Aliskiren Administration during Early Postnatal Life Sex-Specifically Alleviates Hypertension Programmed by Maternal High Fructose Consumption
Chien-Ning Hsu, Kay L. H. Wu, Wei-Chia Lee, Steve Leu, Julie Y. H. Chan, You-Lin Tain (Source: Frontiers in Physiology)
Source: Frontiers in Physiology - July 12, 2016 Category: Physiology Source Type: research
Aliskiren suppresses atrial electrical and structural remodeling in a canine model of atrial fibrillation
Abstract
Aliskiren, a direct renin inhibitor is expected to achieve sufficient suppression of renin–angiotensin system. We evaluated the effect of aliskiren on the electrical and structural remodeling in a canine atrial fibrillation (AF) model. Twenty-eight dogs were divided into three groups: (1) pacing control group (n = 12), with continuous atrial rapid pacing for 3 or 6 weeks, (2) pacing + aliskiren group (n = 12), with oral aliskiren (30 mg/kg/day), and (3) sham group (n = 4), no pacing nor drug administration. Electrophysiological properties and AF inducibility were evaluated every week....
Source: Heart and Vessels - July 10, 2016 Category: Cardiology Source Type: research
Simultaneous analysis of aliskiren and hydrochlorothiazide in pharmaceutical preparations and spiked human plasma by HPTLC
Publication date: Available online 13 May 2016 Source:Journal of Taibah University for Science Author(s): Jui J. Pandya, Nejal M. Bhatt, Vijay D. Chavada, Primal Sharma, Mallika Sanyal, Pranav S. Shrivastav A simple, selective and precise method based on HPTLC has been developed for the simultaneous determination of aliskiren and hydrochlorothiazide in a fixed-dose tablet formulation and human plasma. The chromatography was performed on silica gel 60 GF254 plates, with a mobile phase consisting of methanol–chloroform (6:4, v/v). Densitometric analysis of the analytes was carried out at 225nm. Under optimi...
Source: Journal of Taibah University for Science - June 26, 2016 Category: Science Source Type: research
Utilization and Tolerability of Aliskiren (Rasilez) in the Primary Care Setting in England
Aliskiren (Rasilez), a direct renin inhibitor, is indicated for the treatment of essential hypertension. A postmarketing prescription‐event monitoring (PEM) study was conducted in England to monitor the safety and utilization of aliskiren. Summary statistics and event incidence densities were calculated. The cohort consisted of 6385 individuals with a median age of 68 years (interquartile range, 59–76). Aliskiren was largely prescribed for its licensed indication of hypertension (93.3%) and was reported as “effective” by the prescriber in 77.4% of individuals. Frequently reported clinical events during treatment we...
Source: The Journal of Clinical Hypertension - June 2, 2016 Category: Cardiology Authors: Abigail L. Coughtrie, Claire Doe, Deborah Layton, Saad A. W. Shakir Tags: Original Paper Source Type: research
Utilisation and Tolerability of Aliskiren in the Primary Care Setting in England
Aliskiren (Rasilez), a direct renin inhibitor, is indicated for the treatment of essential hypertension. A postmarketing prescription‐event monitoring (PEM) study was conducted in England to monitor the safety and utilization of aliskiren. Summary statistics and event incidence densities were calculated. The cohort consisted of 6385 individuals with a median age of 68 years (interquartile range, 59–76). Aliskiren was largely prescribed for its licensed indication of hypertension (93.3%) and was reported as “effective” by the prescriber in 77.4% of individuals. Frequently reported clinical events during treatment we...
Source: The Journal of Clinical Hypertension - June 2, 2016 Category: Cardiology Authors: Abigail L. Coughtrie, Claire Doe, Deborah Layton, Saad A. W. Shakir Tags: Original Paper Source Type: research
Feasibility of fluorescence energy transfer system for imaging the renoprotective effects of aliskiren in diabetic mice
Conclusion:
Fluorescence resonance energy transfer could provide a new tool for evaluating tissue and plasma enzymatic activity. (Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS)
Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS - May 22, 2016 Category: Biomedical Science Authors: Kidokoro, K., Satoh, M., Itano, S., Kuwabara, A., Sasaki, T., Kashihara, N. Tags: Original Article Source Type: research
Protective Effect of Aliskiren in Experimental Ischemic Stroke: Up-Regulated p-PI3K, p-AKT, Bcl-2 Expression, Attenuated Bax Expression.
This study aimed to investigate the role of ALK and its potential mechanism in cerebral ischemia. C57/BL6 mice were subjected to transient middle cerebral artery occlusion (tMCAO) and treated for 5 days with Vehicle or ALK (10 or 25 mg/kg per day via intragastric administration), whereas Sham-operated animals served as controls. Treatment with ALK significantly improved neurological deficits, infarct volume, brain water content and Nissl bodies after stroke (P < 0.05), which did not affect systemic blood pressure. Furthermore, the protection of ALK was also related to decreased levels of apoptosis in mice by enhance...
Source: Neurochemical Research - May 13, 2016 Category: Neuroscience Authors: Miao J, Wang L, Zhang X, Zhu C, Cui L, Ji H, Liu Y, Wang X Tags: Neurochem Res Source Type: research
Simultaneous Analysis of Aliskiren and Hydrochlorothiazide in their Combined Dosage Form and Spiked Human Plasma by HPTLC
Publication date: Available online 13 May 2016 Source:Journal of Taibah University for Science Author(s): Jui J. Pandya, Nejal M. Bhatt, Vijay D. Chavada, Primal Sharma, Mallika Sanyal, Pranav S. Shrivastav A simple, selective and precise method based on HPTLC has been developed for the simultaneous determination of aliskiren and hydrochlorothiazide in a fixed dose tablet formulation and human plasma. The chromatography was performed on silica gel 60 GF254 plates, with a mobile phase consisting of methanol-chloroform (6:4, v/v). Densitometric analysis of the analytes was carried out at 225nm. Under the opti...
