How inflammation heats the heart
(Source: European Heart Journal)
Source: European Heart Journal - March 1, 2021 Category: Cardiology Source Type: research

Re-purposed antiviral drugs without a purpose in COVID-19: a valuable lesson for clinicians
Comment on the interim results of the WHO Solidarity Trial, which were published in theNew England Journal of Medicine (DOI: 10.1056/NEJMoa2023184) (Source: European Heart Journal)
Source: European Heart Journal - February 11, 2021 Category: Cardiology Source Type: research

Unfolding and disentangling coronary vascular disease through genome-wide association studies
This editorial refers to ‘Genome-wide analysis identifies novel susceptibility loci for myocardial infarction’††, by J. Hartialaet al., on page919. (Source: European Heart Journal)
Source: European Heart Journal - February 9, 2021 Category: Cardiology Source Type: research

A new era for the young community of the ESC
The new ESC Board Committee for Young Cardiovascular Professionals was launched in 2020 and is discussed by the inaugural chair Dr Afzal Sohaib (Source: European Heart Journal)
Source: European Heart Journal - February 3, 2021 Category: Cardiology Source Type: research

Genome-wide analysis identifies novel susceptibility loci for myocardial infarction
ConclusionsA large-scale analysis comprising ∼831 000 subjects revealed novel genetic determinants of MI and implicatedSLC44A3 in the pathophysiology of vulnerable plaques. (Source: European Heart Journal)
Source: European Heart Journal - February 3, 2021 Category: Cardiology Source Type: research

Australia and colchicine for coronary heart disease
Mark Nicholls speaks to Dr Mark Nidorf and Professor Peter Thompson about the repurposing of colchicine as a coronary heart disease drug and how Australia has become a focus for research in this field (Source: European Heart Journal)
Source: European Heart Journal - February 1, 2021 Category: Cardiology Source Type: research

The REDUCE-IT verdict on eicosapentaenoic acid and cardiovascular outcome challenged with STRENGTH
Key pointsSTRENGTH,1 an industry-sponsored, double-blind, randomized, controlled trial investigated the effects of a carboxylic acid (CA) formulation of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) (omega-3 CA) vs. corn oil in 13 078 participants with high cardiovascular (CV) risk, hypertriglyceridaemia, and low levels of high-density lipoprotein cholesterol.Eligible patients were randomized to receive 4 g/day of omega-3 CA or corn oil in addition to standard preventive therapies, including statins (high-intensity in 50%), renin-angiotensin-aldosterone system (RAAS) blockers (in 81%), and antiplatelet agents ...
Source: European Heart Journal - February 1, 2021 Category: Cardiology Source Type: research

Becoming a Cardiologist: Is it sporadic, inherited or is it a combination of genetics and environment?
Dr Alfred F.W. Gr äni a general practitioner father and son Prof. Christoph Gräni, MD, PhD a non-invasive cardiovascular imaging specialist (Source: European Heart Journal)
Source: European Heart Journal - January 30, 2021 Category: Cardiology Source Type: research

The Cardiology Society of Serbia
A review of the Society from the origin of the cardiology section of the Serbian Medical Society to the present day is discussed by Prof. Sinisa Stojkovic, President of the Cardiology Society of Serbia and Milorad Tesic MD (Source: European Heart Journal)
Source: European Heart Journal - January 30, 2021 Category: Cardiology Source Type: research

Management of ischaemic stroke, prognostic impact of procedural myocardial injury, and antiplatelet treatment: the many facets of interventional cardiology
(Source: European Heart Journal)
Source: European Heart Journal - January 30, 2021 Category: Cardiology Source Type: research

Emergency Room visits in the COVID-19 pandemic
The importance of safe and secure access to healthcare facilities and the value of inappropriate visits to the Emergency Room during the COVID pandemic (Source: European Heart Journal)
Source: European Heart Journal - January 28, 2021 Category: Cardiology Source Type: research

Focus on atrial fibrillation, syncope, and arrhythmias during COVID-19 pandemic
(Source: European Heart Journal)
Source: European Heart Journal - January 28, 2021 Category: Cardiology Source Type: research

