Contents
Blood Purif 2020;49:I –X (Source: Blood Purification)
Source: Blood Purification - November 13, 2020 Category: Hematology Source Type: research

Acknowledgement to Reviewers
Blood Purif 2020;49:767 –768 (Source: Blood Purification)
Source: Blood Purification - November 13, 2020 Category: Hematology Source Type: research

Hemoperfusion with CytoSorb as Adjuvant Therapy in Critically Ill Patients with SARS-CoV2 Pneumonia
We report a preliminary experience of adjuvant therapy with Hemoperfusion (HP) in patients with Severe Acute Respiratory Syndrome-CoronaVirus 2 (SARS-CoV2) pneumonia. Currently, there are no approved treatments for CoronaVirus Disease 19 (COVID-19); however, therapeutic strategies based on the preclinical evidence include supportive measures, such as oxygen supplementation, antiviral, and anticoagulant agents. Despite these treatments, 10% of patients worsen and develop severe acute respiratory distress syndrome (ARDS). Since the pathogenic mechanism of ARDS is an uncontrolled inflammatory state, we speculate that removing...
Source: Blood Purification - November 12, 2020 Category: Hematology Source Type: research

Impact of Medium Cut-Off Dialyzers on Patient-Reported Outcomes: COREXH Registry
Conclusions: In conventional HD patients, the expanded clearance of large middle molecules with MCO-HD membranes was associated with higher health-related quality of life scores and a decrease in the prevalence of RLS.Blood Purif (Source: Blood Purification)
Source: Blood Purification - November 11, 2020 Category: Hematology Source Type: research

Hemoperfusion as a Potential Treatment for Critically Ill COVID-19 Patients with Cytokine Storm
Blood Purif (Source: Blood Purification)
Source: Blood Purification - November 10, 2020 Category: Hematology Source Type: research

Deployment of a New CRRT/PIRRT Device during the COVID-19 Pandemic Emergency: Organizational Challenges and Implementation Results
Conclusion: Assembly of the SAMI and training of nurses remotely are possible when access to vendor employees is restricted during states of emergency. The successful deployment of the SAMI in our institution during the pandemic with only 3-h virtual training supports that operating the SAMI is simple and safe.Blood Purif (Source: Blood Purification)
Source: Blood Purification - November 10, 2020 Category: Hematology Source Type: research

Through the Storm: Automated Peritoneal Dialysis with Remote Patient Monitoring during COVID-19 Pandemic
Blood Purif (Source: Blood Purification)
Source: Blood Purification - November 6, 2020 Category: Hematology Source Type: research

Association between Dialysis Modality and Infectious Diseases: Peritoneal Dialysis versus Hemodialysis
Conclusions: ID events were not associated with dialysis modality when modality-specific ID was excluded, whereas the risk of modality-specific IDs was higher in PD than HD. Serum ferritin and ALP as well as age, male sex, CRP, and CCI were the risk factors for ID events.Blood Purif (Source: Blood Purification)
Source: Blood Purification - October 29, 2020 Category: Hematology Source Type: research

Outcome and Safety of Unplanned-Start Peritoneal Dialysis according to Break-In Periods: A Systematic Review and Meta-Analysis
Conclusions: Evidence suggests that patients receiving unplanned-start PD may have higher risks of mechanical complications, transition to HD, and even mortality rate while worsening early technical survival, which may not be associated with infectious complications. Rigorous studies are required to be performed.Blood Purif (Source: Blood Purification)
Source: Blood Purification - October 29, 2020 Category: Hematology Source Type: research

Effect of Extracorporeal Blood Purification on Mortality in Sepsis: A Meta-Analysis and Trial Sequential Analysis
Conclusion: There are inadequate data at present to conclude that the use of extracorporeal blood purification techniques in sepsis is beneficial. Further adequately powered RCTs are required to confirm any potential mortality benefit, which may be most evident in patients at greatest risk of death.Blood Purif (Source: Blood Purification)
Source: Blood Purification - October 28, 2020 Category: Hematology Source Type: research

Comparison of Psychological Distress and Demand Induced by COVID-19 during the Lockdown Period in Patients Undergoing Peritoneal Dialysis and Hemodialysis: A Cross-Section Study in a Tertiary Hospital
Conclusions: HD patients had more severe trauma-related stress symptoms than PD patients. When major public healthy events occurred, careful psychological estimate and sufficient psychological support should be provided to the dialysis patients, especially to the HD patients.Blood Purif (Source: Blood Purification)
Source: Blood Purification - October 28, 2020 Category: Hematology Source Type: research

