Dietary supplements and bleeding
In conclusion, physicians must be aware of the potential anticoagulant effects of these supplements. It is imperative to report dietary and herbal supplement usage to physicians and is best to discontinue nonessential supplement use 2 weeks prior to surgery.PMID:36304597 | PMC:PMC9586694 | DOI:10.1080/08998280.2022.2121575 (Source: Baylor University Medical Center Proceedings)
Source: Baylor University Medical Center Proceedings - October 28, 2022 Category: Universities & Medical Training Authors: Jess Hatfield Saadeddine Saad Chad Housewright Source Type: research
Dietary supplements and bleeding
In conclusion, physicians must be aware of the potential anticoagulant effects of these supplements. It is imperative to report dietary and herbal supplement usage to physicians and is best to discontinue nonessential supplement use 2 weeks prior to surgery.PMID:36304597 | PMC:PMC9586694 | DOI:10.1080/08998280.2022.2121575 (Source: Baylor University Medical Center Proceedings)
Source: Baylor University Medical Center Proceedings - October 28, 2022 Category: Universities & Medical Training Authors: Jess Hatfield Saadeddine Saad Chad Housewright Source Type: research
Dietary supplements and bleeding
In conclusion, physicians must be aware of the potential anticoagulant effects of these supplements. It is imperative to report dietary and herbal supplement usage to physicians and is best to discontinue nonessential supplement use 2 weeks prior to surgery.PMID:36304597 | PMC:PMC9586694 | DOI:10.1080/08998280.2022.2121575 (Source: Baylor University Medical Center Proceedings)
Source: Baylor University Medical Center Proceedings - October 28, 2022 Category: Universities & Medical Training Authors: Jess Hatfield Saadeddine Saad Chad Housewright Source Type: research
Dietary supplements and bleeding
In conclusion, physicians must be aware of the potential anticoagulant effects of these supplements. It is imperative to report dietary and herbal supplement usage to physicians and is best to discontinue nonessential supplement use 2 weeks prior to surgery.PMID:36304597 | PMC:PMC9586694 | DOI:10.1080/08998280.2022.2121575 (Source: Baylor University Medical Center Proceedings)
Source: Baylor University Medical Center Proceedings - October 28, 2022 Category: Universities & Medical Training Authors: Jess Hatfield Saadeddine Saad Chad Housewright Source Type: research
Natural Products for the Treatment of Drug Addiction: a Narrative review
Chem Biodivers. 2022 Oct 26. doi: 10.1002/cbdv.202200702. Online ahead of print.ABSTRACTDrug addiction is considered a chronic disorder affecting the individual's life, his/her family and society. Up till now the treatment of drug addiction is considered a problematic issue. Synthetic drugs available for the treatment of drug addiction are few, of limited efficacy and associated with serious side effects. Therefore, there is a continuous search for better therapeutic agents for drug addiction. Natural products represent a promising source for drug addiction treatment. This review summaries drug addiction definition, its me...
Source: Chemistry and Biodiversity - October 26, 2022 Category: Biochemistry Authors: Mona Raslan Source Type: research
Natural Products for the Treatment of Drug Addiction: a Narrative review
Chem Biodivers. 2022 Oct 26. doi: 10.1002/cbdv.202200702. Online ahead of print.ABSTRACTDrug addiction is considered a chronic disorder affecting the individual's life, his/her family and society. Up till now the treatment of drug addiction is considered a problematic issue. Synthetic drugs available for the treatment of drug addiction are few, of limited efficacy and associated with serious side effects. Therefore, there is a continuous search for better therapeutic agents for drug addiction. Natural products represent a promising source for drug addiction treatment. This review summaries drug addiction definition, its me...
Source: Chemistry and Biodiversity - October 26, 2022 Category: Biochemistry Authors: Mona Raslan Source Type: research
Rapid screening of α-glucosidase inhibitors in Hypericum perforatum L. by bio-affinity chromatography coupled with UPLC/MS
In this study, the extract of Hypericum perforatum L. (HPE) has been confirmed to have α-glucosidase inhibitory activity in vitro and in vivo. Seven active compounds including rutin, hyperoside, isoquercitrin, avicularin, quercitrin, quercetin, and biapigenin were screened based on a bio-affinity chromatography column with α-glucosidase enzyme-conjugated solid phase and UPLC/MS, which exhibited excellent α-glycosidase inhibitory effects by the determined IC50 values. The mechanism of α-glycosidase inhibitory activity of biapigenin was studied for the first time. The results showed that biapigenin was a high potential r...
Source: Biomedical Chromatography : BMC - October 20, 2022 Category: Biomedical Science Authors: Qi Dong Na Hu Huilan Yue Honglun Wang Yue Wei Source Type: research
Rapid screening of α-glucosidase inhibitors in Hypericum perforatum L. by bio-affinity chromatography coupled with UPLC/MS
In this study, the extract of Hypericum perforatum L. (HPE) has been confirmed to have α-glucosidase inhibitory activity in vitro and in vivo. Seven active compounds including rutin, hyperoside, isoquercitrin, avicularin, quercitrin, quercetin, and biapigenin were screened based on a bio-affinity chromatography column with α-glucosidase enzyme-conjugated solid phase and UPLC/MS, which exhibited excellent α-glycosidase inhibitory effects by the determined IC50 values. The mechanism of α-glycosidase inhibitory activity of biapigenin was studied for the first time. The results showed that biapigenin was a high potential r...
