Metabolic profiling of angiopoietin-like protein 3 and 4 inhibition: a drug-target Mendelian randomization analysis
Conclusions Genetic mimicry of ANGPTL4 inhibition and LPL enhancement have very similar systemic metabolic effects, whereas genetic mimicry of ANGPTL3 inhibition showed differing metabolic effects, suggesting potential involvement of pathways independent of LPL. Genetic mimicry of ANGPTL4 inhibition and LPL enhancement were associated with a lower risk of coronary heart disease and type 2 diabetes. These findings reinforce evidence that enhancing LPL activity (either directly or via upstream effects) through pharmacological approaches is likely to yield benefits to human health. (Source: European Heart Journal)
Source: European Heart Journal - December 22, 2020 Category: Cardiology Source Type: research
The dawn of cardiovascular medicine in the Serenissima Republic of Venice, Land of the Doges
(Source: European Heart Journal)
Source: European Heart Journal - December 22, 2020 Category: Cardiology Source Type: research
COVID-19 pandemic: complex interactions with the arrhythmic profile and the clinical course of patients with cardiovascular disease
This editorial refers to ‘Ventricular arrhythmia burden during the coronavirus disease 2019 (COVID-19) pandemic’††, by C.J. O ’Sheaet al., on page520. (Source: European Heart Journal)
Source: European Heart Journal - December 22, 2020 Category: Cardiology Source Type: research
Corrigendum to: Interdisciplinary management of acute ischaemic stroke: Current evidence training requirements for endovascular stroke treatment: Position Paper from the ESC Council on Stroke and the European Association for Percutaneous Cardiovascular Interventions with the support of the European Board of Neurointervention
(Source: European Heart Journal)
Source: European Heart Journal - December 22, 2020 Category: Cardiology Source Type: research
From heart auscultation to advanced intravascular imaging
(Source: European Heart Journal)
Source: European Heart Journal - December 21, 2020 Category: Cardiology Source Type: research
Molecular map of the human heart
Scientists have created a unique cellular and molecular map of the healthy human heart. Mark Nicholls speaks to Dr Michela Noseda about the implications of this advance (Source: European Heart Journal)
Source: European Heart Journal - December 21, 2020 Category: Cardiology Source Type: research
Colchicine for secondary prevention in coronary disease
The well-known merits of colchicine for gout are now discussed for use in coronary artery disease by researchers in the Netherlands and Australia (Source: European Heart Journal)
Source: European Heart Journal - December 21, 2020 Category: Cardiology Source Type: research
Aldosterone receptor antagonism in patients with diabetes and chronic kidney disease: new promises and old problems
The results of “Effect of Finerenone on Chronic Kidney Disease Outcomes in Type 2 Diabetes” have been published in theNew England Journal of Medicine (DOI: 10.1056/NEJMoa2025845) (Source: European Heart Journal)
Source: European Heart Journal - December 21, 2020 Category: Cardiology Source Type: research
Sir John Vane 1927 –2004
John Vane received the 1982 Nobel Prize for Medicine or Physiology for his discovery of prostacyclin and previous work on aspirin (Source: European Heart Journal)
Source: European Heart Journal - December 21, 2020 Category: Cardiology Source Type: research
A fresh look at ischaemic heart disease: from artificial intelligence to reappraisal of old drugs
(Source: European Heart Journal)
Source: European Heart Journal - December 21, 2020 Category: Cardiology Source Type: research
Delayed diffuse inflammatory myocardial damage in a child with a history of systemic inflammatory syndrome related to COVID-19
A 4-year-old girl presented to the emergency unit with respiratory distress and tachycardia. She had a history of admission due to COVID-19 related systemic inflammatory syndrome. The real -time polymerase chain reaction (RT ‐PCR) for SARS-COV2 had been positive, and 2 weeks before, she was discharged with good condition and preserved left ventricular function. At the current admission, she was afebrile, the blood pressure 90 mmHg/pulse, heart rate 140 b.p.m., respiratory rate 40 breath/min, and the O2 saturation was 92% in room air. The point of care echocardiography revealed severe left and right ventricular dysfun...
Source: European Heart Journal - December 20, 2020 Category: Cardiology Source Type: research
Leukocytoclastic vasculitis associated myocarditis: differentiating inflammatory from inherited heart muscle disease
A 31-year-old man with a history of asthma presented with chest tightness and breathlessness. About 6-weeks prior, he had returned from the Hajj pilgrimage with a sore throat, dry cough and developed a vasculitic leg rash and microscopic haematuria. Investigations confirmed Influenza A (H1N1) and elevated serum antistreptolyson O (ASO) titre (595 Kunits/L, normal 0 –200). Renal function and ultrasound were normal. Skin biopsy confirmed leukocytoclastic vasculitis and a tapering dose of oral prednisolone and amoxicillin was initiated. (Source: European Heart Journal)
Source: European Heart Journal - December 18, 2020 Category: Cardiology Source Type: research
EHJ Dialogues
A new addition to theEuropean Heart Journal online the webinarEHJ Dialogues has begun (Source: European Heart Journal)
Source: European Heart Journal - December 18, 2020 Category: Cardiology Source Type: research
Medical Volunteers and their role in CVD prevention
A volunteer organization formed 8 years ago in Russia has been working to promote awareness of cardiovascular diseases in the population. Education begins with children and continues into adulthood (Source: European Heart Journal)
Source: European Heart Journal - December 18, 2020 Category: Cardiology Source Type: research
Alarmin-activated B cells accelerate murine atherosclerosis after myocardial infarction via plasma cell-immunoglobulin-dependent mechanisms
Conclusion Our data implicate early B-cell activation and autoantibodies as a central cause for accelerated atherosclerosis post-MI and identifies novel therapeutic strategies towards preventing recurrent cardiovascular events such as MI and stroke. (Source: European Heart Journal)
Source: European Heart Journal - December 18, 2020 Category: Cardiology Source Type: research
