Extracorporeal Albumin Dialysis in Liver Failure with MARS and SPAD: A Randomized Crossover Trial
Conclusion: A simple-to-perform SPAD therapy with equal to MARS dialysate flow parameters provides the same efficacy in bilirubin and bile acid removal. However, clinically relevant endpoints have to be evaluated in randomized trials to compare MARS and SPAD therapies and to define the place of SPAD in the liver failure care program.Blood Purif (Source: Blood Purification)
Source: Blood Purification - June 17, 2021 Category: Hematology Source Type: research

Erratum
Blood Purif (Source: Blood Purification)
Source: Blood Purification - June 15, 2021 Category: Hematology Source Type: research

Incidence and Outcomes of Acute Kidney Injury in COVID-19: A Systematic Review
Conclusion: This comprehensive systematic review summarizes the available literature pertaining to AKI epidemiology in COVID-19 patients and highlights the incidence, associated mortality, and the need for KRT in this susceptible population.Blood Purif (Source: Blood Purification)
Source: Blood Purification - June 15, 2021 Category: Hematology Source Type: research

Early Goal-Directed Renal Replacement Therapy in Acute Decompensated Heart Failure Patients with Cardiorenal Syndrome
Conclusion: This study clarified the effectiveness of the early GDRRT strategy in ADHF patients suffered from CRS, which reduced inhospital mortality and improved the urine output and clinical kidney recovery outcome.Blood Purif (Source: Blood Purification)
Source: Blood Purification - June 15, 2021 Category: Hematology Source Type: research

Extracorporeal Blood Purification in Moderate and Severe COVID-19 Patients: A Prospective Cohort Study
Conclusion: EBP with CAH was associated with a decrease in CRP, and control of IL-6 and procalcitonin.Blood Purif (Source: Blood Purification)
Source: Blood Purification - June 14, 2021 Category: Hematology Source Type: research

The Association between Baseline Serum Lipids and Mortality in Peritoneal Dialysis Patients
Conclusion: Lower total cholesterol/LDL levels at the initiation of PD were associated with overall mortality in PD patients. The association could be potentially modified by malnutrition, inflammation, and residual renal function or disappeared after 24 months.Blood Purif (Source: Blood Purification)
Source: Blood Purification - June 11, 2021 Category: Hematology Source Type: research

Relationship between Monocytes and Stenosis-Related Autologous Arteriovenous Fistula Dysfunction
Conclusion: Monocyte count ≥0.51 × 109/L is an independent risk factor for AVF failure, and AVF failure caused by monocytes may be driven by inflammation.Blood Purif (Source: Blood Purification)
Source: Blood Purification - June 10, 2021 Category: Hematology Source Type: research

COVID-19 Infection and Acute Kidney Injury: Cause or Complication?
Management of COVID-19 infection is the trend topic in the scientific community and case identification is a key step to contain the pandemic. While pneumonia and acute respiratory distress syndrome represent the typical severe manifestations of the disease, atypical presentations pose significant diagnostic and therapeutic challenges for physicians, especially when diagnostic tests are repeatedly negative. Clinical picture of COVID-19 patients is often complicated by bacterial infections or thrombotic events. Here, we present and discuss a case report identified in our center as example of a challenging diagnosis and 2 un...
Source: Blood Purification - June 9, 2021 Category: Hematology Source Type: research

The Efficacy of Resin Hemoperfusion Cartridge on Inflammatory Responses during Adult Cardiopulmonary Bypass
Conclusion: The HA380 hemoperfusion cartridge could effectively reduce the systemic inflammatory responses and improve postoperative recovery of patients during adult CPB.Blood Purif (Source: Blood Purification)
Source: Blood Purification - June 9, 2021 Category: Hematology Source Type: research

Erratum
Blood Purif (Source: Blood Purification)
Source: Blood Purification - June 8, 2021 Category: Hematology Source Type: research

Inflammation-Based Prognostic Markers and Outcome of CAPD Patients: Fact or Fiction?
Blood Purif (Source: Blood Purification)
Source: Blood Purification - May 28, 2021 Category: Hematology Source Type: research

