Renin-Angiotensin System Inhibitors Suppress the Growth of Leukemia Cells
CONCLUSION: RAS inhibitors can be repurposed as molecular-targeted drugs for leukemia. However, the concentrations of the inhibitors were much higher than those in the plasma of patients with hypertension. Therefore, further investigation is required for their clinical use.PMID:38423665 | DOI:10.21873/anticanres.16913 (Source: Cell Research)
Source: Cell Research - February 29, 2024 Category: Cytology Authors: Mai Itoh Shun Sasaki Shuji Tohda Source Type: research
Effective Management of Hypertensive Emergencies with Aliskiren Treatment in a Patient Before and After Introducing Hemodialysis Secondary to Scleroderma Renal Crisis-like Condition Under Corticosteroid Treatment for Sj ögren Syndrome-associated Multiple Mononeuropathy
Intern Med. 2024 Jan 2. doi: 10.2169/internalmedicine.2970-23. Online ahead of print.ABSTRACTA middle-aged woman presented with hypertensive emergency after corticosteroid treatment for Sjögren syndrome-associated multiple mononeuropathy with suspected systemic sclerosis. Hypertensive heart failure with hyperreninemia improved with antihypertensives, including aliskiren; however, she became hemodialysis-dependent. Clinical findings and biopsy-proven thrombotic microangiopathy indicated conditions resembling scleroderma renal crisis (SRC). Severe hypertension and heart failure with hyperreninemia occurred after stopping al...
Source: Internal Medicine - January 3, 2024 Category: Internal Medicine Authors: Osamu Yamazaki Masataka Murakawa Fumika Ochiai Wataru Fujii Shinichiro Asakawa Michito Nagura Shigeyuki Arai Yoshifuru Tamura Ryuji Ohashi Shigeru Shibata Yoshihide Fujigaki Source Type: research
Identification of novel compounds and repurposing of FDA drugs for 1-deoxy-D-xylulose 5-phosphate reductoisomerase enzyme of Plasmodium falciparum to combat malaria resistance
Int J Biol Macromol. 2023 Dec 11:128672. doi: 10.1016/j.ijbiomac.2023.128672. Online ahead of print.ABSTRACTThe rise of Plasmodium falciparum resistance to Artemisinin-based combination therapies (ACTs) is a significant concern in the fight against malaria. This situation calls for the search for novel anti-malarial candidates. 1-deoxy-D-xylulose 5-phosphate reductoisomerase (IspC) is a potential target involved in various cellular processes in P. falciparum (Pf). We screened ~0.69 billion novel compounds from the ZINC20 library and repurposed ~1400 FDA drugs using computational drug discovery methods against PfIspC. Follo...
Source: International Journal of Biological Macromolecules - December 13, 2023 Category: Biochemistry Authors: Shahkaar Aziz Muhammad Waqas Hafiza Farah Naz Sobia Ahsan Halim Afnan Jan Abdullatif Bin Muhsinah Ajmal Khan Ahmed Al-Harrasi Source Type: research
Dynamic changes in renal sodium handling during sympathetic stimulation in healthy human males
CONCLUSION: Sympathetic stimulation for 90 min via LBNP at -30 mmHg LBNP compared to -15 mmHg did not result in a greater response in fractional Na+ excretion, suggesting that additional baroreceptor unloading did not cause further increases in renal sodium reabsorption. Changes in distal Na+ excretion were linear with respect to time (dose) of intervention, but seem to exhibit a saturation-like effect at a level around 4 %. The lack of recovery after 1 h is also a new finding that warrants further investigation.PMID:37984257 | DOI:10.1016/j.autneu.2023.103131 (Source: Autonomic Neuroscience)
Source: Autonomic Neuroscience - November 20, 2023 Category: Neuroscience Authors: J C G Petersen T E N Jonassen N-H Holstein-Rathlou L G Petersen C M Sorensen Source Type: research
Dynamic changes in renal sodium handling during sympathetic stimulation in healthy human males
CONCLUSION: Sympathetic stimulation for 90 min via LBNP at -30 mmHg LBNP compared to -15 mmHg did not result in a greater response in fractional Na+ excretion, suggesting that additional baroreceptor unloading did not cause further increases in renal sodium reabsorption. Changes in distal Na+ excretion were linear with respect to time (dose) of intervention, but seem to exhibit a saturation-like effect at a level around 4 %. The lack of recovery after 1 h is also a new finding that warrants further investigation.PMID:37984257 | DOI:10.1016/j.autneu.2023.103131 (Source: Autonomic Neuroscience)
Source: Autonomic Neuroscience - November 20, 2023 Category: Neuroscience Authors: J C G Petersen T E N Jonassen N-H Holstein-Rathlou L G Petersen C M Sorensen Source Type: research
