Protocol and Baseline Data on Renal Autologous Cell Therapy Injection in Adults with Chronic Kidney Disease Secondary to Congenital Anomalies of the Kidney and Urinary Tract
Conclusion: REACT is demonstrating feasibility and patient safety in preliminary analysis. Autologous cell therapy treatment has the potential to stabilize or improve renal function in CAKUT-associated CKD to delay or avert dialysis. Patient enrollment and follow-up are underway.Blood Purif (Source: Blood Purification)
Source: Blood Purification - March 1, 2021 Category: Hematology Source Type: research
Comparison of Approaches for Prediction of Renal Replacement Therapy-Free Survival in Patients with Acute Kidney Injury
Conclusions: A MLP + LSTM model outperformed other approaches for predicting RRTFS. Performance could be further improved by incorporating other data types.Blood Purif (Source: Blood Purification)
Source: Blood Purification - February 25, 2021 Category: Hematology Source Type: research
Higher Prevalence of Concurrent Thrombocytopenia in Patients Receiving Continuous Renal Replacement Therapy in the Cardiac Intensive Care Unit
Conclusion: Safe delivery of dialysis care in the ICU is paramount and creating awareness of potential risks such as concurrent TCP in patients receiving CRRT should be part of this care.Blood Purif (Source: Blood Purification)
Source: Blood Purification - February 25, 2021 Category: Hematology Source Type: research
Antibiotics Removal by Continuous Venovenous Hemofiltration with a Novel Asymmetric Triacetate Membrane Hemofilter: An in vitro Study
Conclusions: The clearances and SCs presented are comparable with findings of other authors. Meropenem and vancomycin, which exhibit low and medium PB, respectively, were strongly removed, while considerably less daptomycin was removed because of its high PB. Our results suggest that in clinical use of the tested antibiotics during CRRT with the ATA hemofilter, the same factors have to be considered for determining the dosing strategy as with filters with other commonly applied membrane materials.Blood Purif (Source: Blood Purification)
Source: Blood Purification - February 25, 2021 Category: Hematology Source Type: research
Health Outcomes and Cost Considerations of Assisted Peritoneal Dialysis: A Narrative Review
Background: Peritoneal dialysis (PD) is underutilized in many parts of the world despite pro-PD health policies. The physical and cognitive demands of PD means that over half of eligible patients require some form of assistance. As such, many countries now offer assisted PD (aPD) programs to help patients start or stay on PD as opposed to in-center hemodialysis (HD). In order to evaluate the potential scope of aPD, it is important to review the outcomes and cost considerations of aPD.Summary: We reviewed available data from different countries and regions for health outcomes between aPD and in-center HD, with a focus on qu...
Source: Blood Purification - February 24, 2021 Category: Hematology Source Type: research
Elevated Serum Trimethylamine N-Oxide Levels Are Associated with Mortality in Male Patients on Peritoneal Dialysis
Conclusions: Higher serum TMAO levels were independently associated with all-cause and CV mortality in male patients treated with PD.Blood Purif (Source: Blood Purification)
Source: Blood Purification - February 17, 2021 Category: Hematology Source Type: research
Sleep Apnea as a Cardiorenal Risk Factor in CKD and Renal Transplant Patients
Background: Chronic kidney disease (CKD) is a public health priority of increasing concern worldwide. Sleep apnea (SA) of moderate-to-severe degree has a 3 –9% prevalence in women and 10–17% in men in the general population.Summary: In CKD patients, the prevalence of SA parallels the decline of the GFR being 27% in CKD patients with a GFR of #x3e;60 mL/min/1.73 m2 and 57% in patients with end-stage kidney disease (ESKD). In the early CKD stages, fluid overload is probably the sole risk factor for SA in this population. At more severe CKD stages, disturbed central and peripheral chemosensitivity and the accumulation of ...
