Protocol and Baseline Data on Renal Autologous Cell Therapy Injection in Adults with Chronic Kidney Disease Secondary to Congenital Anomalies of the Kidney and Urinary Tract
Conclusion: REACT is demonstrating feasibility and patient safety in preliminary analysis. Autologous cell therapy treatment has the potential to stabilize or improve renal function in CAKUT-associated CKD to delay or avert dialysis. Patient enrollment and follow-up are underway.Blood Purif (Source: Blood Purification)
Source: Blood Purification - March 1, 2021 Category: Hematology Source Type: research

Comparison of Approaches for Prediction of Renal Replacement Therapy-Free Survival in Patients with Acute Kidney Injury
Conclusions: A MLP + LSTM model outperformed other approaches for predicting RRTFS. Performance could be further improved by incorporating other data types.Blood Purif (Source: Blood Purification)
Source: Blood Purification - February 25, 2021 Category: Hematology Source Type: research

Higher Prevalence of Concurrent Thrombocytopenia in Patients Receiving Continuous Renal Replacement Therapy in the Cardiac Intensive Care Unit
Conclusion: Safe delivery of dialysis care in the ICU is paramount and creating awareness of potential risks such as concurrent TCP in patients receiving CRRT should be part of this care.Blood Purif (Source: Blood Purification)
Source: Blood Purification - February 25, 2021 Category: Hematology Source Type: research

Antibiotics Removal by Continuous Venovenous Hemofiltration with a Novel Asymmetric Triacetate Membrane Hemofilter: An in vitro Study
Conclusions: The clearances and SCs presented are comparable with findings of other authors. Meropenem and vancomycin, which exhibit low and medium PB, respectively, were strongly removed, while considerably less daptomycin was removed because of its high PB. Our results suggest that in clinical use of the tested antibiotics during CRRT with the ATA hemofilter, the same factors have to be considered for determining the dosing strategy as with filters with other commonly applied membrane materials.Blood Purif (Source: Blood Purification)
Source: Blood Purification - February 25, 2021 Category: Hematology Source Type: research

Health Outcomes and Cost Considerations of Assisted Peritoneal Dialysis: A Narrative Review
Background: Peritoneal dialysis (PD) is underutilized in many parts of the world despite pro-PD health policies. The physical and cognitive demands of PD means that over half of eligible patients require some form of assistance. As such, many countries now offer assisted PD (aPD) programs to help patients start or stay on PD as opposed to in-center hemodialysis (HD). In order to evaluate the potential scope of aPD, it is important to review the outcomes and cost considerations of aPD.Summary: We reviewed available data from different countries and regions for health outcomes between aPD and in-center HD, with a focus on qu...
Source: Blood Purification - February 24, 2021 Category: Hematology Source Type: research

Elevated Serum Trimethylamine N-Oxide Levels Are Associated with Mortality in Male Patients on Peritoneal Dialysis
Conclusions: Higher serum TMAO levels were independently associated with all-cause and CV mortality in male patients treated with PD.Blood Purif (Source: Blood Purification)
Source: Blood Purification - February 17, 2021 Category: Hematology Source Type: research

Sleep Apnea as a Cardiorenal Risk Factor in CKD and Renal Transplant Patients
Background: Chronic kidney disease (CKD) is a public health priority of increasing concern worldwide. Sleep apnea (SA) of moderate-to-severe degree has a 3 –9% prevalence in women and 10–17% in men in the general population.Summary: In CKD patients, the prevalence of SA parallels the decline of the GFR being 27% in CKD patients with a GFR of #x3e;60 mL/min/1.73 m2 and 57% in patients with end-stage kidney disease (ESKD). In the early CKD stages, fluid overload is probably the sole risk factor for SA in this population. At more severe CKD stages, disturbed central and peripheral chemosensitivity and the accumula...
Source: Blood Purification - February 15, 2021 Category: Hematology Source Type: research

Effects of Polymyxin B Hemoperfusion on Septic Shock Patients Requiring Noradrenaline: Analysis of a Nationwide Administrative Database in Japan
Conclusion: Analysis of large Japanese databases showed that septic shock patients who received noradrenaline might benefit from PMX treatment.Blood Purif (Source: Blood Purification)
Source: Blood Purification - February 12, 2021 Category: Hematology Source Type: research

