Dynamic changes in renal sodium handling during sympathetic stimulation in healthy human males

CONCLUSION: Sympathetic stimulation for 90 min via LBNP at -30 mmHg LBNP compared to -15 mmHg did not result in a greater response in fractional Na+ excretion, suggesting that additional baroreceptor unloading did not cause further increases in renal sodium reabsorption. Changes in distal Na+ excretion were linear with respect to time (dose) of intervention, but seem to exhibit a saturation-like effect at a level around 4 %. The lack of recovery after 1 h is also a new finding that warrants further investigation.PMID:37984257 | DOI:10.1016/j.autneu.2023.103131

Source: Autonomic Neuroscience - November 20, 2023 Category: Neuroscience Authors: J C G Petersen T E N Jonassen N-H Holstein-Rathlou L G Petersen C M Sorensen Source Type: research