer cancer therapies, global cancer survival has dramatically increased, with an expected overall survival of over 18 million persons by 2030.5 Increasingly, the profile of patients presenting with AF has disproportionately shifted to encompass patients with current or prior cancer diagnoses. (Source: European Heart Journal)
Source: European Heart Journal - September 21, 2019 Category: Cardiology Source Type: research

New Frontiers in Cardiovascular Research 2019Report from the Cardiovascular Research International Editors Symposium in Krakow, Poland
(Source: European Heart Journal)
Source: European Heart Journal - September 14, 2019 Category: Cardiology Source Type: research

Ischaemic and genetic causes of fatal arrhythmias and sudden death
(Source: European Heart Journal)
Source: European Heart Journal - September 14, 2019 Category: Cardiology Source Type: research

The British Cardiovascular Society Annual Conference 2019
(Source: European Heart Journal)
Source: European Heart Journal - September 14, 2019 Category: Cardiology Source Type: research

Gaetano Maria De Ferrari
(Source: European Heart Journal)
Source: European Heart Journal - September 14, 2019 Category: Cardiology Source Type: research

The role of advanced cardiac imaging in occupational cardiologyThe role of advanced cardiac imaging in individuals undertaking high-hazard occupations
New techniques in cardiac imaging, particularly in cardiac computed tomography (CCT) and cardiac magnetic resonance (CMR) have become increasingly accessible as their indications have broadened over the last 10 –15 years. Their ability to assess cardiac structure and function, coronary anatomy, and myocardial tissue characterization, means that they can greatly assist in the occupational cardiology assessment of those involved in high-risk activities. For those engaged in high-hazard occupations, estab lishing a definitive diagnosis or excluding significant pathology, with the highest degree of certainty, is v...
Source: European Heart Journal - September 14, 2019 Category: Cardiology Source Type: research

Causal association between adiposity and cardiovascular disease
Obesity along with smoking, poor diet, heavy alcohol use, and sedentary lifestyle are major causes of premature death. A number of observational studies have indicated that a high body mass index (BMI) is associated with an increased risk of coronary heart disease. However, the causal association between BMI and several other cardiovascular diseases, in particular aortic valve stenosis, was unknown. (Source: European Heart Journal)
Source: European Heart Journal - September 14, 2019 Category: Cardiology Source Type: research

Perspective on the treatment of functional mitral regurgitation using the Cardioband System
This commentary refers to ‘Transcatheter mitral valve repair for functional mitral regurgitation using the Cardioband system: 1 year outcomes’, by D. Messika-Zeitounet al., 2019;40:466 –472. (Source: European Heart Journal)
Source: European Heart Journal - September 9, 2019 Category: Cardiology Source Type: research

The Sri Jayadeva Institute of Cardiovascular Sciences and Research, Bangalore, India
The Sri Jayadeva Institute of Cardiovascular Sciences and Research (SJICS&R) is a state-of-art, government-run, cardiac tertiary care centre located in Bengaluru (Bangalore), the capital city of Karnataka State of India. With a bed capacity of 1300, this centre is one of the largest exclusively cardiac care destinations in this part of the continent. (Source: European Heart Journal)
Source: European Heart Journal - September 7, 2019 Category: Cardiology Source Type: research

Fifth European Congress on eCardiology and eHealth, Moscow 2018Conclusions and Take Home Messages are discussed by Hugo Saner
(Source: European Heart Journal)
Source: European Heart Journal - September 7, 2019 Category: Cardiology Source Type: research

Konrad Emil Bloch for CholesterolKonrad E. Bloch was jointly awarded the Nobel Prize in Physiology or Medicine in 1964 with Fyodor Lynen for their discoveries surrounding cholesterol
(Source: European Heart Journal)
Source: European Heart Journal - September 7, 2019 Category: Cardiology Source Type: research

Novel insights into body fat distribution and cardiometabolic risk
(Source: European Heart Journal)
Source: European Heart Journal - September 7, 2019 Category: Cardiology Source Type: research

Occupational coronary artery disease assessment: moving beyond the stenosis paradigm
As already outlined in this series of papers on occupational cardiology, it is necessary to mitigate the risk of distraction and/or incapacitation in individuals undertaking high-hazard occupations, to ensure safety of the individual worker, co-workers, and often the general public. As a result, many organizations that employ individuals in these roles (the emergency services; the military; the transport and logistic industry, including aviation, railway, and haulage companies; and those operating in remote or physically demanding environments) screen for cardiovascular disease and make a determination of (acceptable) risk...
Source: European Heart Journal - September 7, 2019 Category: Cardiology Source Type: research

European Congress on eCardiology and eHealth 2018Hugo Saner reports on the 5th European Congress on eCardiology and eHealth held in Moscow, Russia
(Source: European Heart Journal)
Source: European Heart Journal - September 7, 2019 Category: Cardiology Source Type: research

A great first step, but a long way to go
This editorial refers to ‘Predicting cardiac electrical response to sodium-channel blockade and Brugada syndrome using polygenic risk scores’††, by R. Tadroset al., on page 3097. (Source: European Heart Journal)
Source: European Heart Journal - September 5, 2019 Category: Cardiology Source Type: research

Clinical presentation, aetiology and outcome of infective endocarditis. Results of the ESC-EORP EURO-ENDO (European infective endocarditis) registry: a prospective cohort study
ConclusionInfective endocarditis is still a life-threatening disease with frequent lethal outcome despite profound changes in its clinical, microbiological, imaging, and therapeutic profiles. (Source: European Heart Journal)
Source: European Heart Journal - September 3, 2019 Category: Cardiology Source Type: research

