Biomarkers in Cardiac Surgery
Blood Purif (Source: Blood Purification)
Source: Blood Purification - July 4, 2019 Category: Hematology Source Type: research

Erratum
Blood Purif 2019;48:1 (Source: Blood Purification)
Source: Blood Purification - July 3, 2019 Category: Hematology Source Type: research

Where Is the Catheter? Identifying Misplacement of a Dialysis Catheter. Reply to Dr. Zhang et al.
Blood Purif (Source: Blood Purification)
Source: Blood Purification - June 19, 2019 Category: Hematology Source Type: research

Safety and Efficacy of Regional Citrate Anticoagulation during Plasma Adsorption Plus Plasma Exchange Therapy for Patients with Acute-on-Chronic Liver Failure: A Pilot Study
Conclusions: RCA might be safe and effective in patients with ACLF receiving plasma adsorption plus PE therapy. RCA method might offer an alternative anticoagulation method for them.Blood Purif (Source: Blood Purification)
Source: Blood Purification - June 19, 2019 Category: Hematology Source Type: research

Are We Barking Up the Wrong Tree? Rise in Serum Creatinine and Heart Failure
A significant subset of patients with heart failure (HF) experience small to moderate rise in serum creatinine (RSC) in the setting of otherwise beneficial therapies such as aggressive diuresis or renin-angiotensin-aldosterone system (RAAS) inhibition. Accumulating data suggest that RSC in this setting is dissimilar from conventional causes of renal insult in that it has a negligible impact on the outcomes. There is also emerging evidence on the lack of association between biomarkers of renal injury and RSC in the setting of aggressive diuresis. A similar pattern has been observed in recent hypertension trials where the RS...
Source: Blood Purification - June 19, 2019 Category: Hematology Source Type: research

Prelims
Blood Purif 2019;19:I –II (Source: Blood Purification)
Source: Blood Purification - June 5, 2019 Category: Hematology Source Type: research

Abstracts
Blood Purif (Source: Blood Purification)
Source: Blood Purification - May 22, 2019 Category: Hematology Source Type: research

Contents Vol. 47, 2019
Blood Purif 2019;47:I –0 (Source: Blood Purification)
Source: Blood Purification - May 21, 2019 Category: Hematology Source Type: research

Rationale of Hemoadsorption during Extracorporeal Membrane Oxygenation Support
Extracorporeal membrane oxygenation (ECMO) and extracorporeal life support are increasingly used for treating various forms of shock, lung failure, protected interventions and life support including resuscitation. Most patients on ECMO are affected by a systemic inflammatory response caused by the underlying disease as well as the ECMO support itself, which contributes to vasoplegia, multi-organ failure, deterioration and death. Unfortunately, effective strategies for control of inflammation and related organ failure and shock on ECMO are lacking. Recently, a new polystyrene-based device for hemoadsorption, which aims to r...
Source: Blood Purification - May 17, 2019 Category: Hematology Source Type: research

Plasma Biomarkers in Predicting Renal Recovery from Acute Kidney Injury in Critically Ill Patients
Conclusions: pNGAL and pBNP can improve the accuracy of clinical parameters in predicting AKI recovery and a full model using biomarkers together with age achieved adequate discrimination.Blood Purif (Source: Blood Purification)
Source: Blood Purification - May 10, 2019 Category: Hematology Source Type: research

The Role of Supportive Treatment in the Management of Hyperammonemia in Neonates and Infants
Conclusions: CRRT achieves timely control of hypeammonemic states. Hemodynamic instability necessitating intervention with vasoactive medications is a common finding in patients with hyperammonemia.Blood Purif (Source: Blood Purification)
Source: Blood Purification - May 8, 2019 Category: Hematology Source Type: research

Where Is the Catheter? Identifying Misplacement of a Dialysis Catheter
Blood Purif (Source: Blood Purification)
Source: Blood Purification - May 8, 2019 Category: Hematology Source Type: research

Risk Factors for Primary Arteriovenous Fistula Dysfunction in Hemodialysis Patients: A Retrospective Survival Analysis in Multiple Medical Centers
Conclusion: These findings suggest that primary AVF dysfunction in HD patients is associated with gender, ageing, PLT counting number, hemoglobin level, and retention time of temporary catheter.Blood Purif (Source: Blood Purification)
Source: Blood Purification - May 8, 2019 Category: Hematology Source Type: research