Russian Society of Cardiology Activities in 2020
(Source: European Heart Journal)
Source: European Heart Journal - January 27, 2021 Category: Cardiology Source Type: research

Valvular atrial fibrillation and a CHA2DS2-VASc score of 1 —a statement of the ESC working group on cardiovascular pharmacotherapy and ESC council on stroke
This commentary refers to ‘2020 ESC Guidelines for the diagnosis and management of atrial fibrillation developed in collaboration with the European Association of Cardio-Thoracic Surgery (EACTS)’ by G. Hindrickset al., 2021;42:373--498. (Source: European Heart Journal)
Source: European Heart Journal - January 26, 2021 Category: Cardiology Source Type: research

Risk stratification and treatment of acute and chronic coronary syndromes: focus on angina without obstructive coronary arteries, refractory angina, lipids, and clonal haematopoiesis
(Source: European Heart Journal)
Source: European Heart Journal - January 20, 2021 Category: Cardiology Source Type: research

Women who experience a myocardial infarction at a young age
This commentary refers to ‘Women who experience a myocardial infarction at a young age have worse outcomes compared with men: the Mass General Brigham YOUNG-MI registry’ by E.M. DeFilippiset al., 2020;41:4127 –4137. (Source: European Heart Journal)
Source: European Heart Journal - January 19, 2021 Category: Cardiology Source Type: research

Machine learning-guided phenotyping of dilated cardiomyopathy and treatment of heart failure by antisense oligonucleotides: the future has begun
(Source: European Heart Journal)
Source: European Heart Journal - January 18, 2021 Category: Cardiology Source Type: research

Women experiencing myocardial infarction at a young age have worse outcomes compared with men: only for non-cardiovascular deaths and when treated inadequately?
This commentary refers to ‘Women who experience a myocardial infarction at a young age have worse outcomes compared with men: the Mass General Brigham YOUNG-MI registry’, by E.M. DeFilippiset al., 2020;41:4127 –4137. (Source: European Heart Journal)
Source: European Heart Journal - January 17, 2021 Category: Cardiology Source Type: research

Changing the paradigm for post-MI cholesterol lowering from intensive statin monotherapy towards intensive lipid-lowering regimens and individualized care
This editorial refers to ‘Low-density lipoprotein cholesterol reduction and statin intensity in myocardial infarction patients and major adverse outcomes: a Swedish nationwide cohort study’††, by J. Schubertet al., on page243. (Source: European Heart Journal)
Source: European Heart Journal - January 17, 2021 Category: Cardiology Source Type: research

Learning whether to subtract beta-blockers: it ’s about time
Graphical AbstractProposed framework for foundational and provisional secondary prevention therapy over time in low-risk post-MI patients. Foundational therapies should be considered in all patients without contraindications, while provisional therapies should be considered in selected patients with comorbidities or post-infarction complications. The horizontal time axis proposes duration of therapies and timeframes for pharmacotherapeutic re-assessment, and should be responsive to the temporal evolution of post-MI risk and events. ADP, adenosine diphosphate receptor inhibitors; ASA, acetylsalicylic acid; CKD, chronic kidn...
Source: European Heart Journal - January 11, 2021 Category: Cardiology Source Type: research

Effect of long-term beta-blocker treatment following myocardial infarction among stable, optimally treated patients without heart failure in the reperfusion era: a Danish, nationwide cohort study
ConclusionsIn this nationwide cohort study of stable, optimally treated MI patients without HF, we found no long-term effect of BB treatment on CV prognosis following the patients from 3 months to 3 years after MI admission. (Source: European Heart Journal)
Source: European Heart Journal - January 11, 2021 Category: Cardiology Source Type: research

The new frontiers in prevention: from sports cardiology to spaceflight, and back to earth with cardiovascular disease and cancer
(Source: European Heart Journal)
Source: European Heart Journal - January 11, 2021 Category: Cardiology Source Type: research

Immune cell-based cardiovascular risk assessment: spotlight on the neutrophil –lymphocyte ratio
This editorial refers to ‘The neutrophil–lymphocyte ratio and incident atherosclerotic events: analyses from five contemporary randomized trials’††, by N.H. Adamsteinet al., on page896. (Source: European Heart Journal)
Source: European Heart Journal - January 9, 2021 Category: Cardiology Source Type: research