Recent Understanding of Peritoneal Pathology in Peritoneal Dialysis Patients in Japan
The thin peritoneum covering the peritoneal cavity has been used as a dialysis membrane for peritoneal dialysis (PD) because it is highly vascularized and has a large body surface area. However, it has been reported that peritoneal membranes affected by peritonitis, as well as those exposed to the nonphysiological high glucose levels containing PD dialysate, may undergo histological and functional changes. Patients undergoing PD may experience encapsulating peritoneal sclerosis (EPS), which is a life-threatening serious complication of PD that can significantly impair activities of daily living. The incidence of EPS was 1....
Source: Blood Purification - February 10, 2021 Category: Hematology Source Type: research

Association of Retinol-Binding Protein 4 with Arteriovenous Fistula Dysfunction in Hemodialysis Patients
Conclusions: HD patients with higher serum RBP4 concentrations had a relevant higher incidence of arteriovenous dysfunction events. Serum RBP4 level was an independent risk factor for AVF dysfunction events in HD patients.Blood Purif (Source: Blood Purification)
Source: Blood Purification - February 8, 2021 Category: Hematology Source Type: research

Measurement of the Concentration of Citrate in Human Biofluids in Patients Undergoing Continuous Renal Replacement Therapy Using Regional Citrate Anticoagulation: Application of a Two-Step Enzymatic Assay
Conclusions: Plasma concentrations of citrate rose significantly during episodes of CRRT using RCA returning back to normal after cessation of treatment.Blood Purif (Source: Blood Purification)
Source: Blood Purification - February 5, 2021 Category: Hematology Source Type: research

Improvements in Inflammation and Calcium Balance of Citrate versus Acetate as Dialysate Buffer in Maintenance Hemodialysis: A Unicentric, Cross-Over, Prospective Study
Conclusions: The use of citrate provides interesting advantages when compared to acetate. It maintains iCa levels stable during dialysis sessions with a neutral or negative effect on calcium balance, and it improves the chronic inflammatory condition that comes with long-time hemodialysis treatment. These beneficial effects may lead to an improvement in clinical outcomes.Blood Purif (Source: Blood Purification)
Source: Blood Purification - February 3, 2021 Category: Hematology Source Type: research

Effect of -55C/T Polymorphism of Uncoupling Protein 3 Gene on Risk for New-Onset Diabetes in Chinese Peritoneal Dialysis Patients: A Prospective Cohort Study
Conclusions: The variant of T allele of UCP3 −55C/T polymorphism was an independent predictor for NOD in PD patients. Early identification of the genotype may provide scientific basis for patients’ clinic management.Blood Purif (Source: Blood Purification)
Source: Blood Purification - February 3, 2021 Category: Hematology Source Type: research

How to Reduce the Risk of Arteriovenous Fistula Dysfunction by Observing Prepump Arterial Pressure during Hemodialysis: A Multicenter Retrospective Study
Conclusions: The appropriate range of |Pa/Qb| is between 0.30 and 0.52. When |Pa/Qb| is #x3c;0.30 or #x3e;0.52, the patient ’s AVF function or Qb setting should be reevaluated to prevent subsequent failure.Blood Purif (Source: Blood Purification)
Source: Blood Purification - February 2, 2021 Category: Hematology Source Type: research

Inflated Cost Burden of Hemodialysis during COVID-19 Pandemic
Blood Purif (Source: Blood Purification)
Source: Blood Purification - February 1, 2021 Category: Hematology Source Type: research

Selected Abstracts from the 38th Vicenza Course on AKI & CRRT
Blood Purif (Source: Blood Purification)
Source: Blood Purification - January 29, 2021 Category: Hematology Source Type: research

Hepatitis B Vaccination Response in Hemodialysis Patients: The Impact of Dialysis Shift
Conclusion: While better sleep following vaccination is associated with seroconversion in the general population, this is not the case in hemodialysis patients after multivariate adjustment. In the context of end-stage kidney disease, early dialysis start is not a significant predictor of HB vaccination response. The association between objectively measured postvaccination sleep duration and seroconversion rate should be investigated.Blood Purif (Source: Blood Purification)
Source: Blood Purification - January 28, 2021 Category: Hematology Source Type: research

