Authenticity study of commercial samples of St. John's wort by paper spray ionization mass spectrometry and chemometric tools
AbstractHypericum perforatum L. (St. John's wort) is one of the world's most consumed medicinal plants for treating depression and psychiatric disorders. Counterfeiting can occur in the medicinal plant trade, either due to the lack of active ingredients or the addition of substances not mentioned on the labels, often without therapeutic value or even harmful to health. Hence, 43 samples of St. John's wort commercially acquired in different Brazilian regions and other countries were analyzed by paper spray ionization mass spectrometry (PS-MS) and modeled by principal component analysis. Hence, samples (plants, capsules, and...
Source: Journal of Mass Spectrometry - July 13, 2023 Category: Chemistry Authors: Ana Gabriella Carvalho Miguita,
Rodinei Augusti,
Marcelo Martins Sena,
Cl ésia Cristina Nascentes Tags: RESEARCH ARTICLE Source Type: research
Treatment of Mood and Depressive Disorders With Complementary and Alternative Medicine: Efficacy Review
AbstractThere has been a steady increase in people with symptoms of depression over the past several years (since 2011). The further increase in stress and depression in the early part of the COVID-19 pandemic was accompanied by an increase in unmet mental health needs. Many have turned to complementary and alternative medicine (CAM) therapies such as bright-light therapy, yoga, meditation, and dietary supplements like St. John's wort or folic acid. The reliability of evidence for use of CAM therapies for depression has remained low. There are few randomized controlled trials (RCTs) in the current literature and poor metho...
Source: Journal of Midwifery and Women's Health - June 25, 2023 Category: Midwifery Authors: Jasmine B.R. Cutler,
Olivia Pane,
Simran K. Panesar,
Wendy Updike,
Thea R. Moore Tags: Review Source Type: research
< em > In Vitro < /em > Antibacterial and Phytochemical Screening of < em > Hypericum perforatum < /em > Extract as Potential Antimicrobial Agents against Multi-Drug-Resistant (MDR) Strains of Clinical Origin
CONCLUSION: Future inhibitors that target MDR strains may be revealed by these findings. Additionally, the extracts that were put to the test demonstrated strong antioxidant effects as shown by DPPH or ABTS radical-scavenging assays.PMID:37090192 | PMC:PMC10121355 | DOI:10.1155/2023/6934398 (Source: Biomed Res)
Source: Biomed Res - April 24, 2023 Category: Research Authors: Momen M Sherif Hussien H Elshikh Marwa M Abdel-Aziz Mahmoud M Elaasser Mohammed Yosri Source Type: research
Intestinal permeability and gut microbiota interactions of pharmacologically active compounds in valerian and St. John's wort
Biomed Pharmacother. 2023 Apr 5;162:114652. doi: 10.1016/j.biopha.2023.114652. Online ahead of print.ABSTRACTPhytomedicines such as valerian and St. John's wort are widely used for the treatment of sleeping disorders, anxiety and mild depression. They are perceived as safe alternatives to synthetic drugs, but limited information is available on the intestinal absorption and interaction with human intestinal microbiota of pharmacologically relevant constituents valerenic acid in valerian, and hyperforin and hypericin in St. John's wort. The intestinal permeability of these compounds and the antidepressant and anxiolytic dru...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - April 7, 2023 Category: Drugs & Pharmacology Authors: Antoine Chauveau Andrea Treyer Annelies Geirnaert Lea Bircher Angela Babst Vanessa Fabienne Abegg Ana Paula Sim ões-Wüst Christophe Lacroix Olivier Potterat Matthias Hamburger Source Type: research
Impact of St. John's wort extract Ze 117 on stress induced changes in the lipidome of PBMC
CONCLUSION: The increase in membrane rigidity after Ze 117 treatment and therefore the ability to normalize membrane structure points to a new mechanism of antidepressant action of the extract.PMID:37029349 | DOI:10.1186/s10020-023-00644-3 (Source: Molecular Medicine)
Source: Molecular Medicine - April 7, 2023 Category: Molecular Biology Authors: Hendrik Bussmann Swen Bremer Hanns H äberlein Georg Boonen J ürgen Drewe Veronika Butterweck Sebastian Franken Source Type: research
Intestinal permeability and gut microbiota interactions of pharmacologically active compounds in valerian and St. John's wort
Biomed Pharmacother. 2023 Apr 5;162:114652. doi: 10.1016/j.biopha.2023.114652. Online ahead of print.ABSTRACTPhytomedicines such as valerian and St. John's wort are widely used for the treatment of sleeping disorders, anxiety and mild depression. They are perceived as safe alternatives to synthetic drugs, but limited information is available on the intestinal absorption and interaction with human intestinal microbiota of pharmacologically relevant constituents valerenic acid in valerian, and hyperforin and hypericin in St. John's wort. The intestinal permeability of these compounds and the antidepressant and anxiolytic dru...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - April 7, 2023 Category: Drugs & Pharmacology Authors: Antoine Chauveau Andrea Treyer Annelies Geirnaert Lea Bircher Angela Babst Vanessa Fabienne Abegg Ana Paula Sim ões-Wüst Christophe Lacroix Olivier Potterat Matthias Hamburger Source Type: research
IJERPH, Vol. 20, Pages 5298: Adaptogens on Depression-Related Outcomes: A Systematic Integrative Review and Rationale of Synergism with Physical Activity
A. Bonilla
Depression is considered the most important disorder affecting mental health. The aim of this systematic integrative review was: (i) to describe the effects of supplementation with adaptogens on variables related to depression in adults; and (ii) to discuss the potential combination with physical exercise to aid planning and commissioning future clinical research. An integrative review was developed complementing the Preferred Reporting Items for Systematic reviews and Meta-Analyses statement (PROSPERO registration: CRD42021249682). A total of 41 articles met the inclusion criteria. With a Price index of 46...
