Clinician guidelines for the treatment of psychiatric disorders with nutraceuticals and phytoceuticals: The World Federation of Societies of Biological Psychiatry (WFSBP) and Canadian Network for Mood and Anxiety Treatments (CANMAT) Taskforce
CONCLUSIONS: Based on the current data and clinician input, a range of nutraceuticals and phytoceuticals were given either a supportive recommendation or a provisional recommendation across a range of various psychiatric disorders. However several had only a weak endorsement for potential use; for a few it was not possible to reach a clear recommendation direction, largely due to mixed study findings; while some other agents showed no obvious therapeutic benefit and were clearly not recommended for use. It is the intention of these guidelines to inform psychiatric/medical, and health professional practice globally.PMID:353...
Source: The World Journal of Biological Psychiatry - March 21, 2022 Category: Psychiatry Authors: Jerome Sarris Arun Ravindran Lakshmi N Yatham Wolfgang Marx Julia J Rucklidge Roger S McIntyre Shahin Akhondzadeh Francesco Benedetti Constanza Caneo Holger Cramer Lachlan Cribb Michael de Manincor Olivia Dean Andrea Camaz Deslandes Marlene P Freeman Bang Source Type: research
Comparing the effects of Elaegnus Angustifolia, Hypericum Perforatum and Psidium Guajava extracts on metabolic activity of dental pulp-derived mesenchymal stem cells
AbstractDental pulp derived-mesenchymal stem cells (DP-MSCs) is considered a suitable are candidate for tissue engineering techniques and osseous reconstruction. Based on the hypothesis thatHypericum perforatum,Elaeagnus Angustifolia andPsidium guajava extracts can be used in cell-based bone tissue engineering due to meagre cytotoxicity response in the cell culture medium, their effects on the viability and metabolic activity of DP-MSCs were investigated and compared with each extract. DP-MSCs were extracted from human dental pulp, characterized by flow cytometry, and differentiated into Osteogenic and adipogenic lineages ...
Source: Cell and Tissue Banking - February 18, 2022 Category: Stem Cells Source Type: research
Molecules, Vol. 27, Pages 1221: Novel Evidence-Based Combination of Plant Extracts with Multitarget Mechanisms of Action for the Elimination of Hot Flashes during Menopause
a Andreadou
Hot flashes are considered the most bothersome complaint during menopause. Although hormone therapy is an effective option to relieve hot flashes, it has been associated with significant side effects. The aim of our study is to suggest a novel combination of different plant extracts with distinct mechanisms of action against hot flashes. We selected the rhizome of Glycyrrhiza glabra L. (Fabaceae), the rhizome of Actaea racemosa L. (Ranunculaceae), the aerial parts of Hypericum perforatum L. (Hypericaceae) to produce extracts rich in bioactive phytochemicals and the seed oil of Oenothera biennis L. (Onagrace...
Source: Molecules - February 11, 2022 Category: Chemistry Authors: Maria Tsoumani Panagiota Efstathia Nikolaou Aikaterini Argyropoulou Ioulia Tseti Sofia Mitakou Ioanna Andreadou Tags: Article Source Type: research
Molecules, Vol. 27, Pages 1132: Supercritical CO2 Plant Extracts Show Antifungal Activities against Crop-Borne Fungi
This study shows that some of these SFE-CO2 extracts have promising potential for use as antifungal agents for selected crop-borne fungi. (Source: Molecules)
Source: Molecules - February 8, 2022 Category: Chemistry Authors: Katja Schoss Nina Ko čevar Glavač Jasna Dolenc Koce Sabina An žlovar Tags: Article Source Type: research
Substrate-dependent inhibition of hypericin on human carboxylesterase 2: implications for herb-drug combination
CONCLUSION: These findings are of considerable clinical significance to the combination of hypericin-containing herbs and drugs metabolized by hCE2.PMID:35114918 | DOI:10.2174/1389200223666220202093303 (Source: Current Drug Metabolism)
Source: Current Drug Metabolism - February 4, 2022 Category: Drugs & Pharmacology Authors: Dalong Wang Tingting Zhao Shan Zhao Jing Chen Tongyi Dou Guangbo Ge Changyuan Wang Huijun Sun Kexin Liu Qiang Meng Jingjing Wu Source Type: research
Substrate-dependent inhibition of hypericin on human carboxylesterase 2: implications for herb-drug combination
CONCLUSION: These findings are of considerable clinical significance to the combination of hypericin-containing herbs and drugs metabolized by hCE2.PMID:35114918 | DOI:10.2174/1389200223666220202093303 (Source: Current Drug Metabolism)