Efficiency of Double Plasma Molecular Absorption System on the Acute Severe Cholestatic Hepatitis
Conclusions: DPMAS could significantly eliminate the necessity of liver transplantation. The artificial liver support system should be conducted to bring down the bilirubin level and the ratio of cases with severe conditions. In general, DPMAS should be preferred as an artificial liver support therapy for the patients with acute severe CH.Blood Purif (Source: Blood Purification)
Source: Blood Purification - January 28, 2021 Category: Hematology Source Type: research

Predialytic versus Intradialytic Nutrition: A Study to Assess Effects on Intradialytic Blood Pressure, Dialysis Adequacy, and Urea Removal
Conclusions: Predialytic supplementation was associated with better dialysis adequacy and urea removal than intradialytic supplementation. However, both timings were equally tolerated and not associated with underdialysis.Blood Purif (Source: Blood Purification)
Source: Blood Purification - January 28, 2021 Category: Hematology Source Type: research

Neutrophil to Lymphocyte Ratio as a Predictor of Long-Term Outcome in Peritoneal Dialysis Patients: A 5-Year Cohort Study
Conclusions: NLR could be a strong predictor of long-term outcome in PD patients.Blood Purif (Source: Blood Purification)
Source: Blood Purification - January 28, 2021 Category: Hematology Source Type: research

Home Dialysis: A Majority Chooses It, a Minority Gets It
Conclusions: A large discrepancy between informed patients ’ choices and the reality of the current dialysis landscape. Absence of a care partner, lack of home space, and patients not deemed appropriate surgical candidates were the main driving forces in their not opting for a home modality.Blood Purif (Source: Blood Purification)
Source: Blood Purification - January 27, 2021 Category: Hematology Source Type: research

“To Be, or Not to Be” a Nephrologist: Students’ Dilemma and a Strategy for the Field
The attractiveness of a career in nephrology has diminished over the past decades, leading to global concerns about the future of the specialty ’s workforce. The reasons physicians choose (and do not choose) a career in the field must be identified in order to boost recruitment of new nephrologists. In this article, a multilevel strategy is proposed to deal with the declining interest in the specialty: (1) increasing contact and providing early exposure to nephrology; (2) promoting mentoring and role models in medical schools; (3) improving the experience of trainees and medical students; (4) incorporating procedural...
Source: Blood Purification - January 27, 2021 Category: Hematology Source Type: research

Pumpless Extracorporeal Hemadsorption Technique: A New Method for Early Cytokine Elimination?
In recent years, extracorporeal hemadsorption (HA) techniques capable of adsorbing pro- and anti-inflammatory cytokines are increasingly used in various clinical situations. The therapeutic benefit of cytokine elimination likely depends on timing. Although treatment seems to be most effective when started within the first 24 h, therapy is often delayed as it must be combined with another extracorporeal circuit. Thus, using a pumpless extracorporeal HA technique might be a valuable option in order to expedite the commencement of cytokine elimination in critically ill patients.Blood Purif (Source: Blood Purification)
Source: Blood Purification - January 27, 2021 Category: Hematology Source Type: research

QT Prolongation in Dialysis Patients: An Epidemiological Study with a Focus on Malnutrition
Conclusion: These results suggest that QT prolongation is a common complication and is more frequent in women and diabetic patients. The decreases in serum albumin and Cr levels, GNRI, BMI, %TBW, %ICW, FFM, and MM together coincided with malnutrition and thus suggest a close relationship of QT prolongation with malnutrition. Management of QT prolongation may be achieved better in the future by understanding these biochemical and biophysical changes, particularly those regarding malnutrition.Blood Purif (Source: Blood Purification)
Source: Blood Purification - January 26, 2021 Category: Hematology Source Type: research

