Routine Is the Worst Enemy of the Dialysis Patient
Blood Purif (Source: Blood Purification)
Source: Blood Purification - April 18, 2019 Category: Hematology Source Type: research

Counteracting the Metabolic Effects of Glucose Load in Peritoneal Dialysis Patients; an Exercise-Based Approach
Glucose-based peritoneal dialysis (PD) solutions are the predominantly used dialysate in PD patients. Glucose absorption has been shown to be associated with several unfavorable metabolic complications. Several studies have shown positive effects of exercise in end-stage renal disease patients. This paper provides an overview of glucose-associated metabolic complications, and proposed exercise regimens to counteract the caloric load associated with glucose absorption.Blood Purif (Source: Blood Purification)
Source: Blood Purification - April 15, 2019 Category: Hematology Source Type: research

Introduction
Blood Purif 2019;47(suppl 3):1 –2 (Source: Blood Purification)
Source: Blood Purification - April 15, 2019 Category: Hematology Source Type: research

Extracorporeal Blood Purification Therapies for Sepsis
Extracorporeal blood purification is proposed as an adjuvant therapy for sepsis, aiming at controlling the associated dysregulation of the immune system, which is known to induce organ dysfunctions. Different therapies have been developed to address certain steps of the immune dysregulation. Most of the available blood purification devices focus on a single target, such as the endotoxin that triggers the immune cascade, or the cytokine storm that causes organ damages. However, the highly adsorptive membrane named oXiris ® is a unique 4-in-1 device that combines cytokine and endotoxin removal properties, renal replaceme...
Source: Blood Purification - April 15, 2019 Category: Hematology Source Type: research

Practice of Extracorporeal Therapies for Septic Acute Kidney Injury Patients in Intensive Care Units in Mainland China
Background: Continuous renal replacement therapy (CRRT) and other extracorporeal therapies for acute kidney injury (AKI) and other organ dysfunction syndromes in critically ill patients are common in the intensive care unit (ICU). Many studies have focused on clinical practice for managing these conditions. However, there are few studies that describe the utilization of extracorporeal therapies, especially CRRT, in patients with sepsis-associated AKI.Summary: Two hundred ICU physicians were included in a survey from February 28, 2017, to March 20, 2017, on the current status of septic AKI and clinical practice in CRRT. Acc...
Source: Blood Purification - April 15, 2019 Category: Hematology Source Type: research

oXiris ® Use in Septic Shock: Experience of Two French Centres
This study reports our experience with the use of the oXiris ® membrane for septic shock patients requiring continuous renal replacement therapy (CRRT).Summary: Thirty-one patients were diagnosed with septic shock and underwent CRRT with the oXiris ® membrane between 2014 and 2019. We compared the observed hospital mortality with that predicted by the Simplified Acute Physiology Score II (SAPS II). Change in the Sequential Organ Failure Assessment (SOFA) score and of the main clinical and biological parameters over time were analyzed. Hospita l mortality was lower than predicted for the most severe patients (60 vs....
Source: Blood Purification - April 15, 2019 Category: Hematology Source Type: research

Sepsis Management with a Blood Purification Membrane: European Experience
Conclusion: In the absence of established guidelines, users of hollow-fibre purification devices such as oXiris may benefit from standardised approaches to selecting patients and initiating and terminating treatment, as well as measuring success. Further evidence in the form of randomised clinical trials is urgently required.Blood Purif 2019;47(suppl 3):1 –9 (Source: Blood Purification)
Source: Blood Purification - April 15, 2019 Category: Hematology Source Type: research

Hemofilter with Adsorptive Capacities: Case Report Series
Background: oXiris is a blood purification product that has been launched recently in China. In addition to renal function support and fluid management capabilities, it can also adsorb cytokines and endotoxins. This may complement standard treatment for septic acute kidney injury (AKI) patients to control the amplitude of systemic inflammatory response responsible for acute tissue and organ damage. Objectives of our study are to elucidate characteristics of septic AKI patients who respond to treatment with oXiris and to describe the performance of oXiris through patient cases in the absence of large randomized trials on cl...
Source: Blood Purification - April 15, 2019 Category: Hematology Source Type: research

