Molormer: a lightweight self-attention-based method focused on spatial structure of molecular graph for drug-drug interactions prediction
Brief Bioinform. 2022 Jul 19:bbac296. doi: 10.1093/bib/bbac296. Online ahead of print.ABSTRACTMulti-drug combinations for the treatment of complex diseases are gradually becoming an important treatment, and this type of treatment can take advantage of the synergistic effects among drugs. However, drug-drug interactions (DDIs) are not just all beneficial. Accurate and rapid identifications of the DDIs are essential to enhance the effectiveness of combination therapy and avoid unintended side effects. Traditional DDIs prediction methods use only drug sequence information or drug graph information, which ignores information a...
Source: Briefings in Bioinformatics - July 18, 2022 Category: Bioinformatics Authors: Xudong Zhang Gan Wang Xiangyu Meng Shuang Wang Ying Zhang Alfonso Rodriguez-Paton Jianmin Wang Xun Wang Source Type: research
Novel therapeutic modalities target cell signaling of Renin-Angiotensin system/NF-κB-induced cell cycle arrest and apoptosis in urethane-induced lung cancer in mice: An in vivo study
CONCLUSION: RAS/NF-B cell signaling is a potential therapeutic target for preventing and treating lung adenocarcinoma, evidenced by the fundamental cytotoxic mechanism and attenuation of metastasis and angiogenesis induced by the treatment of NSCLC mice with aliskiren.PMID:35822566 | DOI:10.1002/jbt.23162 (Source: Cancer Control)
Source: Cancer Control - July 13, 2022 Category: Cancer & Oncology Authors: Marwa M Khalaf Amira M Abo-Youssef Marina N Malak Mohamed A Hamzawy Source Type: research
The Prevalence of Adverse Drug Reactions and Adverse Drug Events from Heart Failure Medications in Frail Older Adults: A Systematic Review
ConclusionThe potential harms from heart failure medications in frail older people are poorly studied and understood. Clinical trials and pharmacovigilance studies should include frailty as a covariate to inform medication optimisation for this vulnerable and growing population.RegistrationProspero registration number: CRD 42021253762.Graphical Abstract (Source: Drugs and Aging)
Source: Drugs and Aging - June 28, 2022 Category: Geriatrics Source Type: research
The influence of prorenin/(pro)renin receptor on progesterone secretion by the bovine corpus luteum
Anim Reprod Sci. 2022 Apr 29;241:106985. doi: 10.1016/j.anireprosci.2022.106985. Online ahead of print.ABSTRACTThe aim of this study was to evaluate the role of prorenin/(pro)renin receptor activation on luteal progesterone (P4) secretion. Our hypothesis was that the nonproteolytic activation of (pro)renin receptor [P(RR)] is part of the regulatory mechanism responsible for corpus luteum (CL) function. In the first three experiments, prorenin was found to stimulate the production of P4, which is not inhibited by an angiotensin receptor antagonist (saralasin), but rather by a renin/prorenin inhibitor (aliskiren), a MAPK1/3 ...
Source: Animal Reproduction Science - May 15, 2022 Category: Zoology Authors: Andressa Minussi Pereira Dau Paulo Roberto da Rosa Joabel Dos Santos Juliana Ferst Mariana de Macedo Monique Rovani Fabio Comim Alfredo Quites Antoniazzi Bernardo Gasperin Rog ério Ferreira Paulo Bayard Gon çalves Source Type: research
The influence of prorenin/(pro)renin receptor on progesterone secretion by the bovine corpus luteum
Anim Reprod Sci. 2022 Apr 29;241:106985. doi: 10.1016/j.anireprosci.2022.106985. Online ahead of print.ABSTRACTThe aim of this study was to evaluate the role of prorenin/(pro)renin receptor activation on luteal progesterone (P4) secretion. Our hypothesis was that the nonproteolytic activation of (pro)renin receptor [P(RR)] is part of the regulatory mechanism responsible for corpus luteum (CL) function. In the first three experiments, prorenin was found to stimulate the production of P4, which is not inhibited by an angiotensin receptor antagonist (saralasin), but rather by a renin/prorenin inhibitor (aliskiren), a MAPK1/3 ...