Ultrasonographic Intraparenchymal Renal Resistive Index Variation for Assessing Renal Functional Reserve in Patients Scheduled for Cardiac Surgery: A Pilot Study
Conclusion: This pilot study suggests that a positive IRRIV test can significantly predict the presence of RFR in patients scheduled for cardiac surgery. RFR measured by the protein loading test or by the US IRRIV test can predict the occurrence of subclinical postoperative AKI. The findings of this study need to be confirmed in large patient cohorts.Blood Purif (Source: Blood Purification)
Source: Blood Purification - May 27, 2021 Category: Hematology Source Type: research

COVID-19 Prevention and Control in Dialysis Centers during the Pandemic: A Single-Center Experience
This article provides key points in coping with COVID-19 in dialysis centers during this pandemic based on experience: (1) enforcing infection control management of dialysis centers, (2) training of hemodialysis patients and medical staffs, (3) screening for COVID-19 among patients and medical staffs, and (4) providing graded isolated dialysis to close contacts, suspected cases, and confirmed cases of COVID-19. We hope our single-center experience can be referenced by other dialysis centers around the world in coping with the COVID-19 pandemic.Blood Purif (Source: Blood Purification)
Source: Blood Purification - May 26, 2021 Category: Hematology Source Type: research

Flow Dynamic Analysis by Contrast-Enhanced Imaging Techniques of Medium Cutoff Membrane Hemodialyzer
Conclusion: The MCO dialyzer Theranova 400 appears to have a design optimized to perform expanded hemodialysis (HDx).Blood Purif (Source: Blood Purification)
Source: Blood Purification - May 25, 2021 Category: Hematology Source Type: research

Low Blood Flow Continuous Veno-Venous Haemodialysis Compared with Higher Blood Flow Continuous Veno-Venous Haemodiafiltration: Effect on Alarm Rates, Filter Life, and Azotaemic Control
Conclusion: Low blood flow CVVHD and femoral vascular access reduce alarms while maintaining azotaemic control and circuit patency thus minimizing bedside clinician workload.Blood Purif (Source: Blood Purification)
Source: Blood Purification - May 19, 2021 Category: Hematology Source Type: research

Shall We Use Hydroxychloroquine in Hemodialysis Patients?
Blood Purif (Source: Blood Purification)
Source: Blood Purification - May 12, 2021 Category: Hematology Source Type: research

Efficacy, Safety, and Calcium Balance of an Accelerated Citrate Anticoagulated Membrane-Based Plasma Exchange Algorithm
Conclusion: An accelerated algorithm for regional citrate anticoagulation achieves substantial time saving while maintaining efficacy and safety. The 4 episodes of systemic ionized calcium #x3c;0.81 mmol/L may have been due to recirculation of infused citrate but, probably more likely, are due to the additional citrate load imposed by use of fresh frozen plasma in these sessions. Future algorithms need to better account for the citrate load present in fresh frozen plasma.Blood Purif (Source: Blood Purification)
Source: Blood Purification - May 11, 2021 Category: Hematology Source Type: research

Survival Outcomes of Hemoperfusion and Hemodialysis versus Hemodialysis in Patients with End-Stage Renal Disease: A Systematic Review and Meta-Analysis
Conclusions: This meta-analysis suggests that the OS rates of ESRD patients treated with HP + HD were better than those of patients treated with HD. A speculative hypothesis for why this is the case may be that HP + HD can achieve the complementary elimination of metabolites, effectively preventing and treating complications caused by long-term dialysis and prolonging life expectancy. Therefore, HP + HD should be widely used in ESRD patients.Blood Purif (Source: Blood Purification)
Source: Blood Purification - May 10, 2021 Category: Hematology Source Type: research

Development of a Multivariable Prediction Model for Citrate Accumulation in Liver Transplant Patients Undergoing Continuous Renal Replacement Therapy with Regional Citrate Anticoagulation
Conclusions: The prediction model integrating multiple clinical variables showed a good predictive value for CA. A nomogram visualized the model for easy application in clinical practice.Blood Purif (Source: Blood Purification)
Source: Blood Purification - May 5, 2021 Category: Hematology Source Type: research

