Development and External Validation of a Model for Predicting Sufficient Filter Lifespan in Anticoagulation-Free Continuous Renal Replacement Therapy Patients
Conclusions: The use of a prediction model instead of an assessment based only on coagulation parameters could facilitate the identification of the patients with filter lifespan of ≥24 h when they accepted anticoagulation-free CRRT.Blood Purif (Source: Blood Purification)
Source: Blood Purification - October 21, 2021 Category: Hematology Source Type: research

Neutrophil-to-Lymphocyte Ratio and Erythropoietin Resistance among Maintenance Hemodialysis Patients
Conclusion: A higher NLR level was shown to be a cheaper method to predict worse EPO responsiveness in HD patients.Blood Purif (Source: Blood Purification)
Source: Blood Purification - October 14, 2021 Category: Hematology Source Type: research

Influence of Early-Onset Peritonitis on Mortality and Clinical Outcomes in ESRD Patients with Diabetes Mellitus on Peritoneal Dialysis: A Retrospective Multicenter Study
Conclusions: The occurrence of EOP is significantly associated with lower rates of PDAP-related death and poorer clinical outcomes in patients with diabetes undergoing PD.Blood Purif (Source: Blood Purification)
Source: Blood Purification - October 12, 2021 Category: Hematology Source Type: research

Experiences of Renal Replacement Therapy Delivery in Swedish Intensive Care Units during the COVID-19 Pandemic
Conclusion: During the first wave of the COVID-19 pandemic, RRT demand increased extensively causing staff and equipment shortages, altered CRRT protocols, and increased use of IHD and PD. The impact on patient outcomes should be assessed to effectively plan for further surge capacity RRT demand.Blood Purif (Source: Blood Purification)
Source: Blood Purification - October 6, 2021 Category: Hematology Source Type: research

Comparison of the Clinical Effectiveness of AN69-oXiris versus AN69-ST Filter in Septic Patients: A Single-Centre Study
Conclusion: Blood purification using the AN69-oXiris or AN69-ST filter proved useful for septic patients, which was associated with reduced cytokine levels and improved clinical condition. Patients treated with AN69-oXiris had a more remarkable improvement in haemodynamic status and lower cytokine levels than those treated with AN69-ST filter, but there were no differences in clinical outcomes. Further investigations are needed to prove this finding.Blood Purif (Source: Blood Purification)
Source: Blood Purification - October 5, 2021 Category: Hematology Source Type: research

The Accuracy of Hemoglobin A1c and Fructosamine Evaluated by Long-Term Continuous Glucose Monitoring in Patients with Type 2 Diabetes Undergoing Hemodialysis
Discussion: HbA1c evaluated by CGM underestimates plasma glucose levels in patients receiving HD. The underestimation represents a clinical challenge in optimizing glycemic control in the HD population. Fructosamine is unaffected by the factors affecting HbA1c and appears to be more accurate for glycemic monitoring. CGM or fructosamine could thus complement HbA1c in obtaining more accurate glycemic control in this patient group.Blood Purif (Source: Blood Purification)
Source: Blood Purification - September 28, 2021 Category: Hematology Source Type: research

Contents Vol. 50, 2021
Blood Purif 2021;50:I –X (Source: Blood Purification)
Source: Blood Purification - September 22, 2021 Category: Hematology Source Type: research

Acknowledgement to Reviewers
Blood Purif 2021;50:1022 –1024 (Source: Blood Purification)
Source: Blood Purification - September 22, 2021 Category: Hematology Source Type: research

Effect of Blood Flow Rate on the Accuracy of Central Venous Pressure Measurement during Continuous Renal Replacement Therapy
Conclusions: Extracorporeal BFR has no influence on the accuracy of CVP measurement during CRRT with the net machine balance adjusted to zero regardless of the location of the catheter and the connection method between catheters and CRRT lines. Thus, CRRT does not need to be discontinued to obtain an accurate CVP measurement.Blood Purif (Source: Blood Purification)
Source: Blood Purification - September 21, 2021 Category: Hematology Source Type: research

