Hemoperfusion in Maintenance Hemodialysis Patients
The accumulation of protein-bound uremic toxins and medium-large molecule toxins in maintenance hemodialysis (MHD) patients is one of the causes of long-term dialysis-related complications. Hemoperfusion can remove these uremic toxins and reduce the complications of MHD patients. Upon a review of the Chinese and international literature, combined with practical experience of clinical diagnosis and treatment, the Shanghai Medical Association Society of Nephrology reached a consensus on the clinical applications of hemoperfusion in MHD patients. This consensus included four aspects: selection of appropriate patients, treatme...
Source: Blood Purification - August 11, 2022 Category: Hematology Source Type: research
The Promise of Adsorption for Chronic Dialysis Patients
Blood Purif (Source: Blood Purification)
Source: Blood Purification - August 11, 2022 Category: Hematology Source Type: research
Molecular Insights and Novel Approaches toward Individualized Arteriovenous Fistula Care
The aim of the paper is to summarize the current understanding of the molecular biology of arteriovenous fistula (AVF). It intends to encourage vascular access teams, care providers, and scientists, to explore new molecular tools for assessing the suitability of patients for AVF as vascular access for maintenance hemodialysis (HD). This review also highlights most recent discoveries and may serve as a guide to explore biomarkers and technologies for the assessment of kidney disease patients choosing to start kidney replacement therapy. Objective criteria for AVF eligibility are lacking partly because the underlying physiol...
Source: Blood Purification - August 2, 2022 Category: Hematology Source Type: research
Efficacy and Safety of a Low-Flow Extracorporeal Carbon Dioxide Removal System in Acute Respiratory Failure, a Pilot Study in China
Conclusion: Our clinical series indicated that LF-ECCO2R seemed to be safely applied in patients with acute respiratory failure. The efficacy of CO2 removal as well as the improved respiratory parameters was also observed. However, large-scale randomized clinical trials are needed to confirm the effects.Blood Purif (Source: Blood Purification)
Source: Blood Purification - July 27, 2022 Category: Hematology Source Type: research
Optimizing Perioperative Renal Replacement Therapy for Patients Undergoing Cardiac Surgical Procedures Requiring Cardiopulmonary Bypass
Coronary artery disease is highly prevalent in patients with end-stage renal disease (ESRD), and cardiovascular complications remain the most common cause of death in this patient population. Accordingly, many cardiac surgical procedures requiring cardiopulmonary bypass support are performed on these patients each year, with morbidity and mortality rates far exceeding patients without ESRD. Anuric patients lack the normal renal homeostatic functions which typically allow for physiologic protection from challenges during the operation, such as volume overload, hyperkalemia, and acidemia. Careful preoperative planning and co...
Source: Blood Purification - July 25, 2022 Category: Hematology Source Type: research
A New Procedure for Guidewire Exchange of Tunneled Hemodialysis Catheters in Chronic Hemodialysis Patients: A Pilot Study
This study was carried out to assess the feasibility of a new procedure in chronic HD patients who needed catheter exchange because of mechanical dysfunction.Methods: The guidewire exchange method was based on the creation of a new exit site and a new subcutaneous tunnel while using the same venous insertion site. This was a retrospective study of exchanged tunneled catheters because of mechanical complications in patients on chronic HD between June 1, 2015, and December 31, 2019. The feasibility of the procedure was defined by successful exchange and catheter patency at 6 months. Catheter survival and immediate complicati...
Source: Blood Purification - July 6, 2022 Category: Hematology Source Type: research
Prolonged Intermittent Renal Replacement Therapy Combined with Hemoperfusion Can Improve Early Recovery of Moderate and Severe Acute Pancreatitis, Especially in Patients with Acute Kidney Injury
Conclusion: PIRRT + HP therapy could not only improve the general conditions, as measured by APACHE II score, but also reduce the inflammatory cascade of patients with acute pancreatitis. For MSAP and SAP patients complicated with AKI, this therapy may accelerate the recovery of renal function.Blood Purif (Source: Blood Purification)
Source: Blood Purification - July 4, 2022 Category: Hematology Source Type: research
Extracorporeal Blood Purification in Burns: For Whom, Why, and How?
Patients with serious thermal burn injuries require immediate and specialized care in order to minimize morbidity and mortality. Optimal fluid resuscitation, nutritional support, pulmonary care, burn wound care, and infection control practices represent key aspects of patient care in burn centers. When severely burned, the patient usually presents a systemic inflammatory response syndrome, soon balanced by a counter anti-inflammatory response syndrome. These may lead to immune dysregulation/exhaustion favoring infectious complications that dramatically impair the prognosis of burn patients. This narrative review provides a...
Source: Blood Purification - June 23, 2022 Category: Hematology Source Type: research
New Targets for Extracorporeal Blood Purification Therapies in Sepsis
As highlighted by the last international consensus definition for sepsis and septic shock (sepsis-3), sepsis comes from a complex relationship between a pathogen and a dysregulated host response. To date, the treatment of sepsis is based on antimicrobial treatment, source control, and organ support. Extracorporeal blood purification therapies have been proposed as adjuvant therapies to modulate the dysregulated inflammatory response. These therapies aim mostly at removing inflammatory mediators (cytokines) and endotoxins from the blood. However, so far, they failed to clearly demonstrate an improvement in patient survival ...
Source: Blood Purification - June 17, 2022 Category: Hematology Source Type: research
Erratum
Blood Purif (Source: Blood Purification)
Source: Blood Purification - June 7, 2022 Category: Hematology Source Type: research
Polymyxin B Hemoperfusion in Septic Shock: Finding the Right Patients by Analyzing Real-World Big Data
Blood Purif (Source: Blood Purification)
Source: Blood Purification - June 2, 2022 Category: Hematology Source Type: research
Effect of oXiris-CVVH on the Clinical Outcomes of Patients with Septic Shock: An Inverse Probability of Treatment-Weighted Analysis
Conclusions: For septic shock patients, the use of oXiris-CVVH was associated with lower mortality and appeared to reduce lactate, NE dosage, PCT, and WBC counts, as compared to AN69-CVVH.Blood Purif (Source: Blood Purification)
Source: Blood Purification - June 1, 2022 Category: Hematology Source Type: research
Validation of a Protocol for Continuous Hemodiafiltration with Regional Citrate Anticoagulation with Omni ®
Conclusion: The proposed protocol for CVVHDF-RCA for Omni ® was associated with similar circuit lifetime, number of required adaptations and clearances to standard CVVHD-RCA. It appears to be safe and feasible.Blood Purif (Source: Blood Purification)
Source: Blood Purification - May 30, 2022 Category: Hematology Source Type: research
Improving Solute Clearances by Hemodialysis
The adequacy of hemodialysis is now assessed by measuring the removal of the single-solute urea. The urea clearance provided by contemporary dialysis is a large fraction of the blood flow through the dialyzer and therefore cannot be increased much further. Other solutes however likely contribute more than urea to the residual uremic illness suffered by hemodialysis patients. We here review methods which could be employed to increase the clearance of nonurea solutes. We will separately consider the clearances of free low-molecular-mass solutes, free larger solutes, and protein-bound solutes. New clinical studies will be req...
Source: Blood Purification - May 25, 2022 Category: Hematology Source Type: research
Efficacy of Hemoperfusion in Severe and Critical Cases of COVID-19
Conclusion: Among critically ill COVID-19 patients, based on our study, the use of hemoperfusion may reduce the mortality rate and improve SPO2 and PaCO2.Blood Purif (Source: Blood Purification)
Source: Blood Purification - May 17, 2022 Category: Hematology Source Type: research