Association of Phosphate Containing Solutions with Incident Hypophosphatemia in Critically Ill Patients Requiring Continuous Renal Replacement Therapy
Conclusions: The use of phosphate containing CRRT solutions was independently associated with reduced risk of incident hypophosphatemia and decreased phosphate supplementation during CRRT. Interventional studies to confirm these findings are needed.Blood Purif (Source: Blood Purification)
Source: Blood Purification - April 29, 2021 Category: Hematology Source Type: research

A Mini Review of Plant-Based Diets in Hemodialysis
This article reviews current literature on the use of plant-based diets in the treatment of patients on dialysis.Blood Purif (Source: Blood Purification)
Source: Blood Purification - April 29, 2021 Category: Hematology Source Type: research

Impact of Extended Duration of Polymyxin B-Immobilized Fiber Column Direct Hemoperfusion on Hemodynamics, Vasoactive Substance Requirement, and Pulmonary Oxygenation in Patients with Sepsis: An Observational Study
Conclusions: Longer duration of PMX-DHP was associated with the improved MAP and decreased volume of vasoactive-inotropic agents compared with the conventional duration. Eight and longer hours duration of PMX-DHP was associated with the improvement in the pulmonary oxygenation. Further studies are needed to confirm the efficacy of longer duration of PMX-DHP in patients with septic shock.Blood Purif (Source: Blood Purification)
Source: Blood Purification - April 28, 2021 Category: Hematology Source Type: research

Serum Cardiac Biomarkers in Asymptomatic Hemodialysis Patients: Role of Soluble Suppression of Tumorigenicity-2
Conclusion: Our study confirms that sST2 is useful for stratifying CV risk in the HD population. sST2 can be evaluated simply as a dichotomous value higher or lower than the normal range, making it easily interpretable. Dialysis and residual diuresis did not affect significantly sST2. A multimarker approach that incorporates sST2 and BNP may improve the prediction of CVE.Blood Purif (Source: Blood Purification)
Source: Blood Purification - April 28, 2021 Category: Hematology Source Type: research

Intermittent Convective Therapies in Patients with Acute Kidney Injury: A Systematic Review with Meta-Analysis
Conclusion: This meta-analysis suggests that there is no significant difference in short-term mortality and renal recovery in patients with severe AKI when treated with intermittent HF or HDF compared to conventional HD. This systematic review emphasizes the need for further trials evaluating optimal convective parameters in AKI patients treated with intermittent dialysis.Blood Purif (Source: Blood Purification)
Source: Blood Purification - April 26, 2021 Category: Hematology Source Type: research

Successful Treatment with Belimumab in a Patient with Refractory Systemic Lupus Erythematosus after Initiation of Hemodialysis: Considering the Synergistic Effect of Belimumab and Immunological Burn-Out Phenomenon in End-Stage Renal Disease Patients on Hemodialysis
Conclusions: ESRD patients with SLE show no significant decrease in transitional B cells and have elevated levels of B-cell activating factor (BAFF). Both transitional B cells and BAFF are important therapeutic targets for belimumab, indicating that patients with ESRD may benefit from belimumab therapy. However, the effects of belimumab may be potentiated in patients with uremia, who may be more susceptible to adverse events such as infections. Patients with SLE who receive belimumab after initiation of hemodialysis therefore require careful follow-up. Here, we report the first case of belimumab administration in a patient...
Source: Blood Purification - April 23, 2021 Category: Hematology Source Type: research

Hypomagnesemia Is a Risk Factor for Cardiovascular Disease- and Noncardiovascular Disease-Related Mortality in Peritoneal Dialysis Patients
Conclusions: Hypomagnesemia (serum magnesium #x3c;0.7 mmol/L) during stable dialysis in PD patients is a risk factor for CVD- and non-CVD-related mortality, especially infection-related death causes.Blood Purif (Source: Blood Purification)
Source: Blood Purification - April 21, 2021 Category: Hematology Source Type: research

