Two new constituents from the endophyte of < em > Alternaria alternata < /em > and its anti-neuroinflammatory activity guided by molecular docking
Nat Prod Res. 2023 Dec 11:1-11. doi: 10.1080/14786419.2023.2291705. Online ahead of print.ABSTRACTTwo new compounds, 3-hydroxy-1-(3-hydroxy-5-methoxyphenyl)-2-methyl propan-1-one (1) and 1,2,6-trihydroxy-8-methoxy-2,3,3a,9b-tetrahydrocyclopenta[c] isochromen-5(1H)-one (2), along with nine known compounds 3-11, involving pyranones, phenylpropenoids and alkaloids, were obtained from Alternaria alternata, an endophyte isolated from Hypericum perforatum L. The structures were elucidated by extensive spectroscopic analyses, including 1D NMR, 2D NMR, HRESIMS, IR, UV spectroscopy. The absolute configuration was established via sp...
Source: Natural Product Research - December 12, 2023 Category: Biochemistry Authors: Xiliang Yang Long Chen Guoqing Wan Jinping Liu Binjie Zhao Hucheng Zhu Yonghui Zhang Source Type: research
Two new constituents from the endophyte of < em > Alternaria alternata < /em > and its anti-neuroinflammatory activity guided by molecular docking
Nat Prod Res. 2023 Dec 11:1-11. doi: 10.1080/14786419.2023.2291705. Online ahead of print.ABSTRACTTwo new compounds, 3-hydroxy-1-(3-hydroxy-5-methoxyphenyl)-2-methyl propan-1-one (1) and 1,2,6-trihydroxy-8-methoxy-2,3,3a,9b-tetrahydrocyclopenta[c] isochromen-5(1H)-one (2), along with nine known compounds 3-11, involving pyranones, phenylpropenoids and alkaloids, were obtained from Alternaria alternata, an endophyte isolated from Hypericum perforatum L. The structures were elucidated by extensive spectroscopic analyses, including 1D NMR, 2D NMR, HRESIMS, IR, UV spectroscopy. The absolute configuration was established via sp...
Source: Natural Product Research - December 12, 2023 Category: Biochemistry Authors: Xiliang Yang Long Chen Guoqing Wan Jinping Liu Binjie Zhao Hucheng Zhu Yonghui Zhang Source Type: research
Hyperipersions A-C, three new acylphloroglucinols from the branches and leaves of < em > Hypericum perforatum < /em > L. with antiangiogenic activities
Nat Prod Res. 2023 Dec 5:1-7. doi: 10.1080/14786419.2023.2278176. Online ahead of print.ABSTRACTThree new acylphloroglucinols were isolated from the branches and leaves of Hypericum perforatum L., named as hyperipersions A-C (1-3), together with three known compounds which were identified as elegaphenone (4), 2,6-dihydroxy-3,4-dimethylbenzoic acid methyl ester (5) and 2,3-methylenedioxyxanthone (6), respectively. The structures of isolated compounds were determined by UV, IR, HR-ESI-MS, NMR analysis. Their antiangiogenic activities were studied against HUVECs. The IC50 value of compound 3 was 2.39 ± 0.21 μM against HUVEC...
Source: Natural Product Research - December 5, 2023 Category: Biochemistry Authors: Hao Zhang Kunling Wang Fan Chen Source Type: research
Hyperforin modulates MAPK/CCL11 signaling to reduce the inflammatory response of nasal mucosal epithelial cells caused by allergic rhinitis by targeting BCL6
Exp Ther Med. 2023 Oct 27;26(6):579. doi: 10.3892/etm.2023.12278. eCollection 2023 Dec.ABSTRACTHyperforin is a type of bicyclic tetraketone with four isoprenoid chains extracted from Hypericum perforatum L. that has multiple biological activities such as anti-diabetes, antitumor and anti-inflammation. However, the role and potential mechanism of hyperforin in allergic rhinitis (AR) remains to be clarified. In the present study, cell viability was analyzed using Cell Counting Kit-8 assay, while inflammation was detected using ELISA and reverse transcription-quantitative PCR. Epithelial cell barrier damage was measured using...
Source: Experimental and Therapeutic Medicine - November 29, 2023 Category: General Medicine Authors: Chen Xu Wen Su Source Type: research