Introduction
Blood Purif 2019;19: – (Source: Blood Purification)
Source: Blood Purification - May 6, 2019 Category: Hematology Source Type: research

Foreword
Blood Purif 2019;19: – (Source: Blood Purification)
Source: Blood Purification - May 6, 2019 Category: Hematology Source Type: research

Abstracts
Blood Purif 2019;19: – (Source: Blood Purification)
Source: Blood Purification - May 6, 2019 Category: Hematology Source Type: research

Effects of Beta-Blockers on Cardiovascular Events and Mortality in Dialysis Patients: A Systematic Review and Meta-Analysis
Conclusions:β-blockers seem to be associated with reduced mortality in patients on dialysis. Both the statistical heterogeneity in observational studies and the small number of participants and studies in RCTs limit the strength of these findings. Video Journal Club “Cappuccino with Claudio Ronco” at  htt ps://www.karger.com/Journal/ArticleNews/496083?sponsor=52Blood Purif (Source: Blood Purification)
Source: Blood Purification - May 5, 2019 Category: Hematology Source Type: research

Prelims
Blood Purif 2019;47(suppl 3):I –III (Source: Blood Purification)
Source: Blood Purification - May 5, 2019 Category: Hematology Source Type: research

What Have We Learned about the Use of Cytosorb Adsorption Columns?
Extracorporeal blood purification techniques have emerged and evolved in the recent years as a potential therapy for the purpose of immunomodulation in acute conditions like sepsis. Understanding the extent of immune system dysregulation involved in the pathophysiology of these conditions, resulted in the development of such treatment strategies aiming at restoring a balanced inflammatory response. Beyond conventional continuous renal replacement therapy, high volume hemofiltration, high cut-off membranes, adsorption alone and coupled plasma filtration adsorption are well-described techniques in the literature. The evidenc...
Source: Blood Purification - May 5, 2019 Category: Hematology Source Type: research

Serum Concentration of Indoxyl Sulfate in Peritoneal Dialysis Patients and Low-Flux Hemodialysis Patients
Conclusions: Dialysis modality is the independent risk factor of IS serum concentration and it is substantially lower in patients on CAPD than that in those on low-flux HD. Additionally, RRF was independently associated with IS serum concentration in CAPD patients, and the better the RRF is, the lower IS serum concentration.Blood Purif (Source: Blood Purification)
Source: Blood Purification - May 5, 2019 Category: Hematology Source Type: research

Fluid Dynamics Analysis by CT Imaging Technique of New Sorbent Cartridges for Extracorporeal Therapies
Conclusions: We may conclude that the structural and functional design of the studied cartridges is adequate for haemoperfusion with no channelling phenomena. This ensures maximum and optimal utilization of the sorbent contained in the devices.Blood Purif (Source: Blood Purification)
Source: Blood Purification - May 5, 2019 Category: Hematology Source Type: research

Routine Is the Worst Enemy of the Dialysis Patients: Reply to Drs Basile and Casino
Blood Purif (Source: Blood Purification)
Source: Blood Purification - May 5, 2019 Category: Hematology Source Type: research

Successful Treatment of Severe Hyperammonaemia with Ultra-High Dose Continuous Veno-Venous Haemodiafiltration
In this report, we describe a case of a 40-year-old postpartum woman who developed severe hyperammonaemia due to liver failure and acute kidney injury (AKI) combined with a large intra-abdominal haematoma producing nitrogen waste products. She was treated successfully with continuous veno-venous haemodiafiltration using an ultra-high effluent rate (100 mL/kg/h) and was discharged alive 32 days after the initial admission. Our report indicates that successful ammonia clearance in the setting of AKI can be obtained only by using this high effluent rate. This treatment modality should be considered in all patients with AKI an...
Source: Blood Purification - May 5, 2019 Category: Hematology Source Type: research

Adsorption of Protein-Bound Uremic Toxins Using Activated Carbon through Direct Hemoperfusion in vitro
Conclusion: Activated carbon effectively adsorbed blood PBUTs in vitro. DHP with activated carbon could be a promising strategy for removing circulating PBUTs from the blood of patients with CKD.Blood Purif (Source: Blood Purification)
Source: Blood Purification - May 5, 2019 Category: Hematology Source Type: research

