Herbal Approaches in the Management of Mental Depression
CONCLUSION: Potential compounds isolated from medicinal plants for the treatment of depression disorders need to be established.Herbal plant research could aid in this endeavour.PMID:35088681 | DOI:10.2174/1871527321666220128091408 (Source: CNS and Neurological Disorders Drug Targets)
Source: CNS and Neurological Disorders Drug Targets - January 28, 2022 Category: Drugs & Pharmacology Authors: Preeti Garg Jyoti Alambayan Vandana Garg Source Type: research
Role of nutraceuticals on neurodegenerative diseases: neuroprotective and immunomodulant activity
Nat Prod Res. 2021 Dec 29:1-18. doi: 10.1080/14786419.2021.2020265. Online ahead of print.ABSTRACTNeurodegeneration is a degenerative process characterized by the progressive loss of the structure and function of neurons that involves several immune cells. It is the primary cause of dementia and other several syndromes, known as neurodegenerative diseases. These disorders are age-related and it is estimated that by 2040 there will be approximately 81.1 million people suffering from these diseases. In addition to the traditional pharmacological therapy, in recent years nutraceuticals, naturally based compounds with a broad ...
Source: Natural Product Research - December 29, 2021 Category: Biochemistry Authors: Angelo Fumia Nicola Cicero Marco Gitto Noemi Nicosia Alessio Alesci Source Type: research
Role of nutraceuticals on neurodegenerative diseases: neuroprotective and immunomodulant activity
Nat Prod Res. 2021 Dec 29:1-18. doi: 10.1080/14786419.2021.2020265. Online ahead of print.ABSTRACTNeurodegeneration is a degenerative process characterized by the progressive loss of the structure and function of neurons that involves several immune cells. It is the primary cause of dementia and other several syndromes, known as neurodegenerative diseases. These disorders are age-related and it is estimated that by 2040 there will be approximately 81.1 million people suffering from these diseases. In addition to the traditional pharmacological therapy, in recent years nutraceuticals, naturally based compounds with a broad ...
Source: Natural Product Research - December 29, 2021 Category: Biochemistry Authors: Angelo Fumia Nicola Cicero Marco Gitto Noemi Nicosia Alessio Alesci Source Type: research
Regeneration of Phytochemicals by Structure-Driven Organization of Microbial Biosynthetic Steps
Angew Chem Int Ed Engl. 2021 Dec 20. doi: 10.1002/anie.202114919. Online ahead of print.ABSTRACTMedicinal phytochemicals, such as artemisinin and taxol, have impacted the world, and hypericin might do so if its availability issue could be addressed. Hypericin is the hallmark component of Saint John's wort ( Hypericum perforatum L.), an approved depression alleviator documented in the US, European, and British pharmacopoeias with its additional effectiveness against diverse cancers and viruses. However, the academia-to-industry transition of hypericin remain hampered by its low in planta abundance, unfeasible bulk chemical ...
Source: Angewandte Chemie - December 21, 2021 Category: Chemistry Authors: Xue Ming Wu Qiu Yan Guan Yun Bin Han Xin Cun Wang Wen Ying Zhuang Ren Xiang Tan Source Type: research
Regeneration of Phytochemicals by Structure-Driven Organization of Microbial Biosynthetic Steps
Angew Chem Int Ed Engl. 2021 Dec 20. doi: 10.1002/anie.202114919. Online ahead of print.ABSTRACTMedicinal phytochemicals, such as artemisinin and taxol, have impacted the world, and hypericin might do so if its availability issue could be addressed. Hypericin is the hallmark component of Saint John's wort ( Hypericum perforatum L.), an approved depression alleviator documented in the US, European, and British pharmacopoeias with its additional effectiveness against diverse cancers and viruses. However, the academia-to-industry transition of hypericin remain hampered by its low in planta abundance, unfeasible bulk chemical ...