Source: Biomedical Chromatography : BMC - October 20, 2022 Category: Biomedical Science Authors: Qi Dong Na Hu Huilan Yue Honglun Wang Yue Wei Source Type: research
The efficacy and safety of St. John's wort extract in depression therapy compared to SSRIs in adults: A meta-analysis of randomized clinical trials
CONCLUSION: Our research supports the use of SJW as it reduced the number of depressive patients and their HAMD scores while having fewer risks and side effects than conventional medications.PMID:36226689 | DOI:10.17219/acem/152942 (Source: Adv Data)
Source: Adv Data - October 13, 2022 Category: Epidemiology Authors: Xin Zhao Hong Zhang Yanyan Wu Chun Yu Source Type: research
The efficacy and safety of St. John's wort extract in depression therapy compared to SSRIs in adults: A meta-analysis of randomized clinical trials
CONCLUSION: Our research supports the use of SJW as it reduced the number of depressive patients and their HAMD scores while having fewer risks and side effects than conventional medications.PMID:36226689 | DOI:10.17219/acem/152942 (Source: Adv Data)
Source: Adv Data - October 13, 2022 Category: Epidemiology Authors: Xin Zhao Hong Zhang Yanyan Wu Chun Yu Source Type: research
Evaluation of the Herb-Drug Interaction Potential of Commonly Used Botanicals on the US Market with Regard to PXR- and AhR-Mediated Influences on CYP3A4 and CYP1A2
In this study, hydroethanolic extracts of 30 top-selling botanicals (herbs) commonly used as ingredients of herbal dietary supplements in the US were screened for their potential to activate the human pregnane X receptor (hPXR) and human aryl hydrocarbon receptor (hAhR) and to increase the activities of hPXR- and hAhR-regulated drug metabolizing cytochrome P450 enzymes (i.e., CYP3A4 and CYP1A2, respectively). Of the 30 botanicals tested, 21 induced PXR and 29 induced AhR transcriptional activities. Out of the 21 botanicals that induced hPXR transcriptional activity, 14 yielded >50% induction in CYP3A4 activity at concen...
Source: Journal of Dietary Supplements - August 26, 2022 Category: Nutrition Authors: Mona H Haron Olivia Dale Katherine Martin Bharathi Avula Amar G Chittiboyina Ikhlas A Khan Bill J Gurley Shabana I Khan Source Type: research
Antidepressant and Cardioprotective Effects of Self-Nanoemulsifying Self-Nanosuspension Loaded with Hypericum perforatum on Post-Myocardial Infarction Depression in Rats
In conclusion, HP.SNESNS (100 mg/kg) exerted antidepressant and cardioprotective activities in the post-MI depression rat model.PMID:36028598 | DOI:10.1208/s12249-022-02387-6 (Source: AAPS PharmSciTech)
Source: AAPS PharmSciTech - August 26, 2022 Category: Drugs & Pharmacology Authors: Heba M A Khalil Dina B Mahmoud Riham A El-Shiekh Alaa F Bakr Amira A Boseila Sally Mehanna Reham A Naggar Hesham A Eliwa Source Type: research
Evaluation of the Herb-Drug Interaction Potential of Commonly Used Botanicals on the US Market with Regard to PXR- and AhR-Mediated Influences on CYP3A4 and CYP1A2
In this study, hydroethanolic extracts of 30 top-selling botanicals (herbs) commonly used as ingredients of herbal dietary supplements in the US were screened for their potential to activate the human pregnane X receptor (hPXR) and human aryl hydrocarbon receptor (hAhR) and to increase the activities of hPXR- and hAhR-regulated drug metabolizing cytochrome P450 enzymes (i.e., CYP3A4 and CYP1A2, respectively). Of the 30 botanicals tested, 21 induced PXR and 29 induced AhR transcriptional activities. Out of the 21 botanicals that induced hPXR transcriptional activity, 14 yielded >50% induction in CYP3A4 activity at concen...
Source: Journal of Dietary Supplements - August 26, 2022 Category: Nutrition Authors: Mona H Haron Olivia Dale Katherine Martin Bharathi Avula Amar G Chittiboyina Ikhlas A Khan Bill J Gurley Shabana I Khan Source Type: research
Antidepressant and Cardioprotective Effects of Self-Nanoemulsifying Self-Nanosuspension Loaded with Hypericum perforatum on Post-Myocardial Infarction Depression in Rats
In conclusion, HP.SNESNS (100 mg/kg) exerted antidepressant and cardioprotective activities in the post-MI depression rat model.PMID:36028598 | DOI:10.1208/s12249-022-02387-6 (Source: AAPS PharmSciTech)
Source: AAPS PharmSciTech - August 26, 2022 Category: Drugs & Pharmacology Authors: Heba M A Khalil Dina B Mahmoud Riham A El-Shiekh Alaa F Bakr Amira A Boseila Sally Mehanna Reham A Naggar Hesham A Eliwa Source Type: research
Evaluation of the Herb-Drug Interaction Potential of Commonly Used Botanicals on the US Market with Regard to PXR- and AhR-Mediated Influences on CYP3A4 and CYP1A2
In this study, hydroethanolic extracts of 30 top-selling botanicals (herbs) commonly used as ingredients of herbal dietary supplements in the US were screened for their potential to activate the human pregnane X receptor (hPXR) and human aryl hydrocarbon receptor (hAhR) and to increase the activities of hPXR- and hAhR-regulated drug metabolizing cytochrome P450 enzymes (i.e., CYP3A4 and CYP1A2, respectively). Of the 30 botanicals tested, 21 induced PXR and 29 induced AhR transcriptional activities. Out of the 21 botanicals that induced hPXR transcriptional activity, 14 yielded >50% induction in CYP3A4 activity at concen...
Source: Journal of Dietary Supplements - August 26, 2022 Category: Nutrition Authors: Mona H Haron Olivia Dale Katherine Martin Bharathi Avula Amar G Chittiboyina Ikhlas A Khan Bill J Gurley Shabana I Khan Source Type: research