Single Session and Weekly Beta 2-Microglobulin Removal with Different Dialytic Procedures: Comparison between High-Flux Standard Bicarbonate Hemodialysis, Post-Dilution Hemodiafiltration, Short Frequent Hemodialysis with NxStage Technology and Automated Peritoneal Dialysis
Conclusions: Weekly β2M removal efficiency proved equal and highest in HDF and NSO (at a 6/week prescription), slightly lesser in BHD and lowest in APD.Blood Purif (Source: Blood Purification)
Source: Blood Purification - May 5, 2019 Category: Hematology Source Type: research

Prelims
Blood Purif 2019;47(suppl 2):I –IV (Source: Blood Purification)
Source: Blood Purification - April 26, 2019 Category: Hematology Source Type: research

Author Index
Blood Purif 2019;47(suppl 2):106 (Source: Blood Purification)
Source: Blood Purification - April 26, 2019 Category: Hematology Source Type: research

Subject Index
Blood Purif 2019;47(suppl 2):107 (Source: Blood Purification)
Source: Blood Purification - April 26, 2019 Category: Hematology Source Type: research

Initiation Condition of Hemodialysis Is Independently Associated with All-Cause Mortality in Maintenance Hemodialysis Patients: A Retrospective Study
Conclusions: This study indicated that the status of HD initiation is a risk factor of long-term survival in MHD patients, which were usually ignored for lacking of nephrology care prior and could potentially be identified and modified to improve the survival prognosis. Video Journal Club “Cappuccino with Claudio Ronco” at  https://www.karger.com/Journal/ArticleNews/223997?sponsor=52Blood Purif (Source: Blood Purification)
Source: Blood Purification - April 26, 2019 Category: Hematology Source Type: research

From Multiple Organ Support Therapy to Extracorporeal Organ Support in Critically Ill Patients
Critically ill patients developing severe forms multiple organ dysfunction syndrome (MODS) may not be adequately supported by pharmacologic management. In these complex cases, a single form of extracorporeal organ support (ECOS) may be required, but multiple organ support therapy (MOST) is currently seen as a feasible approach. Severe renal dysfunction is a typical syndrome requiring renal replacement therapy (RRT) in the context of MODS. After more than a decade of RRT application in various intensive care settings, ECOS are not anymore seen as extraordinary or particularly aggressive techniques in MODS patients. Nowadays...
Source: Blood Purification - April 26, 2019 Category: Hematology Source Type: research

Routine Is the Worst Enemy of the Dialysis Patient
Blood Purif (Source: Blood Purification)
Source: Blood Purification - April 18, 2019 Category: Hematology Source Type: research

Counteracting the Metabolic Effects of Glucose Load in Peritoneal Dialysis Patients; an Exercise-Based Approach
Glucose-based peritoneal dialysis (PD) solutions are the predominantly used dialysate in PD patients. Glucose absorption has been shown to be associated with several unfavorable metabolic complications. Several studies have shown positive effects of exercise in end-stage renal disease patients. This paper provides an overview of glucose-associated metabolic complications, and proposed exercise regimens to counteract the caloric load associated with glucose absorption.Blood Purif (Source: Blood Purification)
Source: Blood Purification - April 15, 2019 Category: Hematology Source Type: research

Introduction
Blood Purif 2019;47(suppl 3):1 –2 (Source: Blood Purification)
Source: Blood Purification - April 15, 2019 Category: Hematology Source Type: research

Extracorporeal Blood Purification Therapies for Sepsis
Extracorporeal blood purification is proposed as an adjuvant therapy for sepsis, aiming at controlling the associated dysregulation of the immune system, which is known to induce organ dysfunctions. Different therapies have been developed to address certain steps of the immune dysregulation. Most of the available blood purification devices focus on a single target, such as the endotoxin that triggers the immune cascade, or the cytokine storm that causes organ damages. However, the highly adsorptive membrane named oXiris ® is a unique 4-in-1 device that combines cytokine and endotoxin removal properties, renal replaceme...
Source: Blood Purification - April 15, 2019 Category: Hematology Source Type: research

