Polymethylmethacrylate Membrane Dialyzer: Historic but Modern
Polymethylmethacrylate (PMMA) hollow fiber membranes are one of the synthetic polymer hollow fiber membranes used to the hollow fiber artificial kidney. A PMMA hollow fiber membrane (PMMA membrane) has unique properties including the uniform structure and the adsorption property. Hemodialyzers using PMMA membranes, Filtryzer ®, were approved in Japan in 1977 and have been used worldwide for over 40 years and so is a historical hemodialyzer.Various types in Filtryzer® having different pore sizes are developed and used in the clinical field. Filtryzer® B3 is a low-flux dialyzer. Filtryzer® BK has three types having di ff...
Source: Blood Purification - October 20, 2022 Category: Hematology Source Type: research

Plasma Circulating Tumor Necrosis Factor Receptors at Multiple Time Points Can Predict the Outcome of Severe Acute Kidney Injury
Conclusion: Plasma cTNFR1 concentrations at CRRT initiation and changes in cTNFR1 and 2 levels immediately following CRRT initiation are significant biomarkers for predicting the outcomes of patients with severe AKI.Blood Purif (Source: Blood Purification)
Source: Blood Purification - October 20, 2022 Category: Hematology Source Type: research

“Inflammasome” Activity in Dialysis Patients: The Need to Go beyond Membrane Separation Mechanisms
Blood Purif (Source: Blood Purification)
Source: Blood Purification - October 12, 2022 Category: Hematology Source Type: research

Comparison of High-Flux, Super High-Flux, Medium Cut-Off Hemodialysis and Online Hemodiafiltration on the Removal of Uremic Toxins
Conclusion: This study confirms that albumin loss and removal of MM are similar using conventional Elisio 21H ™ OL-HDF, MCO-HD, and SHF type V dialyzers. Although Renak PS-2.0W™ OL-HDF provides high performance for MM depuration, this protein-permeable dialyzer should not be used in OL-HDF because of excessive albumin loss.Blood Purif (Source: Blood Purification)
Source: Blood Purification - October 10, 2022 Category: Hematology Source Type: research

Barriers to Home Haemodialysis
Conclusion: Most patients who choose HHD do not receive HHD. Many patients never start HHD because of potentially reversible barriers including inadequate communication among clinicians about patient choices, patients changing their minds once in a dialysis unit, and inadequate timely training support.Blood Purif (Source: Blood Purification)
Source: Blood Purification - October 7, 2022 Category: Hematology Source Type: research

Subjective Thirst in Relation to Interdialytic Weight Gain: A Systematic Review of Observational Studies
Conclusion: These data suggest that strategies are needed to reduce thirst to control IDWG in HD patients.Blood Purif (Source: Blood Purification)
Source: Blood Purification - October 4, 2022 Category: Hematology Source Type: research

A Novel Anticoagulation Method Based on Electrochemical Characteristics of Blood: An in vitro Study
This in vitro experimental investigation aimed to provide a novel method for preventing blood clotting based on the electrochemical characteristics of blood. Using this method in cases such as dialysis can minimize the risk of blood clots and also avoid hemorrhagic risk for patients. Blood samples were collected from 13 sheep (45 kg) (25 mL), and the clotting time (CT) was measured using a 20-min cutoff after they were separated into control and experimental samples. The test blood sample was put in a cell designed with two aluminum electrodes (positive pole/anode) located in a container containing 0.9% sodium chloride (as...
Source: Blood Purification - September 20, 2022 Category: Hematology Source Type: research

Vancomycin Adsorption during in vitro Model of Hemoperfusion with Mini-Module of HA380 Cartridge
Conclusion: HA380 adsorbs significant amounts of vancomycin. Adjusting the achieved results with the experimental mini-module to a full-scale cartridge, a total of 25 g of antibiotic can be removed. This might have affected outcome results in clinical trials. This suggests prescribing administration to critically ill patients requiring hemoperfusion, immediately after or in the inter-session time window. In case of administration during hemoperfusion, adequate adjustment and plasma level monitoring is strongly recommended.Blood Purif (Source: Blood Purification)
Source: Blood Purification - September 12, 2022 Category: Hematology Source Type: research