Quality of Life Is Associated with Cardiac Biomarkers, Echocardiographic Indices, and Mortality in CKD Stage 4 –5 Patients Not on Dialysis
Conclusion: Impaired QoL in CKD stage 4 –5 patients not on dialysis is associated with cardiac biomarker levels, echocardiographic indices, and mortality.Blood Purif (Source: Blood Purification)
Source: Blood Purification - October 26, 2020 Category: Hematology Source Type: research

Prolonged Intermittent Renal Replacement Therapy for Acute Kidney Injury in COVID-19 Patients with Acute Respiratory Distress Syndrome
Conclusions: PIRRT was feasible in the majority of COVID-19 patients with ARDS and severe AKI, despite frequent transitory intradialytic hypotensive episodes. PIRRT may represent an acceptable alternative of renal replacement therapy during the COVID-19 outbreak.Blood Purif (Source: Blood Purification)
Source: Blood Purification - October 26, 2020 Category: Hematology Source Type: research

The Influence of Altitude on Erythropoietin Resistance Index in Maintenance Hemodialysis Patients: Data from Tibetan Plateau
Conclusion: Altitude had an independent negative correlation with ERI. This result supported the hypothesis that altitude-associated hypoxia improved EPO responsiveness in MHD patients.Blood Purif (Source: Blood Purification)
Source: Blood Purification - October 22, 2020 Category: Hematology Source Type: research

Membrane-Based Therapeutic Plasma Exchange in Intensive Care
The principles and use of plasmapheresis are often little understood by intensivists. We propose to review the principles, the main indications, and the methods of using this technique.Blood Purif (Source: Blood Purification)
Source: Blood Purification - October 22, 2020 Category: Hematology Source Type: research

Does Prior Abdominal Surgery Influence Peritoneal Transport Characteristics or Technique Survival of Peritoneal Dialysis Patients?
Conclusion: Prior abdominal surgical procedures do not appear to compromise peritoneal membrane function or technique survival in patients successfully started on PD.Blood Purif (Source: Blood Purification)
Source: Blood Purification - October 22, 2020 Category: Hematology Source Type: research

Exercise Parameters Predict Technique Survival in Patients on Peritoneal Dialysis
Conclusion: The ISWT is an important predictor of technique survival for patients on PD. Monitoring and enhancing ISWT as a marker of aerobic capacity might improve PD-related outcomes.Blood Purif (Source: Blood Purification)
Source: Blood Purification - October 22, 2020 Category: Hematology Source Type: research

Evaluation of Residual Kidney Function during Once-Weekly Incremental Hemodialysis
Conclusion: The parameters evaluated are suitable for use as a routine daily method indicating the commencement and continued use of the 1WHD Incremental Program.Blood Purif (Source: Blood Purification)
Source: Blood Purification - October 20, 2020 Category: Hematology Source Type: research

Sudden Cardiac Death in Haemodialysis Patients under Hydroxychloroquine Treatment for COVID-19: A Report of Two Cases
Hydroxychloroquine (HQ) has been used for the treatment of novel coronavirus disease (COVID-19) even though there is no clear evidence for its effectiveness yet. In contrary, HQ has major side effects like QTc prolongation and subsequent development of ventricular arrhythmias. Such side effects may possess additional risks on end-stage renal disease (ESRD) patients who have higher cardiovascular risks than general population. We herein present 2 cases of sudden cardiac death in 2 ESRD patients with COVID-19 for whom a treatment regimen including HQ was preferred. Both patients were clinically stable at the time of arrest. ...
Source: Blood Purification - October 8, 2020 Category: Hematology Source Type: research

Heterogeneity of Effect of Net Ultrafiltration Rate among Critically Ill Adults Receiving Continuous Renal Replacement Therapy
Conclusions: In CRRT patients, both high and low NUF rates may be harmful, especially in those with edema, sepsis, and greater illness severity. Cardiovascular SOFA scores modulate this association. Additional studies are needed to test these hypotheses, and targeted trials of NUF rates based on risk stratification appear justified.Trial Registration: ClinicalTrials.gov identifier: NCT00221013.Blood Purif (Source: Blood Purification)
Source: Blood Purification - October 7, 2020 Category: Hematology Source Type: research