Source: Animal Reproduction Science - May 15, 2022 Category: Zoology Authors: Andressa Minussi Pereira Dau Paulo Roberto da Rosa Joabel Dos Santos Juliana Ferst Mariana de Macedo Monique Rovani Fabio Comim Alfredo Quites Antoniazzi Bernardo Gasperin Rog ério Ferreira Paulo Bayard Gon çalves Source Type: research
Divergent roles of angiotensin II upon the immediate and sustained increases of renal blood flow following unilateral nephrectomy
Am J Physiol Renal Physiol. 2022 Feb 28. doi: 10.1152/ajprenal.00376.2021. Online ahead of print.ABSTRACTAlthough the molecular and functional responses related to the renal compensatory hypertrophy after unilateral nephrectomy (UNX) has been well described, many aspects of these events remain unclear. One question is how the remaining kidney senses the absence of the contralateral organ and another what the role of the renin-angiotensin system is in these responses. Both acute anesthetized and chronic unanesthetized studies were performed using the AT1-receptor blocker losartan and the renin inhibitor aliskiren to determi...
Source: Am J Physiol Renal P... - February 28, 2022 Category: Urology & Nephrology Authors: Satoshi Shimada Chun Yang Theresa Kurth Allen W Cowley Source Type: research
Divergent roles of angiotensin II upon the immediate and sustained increases of renal blood flow following unilateral nephrectomy
Am J Physiol Renal Physiol. 2022 Feb 28. doi: 10.1152/ajprenal.00376.2021. Online ahead of print.ABSTRACTAlthough the molecular and functional responses related to the renal compensatory hypertrophy after unilateral nephrectomy (UNX) has been well described, many aspects of these events remain unclear. One question is how the remaining kidney senses the absence of the contralateral organ and another what the role of the renin-angiotensin system is in these responses. Both acute anesthetized and chronic unanesthetized studies were performed using the AT1-receptor blocker losartan and the renin inhibitor aliskiren to determi...
Source: American Journal of Physiology. Renal Physiology - February 28, 2022 Category: Physiology Authors: Satoshi Shimada Chun Yang Theresa Kurth Allen W Cowley Source Type: research
Divergent roles of angiotensin II upon the immediate and sustained increases of renal blood flow following unilateral nephrectomy
Am J Physiol Renal Physiol. 2022 Feb 28. doi: 10.1152/ajprenal.00376.2021. Online ahead of print.ABSTRACTAlthough the molecular and functional responses related to the renal compensatory hypertrophy after unilateral nephrectomy (UNX) has been well described, many aspects of these events remain unclear. One question is how the remaining kidney senses the absence of the contralateral organ and another what the role of the renin-angiotensin system is in these responses. Both acute anesthetized and chronic unanesthetized studies were performed using the AT1-receptor blocker losartan and the renin inhibitor aliskiren to determi...
Source: Am J Physiol Renal P... - February 28, 2022 Category: Urology & Nephrology Authors: Satoshi Shimada Chun Yang Theresa Kurth Allen W Cowley Source Type: research
Divergent roles of angiotensin II upon the immediate and sustained increases of renal blood flow following unilateral nephrectomy
Am J Physiol Renal Physiol. 2022 Feb 28. doi: 10.1152/ajprenal.00376.2021. Online ahead of print.ABSTRACTAlthough the molecular and functional responses related to the renal compensatory hypertrophy after unilateral nephrectomy (UNX) has been well described, many aspects of these events remain unclear. One question is how the remaining kidney senses the absence of the contralateral organ and another what the role of the renin-angiotensin system is in these responses. Both acute anesthetized and chronic unanesthetized studies were performed using the AT1-receptor blocker losartan and the renin inhibitor aliskiren to determi...
Source: American Journal of Physiology. Renal Physiology - February 28, 2022 Category: Physiology Authors: Satoshi Shimada Chun Yang Theresa Kurth Allen W Cowley Source Type: research
Divergent roles of angiotensin II upon the immediate and sustained increases of renal blood flow following unilateral nephrectomy
Am J Physiol Renal Physiol. 2022 Feb 28. doi: 10.1152/ajprenal.00376.2021. Online ahead of print.ABSTRACTAlthough the molecular and functional responses related to the renal compensatory hypertrophy after unilateral nephrectomy (UNX) has been well described, many aspects of these events remain unclear. One question is how the remaining kidney senses the absence of the contralateral organ and another what the role of the renin-angiotensin system is in these responses. Both acute anesthetized and chronic unanesthetized studies were performed using the AT1-receptor blocker losartan and the renin inhibitor aliskiren to determi...