Predicting cardiac electrical response to sodium-channel blockade and Brugada syndrome using polygenic risk scores
AbstractAimsSodium-channel blockers (SCBs) are associated with arrhythmia, but variability of cardiac electrical response remains unexplained. We sought to identify predictors of ajmaline-induced PR and QRS changes and Type I Brugada syndrome (BrS) electrocardiogram (ECG).Methods and resultsIn 1368 patients that underwent ajmaline infusion for suspected BrS, we performed measurements of 26  721 ECGs, dose–response mixed modelling and genotyping. We calculated polygenic risk scores (PRS) for PR interval (PRSPR), QRS duration (PRSQRS), and Brugada syndrome (PRSBrS) derived from published genome-wide association st...
Source: European Heart Journal - September 3, 2019 Category: Cardiology Source Type: research

A treadmill workstation for reading echocardiogramsCombating sedentary time in the echocardiography laboratory with a treadmill workstation. The experience of cardiologists in Minneapolis, Minnesota is discussed
(Source: European Heart Journal)
Source: European Heart Journal - September 1, 2019 Category: Cardiology Source Type: research

EuroHeart: European Unified Registries On Heart Care Evaluation and Randomized TrialsAn ESC project to develop a new IT registry system which will encompass multiple features of cardiovascular medicine
In July 2019, the ESC Board agreed to co-ordinate and sponsor the development of the European Unified Registries On Heart care Evaluation And Randomized Trials (EuroHeart) for supporting assessment and improvement of quality of cardiovascular care in Europe based on continuous recording of individual patient data. EuroHeart will offer a common IT- and dataset infrastructure, which will allow participating countries to undertake continuous quality improvement, with the added value of providing a platform for observational and randomized research and post-marketing surveillance of new devices and pharmacotherapies. The natio...
Source: European Heart Journal - September 1, 2019 Category: Cardiology Source Type: research

The assessment of asymptomatic inherited QT prolongation for high-hazard occupations
Individuals undertaking high-hazard professions such as aircrew, commercial divers, firefighters, policemen, and professional drivers typically undergo more intensive medical screening than in other occupations. Conditions with a risk of life-threatening cardiac events, either directly, or as a result of incapacitation or distraction, should, as far as possible be excluded. (Source: European Heart Journal)
Source: European Heart Journal - September 1, 2019 Category: Cardiology Source Type: research

The Story of AmiodaroneDiscovery of an anti-arrhythmic drug by exploring a medicinal plant, from history to clinical practice
Medicinal plants have been targets for the development of new drugs since ancient times.1 Several common cardiovascular agents —including digoxin, quinidine, atropine, and amiodarone—have originated from plants. Among these, amiodarone is the most recently discovered. It was derived from the plantAmmi visnaga (L.) Lam., a medicinal herb traditionally and historically prescribed for a variety of conditions, including, but not limited to, urinary stones, asthma, chest pain, and menstrual disorders in different civilizations since ancient times.2 It was prescribed for such clinical use at least more than 1000 &thi...
Source: European Heart Journal - September 1, 2019 Category: Cardiology Source Type: research

Frontiers in lipid research: lipoprotein(a), apolipoprotein C-III and E, and PCSK9 and inflammation
(Source: European Heart Journal)
Source: European Heart Journal - September 1, 2019 Category: Cardiology Source Type: research

SUNecho 2019Promoting echocardiographic excellence in Africa for 10  years
There has been a major increase in cardiovascular disease and thus the utility and demand for echocardiographic services have increased significantly worldwide.1,2 Echocardiography as a tool, provides accurate haemodynamic and anatomical information non-invasively. Previously what was considered a cardiology-driven diagnostic modality has now found wider uptake and applicability in other fields including anaesthesia, intensive care and emergency medicine.3 (Source: European Heart Journal)
Source: European Heart Journal - September 1, 2019 Category: Cardiology Source Type: research

The role of sleep disorders breathing treatment as a modifiable condition for cardiovascular risk associated hypertension
This commentary refers to ‘Asleep blood pressure: significant prognostic marker of vascular risk and therapeutic target, for prevention’, by R.C. Hermidaet al., 4159 –4171. (Source: European Heart Journal)
Source: European Heart Journal - August 29, 2019 Category: Cardiology Source Type: research

Treatment of sleep-disordered breathing, alone, is insufficient for proper management of sleep-time hypertension
This commentary refers to ‘Asleep blood pressure: significant prognostic marker of vascular risk and therapeutic target for prevention’, by R.C. Hermidaet al., 4159 –4171. (Source: European Heart Journal)
Source: European Heart Journal - August 29, 2019 Category: Cardiology Source Type: research

Corrigendum to: Uninterrupted edoxaban vs. vitamin K antagonists for ablation of atrial fibrillation: the ELIMINATE-AF trial
[Eur Heart J (2019);40:3013 –3021]. (Source: European Heart Journal)
Source: European Heart Journal - August 29, 2019 Category: Cardiology Source Type: research

Infective endocarditis after transcatheter aortic valve implantation: a nationwide study
AbstractAims  Transcatheter aortic valve implantation (TAVI), now a common procedure to treat high-risk patients with severe aortic stenosis, has rapidly been expanding into younger and lower-risk populations, creating a need to better understand long-term outcome after TAVI. The aim of the present investigation was to determine the incidence, risk factors for, clinical presentation of, and outcome after prosthetic valve endocarditis (PVE) in patients treated with TAVI in a nationwide study.Methods and results  Three registries were used: a national TAVI registry, a national diagnosis registry, and a national inf...
Source: European Heart Journal - August 21, 2019 Category: Cardiology Source Type: research