Comparison of Outcomes between Percutaneous and Surgical Placement of Peritoneal Dialysis Catheters in Uremic Patients: A Meta-Analysis
Conclusions: The blind percutaneous method performed better with fewer overall mechanical complications and less malposition than open surgery. The leakage risk was higher in the blind percutaneous group, while the guided percutaneous placement group showed similar outcomes to the surgical method groups. Percutaneous methods also had a lower infection risk, which needs further evidence to be confirmed.Blood Purif (Source: Blood Purification)
Source: Blood Purification - September 20, 2021 Category: Hematology Source Type: research

Polymyxin B-Immobilized Fiber Column Direct Hemoperfusion for Micro-Preemie Infants with Septic Shock. Is Extended Duration Better than Early Start? Comment to the Letter to the Editor of Nishizaki and Colleagues
Blood Purif (Source: Blood Purification)
Source: Blood Purification - September 16, 2021 Category: Hematology Source Type: research

Polymyxin B-Immobilized Fiber Column Direct Hemoperfusion for Micro-Preemie Infants: Is Extended Duration Better than Early Start?
Blood Purif (Source: Blood Purification)
Source: Blood Purification - September 15, 2021 Category: Hematology Source Type: research

Benefit of an Internet-Based Management System among Hemodialysis Patients at the Risk of Intradialytic Hypotension and Muscle Cramps: A Controlled before and after Study
Conclusion: The study found that the internet-based hemodialysis management system was effective in reducing the IDH and muscle cramp events and improving self-management. It provided a significant implication for the development and application of internet-based programs in hemodialysis management.Blood Purif (Source: Blood Purification)
Source: Blood Purification - September 15, 2021 Category: Hematology Source Type: research

Sublingual Microcirculatory Evaluation of Extracorporeal Hemoadsorption with CytoSorb ® in Abdominal Sepsis: A Case Report
Cytokemia is associated with microcirculatory alterations often with persistent loss of coherence between the micro- and macrocirculation, linked to organ failure and poor outcome of septic patients. Addition of a hemoadsorbant filter to an extracorporeal circuit next to conventional treatment of septic shock results in the hematological clearance of cytokines, hypothetically leading to normalization of the microcirculation and thus organ perfusion. Bedside sublingual microcirculatory assessment using handheld vital microscopy allows real-time direct visualization of the microcirculation and its response to therapy. This i...
Source: Blood Purification - September 15, 2021 Category: Hematology Source Type: research

Patients with Severe Lactic Acidosis in the Intensive Care Unit: A Retrospective Study of Contributing Factors and Impact of Renal Replacement Therapy
Conclusions: Our analysis confirms the high mortality rate of patients with SLA. It adds that odds for mortality is even higher in patients who were started on RRT versus not. We suggest keeping an open mind to the factors that may influence the decision to start dialysis and bear in mind that without being a bridge to correction of the underlying condition, dialysis is unlikely to affect the outcome.Blood Purif (Source: Blood Purification)
Source: Blood Purification - September 15, 2021 Category: Hematology Source Type: research

Platelet Decreases following Continuous Renal Replacement Therapy Initiation as a Novel Risk Factor for Renal Nonrecovery
Conclusions: Platelet nadir #x3c;100 × 103/ µL and platelet decrease by #x3e;50% following CRRT initiation were both associated with lower rates of renal recovery. Further research is needed to evaluate mechanisms-linking platelet changes and renal nonrecovery in CRRT.Blood Purif (Source: Blood Purification)
Source: Blood Purification - September 14, 2021 Category: Hematology Source Type: research

Roxadustat Improves Erythropoietin Antibody-Mediated Pure Red Cell Aplasia in a Patient with Hemodialysis
We presented a case of 75-year-old man, who underwent hemodialysis for 2 years. He developed PRCA during rHu-EPO treatment. The rHu-EPO was immediately discontinued, and the patient was given roxadustat treatment. After 6 months of roxadustat treatment, the anti-EPO antibody was disappeared, and hemoglobin recovered normal range. The results suggest that roxadustat can be used to treat patients with anti-EPO antibody-mediated PRCA without immunosuppressive therapy.Blood Purif (Source: Blood Purification)
Source: Blood Purification - September 9, 2021 Category: Hematology Source Type: research