Peritoneal Dialysis Is an Option for Acute Kidney Injury Management in Patients with COVID-19
In December 2019, cases of acute respiratory illness of unknown origin were reported in Wuhan, China. The disease is caused by “severe acute respiratory syndrome coronavirus 2”. After identifying severe lung damage, injury to other organs, such as the kidney, has been identified. Peritoneal dialysis is a renal replacement therapy (RRT) and is at least as effective as other extracorporeal therapy options, with significan t cost-effective advantages. However, this strategy is rarely used for the management of acute kidney injury in severe lung disease. In this review, we explore PD as an RRT strategy that may be ...
Source: Blood Purification - October 5, 2020 Category: Hematology Source Type: research

The Effects of Nebivolol and Irbesartan on Ambulatory Aortic Blood Pressure and Arterial Stiffness in Hemodialysis Patients with Intradialytic Hypertension
Conclusions: This is the first randomized evaluation on the effects of pharmacological interventions on central BP and PWV in patients with intradialytic hypertension. Weekly administration of both nebivolol and irbesartan reduced 24-h central BP and PWV, but not AIx(75).Blood Purif (Source: Blood Purification)
Source: Blood Purification - October 5, 2020 Category: Hematology Source Type: research

Early Selective C-Reactive Protein Apheresis in a Patient with Acute ST Segment Elevation Myocardial Reinfarction
The patient was admitted for urgent coronary angiography following an acute anterior ST segment elevation myocardial reinfarction (STEMI) caused by acute stent thrombosis. A stent had been implanted 10 days prior to the reinfarction for an acute anterior STEMI. However, the patient had stopped taking ticagrelor post-discharge. Primary percutaneous coronary intervention of the left anterior descending artery was performed. Subsequently, due to a high C-reactive protein (CRP) level, 3 CRP apheresis sessions were performed, with the first session starting 12 h after the onset of symptoms. A significant drop in CRP was noted a...
Source: Blood Purification - September 30, 2020 Category: Hematology Source Type: research

Practice Patterns and Outcomes of Online Hemodiafiltration: A Real-World Evidence Study in a Russian Dialysis Network
Conclusions: Both center-dependent clinical practice standards and patient clinical conditions substantially contributed to the risk of lowQsub. We confirmed previous evidence indicating better survival among patients withQsub≥ 21 L/session.Blood Purif (Source: Blood Purification)
Source: Blood Purification - September 23, 2020 Category: Hematology Source Type: research

Reinforcing the Team: A Call to Critical Care Nephrology in the COVID-19 Epidemic
Blood Purif (Source: Blood Purification)
Source: Blood Purification - September 21, 2020 Category: Hematology Source Type: research

Successful Treatment of Severe Digitoxin Intoxication with CytoSorb ® Hemoadsorption
We report on an 81-year-old female patient treated in our intensive care unit (ICU) with severe digitoxin intoxication, acute renal failure, and urinary tract infection (UTI). As physiological digitoxin elimination kinetics are known to appear slow, and also in regard to the renal failure, the decision was made to initiate continuous renal replacement therapy combined with CytoSorb hemoadsorption. The patient was hemodynamically stabilized within the first 4 h of treatment and initially required catecholamines to be stopped within 24 h of treatment. Pre- and post-adsorber drug level measurements showed a rapid elimination ...
Source: Blood Purification - September 16, 2020 Category: Hematology Source Type: research

Erratum
Blood Purif (Source: Blood Purification)
Source: Blood Purification - September 11, 2020 Category: Hematology Source Type: research

Cytokine Adsorption to Polymyxin B-Immobilized Fiber: An in vitro Study
Conclusions: Various cytokines involved in inflammation, fibrosis, and vascular permeability were shown to be adsorbed onto PMX-F. Removal of multiple cytokines may be associated with positive impacts of PMX-DHP in patients with AE-IPF.Blood Purif (Source: Blood Purification)
Source: Blood Purification - September 7, 2020 Category: Hematology Source Type: research

Clinical Characteristics and Risk Factors for Mortality due to Bloodstream Infection of Unknown Origin in Hemodialysis Patients: A Single-Center, Retrospective Study
Conclusions: Serum albumin level of 2.5 g/dL is a cutoff value, which could predict the mortality due to BSI in hemodialysis patients. Considering the high mortality rate of MRSA-associated BSI of unknown origin, wherein no focus of infection was identified in the present study, initial empiric treatment should be considered for MRSA-associated BSI of unknown origin.Blood Purif (Source: Blood Purification)
Source: Blood Purification - September 4, 2020 Category: Hematology Source Type: research

Effects of Hemoadsorption with Cytosorb during Severe Rhabdomyolysis: Reply to the Letter to the Editor of Daum and Colleagues
Blood Purif (Source: Blood Purification)
Source: Blood Purification - September 3, 2020 Category: Hematology Source Type: research