Source: Blood Purification - February 15, 2021 Category: Hematology Source Type: research
Effects of Polymyxin B Hemoperfusion on Septic Shock Patients Requiring Noradrenaline: Analysis of a Nationwide Administrative Database in Japan
Conclusion: Analysis of large Japanese databases showed that septic shock patients who received noradrenaline might benefit from PMX treatment.Blood Purif (Source: Blood Purification)
Source: Blood Purification - February 12, 2021 Category: Hematology Source Type: research
Recent Understanding of Peritoneal Pathology in Peritoneal Dialysis Patients in Japan
The thin peritoneum covering the peritoneal cavity has been used as a dialysis membrane for peritoneal dialysis (PD) because it is highly vascularized and has a large body surface area. However, it has been reported that peritoneal membranes affected by peritonitis, as well as those exposed to the nonphysiological high glucose levels containing PD dialysate, may undergo histological and functional changes. Patients undergoing PD may experience encapsulating peritoneal sclerosis (EPS), which is a life-threatening serious complication of PD that can significantly impair activities of daily living. The incidence of EPS was 1....
Source: Blood Purification - February 10, 2021 Category: Hematology Source Type: research
Association of Retinol-Binding Protein 4 with Arteriovenous Fistula Dysfunction in Hemodialysis Patients
Conclusions: HD patients with higher serum RBP4 concentrations had a relevant higher incidence of arteriovenous dysfunction events. Serum RBP4 level was an independent risk factor for AVF dysfunction events in HD patients.Blood Purif (Source: Blood Purification)
Source: Blood Purification - February 8, 2021 Category: Hematology Source Type: research
Measurement of the Concentration of Citrate in Human Biofluids in Patients Undergoing Continuous Renal Replacement Therapy Using Regional Citrate Anticoagulation: Application of a Two-Step Enzymatic Assay
Conclusions: Plasma concentrations of citrate rose significantly during episodes of CRRT using RCA returning back to normal after cessation of treatment.Blood Purif (Source: Blood Purification)
Source: Blood Purification - February 5, 2021 Category: Hematology Source Type: research
Improvements in Inflammation and Calcium Balance of Citrate versus Acetate as Dialysate Buffer in Maintenance Hemodialysis: A Unicentric, Cross-Over, Prospective Study
Conclusions: The use of citrate provides interesting advantages when compared to acetate. It maintains iCa levels stable during dialysis sessions with a neutral or negative effect on calcium balance, and it improves the chronic inflammatory condition that comes with long-time hemodialysis treatment. These beneficial effects may lead to an improvement in clinical outcomes.Blood Purif (Source: Blood Purification)
Source: Blood Purification - February 3, 2021 Category: Hematology Source Type: research
Effect of -55C/T Polymorphism of Uncoupling Protein 3 Gene on Risk for New-Onset Diabetes in Chinese Peritoneal Dialysis Patients: A Prospective Cohort Study
Conclusions: The variant of T allele of UCP3 −55C/T polymorphism was an independent predictor for NOD in PD patients. Early identification of the genotype may provide scientific basis for patients’ clinic management.Blood Purif (Source: Blood Purification)
Source: Blood Purification - February 3, 2021 Category: Hematology Source Type: research
How to Reduce the Risk of Arteriovenous Fistula Dysfunction by Observing Prepump Arterial Pressure during Hemodialysis: A Multicenter Retrospective Study
Conclusions: The appropriate range of |Pa/Qb| is between 0.30 and 0.52. When |Pa/Qb| is #x3c;0.30 or #x3e;0.52, the patient ’s AVF function or Qb setting should be reevaluated to prevent subsequent failure.Blood Purif (Source: Blood Purification)
Source: Blood Purification - February 2, 2021 Category: Hematology Source Type: research
Inflated Cost Burden of Hemodialysis during COVID-19 Pandemic
Blood Purif (Source: Blood Purification)
Source: Blood Purification - February 1, 2021 Category: Hematology Source Type: research