Analysis of Endotoxin Adsorption in Two Swedish Patients with Septic Shock
Background: Lipopolysaccharide (endotoxin) from the outer Gram-negative bacterial wall can induce a harmful immunologic response, involving hemodynamic deprivation, and is one important motor driving the septic cascade. The positively charged poly-imine ethylene layer on the oXiris membrane is capable of adsorbing negatively charged endotoxin molecules and removing them from the blood compartment. Endotoxin is detrimental and should be removed from blood.Summary: The adsorbable endotoxin fraction in blood arises from a tight balance between seeding from an infectious focus and removal by an overwhelmed immune system. The n...
Source: Blood Purification - April 15, 2019 Category: Hematology Source Type: research

Continuous Renal Replacement Therapy with the Adsorbing Filter oXiris in Septic Patients: A Case Series
Conclusion: In sepsis/septic shock patients with AKI, CRRT with the adsorbing membrane oXiris may be safe and improves the cardiorenal – function and the clinical condition. The effect on cytokines and endotoxin may explain in part these results. A RCT is warranted to confirm these data.Blood Purif 2019;47(suppl 3):1 –5 (Source: Blood Purification)
Source: Blood Purification - April 15, 2019 Category: Hematology Source Type: research

Augmented Adsorptive Blood Purification during Continuous Veno-Venous Haemodiafiltration in a Severe Septic, Acute Kidney Injury Patient: Use of oXiris ®: A Single Centre Case Report
The use of the oXiris ® haemofilter during continuous veno-venous haemodiafiltration (CVVHDF) for acute kidney injury (AKI) and severe sepsis is not completely understood. Although this filter has in vitro adsorptive properties for blood-borne cytokines and other humoural mediators of sepsis, its clinical usefulness is uncertain. Given its inherent adsorptive limitation for septic mediators, we developed a CVVHDF protocol in which the oXiris haemofilter was electively changed every 12 h even though there was no clotting or adverse circuit pressures. Augmented filter membrane adsorption was conducted for 3 consecut ive ...
Source: Blood Purification - April 15, 2019 Category: Hematology Source Type: research

Prevalence and Severity of Itching in Patients with End-Stage Renal Disease: Treatment with Nalfurafine Hydrochloride
Conclusion: Better skin management is needed for itch in patients with ESRD or CKD. Moisturizing and lifestyle factors are important. Topical or oral medications may also be used. Nalfurafine, a κ receptor agonist, is now available in Japan for the treatment of uremic pruritus in these patients.Blood Purif 2019;47(suppl 2):1 –5 (Source: Blood Purification)
Source: Blood Purification - April 3, 2019 Category: Hematology Source Type: research

Pre- and Postdialysis Uric Acid Difference and Risk of Long-Term All-Cause and Cardiovascular Mortalities in Japanese Hemodialysis Patients; Miyazaki Dialysis Cohort Study
Conclusion: UAD correlated with all-cause mortality. UAD may be the most appropriate reference for controlling UA in HD patients.Blood Purif 2019;47(suppl 2):1 –6 (Source: Blood Purification)
Source: Blood Purification - April 3, 2019 Category: Hematology Source Type: research

Analysis of Extracellular Fluid Volume in Peritoneal Dialysis Patients before and after Kidney Transplantation
Conclusion: ECF volume and osmotic excess occurred in the PD and preemptive groups compared with the HD group pre-transplantation. Although PD maintains MDV and residual and total urine volume, ECF volume and osmotic excess should be monitored before transplant; pre-transplant HD support should always be considered in PD and preemptive transplant patients.Blood Purif 2019;47(suppl 2):1 –7 (Source: Blood Purification)
Source: Blood Purification - April 3, 2019 Category: Hematology Source Type: research