The neutrophil –lymphocyte ratio and incident atherosclerotic events: analyses from five contemporary randomized trials
AbstractAimsThe neutrophil –lymphocyte ratio (NLR) is a readily available inflammatory biomarker that may associate with atherosclerosis and predict cardiovascular (CV) events. The aims of this study are to determine whether the NLR predicts incident major adverse cardiovascular events (MACE) and is modified by anti-inflamm atory therapy.Methods and resultsBaseline and on-treatment NLRs were calculated from complete blood counts among 60  087 participants randomized in the CANTOS, JUPITER, SPIRE-1, SPIRE-2, and CIRT trials to receive placebo or canakinumab, rosuvastatin, bococizumab, or methotrexate, respectivel...
Source: European Heart Journal - January 8, 2021 Category: Cardiology Source Type: research

Cardiac troponin elevation after elective PCI: adding infarct to major injury
This editorial refers to ‘Cardiac procedural myocardial injury, infarction, and mortality in patients undergoing elective percutaneous coronary intervention: a pooled analysis of patient-level data’††, by J. Silvainet al., on page323. (Source: European Heart Journal)
Source: European Heart Journal - January 7, 2021 Category: Cardiology Source Type: research

Significant pinching of dominant left circumflex artery  during provisional left main bifurcation angioplasty: what next?
A 51-year-old male, a case of ST elevation anterior wall myocardial infarction, thrombolysed with tenecteplase 10  days ago, presented with complaints of rest angina. At presentation, ECG showed poor R wave progression and ST elevation in anterior chest leads. 2D echocardiography showed severe left anterior descending (LAD) territory hypokinesia with preserved thickness and ejection fraction of 30%. Coronary angiography revealed left dominant circulation, left main (LM) bifurcation lesion (Medina class 1,1,0) with 90% distal LM stenosis (Panel A). The patient was planned for provisional LM bifurcation angioplasty. I...
Source: European Heart Journal - January 6, 2021 Category: Cardiology Source Type: research

Preventing a diabetes pandemic through lifestyle intervention
Comment on the Norfolk Diabetes Prevention Study (NDPS) published inthe JAMA Internal Medicine (https://doi : 10.1001/jamainternmed.2020.5938I)Key PointsThis parallel, three-arm, group-based, randomized clinical trial, involving 135 primary care practices and eight intervention sites in the East of England, recruited 1028 participants who had either impaired fasting glucose (IFG) with elevated fasting plasma glucose (FPG) level alone ( ≥110 and
Source: European Heart Journal - January 5, 2021 Category: Cardiology Source Type: research

Does a myocardial infarction boost your (B cell) memory?
AbstractGraphical abstractEstablishment of an autoreactive B cell memory after myocardial infarction: a working hypothesis. The demise of cardiac cells leads to the release of cryptoantigens that induce a humoral immune response that leads to accumulation of immunoglobulins in plaques and eventually amplifies atherogenesis at remote sites. (Source: European Heart Journal)
Source: European Heart Journal - January 4, 2021 Category: Cardiology Source Type: research

Truly galactic?
Comment on ‘Cardiac Myosin Activation with Omecamtiv Mecarbil in Systolic Heart Failure’ which was published in theNew England Journal of Medicine (DOI: 10.1056/NEJMoa2025797) (Source: European Heart Journal)
Source: European Heart Journal - January 4, 2021 Category: Cardiology Source Type: research

The year in cardiovascular medicine 2020: acute coronary syndromes and intensive cardiac care
(Source: European Heart Journal)
Source: European Heart Journal - January 3, 2021 Category: Cardiology Source Type: research

The year in cardiovascular medicine 2020: arrhythmias
Summary of the progress in arrhythmias in 2020. RACE4 and ALL-IN indicated that integrated nurse-led care improves outcomes in AF patients.3,4 The same was reported for early rhythm control therapy15 and cryoablation as initial AF treatment.25,26 Subcutaneous ICD was non-inferior to classical transvenous ICD therapy in PRAETORIAN.54 One mechanistic study showed that autoantibodies against misexpressed actin, keratin, and connexin-43 proteins create a blood-borne biomarker profile enhancing diagnosis of Brugada syndrome.50 Another mechanistic study indicated that transseptal LV pacing yields similar improvement in contracti...
Source: European Heart Journal - January 3, 2021 Category: Cardiology Source Type: research

