Inhibition of IL-1 β by Aliskiren Improved Renal AQP2 Expression and Urinary Concentration Defect in Ureteral Obstruction and Release
We previously demonstrated that ureteral obstruction is associated with a urinary concentrating defect and reduced expression of renal aquaporins (AQPs), in which the renin–angiotensin system (RAS) may play an important role. The aims of the present study were to examine whether the renin inhibitor aliskiren could prevent the reduction in AQP expression and improve the urinary concentrating capacity in mice with bilateral ureteral obstruction (BUO) and BUO release. BUO was performed for 24 h, and BUO release was performed for 1 (B-R1D) or 3 days (B-R3D) with or without aliskiren treatment. Aliskiren prevented polyuria an...
Source: Frontiers in Physiology - September 12, 2019 Category: Physiology Source Type: research
Central Application of Aliskiren, a Renin Inhibitor, Improves Outcome After Experimental Stroke Independent of Its Blood Pressure Lowering Effect
Epidemiological studies suggest that pharmacological reduction of systemic hypertension lowers incidence and severity of stroke. However, whether the reduction of blood pressure per se or the compounds used to reduce hypertension are responsible for this effect received little attention. In the current study we therefore aimed to investigate whether Aliskiren, a renin-inhibitor used to treat arterial hypertension, may improve outcome in a mouse model of ischemic stroke when applied centrally and in a dose not affecting blood pressure.
Male C57BL/6 mice received 0.6, 2.0, or 6.0 µg Aliskiren or vehicle by intracerebroven...
Source: Frontiers in Neurology - September 3, 2019 Category: Neurology Source Type: research
Aliskiren, Fosinopril, and Their Outcome on Renin-Angiotensin-Aldosterone System (RAAS) in Rats with Thyroid Dysfunction.
Conclusion: Aliskiren and Fosinopril in hyperthyroid rats decreased serum angiotensin I, angiotensin II, and aldosterone. Blockade of renin and inhibition of angiotensin-converting enzyme both resulted in a rebound increase in level of renin in hypothyroid rats. Aliskiren is better at controlling blood pressure in hyperthyroid rats. Urine flow, sodium excretion, and potassium excretion rates were improved by the use of Aliskiren and Fosinopril in hyperthyroid rats.
PMID: 31396276 [PubMed] (Source: International Journal of Endocrinology)
Source: International Journal of Endocrinology - August 10, 2019 Category: Endocrinology Tags: Int J Endocrinol Source Type: research
Molecules, Vol. 24, Pages 2807: Estimating the Solubility, Solution Thermodynamics, and Molecular Interaction of Aliskiren Hemifumarate in Alkylimidazolium Based Ionic Liquids
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Faiyaz Shakeel
Estimating the solubility and solution thermodynamics parameters of aliskiren hemifumarate (AHF) in three different room temperature ionic liquids (RTILs), Transcutol-HP (THP) and water are interesting as there is no solubility data available in the literature. In the current study, the solubility and solution thermodynamics of AHF in three different RTILs, THP and water at the temperature range from 298.2 to 318.2 K under air pressure 0.1 MP were evaluated. The solid phase evaluation by Differential Scanning Calorimetry (DSC) and Powder X-ray Diffraction (PXRD) indicated no conversion of AHF into p...