Endotoxin Adsorbent Therapy in Severe COVID-19 Pneumonia
Conclusions: We demonstrated the clinical improvement of severe COVID-19 patients with elevated EAA level upon receiving EA therapy. However, the benefit of EA therapy in COVID-19 ARDS is still unclear and needs to be elucidated with randomized controlled study.Blood Purif (Source: Blood Purification)
Source: Blood Purification - April 15, 2021 Category: Hematology Source Type: research

Artificial Intelligence Methods for Rapid Vascular Access Aneurysm Classification in Remote or In-Person Settings
Conclusion: This is the first quality improvement project to show that an AI instrument can reliably grade vascular access aneurysms in a noninvasive way, allowing rapid assessments to be made on patients who would otherwise be at risk for highly morbid events. Moreover, these AI-assisted assessments can be made without having to schedule separate appointments and potentially even via telehealth.Blood Purif (Source: Blood Purification)
Source: Blood Purification - April 15, 2021 Category: Hematology Source Type: research

Abstracts: RRI 23rd International Conference on Dialysis, Advances in Kidney Disease 2021, April 20-23rd
Blood Purif (Source: Blood Purification)
Source: Blood Purification - April 15, 2021 Category: Hematology Source Type: research

Subarachnoid Hemorrhage and Extracorporeal Blood Purification with HA-380 and High-Volume Hemofiltration: A New Therapeutic Challenge at the Neurocritical Care Unit? A Case Report
We present the case of a patient with subarachnoid hemorrhage (SAH) secondary to a ruptured cerebral aneurysm and a refractory shock with high doses of vasopressors without a proven source of infection. This patient received therapy with high-volume hemofiltration plus adsorption, resolving the hemodynamic deterioration and with good neurological evolution. Our clinical case proposes that extracorporeal therapies may have a feasibility role in the management of complications of SAH.Blood Purif (Source: Blood Purification)
Source: Blood Purification - April 14, 2021 Category: Hematology Source Type: research

Using Patient-Reported Measures to Improve Outcomes in Kidney Disease
Patients with CKD and ESRD are vulnerable to increased mortality rates and other poor outcomes. Among those with ESRD, their health-related quality of life (HRQOL) is shown little to no improvement as they undergo treatments such as dialysis and providers concurrently manage other health issues that complicate their already vulnerable state. This review synthesizes evidence demonstrating that a focus on measuring and monitoring patient-reported outcomes (PRO) such as pain and depression can improve HRQOL. Patient-centered care has the potential to create an efficient way for clinicians to address specific challenges facing...
Source: Blood Purification - April 12, 2021 Category: Hematology Source Type: research

The Relationship between Serum Ferritin Levels and 5-Year All-Cause Mortality in Hemodialysis Patients
Conclusion: Time-averaged serum ferritin levels #x3e;1,500 ng/mL in hemodialysis patients are associated with an increased 5-year all-cause mortality risk.Blood Purif (Source: Blood Purification)
Source: Blood Purification - April 7, 2021 Category: Hematology Source Type: research

WoundClot ® Hemostatic Gauze Reduces Bleeding Time after Arterial Venous Fistula Decannulation
Conclusions: WoundClot hemostatic gauze significantly reduced the time required for hemostasis after AVF decannulation and may be associated with better AVF preservation. We suggest using WoundClot for arterial BT longer than 15 min and for venous BT longer than 12.5 min.Blood Purif (Source: Blood Purification)
Source: Blood Purification - March 31, 2021 Category: Hematology Source Type: research

Convalescent Blood: Current Perspective on the Efficacy of a Legacy Approach in COVID-19 Treatment
Since early 2020, COVID-19 has wreaked havoc in many societies around the world. As of the present, the SARS-CoV-2-borne disease is propagating in almost all countries, affecting hundreds of thousands of people in an unprecedented way. As the name suggests, the novel coronavirus, widely known as SARS-CoV-2, is a new emerging human pathogen. A novel disease of relatively unknown origin, COVID-19 does not seem to be amenable to the currently available medicines since there is no specific cure for the disease. In the absence of any vaccine or effective antiviral medication, we have no tools at our disposal, but the method of ...
Source: Blood Purification - March 31, 2021 Category: Hematology Source Type: research