Safety and Efficacy of Tandem Hemodialysis and Selective Plasma Exchange in Pretransplant Desensitization of ABO-Incompatible Kidney Transplantation
Conclusion: In HD/SePE tandem therapy, internal pressures were higher and TMP and AP tended to increase more compared to SePE monotherapy, but we were able to perform the 2 treatments without any functional problems. Tandem therapy was also effective in decreasing isoagglutinin titers, which suggests that this may be a beneficial treatment modality as apheresis before ABOi kidney transplantation.Blood Purif (Source: Blood Purification)
Source: Blood Purification - January 21, 2021 Category: Hematology Source Type: research

Acute Kidney Injury, Fluid Overload, and Renal Replacement Therapy Differ by Underlying Diagnosis in Neonatal Extracorporeal Support and Impact Mortality Disparately
Conclusions: Physiologically distinct ECMO diagnoses warrant individualized treatment strategies given variable incidence and effects of AKI, FO, and RRT by category on mortality.Blood Purif (Source: Blood Purification)
Source: Blood Purification - January 18, 2021 Category: Hematology Source Type: research

Low-Intensity Intradialytic Exercise Attenuates the Relative Blood Volume Drop Due to Intravascular Volume Loss during Hemodiafiltration
Discussion: Mild exercise during HDF decreased the RBV drop and was associated with less hypotension events. The lack of differences in the hemodynamic variables suggests an adequate acute response of cardiovascular compensation variables to intradialytic hypovolemia.Blood Purif (Source: Blood Purification)
Source: Blood Purification - January 15, 2021 Category: Hematology Source Type: research

COVID-19, Social Media, and the Role of the Public Physician
The COVID-19 pandemic has resulted in an avalanche of information, much of it false or misleading. Social media posts with misleading or dangerous opinions and analyses are often amplified by celebrities and social media influencers; these posts have contributed substantially to this avalanche of information. An emerging force in this information infodemic is public physicians, doctors who view a public presence as a large segment of their mission. These physicians bring authority and real-world experience to the COVID-19 discussion. To investigate the role of public physicians, we interviewed a convenience cohort of physi...
Source: Blood Purification - January 14, 2021 Category: Hematology Source Type: research

Medium Cut-Off Dialysis Membranes: Can They Have Impact on Outcome of COVID-19 Hemodialysis Patients?
Conclusion: It may be an option to use MCO membranes in HD patients with COVID-19 in order to reduce cytokine levels and prevent cytokine storm.Blood Purif (Source: Blood Purification)
Source: Blood Purification - January 14, 2021 Category: Hematology Source Type: research

Storytelling to Inspire Dialysis Patients to Learn about Living Donor Kidney Transplant
Background: Policy changes including the Advancing American Kidney Health initiative and CMS ’s ESRD Quality Incentive Program recommend increasing educational initiatives within dialysis centers to increase living kidney donor transplant (LDKT) rates. LDKT education can be challenging in dialysis centers due to limited provider time to educate, patient fears or reluctance to learn about LDKT, and difficulty educating potential living donors. New educational innovations that increase dialysis patient curiosity about pursuing LDKT are needed.Summary: Digital first-person storytelling, or the sharing of narratives by i...
Source: Blood Purification - January 13, 2021 Category: Hematology Source Type: research

Rationale of Blood Purification in the Post-Resuscitation Syndrome following Out-of-Hospital Cardiac Arrest: A Narrative Review
Even today, little is known about the pathophysiology of the post-resuscitation syndrome. Our narrative review is one of the first summarizing all the knowledge about this phenomenon. We have focused our review upon the potential role of blood purification in attenuating the consequences of the post-resuscitation syndrome. Blood purification can decrease the cytokine storm particularly when using a CytoSorb absorber. Acrylonitrile 69-based oXiris membranes can remove endotoxin and high-mobility group box 1 protein. Blood purification techniques can quickly induce hypothermia. Blood purification can be used with veno-arteri...
Source: Blood Purification - January 13, 2021 Category: Hematology Source Type: research

Acute Kidney Injury and COVID-19: A Picture from an Intensive Care Unit
Conclusion: In critical COVID-19 patients, ICU mortality is particularly high, especially in patients developing AKI. An accurate monitoring of renal function in early phases of respiratory failure should be ensured in order to timely apply any strategy aimed at limiting renal complications during ICU stay.Blood Purif (Source: Blood Purification)
Source: Blood Purification - January 7, 2021 Category: Hematology Source Type: research