Source: Molecules - July 31, 2019 Category: Chemistry Authors: Md. Khalid Anwer Mohammad Muqtader Muzaffar Iqbal Raisuddin Ali Bjad K. Almutairy Abdullah Alshetaili Saad M. Alshahrani Mohammed F. Aldawsari Ahmed Alalaiwe Faiyaz Shakeel Tags: Article Source Type: research
Molecules, Vol. 24, Pages 2710: Protective Effects of Nanoparticle-Loaded Aliskiren on Cardiovascular System in Spontaneously Hypertensive Rats
In conclusion, nanoparticle-loaded aliskiren represents a promising drug with antihypertensive and cardioprotective effects. (Source: Molecules)
Source: Molecules - July 24, 2019 Category: Chemistry Authors: Olga Pechanova Andrej Barta Martina Koneracka Vlasta Zavisova Martina Kubovcikova Jana Klimentova Jozef T ӧrӧk Anna Zemancikova Martina Cebova Tags: Article Source Type: research
Aliskiren Attenuates the Inflammatory Response and Wound Healing Process in Diabetic Mice With Periodontal Disease
In conclusion, these data demonstrated the presence and functional role of local RAS in GT, exacerbating the inflammatory response, periodontal bone loss, and wound healing processes in both N and D animal groups. In addition, Alisk was able to significantly reduce gingival inflammation, excessive wound healing processes, and periodontal bone loss. (Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - July 3, 2019 Category: Drugs & Pharmacology Source Type: research
Action Potential Triangulation Explains Acute Proarrhythmic Effect of Aliskiren in a Whole-Heart Model of Atrial Fibrillation.
Abstract
Recent experimental studies showed a protective effect of the renin inhibitor aliskiren regarding atrial structural remodeling. Purpose of this study was to assess acute electrophysiologic effects of aliskiren in a whole-heart model of atrial fibrillation (AF) and to investigate its impact on the ventricle. Twelve rabbit hearts were excised, retrogradely perfused, and paced at different cycle lengths. To enhance atrial vulnerability, a combination of acetylcholine (ACh) and isoproterenol (Iso) was infused and significantly reduced atrial action potential duration (aAPD90) and atrial effective refr...
Source: Cardiovascular Toxicology - June 6, 2019 Category: Cardiology Authors: Ellermann C, Mittelstedt A, Wolfes J, Willy K, Leitz P, Reinke F, Eckardt L, Frommeyer G Tags: Cardiovasc Toxicol Source Type: research
Role of angiotensin II in chronic blood pressure control of heterozygous Ren-2 transgenic rats: Peripheral vasoconstriction versus central sympathoexcitation
In conclusion, sympathoinhibition represents the main mechanism of BP reduction in heterozygous TGR rats subjected to chronic brain or systemic RAS blockade, while peripheral attenuation of angiotensin II-dependent vasoconstriction during systemic RAS blockade is less important. Our data suggest that the participation of angiotensin II in BP control of adult heterozygous TGR rats is shifted from peripheral vasoconstriction to central sympathoexcitation. Similar mechanisms cannot be excluded in human essential hypertension. (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - May 24, 2019 Category: Drugs & Pharmacology Source Type: research
Role of angiotensin II in chronic blood pressure control of heterozygous Ren-2 transgenic rats: Peripheral vasoconstriction versus central sympathoexcitation.
In conclusion, sympathoinhibition represents the main mechanism of BP reduction in heterozygous TGR rats subjected to chronic brain or systemic RAS blockade, while peripheral attenuation of angiotensin II-dependent vasoconstriction during systemic RAS blockade is less important. Our data suggest that the participation of angiotensin II in BP control of adult heterozygous TGR rats is shifted from peripheral vasoconstriction to central sympathoexcitation. Similar mechanisms cannot be excluded in human essential hypertension.
PMID: 31132670 [PubMed - as supplied by publisher] (Source: Biomedicine and pharmacotherapy =...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - May 22, 2019 Category: Drugs & Pharmacology Authors: Řezáčová L, Hojná S, Kopkan L, Rauchová H, Kadlecová M, Zicha J, Vaněčková I Tags: Biomed Pharmacother Source Type: research
Effects of neprilysin-renin inhibition in comparison with neprilysin-angiotensin inhibition on the neurohumoral changes in rats with heart failure.