Improved Prognostic Prediction by Combination of Early Initiation of Polymyxin B Hemoperfusion with Modified Gender-Age-Physiology Index in Acute Exacerbation of Idiopathic Pulmonary Fibrosis
Conclusions: Early PMX-DHP initiation in patients with AE-IPF, specifically within 48 h after the steroid pulse therapy, may improve prognosis regardless of the severity of chronic phase of IPF before AE-IPF.Blood Purif (Source: Blood Purification)
Source: Blood Purification - September 9, 2021 Category: Hematology Source Type: research

Acute Kidney Injury in Extracorporeal Membrane Oxygenation Patients: National Analysis of Impact of Age
Conclusions: AKI is common and is increasing among patients on ECMO support. Patients on ECMO have high mortality and AKI is an independent predictor of mortality. Though age is also an independent predictor of mortality in patients on ECMO, it is neither a predictor of AKI nor does not modify the relationship between AKI and mortality.Blood Purif (Source: Blood Purification)
Source: Blood Purification - September 7, 2021 Category: Hematology Source Type: research

Endotoxin and Cytokine Sequential Hemoadsorption in Septic Shock and Multi-Organ Failure
The mortality of septic shock remains high [Ann Intensive Care. 2017;7:19], so apart from usual therapy based on source control and antibiotics, some patients may need rescue therapies. Blood purification systems may play a role by facilitating the nonspecific removal of inflammatory mediators and microbiological toxins. There are different hemoadsorption systems, we describe in this case report the sequential use of Polymyxin B (PMX) endotoxin-adsorbing column (Toraymixin PMX-20R; Toray, Tokyo, Japan) and Cytosorb ® (Cytosorbents Corp., New Jersey, USA).Blood Purif (Source: Blood Purification)
Source: Blood Purification - September 7, 2021 Category: Hematology Source Type: research

Sequential Blood Purification for Pediatric Fatal Toxic Epidermal Necrolysis: A Case Series
Conclusion: After sequential TPE and CHF, skin lesions and inflammatory response improved in TEN. Our result indicates extracorporeal therapy could be used as an alternative modality for fatal pediatric TEN.Blood Purif (Source: Blood Purification)
Source: Blood Purification - September 6, 2021 Category: Hematology Source Type: research

Adjunct Use of Continuous Renal Replacement Therapy with Extracorporeal Membrane Oxygenation Achieves Negative Fluid Balance and Enhances Oxygenation Which Improves Survival in Critically Ill Patients without Kidney Failure
Conclusions: The use of CRRT for fluid management is effective and, when resulting in negative fluid balance, improves survival in adult ECMO patients without significant renal dysfunction.Blood Purif (Source: Blood Purification)
Source: Blood Purification - September 2, 2021 Category: Hematology Source Type: research

Tandem Therapeutic Plasma Exchange Reduces Continuous Renal Replacement Therapy Downtime
Conclusions: Interruptions for TPE increase CRRT downtime. Tandem TPE significantly reduces CRRT downtime in patients undergoing both procedures concomitantly.Blood Purif (Source: Blood Purification)
Source: Blood Purification - September 1, 2021 Category: Hematology Source Type: research

Comparative Impact of Isolated Ultrafiltration and Hemodialysis on Fluid Distribution: A Bioimpedance Study
Conclusion: The extracellular fluid reduction effect of HD is stronger than that of IUF. The different changes in effective osmolality and osmolal gap after HD and IUF sessions may be related to the different effects of HD and IUF on fluid distribution.Blood Purif (Source: Blood Purification)
Source: Blood Purification - August 31, 2021 Category: Hematology Source Type: research

Publisher Correction to “Association between Procalcitonin and Acute Kidney Injury in Patients with Bacterial Septic Shock”
Blood Purif (Source: Blood Purification)
Source: Blood Purification - August 27, 2021 Category: Hematology Source Type: research

Erratum
Blood Purif (Source: Blood Purification)
Source: Blood Purification - August 27, 2021 Category: Hematology Source Type: research