Differential Impacts of Intravenous Iron Administration and Iron-Containing Phosphate Binders on Serum Intact Fibroblast Growth Factor 23 Levels
Conclusion: Intravenous iron administration may influence intact FGF23 levels in HD patients independently of phosphate and iron metabolism.Blood Purif 2019;47(suppl 2):1 –7 (Source: Blood Purification)
Source: Blood Purification - April 3, 2019 Category: Hematology Source Type: research

Significance of Content of the Reticulocyte Hemoglobin in the Management of Renal Anemia
This report presents the clinical significance of CHr, the potential use of CHr for the diagnosis of iron deficiency, and tests for optimal iron level using CHr as performed in our hospital.Blood Purif 2019;47(suppl 2):1 –4 (Source: Blood Purification)
Source: Blood Purification - April 3, 2019 Category: Hematology Source Type: research

Complications During Continuous Renal Replacement Therapy in Critically Ill Neonates
Conclusion: Complications during CRRT in neonates comprised IDH at the start of the CRRT, body temperature decline, and thrombocytopenia. These complications need to be analyzed for a safe neonatal CRRT.Blood Purif 2019;47(suppl 2):1 –7 (Source: Blood Purification)
Source: Blood Purification - April 3, 2019 Category: Hematology Source Type: research

Aortic Arch Calcification and Bone-Associated Molecules in Peritoneal Dialysis Patients
Conclusion: AoAC progression was associated with increased aortic stiffness. OPG may be associated with AoAC progression in CAPD.Blood Purif 2019;47(suppl 2):1 –7 (Source: Blood Purification)
Source: Blood Purification - April 3, 2019 Category: Hematology Source Type: research

Serum Magnesium Levels and Mortality in Japanese Maintenance Hemodialysis Patients
Conclusions: Hypermagnesemia tended to be associated with better survival and a higher prescription rate of MgO. Interventional studies are needed to clarify whether Mg supplementation is beneficial for improving patient prognosis.Blood Purif 2019;47(suppl 2):1 –7 (Source: Blood Purification)
Source: Blood Purification - April 3, 2019 Category: Hematology Source Type: research

Strategies for the Super-Aged Dialysis Population: Survival Benefits or Alternative Goals?
Conclusion: Survival of the super-aged population has not improved in the last 2 decades. Thus, withholding or withdrawing dialysis and providing conservative management without dialysis treatment could be an important option for patients aged 90 years or older.Blood Purif 2019;47(suppl 2):1 –11 (Source: Blood Purification)
Source: Blood Purification - April 3, 2019 Category: Hematology Source Type: research

Medium Cut-Off Dialyzer versus Eight Hemodiafiltration Dialyzers: Comparison Using a Global Removal Score
Conclusions: Removal of a wide range of molecular weights, calculated with the proposed global removal score, was almost equal with the MCO dialyzer in HD treatment compared with 8 high-flux dialyzers in high-volume OL-HDF without relevant changes in albumin loss. The global removal score could be a new tool to evaluate the effectiveness of dialyzers and/or different treatment modalities.Blood Purif (Source: Blood Purification)
Source: Blood Purification - April 3, 2019 Category: Hematology Source Type: research

Incidence, Risk factors, and Biomarkers Predicting Ischemic or Hemorrhagic Stroke Associated Acute Kidney Injury and Outcome: A Retrospective Study in a General Intensive Care Unit
Conclusions: Among stroke patients in ICU, we identified significant risk factors of stroke-associated AKI. Serum CysC level at ICU admission was an important biomarker for predicting AKI and 28-day mortality.Blood Purif (Source: Blood Purification)
Source: Blood Purification - March 20, 2019 Category: Hematology Source Type: research