Source: International Journal of Environmental Research and Public Health - March 28, 2023 Category: Environmental Health Authors: Isabel A. S ánchez Jaime A. Cuchimba Mar ía C. Pineda Yenny P. Arg üello Jana Ko čí Richard B. Kreider Jorge L. Petro Diego A. Bonilla Tags: Systematic Review Source Type: research
Correlation Between Toxic Elements and Pesticide Residues in Medicinal Herbs Available in Pharmaceutical Market
Biol Trace Elem Res. 2023 Mar 25. doi: 10.1007/s12011-023-03642-y. Online ahead of print.ABSTRACTThe use of medicinal plants for self-medication of minor health conditions has become a widespread practice in contemporary society. Few consumes, however, question the contamination of these products with toxic factors resulting from the planet's increasingly polluted environment. This paper presents the levels of five toxic elements (As, Cr, Pb, Cd, and Hg) and nine organochlorine pesticides (hexachlorobenzene (HCB), lindane, heptachor, aldrin, dieldrin, endrin, p,p'DDE, p,p'DDD, and p,p'DDT) in 14 brands of regularly consume...
Source: Biological Trace Element Research - March 25, 2023 Category: Biology Authors: Mihaela Mirela Bratu Semaghiul Birghila Corina Birghila Valentina Coatu Diana Andreea Danilov Naliana Lupascu Dan Vasiliu Marius Daniel Radu Source Type: research
Correlation Between Toxic Elements and Pesticide Residues in Medicinal Herbs Available in Pharmaceutical Market
Biol Trace Elem Res. 2023 Mar 25. doi: 10.1007/s12011-023-03642-y. Online ahead of print.ABSTRACTThe use of medicinal plants for self-medication of minor health conditions has become a widespread practice in contemporary society. Few consumes, however, question the contamination of these products with toxic factors resulting from the planet's increasingly polluted environment. This paper presents the levels of five toxic elements (As, Cr, Pb, Cd, and Hg) and nine organochlorine pesticides (hexachlorobenzene (HCB), lindane, heptachor, aldrin, dieldrin, endrin, p,p'DDE, p,p'DDD, and p,p'DDT) in 14 brands of regularly consume...
Source: Biological Trace Element Research - March 25, 2023 Category: Biology Authors: Mihaela Mirela Bratu Semaghiul Birghila Corina Birghila Valentina Coatu Diana Andreea Danilov Naliana Lupascu Dan Vasiliu Marius Daniel Radu Source Type: research
Investigation of the combined effects of cadmium chloride, silver nitrate, lead nitrate, methyl jasmonate, and salicylic acid on morphometric and biochemical characteristics of St. John's wort
Physiol Mol Biol Plants. 2023 Feb;29(2):173-184. doi: 10.1007/s12298-023-01281-0. Epub 2023 Feb 3.ABSTRACTHypericum perforatum L., is a sprawling, leafy herb that grows in open, disturbed areas, known as St. John's wort, has a variety of secondary metabolites that can be used for medicinal and therapeutic purposes. Heavy metals have become the most dangerous pollutants in the environment. The effect of cadmium chloride, lead nitrate, silver nitrate, methyl jasmonate, and salicylic acid was studied on several morphometric and biochemical features of St. John's wort simultaneously using the Taguchi statistical method. The re...