CONCLUSION: Sacubitril in combination with aliskiren or with ramipril effectively reduced plasma cardiac biomarkers, such as CK-MB, MMP9, and NT-proBNP, in rats with heart failure. Both combinations showed significant remediation of renal function through increasing GFR, urine flow, and total solute excretion, as well as reducing plasma level of renin. Net results revealed that the sacubitril-aliskiren combination has similar remediating effects on neurohumoral changes compared to the sacubitril-ramipril combination.
PMID: 31053170 [PubMed - in process] (Source: BMC Pharmacology and Toxicology)
Source: BMC Pharmacology and Toxicology - May 7, 2019 Category: Drugs & Pharmacology Tags: BMC Pharmacol Toxicol Source Type: research
Use of azilsartan medoxomil in the primary-care setting in Germany: A real-world evidence study
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CONCLUSION: Findings from this real-world evidence study demonstrate that AZM was generally utilized for approved indication and in accordance with the summary of product characteristics recommendations.
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PMID: 30848243 [PubMed - as supplied by publisher] (Source: International Journal of Clinical Pharmacology and Therapeutics)
Source: International Journal of Clinical Pharmacology and Therapeutics - March 9, 2019 Category: Drugs & Pharmacology Tags: Int J Clin Pharmacol Ther Source Type: research
Vitamin D Regulates the Expressions of AQP-1 and AQP-4 in Mice Kidneys.
Conclusions: Overall, Vitamin D and renin inhibitors have synergistic effects in regulating water channels in mice kidneys.
PMID: 30809535 [PubMed - in process] (Source: Biomed Res)
Source: Biomed Res - March 1, 2019 Category: Research Authors: Fu Y, Zhu J, Zhang Y, Liu Z, Su H, Kong J Tags: Biomed Res Int Source Type: research
Evidence for angiotensin mediation of the late histopathological effects of pulmonary fat embolism: Protection by losartan in a rat model.
CONCLUSIONS: These findings show that the effects of fat embolism continue to progress to 10 weeks after the initial insult with triolein. The fact that the protective effects of losartan treatment started at 6 weeks supports the involvement of the renin-angiotensin system in late as well as early stages of the histopathological changes following fat embolism. It also supports the use of angiotensin blockade in clinical situations even long after an initial trauma where fat embolism is suspected.
PMID: 30638089 [PubMed - as supplied by publisher] (Source: Experimental Lung Research)
Source: Experimental Lung Research - January 15, 2019 Category: Respiratory Medicine Tags: Exp Lung Res Source Type: research
The role of aliskiren in the management of hypertension and major cardiovascular outcomes: a systematic review and meta-analysis
The role of aliskiren in the management of hypertension and major cardiovascular outcomes: a systematic review and meta-analysis, Published online: 10 January 2019; doi:10.1038/s41371-018-0149-8The role of aliskiren in the management of hypertension and major cardiovascular outcomes: a systematic review and meta-analysis (Source: Journal of Human Hypertension)
Source: Journal of Human Hypertension - January 10, 2019 Category: Cardiology Authors: Henrik L Bjerre Julie B Christensen Niels Henrik Buus Ulf Simonsen Junjing Su Source Type: research
Effects of Aliskiren, an RAAS inhibitor, on a carrageenan-induced pleurisy model of rats.
Abstract
Our aim is to investigate the potentially preventive effects of Aliskiren in a carrageenan-induced lung pleurisy model and to compare the standard anti-inflammatory agents, indomethacin and dexamethasone. The pleurisy model was induced through the injection of carrageenan (0.2 ml-%2) into the pleural cavity. After the experiment, serum and lung tissues were collected and biochemical, molecular and pathological examinations were performed. In our study, pleural inflammation decreased superoxide dismutase activity and the glutathione level and increased the malondialdehyde level in the lung of rats,...
Source: An Acad Bras Cienc - December 17, 2018 Category: Science Authors: Bayir Y, Un H, Cadirci E, Akpinar E, Diyarbakir B, Calik I, Halici Z Tags: An Acad Bras Cienc Source Type: research