Burden, Access, and Disparities in Kidney Disease
Kidney disease is a global public health problem, affecting over 750 million persons worldwide. The burden of kidney disease varies substantially across the world. In many settings, rates of kidney disease and the provision of its care are defined by socioeconomic, cultural, and political factors leading to significant disparities. World Kidney Day 2019 offers an opportunity to raise awareness of kidney disease and highlight disparities in its burden and current state of global capacity for prevention and management. Here, we highlight the need for strengthening basic infrastructure for kidney care services for early detec...
Source: Blood Purification - March 14, 2019 Category: Hematology Source Type: research

Prelims
Blood Purif 2019;47:193 –195 (Source: Blood Purification)
Source: Blood Purification - March 7, 2019 Category: Hematology Source Type: research

Prelims
Blood Purif 2019;47(suppl 1):I –III (Source: Blood Purification)
Source: Blood Purification - March 7, 2019 Category: Hematology Source Type: research

The Effect of Serum Neutrophil Gelatinase-Associated Lipocalin on the Discontinuation of Continuous Renal Replacement Therapy in Critically Ill Patients with Acute Kidney Injury
Conclusions: Serum NGAL was a significant factor for predicting successful CRRT discontinuation in nonseptic AKI patients. However, urine output, rather than serum NGAL, was a significant predictor in septic AKI patients.Blood Purif (Source: Blood Purification)
Source: Blood Purification - March 7, 2019 Category: Hematology Source Type: research

The Association between Long- and Intra-Dialytic Blood Pressure Variability with All-Cause Mortality in Hemodialysis Patients
Conclusions: Our results suggest long-term SBP residual metric to be a better predictor of all-cause mortality in HD patients, which could be used as an additional target for BP management.Blood Purif (Source: Blood Purification)
Source: Blood Purification - February 26, 2019 Category: Hematology Source Type: research

Relationship between Serum Vitamin D Levels and Health-Related Quality of Life in Maintenance Hemodialysis Patients
Conclusion: We first showed the relationship between serum vitamin D levels and KDQOL-36 in hemodialysis patients. Lower serum vitamin D levels were negatively associated with burden of kidney disease, PCS, and MCS subscales.Blood Purif (Source: Blood Purification)
Source: Blood Purification - February 21, 2019 Category: Hematology Source Type: research

Role of Lipoprotein Apheresis in Cardiovascular Disease Risk Reduction
Conclusion: It was concluded that LA is a safe and effective technique that could be considered in the management of hypercholesterolemia and future risk. Randomized control trials would further support a role for LA as a therapeutic option.Blood Purif (Source: Blood Purification)
Source: Blood Purification - February 21, 2019 Category: Hematology Source Type: research

Misplacement of Tunneled Hemodialysis Catheter into Azygos Vein: Left or Right Jugular Insertion Has Similar Susceptibility
Conclusions: Based upon anatomical and case studies, we have found that AV may join posterior aspect of superior vena cava at different directions and levels. Hence, this might explain why AV misplacement might occur whether an HDC is inserted from the LIJV or RIJV approach. By raising the awareness of this potential complication and how we may minimize it, we hope to reduce the future complication of AV misposition.Blood Purif (Source: Blood Purification)
Source: Blood Purification - February 14, 2019 Category: Hematology Source Type: research

Uremic Patients with Increased Vascular Calcification Score Have Serum with High Calcific Potential: Role of Vascular Smooth Muscle Cell Osteoblastic Differentiation and Apoptosis
Conclusions: We conclude that VCS of end-stage renal disease patients significantly correlates with serum-calcific potential induced by high Pi. In addition, uremic patients with higher VCS have sera with a higher potential to induce VSMC osteoblastic trans-differentiation, apoptosis, and necrosis.Blood Purif (Source: Blood Purification)
Source: Blood Purification - February 6, 2019 Category: Hematology Source Type: research

Multi-Biomarkers Panel in Cardiac Surgery Patients
Blood Purif (Source: Blood Purification)
Source: Blood Purification - February 6, 2019 Category: Hematology Source Type: research