Source: Mol Biol Cell - March 6, 2023 Category: Molecular Biology Authors: Ahmad Abdollahi Nader Farsad-Akhtar Elham Mohajel Kazemi Maryam Kolahi Source Type: research
Investigation of the combined effects of cadmium chloride, silver nitrate, lead nitrate, methyl jasmonate, and salicylic acid on morphometric and biochemical characteristics of St. John's wort
Physiol Mol Biol Plants. 2023 Feb;29(2):173-184. doi: 10.1007/s12298-023-01281-0. Epub 2023 Feb 3.ABSTRACTHypericum perforatum L., is a sprawling, leafy herb that grows in open, disturbed areas, known as St. John's wort, has a variety of secondary metabolites that can be used for medicinal and therapeutic purposes. Heavy metals have become the most dangerous pollutants in the environment. The effect of cadmium chloride, lead nitrate, silver nitrate, methyl jasmonate, and salicylic acid was studied on several morphometric and biochemical features of St. John's wort simultaneously using the Taguchi statistical method. The re...
Source: Mol Biol Cell - March 6, 2023 Category: Molecular Biology Authors: Ahmad Abdollahi Nader Farsad-Akhtar Elham Mohajel Kazemi Maryam Kolahi Source Type: research
Molecules, Vol. 28, Pages 2376: Different Types of Hypericum perforatum cvs. (Elixir, Helos, Topas) In Vitro Cultures: A Rich Source of Bioactive Metabolites and Biological Activities of Biomass Extracts
ina Ekiert
Microshoot agitated and bioreactor cultures (PlantForm bioreactors) of three Hypericum perforatum cultivars (Elixir, Helos, Topas) were maintained in four variants of Murashige and Skoog medium (MS) supplemented with 6-benzylaminopurine (BAP) and 1-naphthaleneacetic acid (NAA) (in the range of 0.1&ndash;3.0 mg/L). In both types of in vitro cultures, the accumulation dynamics of phenolic acids, flavonoids, and catechins were investigated during 5- and 4-week growth cycles, respectively. The contents of metabolites in methanolic extracts from biomasses collected in 1-week intervals were estimated by HP...
Source: Molecules - March 4, 2023 Category: Chemistry Authors: Inga Kwiecie ń Natalizia Miceli El żbieta Kędzia Emilia Cav ò Maria Fernanda Taviano Ludger Beerhues Halina Ekiert Tags: Article Source Type: research
Ratio-dependent effects of photoactivated hypericin and manumycin A on their genotoxic and mutagenic potential
In this study we evaluated potential cytotoxic (via trypan blue exclusion test), genotoxic (via DNA-topology and comet assays), and mutagenic effects (via bacterial reverse mutation test) of these compounds and their combinations considering the molecular mechanism of their action in cell-free and cellular systems. Our results did not reveal neither cytotoxic nor mutagenic activities of tested compounds and their combinations. Regarding the genotoxic potential, no damage of plasmid DNA in cell-free system was detected. On the other hand, photoactivated hypericin and manumycin A were able to induce primary DNA damage in hum...
Source: Chemico-Biological Interactions - February 24, 2023 Category: Molecular Biology Authors: Ter ézia Zajičková Stanislav Kyzek Ivana Ďurovcová Andrea Ševčovičová Eli ška Gálová Source Type: research
Ratio-dependent effects of photoactivated hypericin and manumycin A on their genotoxic and mutagenic potential
In this study we evaluated potential cytotoxic (via trypan blue exclusion test), genotoxic (via DNA-topology and comet assays), and mutagenic effects (via bacterial reverse mutation test) of these compounds and their combinations considering the molecular mechanism of their action in cell-free and cellular systems. Our results did not reveal neither cytotoxic nor mutagenic activities of tested compounds and their combinations. Regarding the genotoxic potential, no damage of plasmid DNA in cell-free system was detected. On the other hand, photoactivated hypericin and manumycin A were able to induce primary DNA damage in hum...
Source: Chemico-Biological Interactions - February 24, 2023 Category: Molecular Biology Authors: Ter ézia Zajičková Stanislav Kyzek Ivana Ďurovcová Andrea Ševčovičová Eli ška Gálová Source Type: research
Ratio-dependent effects of photoactivated hypericin and manumycin A on their genotoxic and mutagenic potential
In this study we evaluated potential cytotoxic (via trypan blue exclusion test), genotoxic (via DNA-topology and comet assays), and mutagenic effects (via bacterial reverse mutation test) of these compounds and their combinations considering the molecular mechanism of their action in cell-free and cellular systems. Our results did not reveal neither cytotoxic nor mutagenic activities of tested compounds and their combinations. Regarding the genotoxic potential, no damage of plasmid DNA in cell-free system was detected. On the other hand, photoactivated hypericin and manumycin A were able to induce primary DNA damage in hum...
Source: Chemico-Biological Interactions - February 24, 2023 Category: Molecular Biology Authors: Ter ézia Zajičková Stanislav Kyzek Ivana Ďurovcová Andrea Ševčovičová Eli ška Gálová Source Type: research
