A head ‐to‐head comparison of personal and professional continuous glucose monitoring systems in people with type 1 diabetes: hypoglycaemia remains the weak spot
This article is protected by copyright. All rights reserved. (Source: Diabetes, Obesity and Metabolism)
Source: Diabetes, Obesity and Metabolism - November 28, 2018 Category: Endocrinology Authors: Othmar Moser,
Marlene Pandis,
Felix Aberer,
Harald Kojzar,
Daniel Hochfellner,
Hesham Elsayed,
Melanie Motschnig,
Thomas Augustin,
Philipp Kreuzer,
Thomas R. Pieber,
Harald Sourij,
Julia K. Mader Tags: BRIEF REPORT Source Type: research
DREAM5: An open ‐label, randomized, cross‐over study to evaluate the safety and efficacy of day and night closed‐loop control using the MD‐Logic automated insulin delivery system compared to sensor augmented pump therapy in patients with type 1 diabetes at home
ConclusionsThe MD ‐Logic system was safe and associated with better glycemic control over SAP therapy for day and night use. The lack of remote monitoring did not lead to safety signals in adapting basal rates as well as in administration of automated bolus corrections.This article is protected by copyright. All rights reserved. (Source: Diabetes, Obesity and Metabolism)
Source: Diabetes, Obesity and Metabolism - November 26, 2018 Category: Endocrinology Authors: Torben Biester,
Judith Nir,
Kerstin Remus,
Alon Farfel,
Ido Muller,
Sarah Biester,
Eran Atlas,
Klemen Dovc,
Natasa Bratina,
Olga Kordonouri,
Tadej Battelino,
Moshe Philip,
Thomas Danne,
Revital Nimri Tags: ORIGINAL ARTICLE Source Type: research
Exenatide use and Incidence of Pancreatic and Thyroid Cancer: A Retrospective Cohort Study
This article is protected by copyright. All rights reserved. (Source: Diabetes, Obesity and Metabolism)
Source: Diabetes, Obesity and Metabolism - November 25, 2018 Category: Endocrinology Authors: Caihua Liang,
Monica L. Bertoia,
Yan Ding,
C. Robin Clifford,
Qing Qiao,
Joshua J. Gagne,
David D. Dore Tags: ORIGINAL ARTICLE Source Type: research
Identification of autoimmune type 1 diabetes and multiple organ ‐specific autoantibodies in adult‐onset non‐insulin requiring diabetes in China: a population based multicenter national wide survey
ConclusionsA proportion of phenotypic T2D patients in China have adult ‐onset autoimmune diabetes with diabetes‐associated autoantibodies and theymay be at risk of developing other organ ‐specific autoimmune diseases. Therefore, itmay be clinically relevant to consider screening such Chinese populations.This article is protected by copyright. All rights reserved. (Source: Diabetes, Obesity and Metabolism)
Source: Diabetes, Obesity and Metabolism - November 24, 2018 Category: Endocrinology Authors: Yufei Xiang,
Gan Huang,
Yaxi Zhu,
Xuan Zuo,
Xinyuan Liu,
Qiong Feng,
Xia Li,
Tubao Yang,
Juming Lu,
Zhongyan Shan,
Jie Liu,
Haoming Tian,
Qiuhe Ji,
Dalong Zhu,
Jiapu Ge,
Lixiang Lin,
Li Chen,
Xiaohui Guo,
Zhigang Zhao,
Qiang Li,
Jianpi Tags: ORIGINAL ARTICLE Source Type: research
Reflections on the Sulphonylurea Story. A Drug Class at Risk of Extinction? Or A Drug Class Worth Reviving?