Practice of Extracorporeal Therapies for Septic Acute Kidney Injury Patients in Intensive Care Units in Mainland China
Background: Continuous renal replacement therapy (CRRT) and other extracorporeal therapies for acute kidney injury (AKI) and other organ dysfunction syndromes in critically ill patients are common in the intensive care unit (ICU). Many studies have focused on clinical practice for managing these conditions. However, there are few studies that describe the utilization of extracorporeal therapies, especially CRRT, in patients with sepsis-associated AKI.Summary: Two hundred ICU physicians were included in a survey from February 28, 2017, to March 20, 2017, on the current status of septic AKI and clinical practice in CRRT. Acc...
Source: Blood Purification - April 15, 2019 Category: Hematology Source Type: research

oXiris ® Use in Septic Shock: Experience of Two French Centres
This study reports our experience with the use of the oXiris ® membrane for septic shock patients requiring continuous renal replacement therapy (CRRT).Summary: Thirty-one patients were diagnosed with septic shock and underwent CRRT with the oXiris ® membrane between 2014 and 2019. We compared the observed hospital mortality with that predicted by the Simplified Acute Physiology Score II (SAPS II). Change in the Sequential Organ Failure Assessment (SOFA) score and of the main clinical and biological parameters over time were analyzed. Hospita l mortality was lower than predicted for the most severe patients (60 vs....
Source: Blood Purification - April 15, 2019 Category: Hematology Source Type: research

Sepsis Management with a Blood Purification Membrane: European Experience
Conclusion: In the absence of established guidelines, users of hollow-fibre purification devices such as oXiris may benefit from standardised approaches to selecting patients and initiating and terminating treatment, as well as measuring success. Further evidence in the form of randomised clinical trials is urgently required.Blood Purif 2019;47(suppl 3):1 –9 (Source: Blood Purification)
Source: Blood Purification - April 15, 2019 Category: Hematology Source Type: research

Hemofilter with Adsorptive Capacities: Case Report Series
Background: oXiris is a blood purification product that has been launched recently in China. In addition to renal function support and fluid management capabilities, it can also adsorb cytokines and endotoxins. This may complement standard treatment for septic acute kidney injury (AKI) patients to control the amplitude of systemic inflammatory response responsible for acute tissue and organ damage. Objectives of our study are to elucidate characteristics of septic AKI patients who respond to treatment with oXiris and to describe the performance of oXiris through patient cases in the absence of large randomized trials on cl...
Source: Blood Purification - April 15, 2019 Category: Hematology Source Type: research

Analysis of Endotoxin Adsorption in Two Swedish Patients with Septic Shock
Background: Lipopolysaccharide (endotoxin) from the outer Gram-negative bacterial wall can induce a harmful immunologic response, involving hemodynamic deprivation, and is one important motor driving the septic cascade. The positively charged poly-imine ethylene layer on the oXiris membrane is capable of adsorbing negatively charged endotoxin molecules and removing them from the blood compartment. Endotoxin is detrimental and should be removed from blood.Summary: The adsorbable endotoxin fraction in blood arises from a tight balance between seeding from an infectious focus and removal by an overwhelmed immune system. The n...
Source: Blood Purification - April 15, 2019 Category: Hematology Source Type: research

Continuous Renal Replacement Therapy with the Adsorbing Filter oXiris in Septic Patients: A Case Series
Conclusion: In sepsis/septic shock patients with AKI, CRRT with the adsorbing membrane oXiris may be safe and improves the cardiorenal – function and the clinical condition. The effect on cytokines and endotoxin may explain in part these results. A RCT is warranted to confirm these data.Blood Purif 2019;47(suppl 3):1 –5 (Source: Blood Purification)
Source: Blood Purification - April 15, 2019 Category: Hematology Source Type: research

Augmented Adsorptive Blood Purification during Continuous Veno-Venous Haemodiafiltration in a Severe Septic, Acute Kidney Injury Patient: Use of oXiris ®: A Single Centre Case Report
The use of the oXiris ® haemofilter during continuous veno-venous haemodiafiltration (CVVHDF) for acute kidney injury (AKI) and severe sepsis is not completely understood. Although this filter has in vitro adsorptive properties for blood-borne cytokines and other humoural mediators of sepsis, its clinical usefulness is uncertain. Given its inherent adsorptive limitation for septic mediators, we developed a CVVHDF protocol in which the oXiris haemofilter was electively changed every 12 h even though there was no clotting or adverse circuit pressures. Augmented filter membrane adsorption was conducted for 3 consecut ive ...
Source: Blood Purification - April 15, 2019 Category: Hematology Source Type: research