Source: Journal of Taibah University for Science - May 13, 2016 Category: Science Source Type: research
Benefits and Risks of Aliskiren Treatment in Patients With Type 2 Diabetes: Analyses of the 3A Registry
The authors sought to retrospectively analyze the real‐world evidence on aliskiren in diabetic patients with or without concomitant renin‐angiotensin system (RAS) blocker use based on the Registry for Ambulant Therapy With RAS Inhibitors in Hypertension Patients in Germany (3A). Of 14,986 patients included, 3772 patients had diabetes and 28.5% received aliskiren, 14.3% received angiotensin‐converting enzyme (ACE) inhibitors/angiotensin receptor blockers (ARBs), 35.4% received aliskiren plus an ACE inhibitor/ARB, and 10.5% received other drugs. Ambulatory blood pressure (BP) monitoring (baseline BP 148±15.8/84.0±10....
Source: The Journal of Clinical Hypertension - April 19, 2016 Category: Cardiology Authors: Iris Kistner, Uwe Zeymer, Ralf Dechend, Ina Hagedorn, Thomas Riemer, Peter Bramlage, David Pittrow, Jochen Senges, Roland E. Schmieder Tags: Original Paper Source Type: research
Synthesis of Aliskiren
Synfacts 2016; 12: 0448-0448DOI: 10.1055/s-0035-1561983© Georg Thieme Verlag Stuttgart · New YorkArticle in Thieme eJournals:Table of contents | Full text (Source: Synfacts)
Source: Synfacts - April 17, 2016 Category: Chemistry Tags: Synthesis of Natural Products and Potential Drugs Source Type: research
Bovine ovarian cells have (pro)renin receptors and prorenin induces resumption of meiosis in vitro
This study aimed to identify the (pro)renin receptor in the ovary and to assess the effect of prorenin on meiotic resumption. The (pro)renin receptor protein was detected in bovine cumulus-oocyte complexes, theca cells, granulosa cells, and in the corpus luteum. Abundant (pro)renin receptor messenger ribonucleic acid (mRNA) was detected in the oocytes and cumulus cells, while prorenin mRNA was identified in the cumulus cells only. Prorenin at concentrations of 10−10, 10−9, and 10−8 M incubated with oocytes co-cultured with follicular hemisections for 15h caused the resumption of oocyte meiosis. Aliskiren, which inhib...
Source: Peptides - April 6, 2016 Category: Biochemistry Source Type: research
Maximum renal responses to renin inhibition in healthy study participants: VTP-27999 versus aliskiren
Background: Renin inhibition with aliskiren induced the largest increases in renal plasma flow (RPF) in salt-depleted healthy volunteers of all renin–angiotensin system (RAS) blockers. However, given its side-effects at doses higher than 300 mg, no maximum effect of renin inhibition could be established. We hypothesized that VTP-27999, a novel renin inhibitor without major side-effects at high doses, would allow us to establish this.
Methods and results: The effects of escalating VTP-27999 doses (75–600 mg) on RPF, glomerular filtration rate (GFR), and plasma RAS components were compared with those of 300 mg ali...
Source: Journal of Hypertension - April 1, 2016 Category: Cardiology Tags: ORIGINAL PAPERS: Kidney Source Type: research
Evidence for a mitochondrial angiotensin-(1-7) system in the kidney
Evidence for an intracellular renin-angiotensin system (RAS) in various cell organelles now includes the endoplasmic reticulum, nucleus, and mitochondria (Mito). Indeed, angiotensin (ANG) AT1 and AT2 receptor subtypes were functionally linked to Mito respiration and nitric oxide production, respectively, in previous studies. We undertook a biochemical analysis of the Mito RAS from male and female sheep kidney cortex. Mito were isolated by differential centrifugation followed by a discontinuous Percoll gradient and were coenriched in Mito membrane markers VDAC and ATP synthase, but not β-actin or cathepsin B. Two disti...
Source: AJP: Renal Physiology - March 31, 2016 Category: Urology & Nephrology Authors: Wilson, B. A., Nautiyal, M., Gwathmey, T. M., Rose, J. C., Chappell, M. C. Tags: ARTICLES Source Type: research
The Cooperative Effect of Local Angiotensin-II in Liver with Adriamycin Hepatotoxicity on Mitochondria.
CONCLUSIONS Angiotensin-II may contribute to hepatotoxicity of in the ADR via mitochondrial oxidative production, resulting in the attenuation of MMP and ATP production.
PMID: 27019222 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - March 30, 2016 Category: Research Tags: Med Sci Monit Source Type: research
Mp67-19 aliskiren provides incomplete protection of the kidney in unilateral ureteric obstruction in the rat
Ureteric obstruction (UO) is a common urological condition caused by several conditions such as urolithiasis and might lead to renal impairment. UO induces alterations in renin angiotensin system (RAS) which plays an important role in obstruction-induced renal dysfunction. (Source: The Journal of Urology)
Source: The Journal of Urology - March 28, 2016 Category: Urology & Nephrology Authors: Fayez Hammad, Loay Lubbad Tags: Stone Disease: Basic Research & Pathophysiology II Source Type: research