Distinct Solute Removal Patterns by Similar Surface High-Flux Membranes in Haemodiafiltration: The Adsorption Point of View
Conclusion: Convection improves removal and slightly increases adsorption. Adsorbed proteins do not lead to enhanced PBUTs depuration and limit membrane efficiency due to fouling. Selection of the correct membrane for convective therapies is mandatory to optimize removal efficiency.Blood Purif (Source: Blood Purification)
Source: Blood Purification - March 31, 2021 Category: Hematology Source Type: research

Cumulative C-Reactive Protein Levels and Progression of Malnutrition in Dialysis Patients: A Longitudinal Study
Conclusion: A long-term perspective is needed in the management of malnutrition in dialysis patients because this complication develops progressively and is often irreversible when diagnosed. Cumulative CRP values may be useful in evaluating the degree of the progression of malnutrition in following up individual patients longitudinally.Blood Purif (Source: Blood Purification)
Source: Blood Purification - March 31, 2021 Category: Hematology Source Type: research

Effect of Statewide Lockdown in Response to COVID-19 Pandemic on Physical Activity Levels of Hemodialysis Patients
Conclusion: Lockdown measures were associated with a significant decrease in PAL in hemodialysis patients. Patients who contracted COVID-19 had higher PAL during the incubation period. Methods to increase PAL while allowing for social distancing should be explored and implemented.Blood Purif (Source: Blood Purification)
Source: Blood Purification - March 31, 2021 Category: Hematology Source Type: research

Safety of a Novel Dialyzer Containing a Fluorinated Polyurethane Surface-Modifying Macromolecule in Patients with End-Stage Kidney Disease
Conclusions: The safety of the novel dialyzer with Endexo was generally comparable to the Optiflux dialyzer, while exhibiting a higher β2M removal rate.Blood Purif (Source: Blood Purification)
Source: Blood Purification - March 31, 2021 Category: Hematology Source Type: research

Erythropoietin Resistance Index and the Affecting Factors in Children with Peritoneal Dialysis
Conclusion: We demonstrate that the most important factor affecting ERI value is young age. We also reveal that absence of RKF, large number of hospitalization, and ACEI use are also important variables affecting the ERI value.Blood Purif (Source: Blood Purification)
Source: Blood Purification - March 30, 2021 Category: Hematology Source Type: research

Early Detection of Arteriovenous Fistula Stenosis in Hemodialysis Patients through Routine Measurements of Dialysis Dose (Kt/V)
Conclusion: In hemodialysis patients with AV fistula, treated with online HDF, routine measurements of Kt/V during each HDF are a beneficial, quick, and straightforward method for early detection of hemodynamically significant AV fistula stenosis.Blood Purif (Source: Blood Purification)
Source: Blood Purification - March 30, 2021 Category: Hematology Source Type: research

The Seraph ®-100 Microbind Affinity Blood Filter Does Not Affect Vancomycin, Tacrolimus, and Mycophenolic Acid Plasma Concentrations
Extracorporeal blood purification is considered an adjunct therapy in critically ill patients with life-threatening conditions such as sepsis and septic shock. It consists of cytokine removal, removal of endotoxins, a combination of both, or the removal of pathogens themselves. The latter technique was introduced for clinical application very recently. This case study describes a case of a 69-year-old female lung transplant recipient patient with a persistent VV-ECMO-related septic deep vein thrombosis with continuous renal replacement therapy-dependent acute kidney injury initiated on the Seraph ®-100 Microbind Affini...
Source: Blood Purification - March 29, 2021 Category: Hematology Source Type: research

Analysis of Glycemic Improvement in Hemodialysis Patients Based on Time in Range, Assessed by Flash Glucose Monitoring
Conclusion: TIR seems to be feasible and clinically useful for AGP analysis in dialysis patients with diabetes, and FGM can be used to improve glycemic control.Blood Purif (Source: Blood Purification)
Source: Blood Purification - March 26, 2021 Category: Hematology Source Type: research