Source: Current Drug Metabolism - February 4, 2022 Category: Drugs & Pharmacology Authors: Dalong Wang Tingting Zhao Shan Zhao Jing Chen Tongyi Dou Guangbo Ge Changyuan Wang Huijun Sun Kexin Liu Qiang Meng Jingjing Wu Source Type: research
Substrate-dependent inhibition of hypericin on human carboxylesterase 2: implications for herb-drug combination
CONCLUSION: These findings are of considerable clinical significance to the combination of hypericin-containing herbs and drugs metabolized by hCE2.PMID:35114918 | DOI:10.2174/1389200223666220202093303 (Source: Current Drug Metabolism)
Source: Current Drug Metabolism - February 4, 2022 Category: Drugs & Pharmacology Authors: Dalong Wang Tingting Zhao Shan Zhao Jing Chen Tongyi Dou Guangbo Ge Changyuan Wang Huijun Sun Kexin Liu Qiang Meng Jingjing Wu Source Type: research
Substrate-dependent inhibition of hypericin on human carboxylesterase 2: implications for herb-drug combination
CONCLUSION: These findings are of considerable clinical significance to the combination of hypericin-containing herbs and drugs metabolized by hCE2.PMID:35114918 | DOI:10.2174/1389200223666220202093303 (Source: Current Drug Metabolism)
Source: Current Drug Metabolism - February 4, 2022 Category: Drugs & Pharmacology Authors: Dalong Wang Tingting Zhao Shan Zhao Jing Chen Tongyi Dou Guangbo Ge Changyuan Wang Huijun Sun Kexin Liu Qiang Meng Jingjing Wu Source Type: research
Substrate-dependent inhibition of hypericin on human carboxylesterase 2: implications for herb-drug combination
CONCLUSION: These findings are of considerable clinical significance to the combination of hypericin-containing herbs and drugs metabolized by hCE2.PMID:35114918 | DOI:10.2174/1389200223666220202093303 (Source: Current Drug Metabolism)
Source: Current Drug Metabolism - February 4, 2022 Category: Drugs & Pharmacology Authors: Dalong Wang Tingting Zhao Shan Zhao Jing Chen Tongyi Dou Guangbo Ge Changyuan Wang Huijun Sun Kexin Liu Qiang Meng Jingjing Wu Source Type: research
Substrate-dependent inhibition of hypericin on human carboxylesterase 2: implications for herb-drug combination
CONCLUSION: These findings are of considerable clinical significance to the combination of hypericin-containing herbs and drugs metabolized by hCE2.PMID:35114918 | DOI:10.2174/1389200223666220202093303 (Source: Current Drug Metabolism)
Source: Current Drug Metabolism - February 4, 2022 Category: Drugs & Pharmacology Authors: Dalong Wang Tingting Zhao Shan Zhao Jing Chen Tongyi Dou Guangbo Ge Changyuan Wang Huijun Sun Kexin Liu Qiang Meng Jingjing Wu Source Type: research
Substrate-dependent inhibition of hypericin on human carboxylesterase 2: implications for herb-drug combination
CONCLUSION: These findings are of considerable clinical significance to the combination of hypericin-containing herbs and drugs metabolized by hCE2.PMID:35114918 | DOI:10.2174/1389200223666220202093303 (Source: Current Drug Metabolism)
Source: Current Drug Metabolism - February 4, 2022 Category: Drugs & Pharmacology Authors: Dalong Wang Tingting Zhao Shan Zhao Jing Chen Tongyi Dou Guangbo Ge Changyuan Wang Huijun Sun Kexin Liu Qiang Meng Jingjing Wu Source Type: research
Substrate-dependent inhibition of hypericin on human carboxylesterase 2: implications for herb-drug combination
CONCLUSION: These findings are of considerable clinical significance to the combination of hypericin-containing herbs and drugs metabolized by hCE2.PMID:35114918 | DOI:10.2174/1389200223666220202093303 (Source: Current Drug Metabolism)
Source: Current Drug Metabolism - February 4, 2022 Category: Drugs & Pharmacology Authors: Dalong Wang Tingting Zhao Shan Zhao Jing Chen Tongyi Dou Guangbo Ge Changyuan Wang Huijun Sun Kexin Liu Qiang Meng Jingjing Wu Source Type: research
Pharmacokinetics of tacrolimus following an overdose in a patient with extreme obesity and genotype CYP3A5*3/*3: a case report
J Toxicol Sci. 2022;47(2):71-75. doi: 10.2131/jts.47.71.ABSTRACTThis case involved a 27-year-old man with extreme obesity (body mass index 45.6 kg/m2) who had a history of fulminant hepatitis and living-donor liver transplantation at 11 years of age. He had been receiving oral sustained-release tacrolimus (TAC) 1.5 mg daily, and the trough concentration in the blood was below 2.0 ng/mL. He has an intrinsic cytochrome P450 3A5 (CYP3A5)*3/*3 (G/G) genotype and graft liver with CYP3A5*3 allele donated by his biological father. Additionally, there were no data on the phenotype of P-glycoprotein. He did not take medications, gr...
Source: Journal of Toxicological Sciences - February 3, 2022 Category: Toxicology Authors: Toshinori Hirai Yoshihiko Morikawa Noriko Sasaki Hideo Kato Daisuke Nakato Masahiro Hirayama Tadashi Kaneko Hiroshi Imai Takuya Iwamoto Source Type: research