Takotsubo and cancerTakotsubo cardiomyopathy in the era of emerging cancer therapies
(Source: European Heart Journal)
Source: European Heart Journal - December 31, 2020 Category: Cardiology Source Type: research

Focus on hypertension but also on the ‘the digital twin’ and on kidney function and disease
For the podcast associated with this article, please visit https://academic. oup.com/eurheartj/pages/Podcasts. (Source: European Heart Journal)
Source: European Heart Journal - December 31, 2020 Category: Cardiology Source Type: research

What Makes Us Tick?Jeffrey C. Hall, Michael Rosbash and Michael W. Young all received a share of the 2017 Nobel Prize for Physiology or Medicine, for their discoveries of molecular mechanisms controlling the circadian rhythm
The existence of an internal biological clock has been known since ancient times, but the inner workings of that clock —what makes life on earth tick—remained a mystery until the three American geneticists investigated the clock’s inner workings and explained how plants, mammals, and humans adapt their circadian rhythm to synchronize with the Earth’s rotation. (Source: European Heart Journal)
Source: European Heart Journal - December 31, 2020 Category: Cardiology Source Type: research

Where is renal nerve ablation going?Catheter-based renal denervation (RDN) has been introduced to reduce sympathetic nerve activity by interrupting afferent and efferent sympathetic nerve signalling.1 While early trials demonstrated heterogeneous changes in blood pressure (BP),2,3 the second generation of sham-controlled trials were able to reaffirm proof of concept for RDN.4 –6
In both the absence (SPYRAL HTN-OFF MED)4 and the presence (SPYRAL HTN-ON MED)5 of antihypertensive medication, radiofrequency-based RDN using the Symplicity Spyral multielectrode RDN catheter (Medtronic; Galway, Ireland) lowered office and ambulatory BP.Similarly, in the sham-controlled RADIANCE-HTN SOLO trial, RDN using the ultrasound-based Paradise catheter system (Recor; Palo Alto, CA, USA) significantly reduced daytime ambulatory systolic BP between baseline and 2  months in patients without concomitant antihypertensive medications.6A third catheter system, the Peregrine catheter-system (Ablative Solutions; San...
Source: European Heart Journal - December 31, 2020 Category: Cardiology Source Type: research

COVID 19: in the eye of the cytokine storm
Comment on ‘An inflammatory cytokine signature predicts COVID-19 severity and survival’ was published inNature Medicine 2020; 26: 1636 –1643 (https//doi.org/10.1038/s41591-020-1051-9).Key pointsThe study examined data from 1484 patients hospitalized for suspected or confirmed (n = 1257) COVID-19 at the Mount Sinai Health System in New York between 21 March and 28 April 2020. Serum levels of four inflammatory cytokines were analysed upon admission with a rapid multiplex test: interleukin (IL)-6, IL-8, tumour necrosis factor (TNF)- α, and IL-1β. These results were correlated with clinical and lab...
Source: European Heart Journal - December 27, 2020 Category: Cardiology Source Type: research

Evolution of antithrombotic therapy in patients undergoing percutaneous coronary intervention: a 40-year journey
AbstractSince its introduction in 1977, percutaneous coronary intervention has become one of the most commonly performed therapeutic procedures worldwide. Such widespread diffusion, however, would have not been possible without a concomitant evolution of the pharmacotherapies associated with this intervention. Antithrombotic agents are fundamental throughout the management of patients undergoing coronary stent implantation, starting from the procedure itself to the long-term prevention of cardiovascular events. The last 40 years of interventional cardiology have seen remarkable improvements in both drug therapies and devic...
Source: European Heart Journal - December 26, 2020 Category: Cardiology Source Type: research

Peter Sleight, Emeritus Professor of Cardiovascular Medicine, Oxford University, Chairman of the ISIS Trials Steering Committee
Professor Peter Sleight born 27 June 1929 died peacefully aged 91 on 7 October 2020 and will be remembered as one of the most distinguished and influential cardiologists of his generation (Source: European Heart Journal)
Source: European Heart Journal - December 26, 2020 Category: Cardiology Source Type: research