Impact of First Wave COVID-19 Crisis on Dialysis Parameters of COVID-Free Hemodialysis Patients: A NephoCare France Longitudinal Retrospective Cohort Study
Conclusion: HD delivery to COVID-free HD patients was negatively impacted in the Paris region because of the strong constraints on units ’ organization related to the treatment of COVID-19+ HD patients and with a higher proportion of limited care/self-care units with less staff resources. The 3-month weight loss increase may be related to the suppression of intradialytic snack that impacted mostly the more malnourished patients or patients with lower interdialytic weight gain. These consequences of the COVID-19 crisis on COVID-free HD patients must be recognized and corrected to prevent further deleterious effects on...
Source: Blood Purification - August 26, 2021 Category: Hematology Source Type: research

St. John ’s Wort ( < b > < i > Hypericum perforatum < /i > < /b > )-Related Acute Kidney Injury
Some herbal products were reported to cause nephrotoxicity through different mechanisms. This case report defines an acute kidney injury (AKI) in a patient who usedHypericum perforatum tea as a sleep disorder remedy. The patient developed AKI after ingestion of tea prepared fromHypericum perforatum and underwent hemodialysis because of acute kidney failure. After 1 week, the kidney recovered, and she was discharged with normal kidney function. This is the first case reported having acute kidney failure caused by ingestion ofHypericum perforatum.Blood Purif (Source: Blood Purification)
Source: Blood Purification - August 24, 2021 Category: Hematology Source Type: research

Endotoxemia in Critically Ill Patients with COVID-19
Conclusion: Elevated EA was observed in a large majority of critically ill patients with COVID-19 and multi-organ dysfunction despite a low incidence of concurrent gram-negative bacteremia. While we observed that elevated EA and nonresponsiveness to EA were associated with AKI in critically ill patients with COVID-19, these findings require further validation in larger longitudinal cohorts.Blood Purif (Source: Blood Purification)
Source: Blood Purification - August 20, 2021 Category: Hematology Source Type: research

Hemoperfusion with CytoSorb ® in Critically Ill COVID-19 Patients
Conclusion: Treatment with CytoSorb in critically ill COVID-19 patients was associated with decreased IL-6 improvement in oxygenation. However, these effects cannot be confirmed as the direct effects of CytoSorb owing to lack of controls. Establishing causality requires large-scale randomized clinical trials.Blood Purif (Source: Blood Purification)
Source: Blood Purification - August 18, 2021 Category: Hematology Source Type: research

What Total Body Water Measurement Should Be Used for Prescribing the Dialysis Dose in Low-Flow Home Daily Dialysis?
Conclusion: BIS-TBW and Watson-TBW estimation have a good correlation; however, Watson ’s equation overestimates TBW. This overestimation is negligible for a prescription frequency of #x3e;5 sessions per week.Blood Purif (Source: Blood Purification)
Source: Blood Purification - August 17, 2021 Category: Hematology Source Type: research

Improved Dialysis Removal of Protein-Bound Uraemic Toxins with a Combined Displacement and Adsorption Technique
Conclusions: The concept of combined displacement- and adsorption-based dialysis may open up new avenues and possibilities in the field of dialysis to further enhance PBUTs removal in end-stage renal disease.Blood Purif (Source: Blood Purification)
Source: Blood Purification - August 16, 2021 Category: Hematology Source Type: research

Hyperoncotic Albumin Solution in Continuous Renal Replacement Therapy Patients
Conclusions: RENAL trial patients commonly received albumin in varying concentrations. The administration of 20% HAS was associated with a more negative fluid balance but was not independently associated with increased mortality or RRT dependence when compared to 4% HAS only.Blood Purif (Source: Blood Purification)
Source: Blood Purification - August 12, 2021 Category: Hematology Source Type: research

How Dialysis Patients Cope with a Curfew? A Comparison of Psychological Status between Hemodialysis and Peritoneal Dialysis Patients During the COVID-19 Pandemic
Conclusion: During the social isolation period due to the COVID-19 pandemic, HD patients had better mood profiles than PD patients. A more stable daily routine, an uninterrupted face-to-face contact with health-care workers, and social support among patients in the in-center dialysis environment might be the cause of the favorable mood status. PD patients might need additional psychological support during those periods.Blood Purif (Source: Blood Purification)
Source: Blood Purification - August 12, 2021 Category: Hematology Source Type: research