This article is protected by copyright. All rights reserved. (Source: Diabetes, Obesity and Metabolism)
Source: Diabetes, Obesity and Metabolism - November 24, 2018 Category: Endocrinology Authors: RLM Cordiner,
ER Pearson Tags: REVIEW ARTICLE Source Type: research
Glycaemic Efficacy and Safety of Linagliptin compared to Basal ‐Bolus Insulin Regimen in Patients with Type 2 Diabetes Undergoing Non‐Cardiac Surgery: A Multicenter Randomized Clinical Trial
ConclusionsIn patients with T2D undergoing non ‐cardiac surgery presenting with mild to moderate hyperglycaemia (BG<11.1 mmol/L), daily linagliptin is a safe and effective alternative to multi ‐dose insulin therapy resulting in similar glucose control with lower hypoglycaemia.This article is protected by copyright. All rights reserved. (Source: Diabetes, Obesity and Metabolism)
Source: Diabetes, Obesity and Metabolism - November 20, 2018 Category: Endocrinology Authors: Priyathama Vellanki,
Neda Rasouli,
David Baldwin,
Sara Alexanian,
Isabel Anzola,
Maria Urrutia,
Saumeth Cardona,
Limin Peng,
Francisco J. Pasquel,
Guillermo E. Umpierrez,
Linagliptin Inpatient Research Group Tags: ORIGINAL ARTICLE Source Type: research
Comparison of the HAT study, the largest global hypoglycaemia study to date, with similar large real ‐world studies
ConclusionsThe HAT data on hypoglycaemia incidence were comparable with those from other real ‐world studies and indicate a high incidence of hypoglycaemia among insulin‐treated patients. Differences in rates between studies are mostly explained by differences in patient populations and study methodology. The goal of reducing hypoglycaemia should be a target for continued educational and evidence‐based pharmacological interventions.This article is protected by copyright. All rights reserved. (Source: Diabetes, Obesity and Metabolism)
Source: Diabetes, Obesity and Metabolism - November 20, 2018 Category: Endocrinology Authors: Ulrik Pedersen ‐Bjergaard,
Saud Alsifri,
Ronnie Aronson,
Maja Cigrovski Berković,
Gagik Galstyan,
Helge Gydesen,
Jesper Barner Lekdorf,
Bernhard Ludvik,
Erik Moberg,
Ambady Ramachandran,
Kamlesh Khunti Tags: ORIGINAL ARTICLE Source Type: research
The Impact of Metformin Use on the Cardiovascular Effects of DPP ‐4 Inhibitors: an Analysis of Medicare Claims Data 2007‐2015
ConclusionsIncidence rate differences in multiple cardiovascular outcomes appeared more favorable when DPP ‐4i initiation occurred in the presence of metformin, suggesting a possible interaction between DPP‐4i and metformin.This article is protected by copyright. All rights reserved. (Source: Diabetes, Obesity and Metabolism)
Source: Diabetes, Obesity and Metabolism - November 20, 2018 Category: Endocrinology Authors: Matthew J. Crowley,
Mugdha Gokhale,
Virginia Pate,
Til St ürmer,
John B. Buse Tags: ORIGINAL ARTICLE Source Type: research
Gut microbiota and obesity: An opportunity to alter obesity through faecal microbiota transplant (FMT)
Obesity is a global pandemic with immense health consequences for individuals and societies. Multiple factors, including environmental influences and genetic predispositions, are known to affect the development of obesity. Despite an increasing understanding of the factors driving the obesity epidemic, therapeutic interventions to prevent or reverse obesity are limited in their impact. Manipulation of the human gut microbiome provides a new potential therapeutic approach in the fight against obesity. Specific gut bacteria and their metabolites are known to affect host metabolism and feeding behaviour, and dysbiosis of this...
Source: Diabetes, Obesity and Metabolism - November 20, 2018 Category: Endocrinology Authors: Patrick Lee,
Bruce R. Yacyshyn,
Mary B. Yacyshyn Tags: REVIEW ARTICLE Source Type: research
Of mice and men: is there a future for metformin in the treatment of hepatic steatosis?
