Food Constituent- and Herb-Drug Interactions in Oncology: Influence of Quantitative Modeling on Drug Labeling

CONCLUSIONS: A model-informed decision tree based on mechanistic understanding of transporter and/or enzyme-mediated FC-DI is proposed based on bergamottin, curcumin, and hyperforin FC-DI clinical data. Adopting this quantitative modeling approach should streamline herbal product safety assessments, assist in FC-DI management, and ultimately promote safe clinical use of oncology drugs.PMID:33733472 | DOI:10.1111/bcp.14822
Source: Clinical Genitourinary Cancer - Category: Cancer & Oncology Authors: Source Type: research