Prevalence and Severity of Itching in Patients with End-Stage Renal Disease: Treatment with Nalfurafine Hydrochloride
Conclusion: Better skin management is needed for itch in patients with ESRD or CKD. Moisturizing and lifestyle factors are important. Topical or oral medications may also be used. Nalfurafine, a κ receptor agonist, is now available in Japan for the treatment of uremic pruritus in these patients.Blood Purif 2019;47(suppl 2):1 –5 (Source: Blood Purification)
Source: Blood Purification - April 3, 2019 Category: Hematology Source Type: research

Pre- and Postdialysis Uric Acid Difference and Risk of Long-Term All-Cause and Cardiovascular Mortalities in Japanese Hemodialysis Patients; Miyazaki Dialysis Cohort Study
Conclusion: UAD correlated with all-cause mortality. UAD may be the most appropriate reference for controlling UA in HD patients.Blood Purif 2019;47(suppl 2):1 –6 (Source: Blood Purification)
Source: Blood Purification - April 3, 2019 Category: Hematology Source Type: research

Analysis of Extracellular Fluid Volume in Peritoneal Dialysis Patients before and after Kidney Transplantation
Conclusion: ECF volume and osmotic excess occurred in the PD and preemptive groups compared with the HD group pre-transplantation. Although PD maintains MDV and residual and total urine volume, ECF volume and osmotic excess should be monitored before transplant; pre-transplant HD support should always be considered in PD and preemptive transplant patients.Blood Purif 2019;47(suppl 2):1 –7 (Source: Blood Purification)
Source: Blood Purification - April 3, 2019 Category: Hematology Source Type: research

Differential Impacts of Intravenous Iron Administration and Iron-Containing Phosphate Binders on Serum Intact Fibroblast Growth Factor 23 Levels
Conclusion: Intravenous iron administration may influence intact FGF23 levels in HD patients independently of phosphate and iron metabolism.Blood Purif 2019;47(suppl 2):1 –7 (Source: Blood Purification)
Source: Blood Purification - April 3, 2019 Category: Hematology Source Type: research

Significance of Content of the Reticulocyte Hemoglobin in the Management of Renal Anemia
This report presents the clinical significance of CHr, the potential use of CHr for the diagnosis of iron deficiency, and tests for optimal iron level using CHr as performed in our hospital.Blood Purif 2019;47(suppl 2):1 –4 (Source: Blood Purification)
Source: Blood Purification - April 3, 2019 Category: Hematology Source Type: research

Complications During Continuous Renal Replacement Therapy in Critically Ill Neonates
Conclusion: Complications during CRRT in neonates comprised IDH at the start of the CRRT, body temperature decline, and thrombocytopenia. These complications need to be analyzed for a safe neonatal CRRT.Blood Purif 2019;47(suppl 2):1 –7 (Source: Blood Purification)
Source: Blood Purification - April 3, 2019 Category: Hematology Source Type: research

Aortic Arch Calcification and Bone-Associated Molecules in Peritoneal Dialysis Patients
Conclusion: AoAC progression was associated with increased aortic stiffness. OPG may be associated with AoAC progression in CAPD.Blood Purif 2019;47(suppl 2):1 –7 (Source: Blood Purification)
Source: Blood Purification - April 3, 2019 Category: Hematology Source Type: research

Serum Magnesium Levels and Mortality in Japanese Maintenance Hemodialysis Patients
Conclusions: Hypermagnesemia tended to be associated with better survival and a higher prescription rate of MgO. Interventional studies are needed to clarify whether Mg supplementation is beneficial for improving patient prognosis.Blood Purif 2019;47(suppl 2):1 –7 (Source: Blood Purification)
Source: Blood Purification - April 3, 2019 Category: Hematology Source Type: research

Strategies for the Super-Aged Dialysis Population: Survival Benefits or Alternative Goals?
Conclusion: Survival of the super-aged population has not improved in the last 2 decades. Thus, withholding or withdrawing dialysis and providing conservative management without dialysis treatment could be an important option for patients aged 90 years or older.Blood Purif 2019;47(suppl 2):1 –11 (Source: Blood Purification)
Source: Blood Purification - April 3, 2019 Category: Hematology Source Type: research