Erratum
Blood Purif (Source: Blood Purification)
Source: Blood Purification - September 2, 2020 Category: Hematology Source Type: research

Effect of Expanded Hemodialysis on Body Composition and Nutritional Status
Blood Purif (Source: Blood Purification)
Source: Blood Purification - September 1, 2020 Category: Hematology Source Type: research

Continuous Observation of Serum Total Magnesium Level in Patients Undergoing Hemodialysis
Conclusion: We find that serum total magnesium levels are in the normal range before initiating hemodialysis. However, in patients on MHD, hypermagnesemia is common when 0.5 mmol/L magnesium dialysate is used. Hypomagnesemia is very rare. Hypomagnesemia in patients on MHD is an indicator of poor condition.Blood Purif (Source: Blood Purification)
Source: Blood Purification - August 31, 2020 Category: Hematology Source Type: research

Associations between Cell-Free Mitochondrial DNA and Inflammation, and Their Clinical Implications for Patients on Hemodialysis: A Prospective Multicenter Cohort Study
Conclusion: cf-mtDNA was correlated with poor clinical status and modestly associated with impaired quality of life in patients on hemodialysis. In proinflammatory milieu in end-stage renal disease, these associations may be attributed to the boosting effects of cf-mtDNA on inflammation.Blood Purif (Source: Blood Purification)
Source: Blood Purification - August 28, 2020 Category: Hematology Source Type: research

Treatment of Pyonephritis Complicated by Septic Shock Using Extracorporeal Device Polymyxin B-Hemoperfusion
We report one instance in which PMX-DHP therapy has been used successfully in a 33-year-old woman with septic shock from urosepsis. Although there is lack of recommendations in latest Surviving Sepsis Campaign Guidelines, evidence of PMX-DHP efficacy in this subset of patients is growing.Blood Purif (Source: Blood Purification)
Source: Blood Purification - August 26, 2020 Category: Hematology Source Type: research

Association between Satisfaction with Dialysis Treatment and Quality of Life: A Cross-Sectional Study
Conclusions: The study provides support for the relationship between the care satisfaction and QOL, highlighting the central role of the nephrologist-patient communication in the QOL of dialysis patients.Blood Purif (Source: Blood Purification)
Source: Blood Purification - August 26, 2020 Category: Hematology Source Type: research

Intraperitoneal Pressure in Polycystic and Non-Polycystic Kidney Disease Patients, Treated by Peritoneal Dialysis
Conclusions: Patients with larger BMI have greater IPP, irrespectively to IPV. In PKD patients, hTKV correlate with IPP/IPV ratio. However, given the wide range of distribution of hTKV, increased IPP cannot be presumed because of pre-existing polycystic kidney, but need to be quantified.Blood Purif (Source: Blood Purification)
Source: Blood Purification - August 25, 2020 Category: Hematology Source Type: research

Erratum
Blood Purif (Source: Blood Purification)
Source: Blood Purification - August 20, 2020 Category: Hematology Source Type: research

Early Treatment with Human Albumin Solution in Continuous Renal Replacement Patients
Conclusions: Early albumin was administered to one-third of RENAL trial patients and in those with greater illness severity. Early albumin was not independently associated with mortality risk or rate of recovery to RRT independence.Blood Purif (Source: Blood Purification)
Source: Blood Purification - August 20, 2020 Category: Hematology Source Type: research

Erratum
Blood Purif (Source: Blood Purification)
Source: Blood Purification - August 11, 2020 Category: Hematology Source Type: research

Identification of Complex Pneumonia during the Outbreak of COVID-19: Bacterial Pneumonia Combined with Acute Eosinophilic Pneumonia in Patients with Maintenance Hemodialysis
We present a successfully treated case of a patient with maintenance hemodialysis from acute eosinophilic pneumonia for using meropenem when treating bacterial pneumonia, avoiding possible panic and waste of quarantine materials in dialysis centers.Blood Purif (Source: Blood Purification)
Source: Blood Purification - July 28, 2020 Category: Hematology Source Type: research

Intradialytic Calcium Kinetics and Cardiovascular Disease in Chronic Hemodialysis Patients
Conclusions: In line with our proof-of-concept study, we provide clinical evidence for a rapidly accessible and exchangeable calcium pool involved in intradialytic calcium regulation and for the role of osteocalcin as a potential biomarker. Our findings argue for evaluating the prognostic potential of intradialytic calcium kinetics in prospective clinical trials.Blood Purif (Source: Blood Purification)
Source: Blood Purification - July 24, 2020 Category: Hematology Source Type: research