Gut Microbiome-Derived Uremic Toxin Levels in Hemodialysis Patients on Different Phosphate Binder Therapies
Conclusion: There was no difference in the gut microbiome-derived UTOX levels between phosphate binders (SFO vs. SEV), despite SFO therapy resulting in fewer constipated participants. This pilot study may inform study design of future clinical trials and highlights the importance of including factors beyond bowel habits and their association with UTOX levels.Blood Purif (Source: Blood Purification)
Source: Blood Purification - August 10, 2021 Category: Hematology Source Type: research

Hemoperfusion with CytoSorb to Manage Multiorgan Dysfunction in the Spectrum of Hemophagocytic Lymphohistiocytosis Syndrome in Critically Ill Children
Hemophagocytic lymphohistiocytosis (HLH) is a life-threatening condition characterized by a state of hyperinflammation. Blood purification techniques can blunt the inflammatory process with a rapidly relevant nonselective effect on the cytokine storm, thus potentially translating into survival benefit for these patients. In this cohort, we evaluated the impact of hemoadsorption with CytoSorb combined with continuous kidney replacement therapy used as adjunctive therapy in 6 critically ill children with multiple organ dysfunction due to HLH. In our series, we found a reduction in inflammatory biomarkers in patients with HLH...
Source: Blood Purification - August 3, 2021 Category: Hematology Source Type: research

Cardiometabolic Effects of Irisin in Patients with End-Stage Renal Disease on Regular Hemo- or Peritoneal Dialysis
Conclusions: Our study demonstrated that serum irisin levels are reduced in uremic patients on regular HD/PD but failed to establish significant associations of irisin deficiency with vascular stiffness. However, the significant negative relationship of irisin to HbA1c, iPTH, and alkaline phosphatase suggests that it improves insulin sensitivity, inhibits bone resorption, mitigates bone-vascular interaction, and protects vascular function.Blood Purif (Source: Blood Purification)
Source: Blood Purification - August 2, 2021 Category: Hematology Source Type: research

Morphological Lesion Types Are Associated with Primary and Secondary Patency Rates after High-Pressure Balloon Angioplasty for Dysfunctional Arteriovenous Fistulas
Conclusions: NIH-dominant lesions of AVF evaluated by DU preoperatively were a risk factor for poor primary and secondary patency rate after PTA in hemodialysis patients.Blood Purif (Source: Blood Purification)
Source: Blood Purification - July 28, 2021 Category: Hematology Source Type: research

Renal Outcomes of Dialysis-Dependent Acute Kidney Injury in Noncritically Ill Patients: A Retrospective Study
Conclusions: AKI might represent a risk factor for the development of chronic kidney damage, even in noncritically ill patients.Blood Purif (Source: Blood Purification)
Source: Blood Purification - July 28, 2021 Category: Hematology Source Type: research

An Analysis of Frequency of Continuous Blood Pressure Variation and Haemodynamic Responses during Haemodialysis
Conclusions: EP frequency analysis of continuous BP monitoring during dialysis allows assessment of BP variation and categorization of individuals into low- or high-frequency groups, which were characterized by different haemodynamic responses to dialysis. This may assist in improved individualization of dialysis therapy.Blood Purif (Source: Blood Purification)
Source: Blood Purification - July 22, 2021 Category: Hematology Source Type: research

Association between Net Ultrafiltration Rate and Renal Recovery among Critically Ill Adults with Acute Kidney Injury Receiving Continuous Renal Replacement Therapy: An Observational Cohort Study
Conclusions: Median age was 67.3 (interquartile range [IQR], 57 –76.3) years, 64.4% were male, median Acute Physiology and Chronic Health Evaluation-III score was 100 (IQR, 84–118), and 634 (44.2%) died by day 90. Kidney recovery occurred in 755 patients (52.7%). Using tertiles of UFNET rates, 3 groups were defined: high, #x3e;1.75; middle, 1.01 –1.75; and low, #x3c;1.01 mL/kg/h. Proportion of patients alive and independent of RRT among the groups were 47.8 versus 57.2 versus 53.0%;p = 0.01. Using competing risk regression, higher UFNET rate tertile compared with middle (cause-specific hazard ratio [csHR]...
Source: Blood Purification - July 21, 2021 Category: Hematology Source Type: research

