St John's Wort Research This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Development of a herbal mouthwash containing a mixture of essential oils and plant extracts and in vitro testing of its antimicrobial efficiency against the planktonic and biofilm-enclosed cariogenic bacterium Streptococcus mutans 
Biofouling. 2021 May 24:1-13. doi: 10.1080/08927014.2021.1924693. Online ahead of print.ABSTRACTA herbal mouthwash containing essential oils of holy basil and mountain tea, extracts of St John's wort and European goldenrod (Bucovia™) and cetylpyridinium chloride, was developed and in vitro tested for its efficiency against biofilm formation by Streptococcus mutans, together with its eradicating activity against already preformed (48 h with saccharose) streptococcal biofilm. The minimum inhibitory (MIC) and bactericidal concentrations (MBC) of the final formulation, as well as of its individual components, were initially ...
Source: Biofouling - May 24, 2021 Category: Molecular Biology Authors: Ioanna Dimou Stavros Dritsas Paraskevi Aggelopoulou Katerina Vassilatou Sofia Damianaki Efstathios Giaouris Source Type: research

Effectiveness of Hypericum perforatum Extract in the Treatment of Corrosive Esophageal Burns
CONCLUSION: H. perforatum extract may be effective on inflammation, fibrosis, and necrosis in corrosive esophageal burns.PMID:33998353 | DOI:10.1080/08941939.2021.1921083 (Source: Journal of Investigative Surgery)
Source: Journal of Investigative Surgery - May 17, 2021 Category: Surgery Authors: Rezzan S ümeli Hatice Sonay Yal çın Cömert Haluk Sar ıhan Mustafa İmamoğlu İsmail Saygın Source Type: research

Are the St John's wort Hyp-1 superstructures different?
Two commensurately modulated structures (PDB entries 4n3e and 6sjj) were solved using translational noncrystallographic symmetry (tNCS). The data required the use of large supercells, sevenfold and ninefold, respectively, to properly index the reflections. Commensurately modulated structures can be challenging to solve. Molecular-replacement software such as Phaser can detect tNCS and either handle it automatically or, for more challenging situations, allow the user to enter a tNCS vector, which the software then uses to place the components. Although this approach has been successful in solving these types of challenging ...
Source: Acta Crystallographica Section D - May 14, 2021 Category: Biochemistry Authors: Lovelace, J.J. Borgstahl, G.E.O. Tags: modulation tNCS supercell superspace research papers Source Type: research

Bioactive Compounds Effective Against Type 2 Diabetes Mellitus: A Systematic Review
In conclusion, the data collected in our study indicates that consumption of polyphenolic/flavonoids rich food and vegetables as a routine diet could considerably reduce the risk of T2DM and also benefits insulin sensitivity and other chronic inflammations.PMID:33966619 | DOI:10.2174/1568026621666210509161059 (Source: Current Topics in Medicinal Chemistry)
Source: Current Topics in Medicinal Chemistry - May 10, 2021 Category: Chemistry Authors: Chukwuebuka Egbuna Chinaza G Awuchi Garima Kushwaha Mithun Rudrapal Kingsley C Patrick-Iwuanyanwu Omkar Singh Uchenna E Odoh Johra Khan Jaison Jeevanandam Suresh Kumarasamy Mathiyazhagan Narayanan Vincent O Chukwube Santwana Palai Mihnea-Alexandru G ăman Source Type: research

Hypericum perforatum L. Regulates Glutathione Redox Stress and Normalizes Ggt1/Anpep Signaling to Alleviate OVX-Induced Kidney Dysfunction
Menopause and associated renal complications are linked to systemic redox stress, and the causal factors remain unclear. As the role of Hypericum perforatum L. (HPL) in menopause-induced kidney disease therapy is still ambiguous, we aim to explore the effects of HPL on systemic redox stress under ovariectomy (OVX)-induced kidney dysfunction conditions. Here, using combined proteomic and metabolomic approaches, we constructed a multi-scaled “HPL-disease-gene-metabolite” network to generate a therapeutic “big picture” that indicated an important link between glutathione redox stress and kidney impairment. HPL exhibit...
Source: Frontiers in Pharmacology - April 26, 2021 Category: Drugs & Pharmacology Source Type: research

Molecules, Vol. 26, Pages 2294: Physiological and Transcriptomic Analysis Provide Insight into Low Temperature Enhancing Hypericin Biosynthesis in Hypericum perforatum
i Li Jianhe Wei Hypericin (Hyp), well-known as an antidepressant, is mainly extracted from Hypericum perforatum. Although Hyp accumulation and biomass are greater at lower compared to higher temperature, the regulation mechanism has not been reported. Here, the physiological characteristics and transcriptome of H. perforatum grown at 15 and 22 °C were determined and analyzed by HPLC and de novo sequencing. The results showed that the stomatal density and opening percentages were 1.1- and 1.4-fold more, and the Hyp content was 4.5-fold greater at 15 °C compared to 22 °C. A total of 1584 differentially expressed gen...
Source: Molecules - April 15, 2021 Category: Chemistry Authors: Hongyan Su Jie Li Sijin Chen Ping Sun Hua Xing Delong Yang Xiaona Zhang Mengfei Li Jianhe Wei Tags: Article Source Type: research

Comparing the effects of Elaegnus Angustifolia , Hypericum Perforatum and Psidium Guajava extracts on metabolic activity of dental pulp-derived mesenchymal stem cells
AbstractDental pulp derived-mesenchymal stem cells (DP-MSCs) is considered a suitable are candidate for tissue engineering techniques and osseous reconstruction. Based on the hypothesis thatHypericum perforatum,Elaeagnus Angustifolia andPsidium guajava extracts can be used in cell-based bone tissue engineering due to meagre cytotoxicity response in the cell culture medium, their effects on the viability and metabolic activity of DP-MSCs were investigated and compared with each extract. DP-MSCs were extracted from human dental pulp, characterized by flow cytometry, and differentiated into Osteogenic and adipogenic lineages ...
Source: Cell and Tissue Banking - April 11, 2021 Category: Stem Cells Source Type: research

Food Constituent- and Herb-Drug Interactions in Oncology: Influence of Quantitative Modeling on Drug Labeling
CONCLUSIONS: A model-informed decision tree based on mechanistic understanding of transporter and/or enzyme-mediated FC-DI is proposed based on bergamottin, curcumin, and hyperforin FC-DI clinical data. Adopting this quantitative modeling approach should streamline herbal product safety assessments, assist in FC-DI management, and ultimately promote safe clinical use of oncology drugs.PMID:33733472 | DOI:10.1111/bcp.14822 (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - March 18, 2021 Category: Cancer & Oncology Authors: Venkatesh Pilla Reddy Jo Heeseung Sibylle Neuhoff Source Type: research

Determination of Potential Drug Candidate Molecules of the Hypericum perforatum for COVID-19 Treatment
Curr Pharmacol Rep. 2021 Mar 2:1-7. doi: 10.1007/s40495-021-00254-9. Online ahead of print.ABSTRACTThe novel human coronavirus was firstly emerged in December 2019 in Wuhan, China, and has spread rapidly around the world. There is no known specific effective treatment of COVID-19. The most commonly used agents against this disease both in Turkey and around the world include chloroquine, hydroxychloroquine, lopinavir/ritonavir, favipiravir, and remdesivir. In the study, we investigated the drug potential of molecules that the components of an important medicinal plant Hypericum perforatum by using molecular docking and drug...
Source: Pharmacological Reports - March 8, 2021 Category: Drugs & Pharmacology Authors: Serap Yal çın Seda Yal çınkaya Fahriye Ercan Source Type: research