This article is protected by copyright. All rights reserved. (Source: Diabetes, Obesity and Metabolism)
Source: Diabetes, Obesity and Metabolism - November 19, 2018 Category: Endocrinology Authors: C.J Green,
T Marjot,
J.W Tomlinson,
L Hodson Tags: REVIEW ARTICLE Source Type: research
Liraglutide pharmacotherapy reduces body weight and improves glycemic control in juvenile obese / hyperglycemic male and female rats
ConclusionThese preclinical data suggest that maternal and early ‐life consumption of HFSD increases caloric intake, body weight gain and hyperglycemia, a collective set of unwanted metabolic effects that appear to be treatable in juveniles with liraglutide pharmacotherapy intervention.This article is protected by copyright. All rights reserved. (Source: Diabetes, Obesity and Metabolism)
Source: Diabetes, Obesity and Metabolism - November 19, 2018 Category: Endocrinology Authors: Claudia G. Liberini,
Rinzin Lhamo,
Misgana Ghidewon,
Tyler Ling,
Nina Juntereal,
Jack Chen,
Anh Cao,
Lauren M. Stein,
Matthew R. Hayes Tags: ORIGINAL ARTICLE Source Type: research
Urinary glucose excretion after dapagliflozin treatment: an exposure –response modeling comparison between Japanese and non‐Japanese patients diagnosed with Type 1 Diabetes Mellitus
ConclusionsThere was no difference in dapagliflozin exposure –response in Japanese and non‐Japanese patients with T1DM once differences in renal function, glycemic control and insulin dose reductions between studies were considered. Therefore, no dose adjustment is recommended in Japanese patients with T1DM.This article is protected by copyright. All rights reserved. (Source: Diabetes, Obesity and Metabolism)
Source: Diabetes, Obesity and Metabolism - November 19, 2018 Category: Endocrinology Authors: Victor Sokolov,
Tatiana Yakovleva,
Shinya Ueda,
Joanna Parkinson,
David W. Boulton,
Robert C. Penland,
Weifeng Tang Tags: ORIGINAL ARTICLE Source Type: research
Prevalence of heart failure and diagnostic value of MR ‐proANP in outpatients with type 2 diabetes
In conclusion, HFrEF was rare among outpatients with T2DM, MR ‐proANP rules out HFrEF and adds independent information in diagnosing HF in patients reporting dyspnea.This article is protected by copyright. All rights reserved. (Source: Diabetes, Obesity and Metabolism)
Source: Diabetes, Obesity and Metabolism - November 16, 2018 Category: Endocrinology Authors: Jesper Jensen,
Morten Schou,
Caroline Kistorp,
Jens Faber,
Tine W. Hansen,
Magnus T. Jensen,
Henrik U. Andersen,
Peter Rossing,
Tina Vilsb øll,
Peter G. Jørgensen Tags: BRIEF REPORT Source Type: research
Effect of Canagliflozin Treatment on Hepatic Triglyceride Content and Glucose Metabolism in Patients with Type 2 Diabetes
CONCLUSIONSCanagliflozin improves hepatic insulin sensitivity and insulin secretion and clearance in patients with T2DM. IHTG decreases in proportion to the magnitude of weight loss, which tended to be greater and occur more often with canagliflozin.This article is protected by copyright. All rights reserved. (Source: Diabetes, Obesity and Metabolism)
Source: Diabetes, Obesity and Metabolism - November 16, 2018 Category: Endocrinology Authors: Kenneth Cusi,
Fernando Bril,
Diana Barb,
David Polidori,
Sue Sha,
Atalanta Ghosh,
Kristin Farrell,
Nishanth E. Sunny,
Srilaxmi Kalavalapalli,
Jeremy Pettus,
Theodore P. Ciaraldi,
Sunder Mudaliar,
Robert R. Henry Tags: ORIGINAL ARTICLE Source Type: research
The effect of glycemic control on cardiovascular disease in individuals with type 2 diabetes with pre ‐existing cardiovascular disease ‐ a systematic review and meta‐analysis
In conclusion, in people with diabetes and pre‐existing CVD, intensive glucose control vs. standard care had a neutral effect on incident CV events.This article is protected by copyright. All rights reserved. (Source: Diabetes, Obesity and Metabolism)
Source: Diabetes, Obesity and Metabolism - November 13, 2018 Category: Endocrinology Authors: Yael Barer,
Ohad Cohen,
Tali Cukierman ‐Yaffe Tags: BRIEF REPORT Source Type: research