Hemodynamic Instability during Acute Kidney Injury and Acute Renal Replacement Therapy: Pathophysiology and Clinical Implications
Hemodynamic instability associated with acute renal replacement therapy (aRRT, HIRRT) and/or with acute kidney injury (AKI) is frequently observed in the intensive care unit; it affects patients ’ renal recovery, and negatively impacts short- and long-term mortality. A thorough understanding of mechanisms underlying HIRRT and AKI-related hemodynamic instability may allow the physician in adopting adequate strategies to prevent their occurrence and reduce their negative consequences. The a im of this review is to summarize the main alterations occurring in patients with AKI and/or requiring aRRT of those homeostatic m...
Source: Blood Purification - March 23, 2021 Category: Hematology Source Type: research

Neutrophil Gelatinase-Associated Lipocalin for the Assessment of Reversible versus Persistent Renal Tubular Damage in ST-Segment Myocardial Infarction Patients
Conclusions: Renal tubular damage is common among STEMI patients. Dynamic NGAL measurement may differentiate between reversible and persistent tubular damage. Further trials are needed in order to assess the complex cardiorenal interactions.Blood Purif (Source: Blood Purification)
Source: Blood Purification - March 23, 2021 Category: Hematology Source Type: research

COVID-19 in Chronic Kidney Disease: The Impact of Old and Novel Cardiovascular Risk Factors
Cardiovascular disease is a frequent complication and the most common cause of death in patients with CKD. Despite landmark medical advancements, mortality due to cardiovascular disease is still 20 times higher in CKD patients than in the general population, which is mainly due to the high prevalence of risk factors in this group. Indeed, in addition to traditional cardiovascular risk factors, CKD patients are exposed to nontraditional ones, which include metabolic, hormonal, and inflammatory alterations. The global severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has brought novel challenges for both ...
Source: Blood Purification - March 22, 2021 Category: Hematology Source Type: research

The Impact of Old and Novel Cardiovascular Risk Factors
Cardiovascular disease is a frequent complication and the most common cause of death in patients with CKD. Despite landmark medical advancements, mortality due to cardiovascular disease is still 20 times higher in CKD patients than in the general population, which is mainly due to the high prevalence of risk factors in this group. Indeed, in addition to traditional cardiovascular risk factors, CKD patients are exposed to nontraditional ones, which include metabolic, hormonal, and inflammatory alterations. The global severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has brought novel challenges for both ...
Source: Blood Purification - March 22, 2021 Category: Hematology Source Type: research

Community- and Hospital-Acquired Acute Kidney Injury in COVID-19: Different Phenotypes and Dismal Prognosis
Conclusions: CA-AKI and HA-AKI portend an adverse prognosis in CO ­VID-19. Nevertheless, CA-AKI was associated with a higher comorbidity burden (including CKD and hypertension), while HA-AKI occurred in younger patients by the time severe multiorgan disease developed.Blood Purif (Source: Blood Purification)
Source: Blood Purification - March 19, 2021 Category: Hematology Source Type: research

Serum Uric Acid and Mortality in Patients with Chronic Kidney Disease: A Systematic Review and Meta-Analysis
Conclusions: Higher and lower SUA levels are both associated with significantly increased risk of all-cause mortality in patients with CKD. A appreciate dose of treatment of lowering SUA agents should be confirmed.Blood Purif (Source: Blood Purification)
Source: Blood Purification - March 19, 2021 Category: Hematology Source Type: research

A Scoring Model with Simple Clinical Parameters to Predict Successful Discontinuation of Continuous Renal Replacement Therapy
Conclusions: Scoring system composed of urine output ≥300 mL/day on D-1, and adequate blood pressure, serum potassium #x3c;4.1 mmol/L, and BUN #x3c;35 mg/dL (12.5 mmol/L) on D0 was developed to predict successful discontinuation of CRRT.Blood Purif (Source: Blood Purification)
Source: Blood Purification - March 18, 2021 Category: Hematology Source Type: research

Association between Procalcitonin and Acute Kidney Injury in Patients with Bacterial Septic Shock
Conclusions: Our data revealed a nonlinear relationship between PCT and AKI in septic shock patients, and PCT could be used as a potential biomarker of AKI in female patients younger than 75 years with bacterial septic shock.Blood Purif (Source: Blood Purification)
Source: Blood Purification - March 17, 2021 Category: Hematology Source Type: research