Survival of Vascular Accesses in Chronic Hemodialysis Patients
Conclusions: The survival of the initial VA is greater for the IAVF, followed by the tunneled catheters and the lowest by the non-tunneled catheters, which continue to be frequently used in our setting.Blood Purif (Source: Blood Purification)
Source: Blood Purification - December 23, 2020 Category: Hematology Source Type: research

Medium Cut-Off Membranes: Incremental or Quantum Leap Innovation in Haemodialysis?
Blood Purif (Source: Blood Purification)
Source: Blood Purification - December 22, 2020 Category: Hematology Source Type: research

SARS-CoV-2 Infection in a Spanish Cohort of CKD-5D Patients: Prevalence, Clinical Presentation, Outcomes, and De-Isolation Results
Conclusions: Patients on dialysis have an increased mortality risk if infected with SARS-CoV-2. Preventive measures have proven useful. Thus, proper ones, such as universal screening of the population and isolation when required, need to be generalized. Better de-isolation criteria are necessary to ensure an appropriate use of public health resources.Blood Purif (Source: Blood Purification)
Source: Blood Purification - December 22, 2020 Category: Hematology Source Type: research

Improved Survival beyond 28 Days up to 1 Year after CytoSorb Treatment for Refractory Septic Shock: A Propensity-Weighted Retrospective Survival Analysis
Conclusions: Survival is achieved with CytoSorb and CRRT for patients with septic shock beyond 28 days from ICU admission and may be improved for CytoSorb treatment. Lactate levels above 6.0 mmol/L at the start of CytoSorb therapy are predictive of worse outcome with high specificity and positive predictive value.Blood Purif (Source: Blood Purification)
Source: Blood Purification - December 22, 2020 Category: Hematology Source Type: research

Does Pulse Wave Velocity Increase Over Time in Hemodialysis Patients?
Conclusion: In our small observational study, there was no overall change in PWV, after 5 years of HD, with PWV increasing in 50% and falling in 50%. Changes in PWV were not associated with changes in ECW but were associated with changes in peri-dialytic SBP. Our study demonstrates that PWV does not increase in all HD patients with time, and interventional studies are required to determine whether targeted blood pressure control reduces PWV in HD patients.Blood Purif (Source: Blood Purification)
Source: Blood Purification - December 22, 2020 Category: Hematology Source Type: research

Acute Kidney Injury and Renal Replacement Therapy in Critically Ill COVID-19 Patients: Risk Factors and Outcomes: A Single-Center Experience in Brazil
Conclusions: AKI was common among critically ill COVID-19 patients and occurred early in association with IMV. One in 6 AKI patients received RRT and 1 in 3 patients treated with RRT died in hospital. These findings provide important prognostic information for clinicians caring for these patients.Blood Purif (Source: Blood Purification)
Source: Blood Purification - December 18, 2020 Category: Hematology Source Type: research

Unexpected Complication of Central Venous Catheter Exchange: Catheter Fragment Migration
We report the case hoping to emphasize on and raise awareness of the fact that catheter fragment loss is a completely evitable complication, provided the operator follows the correct safety measures and protocols. However, if catheter fragment loss occurred, the fragment should be retrieved as soon as possible. A gooseneck snare is an ideal option for retrieving catheter fragments that have migrated into deep veins.Blood Purif (Source: Blood Purification)
Source: Blood Purification - December 18, 2020 Category: Hematology Source Type: research

Continuous Renal Replacement Therapy with oXiris ® Membrane in Severe Ebstein-Barr Virus-Mediated Hemophagocytic Lymphohistiocytosis: A Case Report
Hemophagocytic lymphohistiocytosis (HLH), a life-threatening disease with uncontrolled immune activation and inflammatory reaction, often leads to a deadly cytokine storm. In severe Ebstein-Barr virus-triggered HLH receiving standard immunosuppression, continuous renal replacement therapy (CRRT) with oXiris® blood purification membrane resulted in a timely reduction of inflammatory markers and discontinuation of vasopressors. To our knowledge, this is the first report of successful use of the oXiris® membrane in HLH.Blood Purif (Source: Blood Purification)
Source: Blood Purification - December 17, 2020 Category: Hematology Source Type: research