Dynamic changes in renal sodium handling during sympathetic stimulation in healthy human males
CONCLUSION: Sympathetic stimulation for 90 min via LBNP at -30 mmHg LBNP compared to -15 mmHg did not result in a greater response in fractional Na+ excretion, suggesting that additional baroreceptor unloading did not cause further increases in renal sodium reabsorption. Changes in distal Na+ excretion were linear with respect to time (dose) of intervention, but seem to exhibit a saturation-like effect at a level around 4 %. The lack of recovery after 1 h is also a new finding that warrants further investigation.PMID:37984257 | DOI:10.1016/j.autneu.2023.103131 (Source: Autonomic Neuroscience)
Source: Autonomic Neuroscience - November 20, 2023 Category: Neuroscience Authors: J C G Petersen T E N Jonassen N-H Holstein-Rathlou L G Petersen C M Sorensen Source Type: research
Renin inhibition and the long-term renal function in patients with hypertensive emergency: a retrospective cohort study
CONCLUSIONS: DRI can successfully suppress PRA in patients with high-renin hypertensive emergency in both subacute and chronic phases. An efficient RAS blockade is associated with preserved renal function in these patients.PMID:37819695 | DOI:10.1093/ajh/hpad099 (Source: American Journal of Hypertension)
Source: American Journal of Hypertension - October 11, 2023 Category: Cardiology Authors: Masaki Ueno Wataru Fujii Wataru Ono Hiroshi Murata Yoshihide Fujigaki Shigeru Shibata Source Type: research
Renin inhibition and the long-term renal function in patients with hypertensive emergency: a retrospective cohort study
CONCLUSIONS: DRI can successfully suppress PRA in patients with high-renin hypertensive emergency in both subacute and chronic phases. An efficient RAS blockade is associated with preserved renal function in these patients.PMID:37819695 | DOI:10.1093/ajh/hpad099 (Source: American Journal of Hypertension)
Source: American Journal of Hypertension - October 11, 2023 Category: Cardiology Authors: Masaki Ueno Wataru Fujii Wataru Ono Hiroshi Murata Yoshihide Fujigaki Shigeru Shibata Source Type: research
Renin inhibition and the long-term renal function in patients with hypertensive emergency: a retrospective cohort study
CONCLUSIONS: DRI can successfully suppress PRA in patients with high-renin hypertensive emergency in both subacute and chronic phases. An efficient RAS blockade is associated with preserved renal function in these patients.PMID:37819695 | DOI:10.1093/ajh/hpad099 (Source: American Journal of Hypertension)
Source: American Journal of Hypertension - October 11, 2023 Category: Cardiology Authors: Masaki Ueno Wataru Fujii Wataru Ono Hiroshi Murata Yoshihide Fujigaki Shigeru Shibata Source Type: research
Renin inhibition and the long-term renal function in patients with hypertensive emergency: a retrospective cohort study
CONCLUSIONS: DRI can successfully suppress PRA in patients with high-renin hypertensive emergency in both subacute and chronic phases. An efficient RAS blockade is associated with preserved renal function in these patients.PMID:37819695 | DOI:10.1093/ajh/hpad099 (Source: American Journal of Hypertension)
Source: American Journal of Hypertension - October 11, 2023 Category: Cardiology Authors: Masaki Ueno Wataru Fujii Wataru Ono Hiroshi Murata Yoshihide Fujigaki Shigeru Shibata Source Type: research
Renin inhibition and the long-term renal function in patients with hypertensive emergency: a retrospective cohort study
CONCLUSIONS: DRI can successfully suppress PRA in patients with high-renin hypertensive emergency in both subacute and chronic phases. An efficient RAS blockade is associated with preserved renal function in these patients.PMID:37819695 | DOI:10.1093/ajh/hpad099 (Source: American Journal of Hypertension)
Source: American Journal of Hypertension - October 11, 2023 Category: Cardiology Authors: Masaki Ueno Wataru Fujii Wataru Ono Hiroshi Murata Yoshihide Fujigaki Shigeru Shibata Source Type: research
Renin inhibition and the long-term renal function in patients with hypertensive emergency: a retrospective cohort study
CONCLUSIONS: DRI can successfully suppress PRA in patients with high-renin hypertensive emergency in both subacute and chronic phases. An efficient RAS blockade is associated with preserved renal function in these patients.PMID:37819695 | DOI:10.1093/ajh/hpad099 (Source: American Journal of Hypertension)
Source: American Journal of Hypertension - October 11, 2023 Category: Cardiology Authors: Masaki Ueno Wataru Fujii Wataru Ono Hiroshi Murata Yoshihide Fujigaki Shigeru Shibata Source Type: research
