Inhibiting renin angiotensin system in rate limiting step by aliskiren as a new approach for preventing indomethacin induced gastric ulcers
Conclusion Aliskiren exerted its protective effects on stomach tissue by decreasing inflammatory cytokines and oxidative stress as a result of inhibiting the RAAS, at a rate-limiting step, as well as its end product, angiotensin II. Aliskiren also significantly increased protective factors such as PGE2, but not affect aggressive factors such as gastric acidity. (Source: Chemico Biological Interactions)
Source: Chemico Biological Interactions - September 17, 2016 Category: Biochemistry Source Type: research
Inhibiting renin angiotensin system in rate limiting step by aliskiren as a new approach for preventing indomethacin induced gastric ulcers.
CONCLUSION: Aliskiren exerted its protective effects on stomach tissue by decreasing inflammatory cytokines and oxidative stress as a result of inhibiting the RAAS, at a rate-limiting step, as well as its end product, angiotensin II. Aliskiren also significantly increased protective factors such as PGE2, but not affect aggressive factors such as gastric acidity.
PMID: 27645307 [PubMed - as supplied by publisher] (Source: Chemico-Biological Interactions)
Source: Chemico-Biological Interactions - September 15, 2016 Category: Molecular Biology Authors: Halici Z, Polat B, Cadirci E, Topcu A, Karakus E, Kose D, Albayrak A, Bayir Y Tags: Chem Biol Interact Source Type: research
Local renin-angiotensin system mediates endothelial dilator dysfunction in aging arteries
Aging impairs endothelium-dependent NO-mediated dilatation, which results from increased production of reactive oxygen species (ROS). The local generation of angiotensin II (ANG II) is increased in aging arteries and contributes to inflammatory and fibrotic activity of smooth muscle cells and arterial wall remodeling. Although prolonged in vivo ANG II inhibition improves the impaired endothelial dilatation of aging arteries, it is unclear whether this reflects inhibition of intravascular or systemic ANG II systems. Experiments were therefore performed on isolated tail arteries from young (3–4 mo) and old (22–24...
Source: AJP: Heart and Circulatory Physiology - September 6, 2016 Category: Cardiology Authors: Flavahan, S., Chang, F., Flavahan, N. A. Tags: RAPID REPORT Source Type: research
The effect of aliskiren on the renal dysfunction following unilateral ureteral obstruction in the rat.
CONCLUSION: Direct renin inhibition by aliskiren appears to have protective effect on the renal dysfunction and on the markers of renal injury following UO indicating a potential clinical benefit of this agent. Further, this data and the previous studies indicate that blocking renin-angiotensin system at any level has a protective effect in obstructive nephropathy.
PMID: 27570581 [PubMed] (Source: International Journal of Physiology, Pathophysiology and Pharmacology)
Source: International Journal of Physiology, Pathophysiology and Pharmacology - August 30, 2016 Category: Physiology Tags: Int J Physiol Pathophysiol Pharmacol Source Type: research
Mechanistic insight of Diabetic Nephropathy and its pharmacotherapeutic targets: An update.
Abstract
Diabetic nephropathy (DN), a chronic complication of diabetes, is charecterised by glomerular hypertrophy, proteinuria, decreased glomerular filtration, and renal fibrosis resulting in the loss of renal function. Although the exact cause of DN remains unclear, several mechanisms have been postulated, such as hyperglycemia-induced renal hyper filtration and renal injury, AGEs-induced increased oxidative stress, activated PKC-induced increased production of cytokines, chemokines, and different inflammatory and apoptotic signals. Among various factors, oxidative stress has been suggested to play a ma...
Source: European Journal of Pharmacology - August 24, 2016 Category: Drugs & Pharmacology Authors: Bhattacharjee N, Barma S, Konwar N, Dewanjee S, Manna P Tags: Eur J Pharmacol Source Type: research
Aliskiren Regulates Neonatal Fc Receptor and IgG Metabolism with Attenuation of Anti-GBM Glomerulonephritis in Mice
Conclusion: These results suggest that suppression of FcRn and PRR and regulation of IgG metabolism may be related to the attenuation of anti-GBM GN by aliskiren.Nephron (Source: Nephron)
Source: Nephron - August 24, 2016 Category: Urology & Nephrology Source Type: research
Therapeutic modulation of tissue kallikrein expression.