Prelims
Blood Purif 2021;50:588 –590 (Source: Blood Purification)
Source: Blood Purification - July 20, 2021 Category: Hematology Source Type: research

Eosinophilic Reaction at the Time of Catheter Insertion Predicts Survival in Patients Initiating Peritoneal Dialysis
Conclusion: Eosinophilic reaction at the time of PD catheter insertion is a novel marker that may predict outcomes in patients initiating PD.Blood Purif (Source: Blood Purification)
Source: Blood Purification - July 20, 2021 Category: Hematology Source Type: research

A Systematic Review and Meta-Analysis: Hyponatremia Predicted All-Cause and Cardiovascular Mortality in Dialysis Population
Conclusions: Hyponatremia was independently associated with all-cause and cardiovascular mortality, and it might predict adverse outcomes of patients under dialysis.Blood Purif (Source: Blood Purification)
Source: Blood Purification - July 20, 2021 Category: Hematology Source Type: research

Renal Resistive Index as a Predictor of Acute Kidney Injury and Mortality in COVID-19 Critically Ill Patients
Conclusions: Critical care ultrasonography is a noninvasive, reproducible, and accurate bedside method that has proven its usefulness. An elevated RRI may have a role in predicting AKI, RRT initiation, and mortality in patients with severe SARS-CoV-2 pneumonia.Blood Purif (Source: Blood Purification)
Source: Blood Purification - July 19, 2021 Category: Hematology Source Type: research

Seraph-100 Hemoperfusion in SARS-CoV-2-Infected Patients Early in Critical Illness: A Case Series
We report our experience with the Seraph-100 Microbind Affinity Blood Filter (Seraph-100) in 4 patients with COVID-19 early in the course of their critical respiratory illnesses. Patients were diagnosed with COVID-19 and were admitted to intensive care with worsening respiratory failure but did not require dialysis or vasopressors. Patients had to have a PaO2 to FiO2 (P/F ratio) #x3c;150 to qualify for hemoperfusion therapy. All patients received standard medical therapy including oral vitamins C and D and zinc in addition to intravenous dexamethasone and remdesivir. Patients received a single 5- to 7-h session with Seraph...
Source: Blood Purification - July 14, 2021 Category: Hematology Source Type: research

Use of Point-of-Care Ultrasound for Evaluation of Extravascular and Intravascular Fluid Status in Pediatric Patients Maintained on Chronic Hemodialysis
Conclusion: Bedside ultrasound is a single modality that can be used to assess both extravascular and intravascular fluid status. It may contribute to clinical decisions differentiating fluid-related versus fluid-unrelated hypertension and identifying patients with covert fluids.Blood Purif (Source: Blood Purification)
Source: Blood Purification - July 14, 2021 Category: Hematology Source Type: research

Factors Associated with Coronary In-Stent Restenosis after Drug-Eluting Stent Implantation in Patients on Chronic Hemodialysis
Conclusions: ISR was observed in 74 lesions (22.4%). A small MLD, long LL, and the use of rotational atherectomy were independent predictors of ISR after DES implantation in patients on HD. There was no significant difference in the ISR rate between the first- and the second-generation DESs.Blood Purif (Source: Blood Purification)
Source: Blood Purification - July 14, 2021 Category: Hematology Source Type: research

Combined Renal-Pulmonary Extracorporeal Support with Low Blood Flow Techniques: A Retrospective Observational Study (CICERO Study)
Conclusion: ECCO2R-CRRT was effective and safe in patients with aeCOPD and ARDS associated with AKI.Blood Purif (Source: Blood Purification)
Source: Blood Purification - July 8, 2021 Category: Hematology Source Type: research

Use of CRRT and Plasmapheresis to Treat Simultaneous Iron and Acetaminophen Overdose
We present a case of fatal intentional acetaminophen and iron overdose and treatment with extracorporeal methods, including continuous venovenous hemofiltration and plasmapheresis, for removal of both toxins.Blood Purif (Source: Blood Purification)
Source: Blood Purification - July 8, 2021 Category: Hematology Source Type: research