New targets in vascular biology and new challenges in vascular medicine
(Source: European Heart Journal)
Source: European Heart Journal - November 7, 2021 Category: Cardiology Source Type: research

Hot topics in congenital heart disease and new insight into ventricular non-compaction
(Source: European Heart Journal)
Source: European Heart Journal - November 1, 2021 Category: Cardiology Source Type: research

Maternal and neonatal complications in women with congenital heart disease: a nationwide analysis
ConclusionsThis population-based study illustrates a reassuringly low maternal mortality rate in a highly developed healthcare system. Nevertheless, maternal morbidity and neonatal morbidity/mortality were significantly increased in women with ACHD and their offspring compared to non-ACHD controls highlighting the need of specialized care and pre-pregnancy counselling. (Source: European Heart Journal)
Source: European Heart Journal - October 12, 2021 Category: Cardiology Source Type: research

Promising perspectives on pregnancy in women with congenital heart disease
(Source: European Heart Journal)
Source: European Heart Journal - October 12, 2021 Category: Cardiology Source Type: research

Vascular rejuvenation: a new therapeutic target?
Ministero dell ’Istruzione, Università e Ricerca Scientifica549901_2020_Madonna (Source: European Heart Journal)
Source: European Heart Journal - October 1, 2021 Category: Cardiology Source Type: research

The ‘10 commandments’ for the 2021 ESC guidelines on cardiac pacing and cardiac resynchronization therapy
The guidelines on cardiac pacing and cardiac resynchronization therapy provide an updated overview on indications for pacing, peri-operative management, and postoperative follow-up. A special emphasis is given to patient-centred care and shared decision-making. The following 10 commandments summarize main points. (Source: European Heart Journal)
Source: European Heart Journal - September 29, 2021 Category: Cardiology Source Type: research

Breaking the cycle: Succinate in aortic diseases
National Institute of HealthR01HL158801 (Source: European Heart Journal)
Source: European Heart Journal - September 26, 2021 Category: Cardiology Source Type: research

Takayasu arteritis-associated pulmonary hypertension
(Source: European Heart Journal)
Source: European Heart Journal - September 20, 2021 Category: Cardiology Source Type: research

Long-term outcomes of new-generation coronary stents in China
Yaling Han, Editor-in-Chief, reviews two highly interesting papers published inThe Chinese Journal of Cardiology. (Source: European Heart Journal)
Source: European Heart Journal - September 18, 2021 Category: Cardiology Source Type: research

Untargeted metabolomics identifies succinate as a biomarker and therapeutic target in aortic aneurysm and dissection
ConclusionPlasma succinate concentrations allow to distinguish patients with AAD from both healthy controls and patients with AMI or PE. Succinate concentrations are regulated by the p38 α–CREB–OGDH axis in macrophages. (Source: European Heart Journal)
Source: European Heart Journal - September 17, 2021 Category: Cardiology Source Type: research

The “ten commandments” for the 2021 ESC/EACTS Guidelines on valvular heart disease
Since the previous version of the guidelines on the management of patients with valvular heart disease (VHD), new data and experience have accumulated, making a revision of the document necessary. The 10 main messages of the new guidelines are: (Source: European Heart Journal)
Source: European Heart Journal - September 16, 2021 Category: Cardiology Source Type: research

Is tirzepatide in the surpass lane over GLP-1 receptor agonists for the treatment of diabetes?
The results of ‘Efficacy and Safety of a Novel Dual GIP and GLP-1 Receptor Agonist Tirzepatide in Patients with type 2 Diabetes (SURPASS-1): A Double-Blind, Randomised, Phase 3 Trial’ have been published inLancet. doi:10.1016/S0140-6736(21)01324-6. (Source: European Heart Journal)
Source: European Heart Journal - September 13, 2021 Category: Cardiology Source Type: research

LDL-cholesterol drives reversible myelomonocytic skewing in human bone marrow
(Source: European Heart Journal)
Source: European Heart Journal - September 11, 2021 Category: Cardiology Source Type: research

An inflammatory ageing clock to detect cardiovascular and other age-related diseases: a new approach to preventive medicine
Key PointsThe Stanford 1000 Immunomes Project consists of 1001 individuals aged 8 –96 (66% females) recruited between 2007 and 2016 for studies of ageing, vaccination, and chronic fatigue syndrome.1 Peripheral blood samples were analysed for gene expression; serum cytokines, chemokines, and growth factors; cell subset composition; cellular responses to multiple stimuli; and seropositivity to cytomegalovirus infection. A comprehensive health assessment using a 53-feature clinical questionnaire was performed in 902 individuals. Cardiovascular screening was conducted in 97 extremely healthy adults.A deep-learning method tha...
Source: European Heart Journal - September 11, 2021 Category: Cardiology Source Type: research

Clinical features and survival in Takayasu ’s arteritis-associated pulmonary hypertension: a nationwide study
ConclusionPatients with TA-PH were predominantly female and had severely compromised haemodynamics. More than 80% of patients in our cohort survived for at least 3  years. Medical treatment was based on investigators’ personal opinions, and no clear risk-to-benefit ratio can be derived from the presented data. (Source: European Heart Journal)
Source: European Heart Journal - September 10, 2021 Category: Cardiology Source Type: research