Source: Am J Physiol Renal P... - February 28, 2022 Category: Urology & Nephrology Authors: Satoshi Shimada Chun Yang Theresa Kurth Allen W Cowley Source Type: research
Divergent roles of angiotensin II upon the immediate and sustained increases of renal blood flow following unilateral nephrectomy
Am J Physiol Renal Physiol. 2022 Feb 28. doi: 10.1152/ajprenal.00376.2021. Online ahead of print.ABSTRACTAlthough the molecular and functional responses related to the renal compensatory hypertrophy after unilateral nephrectomy (UNX) has been well described, many aspects of these events remain unclear. One question is how the remaining kidney senses the absence of the contralateral organ and another what the role of the renin-angiotensin system is in these responses. Both acute anesthetized and chronic unanesthetized studies were performed using the AT1-receptor blocker losartan and the renin inhibitor aliskiren to determi...
Source: American Journal of Physiology. Renal Physiology - February 28, 2022 Category: Physiology Authors: Satoshi Shimada Chun Yang Theresa Kurth Allen W Cowley Source Type: research
Divergent roles of angiotensin II upon the immediate and sustained increases of renal blood flow following unilateral nephrectomy
Am J Physiol Renal Physiol. 2022 Feb 28. doi: 10.1152/ajprenal.00376.2021. Online ahead of print.ABSTRACTAlthough the molecular and functional responses related to the renal compensatory hypertrophy after unilateral nephrectomy (UNX) has been well described, many aspects of these events remain unclear. One question is how the remaining kidney senses the absence of the contralateral organ and another what the role of the renin-angiotensin system is in these responses. Both acute anesthetized and chronic unanesthetized studies were performed using the AT1-receptor blocker losartan and the renin inhibitor aliskiren to determi...
Source: Am J Physiol Renal P... - February 28, 2022 Category: Urology & Nephrology Authors: Satoshi Shimada Chun Yang Theresa Kurth Allen W Cowley Source Type: research
Divergent roles of angiotensin II upon the immediate and sustained increases of renal blood flow following unilateral nephrectomy
Am J Physiol Renal Physiol. 2022 Feb 28. doi: 10.1152/ajprenal.00376.2021. Online ahead of print.ABSTRACTAlthough the molecular and functional responses related to the renal compensatory hypertrophy after unilateral nephrectomy (UNX) has been well described, many aspects of these events remain unclear. One question is how the remaining kidney senses the absence of the contralateral organ and another what the role of the renin-angiotensin system is in these responses. Both acute anesthetized and chronic unanesthetized studies were performed using the AT1-receptor blocker losartan and the renin inhibitor aliskiren to determi...
Source: American Journal of Physiology. Renal Physiology - February 28, 2022 Category: Physiology Authors: Satoshi Shimada Chun Yang Theresa Kurth Allen W Cowley Source Type: research
Divergent roles of angiotensin II upon the immediate and sustained increases of renal blood flow following unilateral nephrectomy
Am J Physiol Renal Physiol. 2022 Feb 28. doi: 10.1152/ajprenal.00376.2021. Online ahead of print.ABSTRACTAlthough the molecular and functional responses related to the renal compensatory hypertrophy after unilateral nephrectomy (UNX) has been well described, many aspects of these events remain unclear. One question is how the remaining kidney senses the absence of the contralateral organ and another what the role of the renin-angiotensin system is in these responses. Both acute anesthetized and chronic unanesthetized studies were performed using the AT1-receptor blocker losartan and the renin inhibitor aliskiren to determi...
Source: Am J Physiol Renal P... - February 28, 2022 Category: Urology & Nephrology Authors: Satoshi Shimada Chun Yang Theresa Kurth Allen W Cowley Source Type: research
Divergent roles of angiotensin II upon the immediate and sustained increases of renal blood flow following unilateral nephrectomy
Am J Physiol Renal Physiol. 2022 Feb 28. doi: 10.1152/ajprenal.00376.2021. Online ahead of print.ABSTRACTAlthough the molecular and functional responses related to the renal compensatory hypertrophy after unilateral nephrectomy (UNX) has been well described, many aspects of these events remain unclear. One question is how the remaining kidney senses the absence of the contralateral organ and another what the role of the renin-angiotensin system is in these responses. Both acute anesthetized and chronic unanesthetized studies were performed using the AT1-receptor blocker losartan and the renin inhibitor aliskiren to determi...
Source: American Journal of Physiology. Renal Physiology - February 28, 2022 Category: Physiology Authors: Satoshi Shimada Chun Yang Theresa Kurth Allen W Cowley Source Type: research