Source: Angewandte Chemie - December 21, 2021 Category: Chemistry Authors: Xue Ming Wu Qiu Yan Guan Yun Bin Han Xin Cun Wang Wen Ying Zhuang Ren Xiang Tan Source Type: research
Comparative assessment of proliferation and immunomodulatory potential of Hypericum perforatum plant and callus extracts on mesenchymal stem cells derived adipose tissue from multiple sclerosis patients
ConclusionsHigh concentrations of HP extracts showed effectiveness on AT-MSCs proliferation and immunomodulatory properties with a certain consequence in callus extract. HP extracts may be considered as supplementary treatments for the patients who receiving MSCs transplantation. (Source: Inflammopharmacology)
Source: Inflammopharmacology - September 12, 2021 Category: Drugs & Pharmacology Source Type: research
Identification and characterization of glycosyltransferases catalyzing direct xanthone 4 ‐C‐glycosylation in Hypericum perforatum
Xanthones are compounds with a diphenyl ether skeleton mainly found in plants and often glycosylated at carbon atoms. Although manyC-glycosyltransferases (CGTs) participating in flavoneC-glycosylation have been identified, MiCGT fromMangifera indica, adding sugar to an open-chain benzophenone skeleton, is the only identified xanthone biosynthesis-related CGT. Here, we identified two CGTs fromHypericum perforatum that add sugar to the closed-ring xanthone, but not benzophenone. These CGTs catalyze sugar transfer to the C-4 position of norathyriol (1,3,6,7-tetrahydroxyxanthone) to form isomangiferin (1,3,6,7-tetrahydroxy...
Source: FEBS Letters - August 24, 2021 Category: Biochemistry Authors: Kai Uchida,
Tomoyoshi Akashi,
Masami Yokota Hirai Tags: Research Letter Source Type: research
St. John ’s Wort ( < b > < i > Hypericum perforatum < /i > < /b > )-Related Acute Kidney Injury
Some herbal products were reported to cause nephrotoxicity through different mechanisms. This case report defines an acute kidney injury (AKI) in a patient who usedHypericum perforatum tea as a sleep disorder remedy. The patient developed AKI after ingestion of tea prepared fromHypericum perforatum and underwent hemodialysis because of acute kidney failure. After 1 week, the kidney recovered, and she was discharged with normal kidney function. This is the first case reported having acute kidney failure caused by ingestion ofHypericum perforatum.Blood Purif (Source: Blood Purification)
Source: Blood Purification - August 24, 2021 Category: Hematology Source Type: research
Identification and characterization of glycosyltransferases catalyzing direct xanthone 4 ‐C‐glycosylation in Hypericum perforatum
AbstractXanthones are compounds with a diphenyl ether skeleton mainly found in plants and often glycosylated at carbon atoms. Although many C-glycosyltransferases (CGTs) participating in flavone C-glycosylation have been identified, MiCGT fromMangifera indica, adding sugar to an open-chain benzophenone skeleton, is the only identified xanthone biosynthesis-related CGT. Here, we identified two CGTs fromHypericum perforatum that add sugar to the closed-ring xanthone, but not benzophenone. These CGTs catalyze sugar transfer to the C-4 position of norathyriol (1,3,6,7-tetrahydroxyxanthone) to form isomangiferin (1,3,6,7-tetrah...
Source: FEBS Letters - August 16, 2021 Category: Biochemistry Authors: Kai Uchida,
Tomoyoshi Akashi,
Masami Yokota Hirai Tags: RESEARCH LETTER Source Type: research
Pharmacological activities and Therapeutic potential of kaempferitrin in medicine for the treatment of human disorders: A review of medicinal importance and health benefits
CONCLUSIONS: The presented information in this work will be valuable to justify the biological importance and therapeutic potential of kaempferitrin in the scientific field.PMID:34387174 | DOI:10.2174/1871529X21666210812111931 (Source: Cardiovascular and Hematological Disorders Drug Targets)
Source: Cardiovascular and Hematological Disorders Drug Targets - August 13, 2021 Category: Drugs & Pharmacology Authors: Dinesh Kumar Patel Source Type: research