Effect of Hemadsorption Therapy in Critically Ill Patients with COVID-19 (CYTOCOV-19): A Prospective Randomized Controlled Pilot Trial
Conclusion: HT was associated with a non-significant trend toward clinical improvement within the intervention period. In selected patients, HT might be an option for stabilization before transfer and further therapeutic decisions. This finding warrants further investigation in larger trials.Blood Purif (Source: Blood Purification)
Source: Blood Purification - September 8, 2022 Category: Hematology Source Type: research

Extracorporeal Carbon Dioxide Removal in Patients with Acute Respiratory Distress Syndrome or Chronic Obstructive Pulmonary Disease: A Systematic Review and Meta-Analysis
Conclusions: In conclusion, there was no statistically significant difference in the prognosis of patients with and without ECCO2R treatment. ECCO2R significantly reduced PaCO2 and improved PaO2/FiO2 and pH values in patients with ARDS or COPD. Bleeding was the most common ECCO2R-related AE.Blood Purif (Source: Blood Purification)
Source: Blood Purification - August 29, 2022 Category: Hematology Source Type: research

Protein Loss in Peritoneal Effluent: Different Meaning for 24-h versus PET Samples
Conclusion: Different methods sign different pathophysiological pathways. PET protein loss quantification should be regarded as a marker of peritoneal membrane intrinsic permeability. Measurements of a 24-h sample might be closer to patients ’ clinical status and prognosis, signalizing opportunities for therapy intervention.Blood Purif (Source: Blood Purification)
Source: Blood Purification - August 29, 2022 Category: Hematology Source Type: research

Risk Factors and Prognosis of Acute Kidney Injury after Cardiac Surgery in Patients with Chronic Kidney Disease
Conclusions: In the population of patients with CKD, the incidence of CSA-AKI was high, which significantly affected renal and overall prognosis. The prompt intervention of modifiable factors may help improve the prognosis of patients with CKD.Blood Purif (Source: Blood Purification)
Source: Blood Purification - August 26, 2022 Category: Hematology Source Type: research

Histopathological Changes of Long-Term Peritoneal Dialysis Using Physiological Solutions: A Case Report and Review of the Literature
Conclusions: While the biopsy was reassuring with respect to the absence of EPS, significant histopathological changes suggest that avoiding pH trauma may not ameliorate the effects of glucose exposure in long-term PD.Blood Purif (Source: Blood Purification)
Source: Blood Purification - August 25, 2022 Category: Hematology Source Type: research

Exercise in Dialysis: Ready for Prime Time?
It is widely acknowledged that patients with end-stage kidney disease receiving maintenance hemodialysis (HD) may benefit from increasing their physical activity levels. Decades of exercise-related clinical trials have demonstrated improvements in various metrics related to dialysis patient ’s health and quality of life. Yet, the implementation of exercise programs in dialysis clinics today is scarce, and physical inactivity and dysfunction remain a hallmark of the disease. To address this issue, many groups worldwide are beginning to rethink how physical activity and exercise are pr escribed in HD patients, as well as h...
Source: Blood Purification - August 25, 2022 Category: Hematology Source Type: research

Randomized Control Study on Hemoperfusion Combined with Hemodialysis versus Standard Hemodialysis: Effects on Middle-Molecular-Weight Toxins and Uremic Pruritus
Conclusion: The long-term HP + HD can reduce β2M and PTH levels and improve pruritus in MHD patients independently on the use of high- or low-flux dialyzers, showing that the results are linked to the effect of adsorption.Blood Purif (Source: Blood Purification)
Source: Blood Purification - August 11, 2022 Category: Hematology Source Type: research