Application and Efficacy of Vitamin E-Bonded Polysulfone Membrane in Acute Blood Purification Therapy
Conclusions: This study demonstrated that use of the VEPS membrane for BPT increased survival rate and reduced lung injury in a rat model of systemic inflammatory response syndrome (SIRS), suggesting the possible use of VEPS membranes in the treatment of serious conditions related to systemic inflammation.Blood Purif (Source: Blood Purification)
Source: Blood Purification - July 17, 2020 Category: Hematology Source Type: research

Technique Failure in Peritoneal Dialysis: Etiologies and Risk Assessment
Technique failure (TF) is a well-recognized challenge encountered in patients undergoing peritoneal dialysis (PD). Identification of patients at risk for this complication is of utmost importance. Early detection of patients at risk and development of preventative strategies can improve technique survival that may lead to an increased utilization of PD. It will also promote a safe and planned transfer to hemodialysis once a patient identified with TF. The aim of this review is to summarize risk factors and scenarios associated with TF focusing on prevention of remediable factors at their earliest stage. Furthermore, integr...
Source: Blood Purification - July 17, 2020 Category: Hematology Source Type: research

Acute Kidney Injury and Special Considerations during Renal Replacement Therapy in Children with Coronavirus Disease-19: Perspective from the Critical Care Nephrology Section of the European Society of Paediatric and Neonatal Intensive Care
We describe how these shortages might be mitigated. Where machines are limited, one CRRT machine can be used for multiple patients, providing a limited number of hours of CRRT per day. In this case, increased exchange rates can be used to compensate for the decreased duration of CRRT. If consumables are limited, lower doses of CRRT (15 –20 mL/kg/h) for 24 h may be feasible. Hypercoagulability leading to frequent filter clotting is an important issue in these children. Increased doses of unfractionated heparin, combination of heparin and regional citrate anticoagulation, or combination of prostacyclin and heparin migh...
Source: Blood Purification - July 14, 2020 Category: Hematology Source Type: research

Prevalence, Characteristics, Risk Factors, and Outcomes of Invasively Ventilated COVID-19 Patients with Acute Kidney Injury and Renal Replacement Therapy
Conclusions: Among invasively ventilated COVID-19 patients, AKI is very common and CRRT use is common. Both carry a high risk of in-hospital mortality.Blood Purif (Source: Blood Purification)
Source: Blood Purification - July 13, 2020 Category: Hematology Source Type: research

Correlation of Venous Oxygen Saturations from Noninvasive Hematocrit Monitoring Using Blood Gas Measured Oximetry in Chronic Pediatric Hemodialysis Patients
Conclusion: Intradialytic NIVHM O2sat correlates well with mO2sat but yield lower values. Future studies can include NIVHM O2sat changes as a surrogate for central venous O2 saturation changes and potentially yield useful information regarding tissue oxygen consumption in pedHD patients.Blood Purif (Source: Blood Purification)
Source: Blood Purification - July 8, 2020 Category: Hematology Source Type: research

Feasibility of Citrate Dialysis in Hyponatremia: A Case Series
Conclusion: In this small series of patients, with adjustment of the sodium concentration of dialysate and reinjection fluid, the use of citrate was found to be safe.Blood Purif (Source: Blood Purification)
Source: Blood Purification - July 8, 2020 Category: Hematology Source Type: research

Comparison of Circulating Levels of Uremic Toxins in Hemodialysis Patients Treated with Medium Cut-Off Membranes and High-Flux Membranes: Theranova in Sisli Hamidiye Etfal (THE SHE) Randomized Control Study
Conclusion: The decline in circulating levels of several middle and large uremic toxins including VEGF following hemodialysis was more pronounced when using MCO membranes as compared to high-flux membranes while their effect on inflammatory molecules was similar.Blood Purif (Source: Blood Purification)
Source: Blood Purification - July 7, 2020 Category: Hematology Source Type: research

A Combination of Hemodialysis with Hemoperfusion Helped to Reduce the Cardiovascular-Related Mortality Rate after a 3-Year Follow-Up: A Pilot Study in Vietnam
Conclusion: We demonstrated that a combination of hemodialysis and hemoperfusion for 3 years helped to reduce the cardiovascular-related mortality rate.Blood Purif (Source: Blood Purification)
Source: Blood Purification - July 2, 2020 Category: Hematology Source Type: research