Aliskiren restores renal AQP2 expression during unilateral ureteral obstruction by inhibiting the inflammasome
In conclusions, RAS blockade with the direct renin inhibitor aliskiren increased water channel AQP2 expression in obstructed kidneys of UUO mice, at least partially by preventing NLRP3 inflammasome activation in association with ureteral obstruction. (Source: AJP: Renal Physiology)
Source: AJP: Renal Physiology - April 15, 2015 Category: Urology & Nephrology Authors: Wang, W., Luo, R., Lin, Y., Wang, F., Zheng, P., Levi, M., Yang, T., Li, C. Tags: ARTICLES Source Type: research
Expression and functional role of the prorenin receptor in the human adrenocortical zona glomerulosa and in primary aldosteronism
Conclusion: The presence of detectable plasma prorenin in primary aldosteronism patients, and the high expression of PRR in the normal human adrenal cortex, APA tissue, CD56+ aldosterone-producing cells, along with activation of CYP11B2 synthesis and ERK1/2 phosphorylation, suggest that the circulating and locally produced prorenin may contribute to the development or maintenance of human primary aldosteronism. (Source: Journal of Hypertension)
Source: Journal of Hypertension - April 9, 2015 Category: Cardiology Tags: ORIGINAL PAPERS: Pathophysiological aspects Source Type: research
The effects of RAAS inhibition in rate limiting step by Aliskiren on testicular torsion injury in rats
Testicular torsion is a urological emergency. Failure of timely intervention with this issue leads the testicles to go into necrosis, and if left untreated, can lead to the loss of the reproductive organs. The aim of this study was to examine the role of ALS in testicular torsion and detorsion injuries. (Source: The Journal of Urology)
Source: The Journal of Urology - April 4, 2015 Category: Urology & Nephrology Authors: Harun Un, Yasin Bayir, Zekai Halici, Erol Akpinar, Emre Karakus, Akgun Oral, Tevfik Ziypak, Jale Selli Source Type: research
The role of renin angiotensin system antagonists in the prevention of doxorubicin and trastuzumab induced cardiotoxicity
Abstract
Background:
Cardio-Oncology is an evolving discipline that focuses on the management of cancer patients who develop cardiovascular complications as a result of their treatment. Although the current combination of surgical resection, radiation, and chemotherapy may lead to a cure in cancer patients, the administration of anti-cancer drugs, in particular Doxorubicin (DOX) and Trastuzumab (TRZ), is associated with an increased risk of cardiotoxicity. Little is known on the potential cardioprotective role of renin angiotensin system (RAS) antagonists in the prevention of DOX+TRZ mediated cardiotoxicity.ObjectiveThe ai...
Source: Cardiovascular Ultrasound - April 3, 2015 Category: Radiology Authors: Gauri AkolkarNavdeep BhullarHilary BewsBilal ShaikhSheena PremeczKimberly-Ann BordunDavid CheungVineet GoyalAnita SharmaPhilip GarberPawan SingalDavinder Jassal Source Type: research
Advantages of renin inhibition in a patient with reninoma
We describe a case of a reninoma in a young woman, highlighting the possible role of the renin inhibitor aliskiren in the diagnostic evaluation and in the therapeutic management before surgical removal of the tumor. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - March 21, 2015 Category: Cardiology Authors: Claudia Agabiti Rosei, Laura Giacomelli, Massimo Salvetti, Anna Paini, Claudia Corbellini, Guido Tiberio, Maria Lorenza Muiesan Tags: Letter to the Editor Source Type: research