Authors: Campbell DJ
Abstract
The kallikrein kinin system has cardioprotective actions and mediates in part the cardioprotection produced by angiotensin converting enzyme inhibitors and angiotensin type 1 receptor blockers. Additional approaches to exploit the cardioprotective effects of the kallikrein kinin system include the administration of tissue kallikrein and kinin receptor agonists. The renin inhibitor aliskiren was recently shown to increase cardiac tissue kallikrein expression and bradykinin levels, and to reduce myocardial ischemia-reperfusion injury by bradykinin B2 receptor- and angiotensin AT...
Source: Biological Chemistry - August 19, 2016 Category: Chemistry Tags: Biol Chem Source Type: research
Intracellular renin increases the inward calcium current in smooth muscle cells of mesenteric artery of SHR. Implications for hypertension and vascular remodeling
Conclusions: intracellular renin in vascular resistance vessels from SHR due to internalization or expression, contributes to the regulation of vascular tone and control of peripheral resistance-an effect independently of Ang II. Implications for hypertension and vascular remodeling are discussed. (Source: Peptides)
Source: Peptides - August 18, 2016 Category: Biochemistry Source Type: research
Moderate additive effects of endothelin receptor A blockade in Ren-2 transgenic rats subjected to various types of RAS blockade
Conclusions Although the BP-lowering effect of combined ETA and RAS blockades in TGR is predominantly dependent on the effects exerted by RAS blockade, further effects are attributable to decreased calcium influx due to chronic ETA blockade. (Source: Life Sciences)
Source: Life Sciences - August 17, 2016 Category: Biology Source Type: research
Aliskiren, Enalapril, or Both in Heart Failure
New England Journal of Medicine,Volume 375, Issue 7, Page 701-702, August 2016. (Source: New England Journal of Medicine)
Source: New England Journal of Medicine - August 16, 2016 Category: Internal Medicine Source Type: research
Renin-angiotensin system blockers regulate the metabolism of isolated fat cells in vitro.
Authors: Caminhotto RO, Sertié RA, Andreotti S, Campaãa AB, Lima FB
Abstract
Due to the presence of the renin-angiotensin system (RAS) in tissues and its specific influence on white adipose tissue, fat cells are possible targets of pharmacological RAS blockers commonly used as anti-hypertensive drugs. In the present study, we investigated the effects of different RAS blockers on fat cell metabolism, more specifically on lipolysis, lipogenesis and oxidation of energy substrates. Isolated primary adipocytes were incubated with different RAS blockers (aliskiren, captopril and losartan) in vitro for 24 h and...
Source: Brazilian Journal of Medical and Biological Research - August 4, 2016 Category: Research Tags: Braz J Med Biol Res Source Type: research
Aliskiren update
(Source: Practical Diabetes)
Source: Practical Diabetes - August 2, 2016 Category: Endocrinology Authors: Stephen Dobbin, Gerry McKay, Miles Fisher Tags: Drug notes Source Type: research
The beneficial effects on blood pressure, dyslipidemia and oxidative stress of Sambucus nigra extract associated with renin inhibitors.
CONCLUSION: The combination of two different classes of substances, namely, renin inhibitors and natural polyphenol extracts, reduces arterial pressure and also might reduce the side effects of the major classes of antihypertensive agents and improve the quality of live.
PMID: 27417664 [PubMed - as supplied by publisher] (Source: Pharmaceutical Biology)
Source: Pharmaceutical Biology - July 17, 2016 Category: Drugs & Pharmacology Tags: Pharm Biol Source Type: research
Local renin-angiotensin system mediates endothelial dilator dysfunction in aging arteries.
LOCAL RENIN-ANGIOTENSIN SYSTEM MEDIATES ENDOTHELIAL DILATOR DYSFUNCTION IN AGING ARTERIES.
Am J Physiol Heart Circ Physiol. 2016 Jul 15;:ajpheart.00422.2016
Authors: Flavahan S, Chang F, Flavahan NA
Abstract
Aging impairs endothelium-dependent NO-mediated dilatation, which results from increased production of reactive oxygen species (ROS). The local generation of angiotensin II (ANGII) is increased in aging arteries and contributes to inflammatory and fibrotic activity of smooth muscle cells and arterial wall remodeling. Although prolonged in vivo ANGII inhibition improves the imp...
Source: American Journal of Physiology. Heart and Circulatory Physiology - July 14, 2016 Category: Physiology Authors: Flavahan S, Chang F, Flavahan NA Tags: Am J Physiol Heart Circ Physiol Source Type: research