COVID-19: Hyperinflammatory Syndrome and Hemoadsorption with CytoSorb
Blood Purif (Source: Blood Purification)
Source: Blood Purification - December 16, 2020 Category: Hematology Source Type: research

COVID-19 in ESRD and Acute Kidney Injury
The COVID-19 pandemic has greatly affected nephrology. Firstly, dialysis patients appear to be at increased risk for infection due to viral transmission next to an enhanced risk for mortality as compared to the general population, even in the face of an often apparently mild clinical presentation. Derangements in the innate and adaptive immune systems may be responsible for a reduced antiviral response, whereas chronic activation of the innate immune system and endothelial dysfunction provide a background for a more severe course. The presence of severe comorbidity, older age, and a reduction of organ reserve may lead to a...
Source: Blood Purification - December 15, 2020 Category: Hematology Source Type: research

Clinical Features and Outcomes of Acute Kidney Injury in Patients Infected with COVID-19 in Xiangyang, China
Conclusions: Elderly with chronic comorbidities were more susceptible to COVID-19, showing a higher mortality rate due to multiple organ damage, and 35.7% of patients with AKI in ICU received renal replacement therapy. Moreover, part of the cured patients might need additional time to recover for poor lung function.Blood Purif (Source: Blood Purification)
Source: Blood Purification - December 14, 2020 Category: Hematology Source Type: research

Erratum
Blood Purif (Source: Blood Purification)
Source: Blood Purification - December 11, 2020 Category: Hematology Source Type: research

Corneal and Conjunctival Calcification in a Dialysis Patient Reversed by Parathyroidectomy
Mineral and bone metabolism disorders are relatively common among patients with end-stage renal disease on maintenance hemodialysis. Corneal and conjunctival calcification is the main extravascular site for calcification. Recently, this form of calcification has been linked to vascular calcification. Secondary hyperparathyroidism can lead to high levels of calcium and phosphorus and increase the risk of calcification. Here, we report a case of a 38-year-old female with severe hyperparathyroidism who underwent eye examination before and after parathyroidectomy. Anterior segment optical coherence tomography showed an improve...
Source: Blood Purification - December 10, 2020 Category: Hematology Source Type: research

Effects of Hemodialysis and Peritoneal Dialysis on Glycometabolism in Patients with End-Stage Diabetic Nephropathy
Conclusion: HD patients have larger glycemic variability as compared with PD patients, while PD patients have overall increased blood glucose levels. Hypoglycemic programs should be made according to the corresponding changes in blood glucose. The HbA1c value of dialysis patients has a large deviation, so it is necessary to explore its influencing factors and develop more accurate blood glucose assessment indicators.Blood Purif (Source: Blood Purification)
Source: Blood Purification - December 10, 2020 Category: Hematology Source Type: research

Efficacy of Medium Cut-Off Dialyzer and Comparison with Standard High-Flux Hemodialysis
Conclusion: Compared to high-flux membranes, MCO membranes show greater permeability for middle molecules in midterm report.Blood Purif (Source: Blood Purification)
Source: Blood Purification - December 8, 2020 Category: Hematology Source Type: research

Heart Rate Variability and Prognosis in Hemodialysis Patients: A Meta-Analysis
Conclusions: Decreased HRV is associated with higher risk of all-cause and cardiovascular death in the hemodialysis population. Decreased SDANN and LF/HF were identified as predictors of both all-cause and cardiovascular mortality, while the utility of other HRV metrics requires further investigation. The protocol for this study was registered with PROSPERO (CRD42019141886).Blood Purif (Source: Blood Purification)
Source: Blood Purification - December 8, 2020 Category: Hematology Source Type: research

Relationship between Soluble ST2 and Left Ventricular Geometry in Maintenance Hemodialysis Patients
Conclusions: The present study found that sST2 were significantly increased in patients with concentric remodeling and concentric LVH. ST2/interleukin (IL)-33 signaling might participate in the process of cardiac remodeling via its pro-fibrotic action. Future studies on the mechanism of ST2/IL-33 pathway are needed.Blood Purif (Source: Blood Purification)
Source: Blood Purification - December 8, 2020 Category: Hematology Source Type: research