Abstracts
Blood Purif 2019;47:31 –37 (Source: Blood Purification)
Source: Blood Purification - February 4, 2019 Category: Hematology Source Type: research

ACUsmart Continuous Renal Replacement Therapy Platform: Multicenter Pilot Study for Technical and Clinical Assessment (A.M.P. Study)
Conclusion: ACUsmart is a new multifunctional machine that meets most of the features required in a fourth-generation CRRT equipment.Blood Purif (Source: Blood Purification)
Source: Blood Purification - February 1, 2019 Category: Hematology Source Type: research

Chronic Kidney Disease: Exploring Value-Based Healthcare as a Potential Viable Solution
Conclusion: The translation of VBHC into VBRC is possible and even desirable if an optimal treatment pathway for CKD patients could be achieved. This would require an organizational change in health system set up and should include a strategy focusing on full care responsibility. The patient outcome perspective and health economic analysis need to be the centre of attention.Blood Purif (Source: Blood Purification)
Source: Blood Purification - February 1, 2019 Category: Hematology Source Type: research

Maximum Glomerular Filtration Decline Rate is Associated with Mortality and Poor Renal Outcome in Chronic Kidney Disease Patients
Conclusions: The maximum of GFR decline rate was associated with mortality and poor renal outcome in CKD patients, independent of other contributive confounders.Blood Purif (Source: Blood Purification)
Source: Blood Purification - February 1, 2019 Category: Hematology Source Type: research

Ectopic Calcification of Fibrin Sheath on the Catheter
We describe a case of hemodialysis catheter that appeared to be encased in a sleeve-shaped fibrous sheath with calcification. Ectopic calcification is a serious complication in hemodialysis patients with calcium-phosphorus metabolism disorder. Clinical awareness and understanding of this condition is imperative to the prevention and management of ectopic calcification.Blood Purif (Source: Blood Purification)
Source: Blood Purification - January 31, 2019 Category: Hematology Source Type: research

Improved Control of Secondary Hyperparathyroidism in Hemodialysis Patients Switching from Oral Cinacalcet to Intravenous Etelcalcetide, Especially in Nonadherent Patients
Conclusions: Etelcalcetide was more effective than cinacalcet in this patient population, especially in the nonadherent subgroup, leading to better SHPT control without adverse effects.Blood Purif (Source: Blood Purification)
Source: Blood Purification - January 31, 2019 Category: Hematology Source Type: research

Effects of Peritoneal Dialysis on Clinical Factors and Functional Performance
Conclusion: The main determinants of KPSS trend were age, sex, and diabetes in new PD patients.Blood Purif (Source: Blood Purification)
Source: Blood Purification - January 31, 2019 Category: Hematology Source Type: research

Effects of Multidisciplinary Team Care Based on 5E ’s Renal Rehabilitation for Peritoneal Dialysis Patients in Guangxi Zhuang Autonomous Region of China: A Randomized Controlled Trial
Conclusions: MDT care based on 5E ’s renal rehabilitation is beneficial for patients undergoing PD and helpful to improve self-management ability and reduce the incidence of peritonitis.Blood Purif (Source: Blood Purification)
Source: Blood Purification - January 31, 2019 Category: Hematology Source Type: research

Clearance of Magnesium in Peritoneal Dialysis Patients: A Single-Center Study
Conclusions: Serum Mg could be partly cleared by PD. The peritoneal Mg clearance was positively related with serum Mg concentration, which was concentration-dependent. Peritoneal Mg clearance was negatively correlated with the residual renal function, while being positively correlated with the nutritional status and daily peritoneal protein loss. Peritoneal Mg clearance was higher in patients with high transport characteristics or CAPD.Blood Purif (Source: Blood Purification)
Source: Blood Purification - January 31, 2019 Category: Hematology Source Type: research