The ESC Association for Cardiovascular Nursing and Allied Professionals
The Association celebrates its successes during 2020, the World Health Organisation Year of the Nurse (Source: European Heart Journal)
Source: European Heart Journal - December 26, 2020 Category: Cardiology Source Type: research

The Israel Heart Society
(Source: European Heart Journal)
Source: European Heart Journal - December 26, 2020 Category: Cardiology Source Type: research

George H. Hitchings and Gertrude B. Elion
Mark Nicholls focuses on the work of George H. Hitchings and Gertrude B. Elion and their award —with Sir James W. Black—of the Nobel Prize in Physiology or Medicine 1988 ‘for their discoveries of important principles for drug treatment’ (Source: European Heart Journal)
Source: European Heart Journal - December 26, 2020 Category: Cardiology Source Type: research

Arrhythmia-associated risk: from cardiac arrest to stroke and dementia
(Source: European Heart Journal)
Source: European Heart Journal - December 26, 2020 Category: Cardiology Source Type: research

Low-density lipoprotein cholesterol reduction and statin intensity in myocardial infarction patients and major adverse outcomes: a Swedish nationwide cohort study
Conclusions  Larger early LDL-C reduction and more intensive statin therapy after MI were associated with a reduced hazard of all CV outcomes and all-cause mortality. This supports clinical trial data suggesting that earlier lowering of LDL-C after an MI confers the greatest benefit. (Source: European Heart Journal)
Source: European Heart Journal - December 24, 2020 Category: Cardiology Source Type: research

Management of refractory angina: an update
AbstractDespite the use of anti-anginal drugs and/or percutaneous coronary interventions (PCI) or coronary artery bypass grafting, the proportion of patients with coronary artery disease who have daily or weekly angina ranges from 2% to 24%. Refractory angina refers to long-lasting symptoms (for>3  months) due to established reversible ischaemia, which cannot be controlled by escalating medical therapy with the use of 2nd- and 3rd-line pharmacological agents, bypass grafting, or stenting. While there is uncertain prognostic benefit, the treatment of refractory angina is important to improve the quality of life of...
Source: European Heart Journal - December 23, 2020 Category: Cardiology Source Type: research

Scientific integrity: what a journal can and cannot do
(Source: European Heart Journal)
Source: European Heart Journal - December 23, 2020 Category: Cardiology Source Type: research

COVID-19 pandemic: complex interactions with the arrhythmic profile and the clinical course of patients with cardiovascular disease
This editorial refers to ‘Ventricular arrhythmia burden during the coronavirus disease 2019 (COVID-19) pandemic’††, by C.J. O ’Sheaet al., on page520. (Source: European Heart Journal)
Source: European Heart Journal - December 22, 2020 Category: Cardiology Source Type: research

Corrigendum to: Interdisciplinary management of acute ischaemic stroke: Current evidence training requirements for endovascular stroke treatment: Position Paper from the ESC Council on Stroke and the European Association for Percutaneous Cardiovascular Interventions with the support of the European Board of Neurointervention
(Source: European Heart Journal)
Source: European Heart Journal - December 22, 2020 Category: Cardiology Source Type: research

Aldosterone receptor antagonism in patients with diabetes and chronic kidney disease: new promises and old problems
The results of “Effect of Finerenone on Chronic Kidney Disease Outcomes in Type 2 Diabetes” have been published in theNew England Journal of Medicine (DOI: 10.1056/NEJMoa2025845) (Source: European Heart Journal)
Source: European Heart Journal - December 21, 2020 Category: Cardiology Source Type: research

Sir John Vane 1927 –2004
John Vane received the 1982 Nobel Prize for Medicine or Physiology for his discovery of prostacyclin and previous work on aspirin (Source: European Heart Journal)
Source: European Heart Journal - December 21, 2020 Category: Cardiology Source Type: research

A fresh look at ischaemic heart disease: from artificial intelligence to reappraisal of old drugs
(Source: European Heart Journal)
Source: European Heart Journal - December 21, 2020 Category: Cardiology Source Type: research