Study on the Prevalence of Vascular Calcification in Different Types of Arteries and Influencing Factors in Maintenance Peritoneal Dialysis Patients
Conclusions: In PD patients, the occurrence of large artery calcification was higher than others. Among different sites of VC, the abdominal aortic calcification was most likely to occur, and the proportion of small artery calcification was low. Calcification of medium and small arteries can exist alone without calcification of large artery. Large artery calcification was more likely to occur in patients with older age, longer dialysis duration, lower baseline serum iPTH levels and higher CCI scores. Patients with higher CCI scores, higher baseline TG and lower baseline iPTH, and time-average iPTH were more likely to devel...
Source: Blood Purification - January 31, 2019 Category: Hematology Source Type: research

Sclerostin/Receptor Related Protein 4 and Ginkgo Biloba Extract Alleviates β-Glycerophosphate-Induced Vascular Smooth Muscle Cell Calcification By Inhibiting Wnt/β-Catenin Pathway
Conclusion:β-GP induced VSMC calcification by activating the Wnt/β-catenin signaling pathway. Sclerostin and Lrp4 were involved in β-GP-induced VSMC calcification and play an important role. GBE could alleviate VSMC calcification induced by β-GP through inhibiting the Wnt/β-catenin signaling pathway.Blood Purif (Source: Blood Purification)
Source: Blood Purification - January 31, 2019 Category: Hematology Source Type: research

Meta-Analysis of the Association between Fibroblast Growth Factor 23 and Mortality and Cardiovascular Events in Hemodialysis Patients
Conclusions: Elevated serum FGF23 levels are positively associated with all-cause mortality and cardiovascular events in hemodialysis patients, with a 14 or 39% increase in all-cause mortality and a 21% increased risk of cardiovascular events.Blood Purif (Source: Blood Purification)
Source: Blood Purification - January 31, 2019 Category: Hematology Source Type: research

Differential Molecular Modeling Predictions of Mid and Conventional Dialysate Flows
Conclusion: A QD of 300 mL/min can achieve urea clearance targets. Hemodialysis systems using mid-rate QD can be expected to provide adequate hemodialysis, as currently defined.Blood Purif (Source: Blood Purification)
Source: Blood Purification - January 31, 2019 Category: Hematology Source Type: research

Preface – Advances in CKD 2019
Blood Purif (Source: Blood Purification)
Source: Blood Purification - January 13, 2019 Category: Hematology Source Type: research

The Application Analysis of Multiplex Real-Time Polymerase Chain Reaction Assays for Detection of Pathogenic Bacterium in Peritoneal Dialysis-Associated Peritonitis
Conclusion: Our results demonstrated that the multiplex RT-PCR can detect several kinds of bacteria simultaneously and it is also more practical and convenient than monoplex RT-PCR.Blood Purif (Source: Blood Purification)
Source: Blood Purification - January 3, 2019 Category: Hematology Source Type: research

Could there be Haemodynamic Stress Effects on Pro-Inflammatory CD14+CD16+ Monocytes during Convective-Diffusive Treatments? A Prospective Randomized Controlled Trial
Conclusion: We found that Mixed OL-HDF could inhibit the CD14+CD16+ peripheral blood lymphocytes related to a less hemorheology stress inside capillary dialysis filter but in this study there is not still ascertainable its superiority compared to post OL-HDF and post OL-HEH.Blood Purif (Source: Blood Purification)
Source: Blood Purification - January 3, 2019 Category: Hematology Source Type: research

Patient-Centric User-Interface in Automated Peritoneal Dialysis: Impact on Training and Outcomes at a Single Center
Conclusion: AMIA cycler is superior to the conventional cycler in significantly reducing the training time while having similar clinical outcomes. Further studies are needed to validate this data.Blood Purif (Source: Blood Purification)
Source: Blood Purification - January 3, 2019 Category: Hematology Source Type: research

Abstracts
Blood Purif (Source: Blood Purification)
Source: Blood Purification - December 20, 2018 Category: Hematology Source Type: research